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| | HTR2B | 5-hydroxytryptamine receptor 2B. (503 aa) |
| | NF1 | Neurofibromin 1. (2841 aa) |
| | P2RX7 | P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. Belongs to the P2X receptor family. (595 aa) |
| | GADD45A | Growth arrest and DNA damage inducible alpha. (165 aa) |
| | SPRY2 | Sprouty RTK signaling antagonist 2. (315 aa) |
| | MAP3K21 | Mitogen-activated protein kinase kinase kinase. (1035 aa) |
| | NLRP12 | NLR family pyrin domain containing 12. (1060 aa) |
| | DAXX | Death domain associated protein. (740 aa) |
| | MAPK10 | Mitogen-activated protein kinase. (467 aa) |
| | NENF | Neudesin neurotrophic factor; Belongs to the cytochrome b5 family. (158 aa) |
| | BRAP | BRCA1 associated protein. (669 aa) |
| | RIPK1 | Receptor interacting serine/threonine kinase 1. (670 aa) |
| | ATF2 | Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. (498 aa) |
| | MAPK6 | Mitogen-activated protein kinase 6. (722 aa) |
| | POU4F2 | POU domain protein. (392 aa) |
| | NOD2 | Nucleotide oligomerization domain 2 protein. (1013 aa) |
| | MAP4K5 | Mitogen-activated protein kinase kinase kinase kinase 5; May play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. (814 aa) |
| | MAPK4 | Mitogen-activated protein kinase 4. (552 aa) |
| | MAP3K11 | Mitogen-activated protein kinase kinase kinase 11. (839 aa) |
| | EDN1 | Big endothelin-1; Endothelins are endothelium-derived vasoconstrictor peptides (By similarity). Probable ligand for G-protein coupled receptors EDNRA and EDNRB which activates PTK2B, BCAR1, BCAR3 and, GTPases RAP1 and RHOA cascade in glomerular mesangial cells (By similarity). Belongs to the endothelin/sarafotoxin family. (202 aa) |
| | MAP3K10 | Mitogen-activated protein kinase kinase kinase. (935 aa) |
| | MAPK1 | Mitogen-activated protein kinase. (364 aa) |
| | MAPK3 | Mitogen-activated protein kinase. (381 aa) |
| | PRKCE | Protein kinase C epsilon type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays essential roles in the regulation of multiple cellular processes linked to cytoskeletal proteins, such as cell adhesion, motility, migration and cell cycle, functions in neuron growth and ion channel regulation, and is involved in immune response, cancer cell invasion and regulation of apoptosis. Mediates cell adhesion to the extracellular matrix via integrin- dependent signaling, by mediating angiotensin-2-induced activation of integrin beta- [...] (744 aa) |
| | MAPKAPK2 | MAP kinase-activated protein kinase 2; Stress-activated serine/threonine-protein kinase involved in cytokine production, endocytosis, reorganization of the cytoskeleton, cell migration, cell cycle control, chromatin remodeling, DNA damage response and transcriptional regulation. Following stress, it is phosphorylated and activated by MAP kinase p38-alpha/MAPK14, leading to phosphorylation of substrates. Phosphorylates serine in the peptide sequence, Hyd-X-R-X(2)-S, where Hyd is a large hydrophobic residue. Phosphorylates ALOX5, CDC25B, CDC25C, CEP131, ELAVL1, HNRNPA0, HSP27/HSPB1, KRT1 [...] (379 aa) |
| | CAV1 | Caveolin-1; May act as a scaffolding protein within caveolar membranes. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (By similarity). Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependen [...] (178 aa) |
| | MAP3K15 | Mitogen-activated protein kinase kinase kinase 15. (1301 aa) |
| | SPRY1 | Sprouty RTK signaling antagonist 1. (319 aa) |
| | GRB10 | Growth factor receptor bound protein 10. (550 aa) |
| | ASH1L | ASH1 like histone lysine methyltransferase. (2966 aa) |
| | MAP3K20 | Mitogen-activated protein kinase kinase kinase 20. (875 aa) |
| | MAPK7 | Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (818 aa) |
| | MAP3K5 | Mitogen-activated protein kinase kinase kinase 5. (1316 aa) |
| | TAOK1 | TAO kinase 1. (1001 aa) |
| | G1TBF0_RABIT | ANK_REP_REGION domain-containing protein. (621 aa) |
| | EGF | Pro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1198 aa) |
| | ARAF | A-Raf proto-oncogene, serine/threonine kinase. (606 aa) |
| | MAP4K3 | Mitogen-activated protein kinase kinase kinase kinase 3; May play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. (875 aa) |
| | MAP3K4 | Mitogen-activated protein kinase kinase kinase 4. (1496 aa) |
| | PEA15 | Proliferation and apoptosis adaptor protein 15. (128 aa) |
| | FLCN | Folliculin. (579 aa) |
| | MAP2K3 | Mitogen-activated protein kinase kinase 3. (374 aa) |
| | ADRA2B | Alpha-2B adrenergic receptor; Alpha-2 adrenergic receptors mediate the catecholamine- induced inhibition of adenylate cyclase through the action of G proteins. (411 aa) |
| | MOS | MOS proto-oncogene, serine/threonine kinase; Belongs to the protein kinase superfamily. (348 aa) |
| | NPHS1 | NPHS1 adhesion molecule, nephrin. (1251 aa) |
| | C1QL4 | Complement C1q like 4. (238 aa) |
| | GPS2 | G protein pathway suppressor 2. (327 aa) |
| | G1TWC2_RABIT | Uncharacterized protein. (93 aa) |
| | IGF1 | Insulin-like growth factor I; The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]- 2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse maturation. Ca(2+)-dependent exo [...] (195 aa) |
| | IL1B | Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. (234 aa) |
| | CAV3 | Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (151 aa) |
| | SCG2 | Secretogranin II. (621 aa) |
| | SORBS3 | Sorbin and SH3 domain containing 3. (665 aa) |
| | NFKB1 | Nuclear factor kappa B subunit 1. (968 aa) |
| | G1U373_RABIT | SRCR domain-containing protein; Belongs to the heparin-binding growth factors family. (200 aa) |
| | FGF23 | Fibroblast growth factor 23; Belongs to the heparin-binding growth factors family. (252 aa) |
| | EPGN | Epithelial mitogen. (188 aa) |
| | MAP3K9 | Mitogen-activated protein kinase kinase kinase 9. (829 aa) |
| | TRIB1 | Tribbles pseudokinase 1. (206 aa) |
| | BANK1 | B cell scaffold protein with ankyrin repeats 1. (786 aa) |
| | ZFP36L2 | ZFP36 ring finger protein like 2. (467 aa) |
| | SMAD3 | SMAD family member 3. (230 aa) |
| | PLVAP | Plasmalemma vesicle associated protein. (437 aa) |
| | ADRA1A | Alpha-1A adrenergic receptor; This alpha-adrenergic receptor mediates its action by association with G proteins that activate a phosphatidylinositol- calcium second messenger system. Its effect is mediated by G(q) and G(11) proteins. Nuclear ADRA1A-ADRA1B heterooligomers regulate phenylephrine (PE)-stimulated ERK signaling in cardiac myocytes (By similarity); Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRA1A sub-subfamily. (466 aa) |
| | PPM1L | Protein phosphatase, Mg2+/Mn2+ dependent 1L. (360 aa) |
| | MAP2K1 | Dual specificity mitogen-activated protein kinase kinase 1; Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Binding of extracellular ligands such as growth factors, cytokines and hormones to their cell-surface receptors activates RAS and this initiates RAF1 activation. RAF1 then further activates the dual-specificity protein kinases MAP2K1/MEK1 and MAP2K2/MEK2. Both MAP2K1/MEK1 and MAP2K2/MEK2 function specifically in the MAPK/ERK cascade, and catalyze the concomitant phosphorylation of a threonine and a tyrosine resid [...] (396 aa) |
| | MINK1 | Misshapen like kinase 1. (1337 aa) |
| | KARS1 | Lysine--tRNA ligase. (624 aa) |
| | IRAK1 | Interleukin 1 receptor associated kinase 1. (534 aa) |
| | TNIK | TRAF2 and NCK interacting kinase. (1771 aa) |
| | PAK3 | Non-specific serine/threonine protein kinase. (652 aa) |
| | LOC103349690 | DUF3496 domain-containing protein. (645 aa) |
| | ENSOCUP00000047685 | ANK_REP_REGION domain-containing protein. (356 aa) |
| | MEF2C | Myocyte enhancer factor 2C. (483 aa) |
| | MAPK13 | Mitogen-activated protein kinase. (399 aa) |
| | FGF13 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (271 aa) |
| | TAOK3 | Protein kinase domain-containing protein. (473 aa) |
| | MAP3K12 | Mitogen-activated protein kinase kinase kinase 12; May be an activator of the JNK/SAPK pathway. (893 aa) |
| | MBP | Myelin basic protein; Is, with PLP, the most abundant protein component of the myelin membrane in the CNS. Has a role in both the formation and stabilization of this compact multilayer arrangement of bilayers. Each splice variant and charge isomer may have a specialized function in the assembly of an optimized, biochemically functional myelin membrane (By similarity); Belongs to the myelin basic protein family. (417 aa) |
| | ENSOCUP00000045925 | TGFb_propeptide domain-containing protein. (272 aa) |
| | YWHAE | Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon; Belongs to the 14-3-3 family. (436 aa) |
| | AVP | Uncharacterized protein. (285 aa) |
| | MAP3K6 | Mitogen-activated protein kinase kinase kinase 6. (1300 aa) |
| | ENSOCUP00000044310 | ANK_REP_REGION domain-containing protein. (624 aa) |
| | ENSOCUP00000044284 | TGFb_propeptide domain-containing protein. (260 aa) |
| | ENSOCUP00000043905 | PID domain-containing protein. (121 aa) |
| | TAOK2 | TAO kinase 2. (1169 aa) |
| | ENSOCUP00000041840 | TGFb_propeptide domain-containing protein. (219 aa) |
| | ITGAV | Integrin subunit alpha V; Belongs to the integrin alpha chain family. (1047 aa) |
| | ERCC6 | ERCC excision repair 6, chromatin remodeling factor. (1478 aa) |
| | MAP2K5 | Mitogen-activated protein kinase kinase 5. (551 aa) |
| | ENSOCUP00000037329 | TGFb_propeptide domain-containing protein. (263 aa) |
| | ENSOCUP00000037215 | Tis11B_N domain-containing protein. (204 aa) |
| | MAP3K3 | Mitogen-activated protein kinase kinase kinase 3. (681 aa) |
| | ENSOCUP00000036823 | Mitogen-activated protein kinase. (254 aa) |
| | MAP4K4 | Mitogen-activated protein kinase kinase kinase kinase 4. (1323 aa) |
| | RAF1 | Raf-1 proto-oncogene, serine/threonine kinase. (701 aa) |
| | ITPKB | Kinase; Belongs to the inositol phosphokinase (IPK) family. (924 aa) |
| | MAP3K1 | Mitogen-activated protein kinase kinase kinase 1. (1408 aa) |
| | RET | Proto-oncogene tyrosine-protein kinase receptor Ret; Receptor tyrosine-protein kinase involved in numerous cellular mechanisms including cell proliferation, neuronal navigation, cell migration, and cell differentiation upon binding with glial cell derived neurotrophic factor family ligands. (1113 aa) |
| | ENSOCUP00000035650 | Uncharacterized protein. (77 aa) |
| | MAP2K4 | Mitogen-activated protein kinase kinase 4. (520 aa) |
| | MYD88 | Uncharacterized protein. (476 aa) |
| | SMAD1 | Mothers against decapentaplegic homolog. (465 aa) |
| | MAPK12 | Mitogen-activated protein kinase. (416 aa) |
| | ENSOCUP00000033961 | ANK_REP_REGION domain-containing protein. (226 aa) |
| | FGF18 | Fibroblast growth factor 18; Belongs to the heparin-binding growth factors family. (231 aa) |
| | NRG1 | Neuregulin 1. (720 aa) |
| | CTSH | Uncharacterized protein; Belongs to the peptidase C1 family. (601 aa) |
| | HSF1 | Heat shock transcription factor 1. (680 aa) |
| | LOC103345451 | TGFb_propeptide domain-containing protein. (203 aa) |
| | IRAK4 | Interleukin 1 receptor associated kinase 4. (464 aa) |
| | BRAF | B-Raf proto-oncogene, serine/threonine kinase. (767 aa) |
| | TLR3 | TIR domain-containing protein; Belongs to the Toll-like receptor family. (867 aa) |
| | MAPK15 | Mitogen-activated protein kinase. (619 aa) |
| | TNFSF11 | TNF superfamily member 11; Belongs to the tumor necrosis factor family. (322 aa) |
| | CCL2 | C-C motif chemokine 2; Acts as a ligand for C-C chemokine receptor CCR2 (By similarity). Signals through binding and activation of CCR2 and induces a strong chemotactic response and mobilization of intracellular calcium ions (By similarity). Exhibits a chemotactic activity for monocytes and basophils but not neutrophils or eosinophils (By similarity). Plays an important role in mediating peripheral nerve injury-induced neuropathic pain (By similarity). Increases NMDA-mediated synaptic transmission in both dopamine D1 and D2 receptor-containing neurons, which may be caused by MAPK/ERK-d [...] (125 aa) |
| | TBC1D10C | TBC1 domain family member 10C. (447 aa) |
| | ZFP36L1 | Uncharacterized protein. (338 aa) |
| | G1TJQ0_RABIT | PID domain-containing protein. (207 aa) |
| | MAP2K7 | Mitogen-activated protein kinase kinase 7. (435 aa) |
| | RHBDD3 | Rhomboid domain containing 3. (375 aa) |
| | STRADB | STE20 related adaptor beta. (418 aa) |
| | PTK2B | Protein tyrosine kinase 2 beta; Belongs to the protein kinase superfamily. Tyr protein kinase family. (996 aa) |
| | MEF2A | Myocyte enhancer factor 2A. (511 aa) |
| | MAPK8 | Mitogen-activated protein kinase. (427 aa) |
| | MAPK9 | Mitogen-activated protein kinase. (439 aa) |
| | PBK | PDZ binding kinase. (322 aa) |
| | WNT5A | Protein Wnt-5a; Ligand for members of the frizzled family of seven transmembrane receptors. Can activate or inhibit canonical Wnt signaling, depending on receptor context. In the presence of FZD4, activates beta-catenin signaling. In the presence of ROR2, inhibits the canonical Wnt pathway by promoting beta-catenin degradation through a GSK3-independent pathway which involves down-regulation of beta- catenin-induced reporter gene expression (By similarity). Suppression of the canonical pathway allows chondrogenesis to occur. Inhibits tumor formation. Stimulates cell migration. Decrease [...] (380 aa) |
| | FGF2 | Fibroblast growth factor 2; Acts as a ligand for FGFR1, FGFR2, FGFR3 and FGFR4. Also acts as an integrin ligand which is required for FGF2 signaling. Binds to integrin ITGAV:ITGB3. Plays an important role in the regulation of cell survival, cell division, cell differentiation and cell migration. Functions as a potent mitogen in vitro. Can induce angiogenesis. Belongs to the heparin-binding growth factors family. (155 aa) |
| | YWHAZ | Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta; Belongs to the 14-3-3 family. (252 aa) |
| | RIPK2 | Receptor-interacting serine/threonine-protein kinase 2; Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. (538 aa) |
| | MAP3K7 | Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. (606 aa) |
| | G1SGL1_RABIT | ANK_REP_REGION domain-containing protein. (312 aa) |
| | TLR4 | TIR domain-containing protein; Belongs to the Toll-like receptor family. (839 aa) |
| | MAP3K2 | Mitogen-activated protein kinase kinase kinase 2. (623 aa) |
| | MAPK8IP2 | Uncharacterized protein. (558 aa) |
| | CD36 | CD36 molecule; Belongs to the CD36 family. (472 aa) |
| | NRK | Nik related kinase. (1459 aa) |
| | IGFBP4 | Insulin like growth factor binding protein 4. (258 aa) |
| | TMEM248 | Transmembrane protein 248. (368 aa) |
| | ZFP36 | ZFP36 ring finger protein. (338 aa) |
| | IQGAP3 | IQ motif containing GTPase activating protein 3. (1720 aa) |
| | SMAD4 | Mothers against decapentaplegic homolog. (552 aa) |
| | STK3 | Serine/threonine kinase 3. (491 aa) |
| | MAP3K13 | Mitogen-activated protein kinase kinase kinase 13; Activates the JUN N-terminal pathway through activation of the MAP kinase kinase MAP2K7. (1009 aa) |
| | KDR | Uncharacterized protein; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1356 aa) |
| | IL18 | Uncharacterized protein. (408 aa) |
| | NOD1 | Nucleotide binding oligomerization domain containing 1. (953 aa) |
| | NF2 | Neurofibromin 2. (626 aa) |
| | SETX | Senataxin. (2650 aa) |
| | NOX1 | NADPH oxidase 1. (564 aa) |
| | HESX1 | Homeobox expressed in ES cells 1; Required for the normal development of the forebrain, eyes and other anterior structures such as the olfactory placodes and pituitary gland. Possible transcriptional repressor. Binds to the palindromic PIII sequence, 5'-AGCTTGAGTCTAATTGAATTAACTGTAC-3'. (189 aa) |
| | MAP3K8 | Mitogen-activated protein kinase kinase kinase 8. (474 aa) |
| | TNF | Tumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (234 aa) |
| | DUSP10 | Dual specificity phosphatase 10; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (482 aa) |
| | MAP2K6 | Mitogen-activated protein kinase kinase 6; Belongs to the protein kinase superfamily. (334 aa) |
| | NLK | Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (527 aa) |
| | LRRK2 | Leucine rich repeat kinase 2. (2499 aa) |
| | ANKRD26 | Ankyrin repeat domain 26. (1661 aa) |
| | G1SV95_RABIT | Transforming growth factor beta; Belongs to the TGF-beta family. (387 aa) |
| | FGF10 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (220 aa) |
