STRINGSTRING
CAV1 CAV1 RASA1 RASA1 NRP1 NRP1 QKI QKI SETD2 SETD2 GLMN GLMN PDGFRB PDGFRB FOXF1 FOXF1 HOXA13 HOXA13 CITED2 CITED2 ZMIZ1 ZMIZ1 ENSOCUP00000045925 ENSOCUP00000045925 ENSOCUP00000044284 ENSOCUP00000044284 ITGB8 ITGB8 FZD4 FZD4 ENSOCUP00000041840 ENSOCUP00000041840 SPRED1 SPRED1 ITGAV ITGAV CCM2 CCM2 ENSOCUP00000037329 ENSOCUP00000037329 APELA APELA CTNNB1 CTNNB1 TIPARP TIPARP LOC103345451 LOC103345451 TGFBR2 TGFBR2 TBX20 TBX20 CITED1 CITED1 HEY2 HEY2 SMO SMO WNT7A WNT7A MYOCD MYOCD HAS2 HAS2 RAMP2 RAMP2 TMEM100 TMEM100 CUL7 CUL7 G1SED3_RABIT G1SED3_RABIT TBXT TBXT NKX2-5 NKX2-5 APLNR APLNR RASIP1 RASIP1 EPHA2 EPHA2 G1TGC0_RABIT G1TGC0_RABIT GJC1 GJC1 SHH SHH TGFBR3 TGFBR3 MYO1E MYO1E GDF2 GDF2 SOX17 SOX17 WARS2 WARS2 RTN4 RTN4 ACKR3 ACKR3 ADM ADM NTRK2 NTRK2 TIE1 TIE1 TEAD2 TEAD2 G1SV95_RABIT G1SV95_RABIT FBXW7 FBXW7 ENG ENG MYO18B MYO18B ZFPM2 ZFPM2 WT1 WT1 KDR KDR AMOT AMOT
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CAV1Caveolin-1; May act as a scaffolding protein within caveolar membranes. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (By similarity). Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependen [...] (178 aa)
RASA1RAS p21 protein activator 1. (967 aa)
NRP1Neuropilin; Belongs to the neuropilin family. (950 aa)
QKIQKI, KH domain containing RNA binding. (345 aa)
SETD2Uncharacterized protein. (625 aa)
GLMNUncharacterized protein. (592 aa)
PDGFRBPlatelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. (1147 aa)
FOXF1Forkhead box F1. (433 aa)
HOXA13Homeobox A13. (222 aa)
CITED2Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 2. (249 aa)
ZMIZ1Zinc finger MIZ-type containing 1. (1060 aa)
ENSOCUP00000045925TGFb_propeptide domain-containing protein. (272 aa)
ENSOCUP00000044284TGFb_propeptide domain-containing protein. (260 aa)
ITGB8Integrin beta-8; Integrin alpha-V:beta-8 (ITGAV:ITGB8) is a receptor for fibronectin (By similarity). It recognizes the sequence R-G-D in its ligands (By similarity). Integrin alpha-V:beta-6 (ITGAV:ITGB6) mediates R-G-D-dependent release of transforming growth factor beta-1 (TGF-beta- 1) from regulatory Latency-associated peptide (LAP), thereby playing a key role in TGF-beta-1 activation on the surface of activated regulatory T-cells (Tregs) (By similarity). Required during vasculogenesis (By similarity). (772 aa)
FZD4Frizzled class receptor 4; Belongs to the G-protein coupled receptor Fz/Smo family. (537 aa)
ENSOCUP00000041840TGFb_propeptide domain-containing protein. (219 aa)
SPRED1Sprouty related EVH1 domain containing 1. (444 aa)
ITGAVIntegrin subunit alpha V; Belongs to the integrin alpha chain family. (1047 aa)
CCM2CCM2 scaffold protein. (423 aa)
ENSOCUP00000037329TGFb_propeptide domain-containing protein. (263 aa)
APELAUncharacterized protein. (54 aa)
CTNNB1Catenin beta 1. (741 aa)
TIPARPTCDD inducible poly(ADP-ribose) polymerase. (685 aa)
LOC103345451TGFb_propeptide domain-containing protein. (203 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (592 aa)
TBX20T-box transcription factor 20. (460 aa)
CITED1Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 1. (360 aa)
HEY2Hes related family bHLH transcription factor with YRPW motif 2. (338 aa)
SMOSmoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (787 aa)
WNT7AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (325 aa)
MYOCDMyocardin. (989 aa)
HAS2Uncharacterized protein. (556 aa)
RAMP2Receptor activity modifying protein 2. (100 aa)
TMEM100Transmembrane protein 100. (134 aa)
CUL7Cullin 7; Belongs to the cullin family. (1728 aa)
G1SED3_RABITUncharacterized protein. (590 aa)
TBXTT-box transcription factor T. (365 aa)
NKX2-5NK2 homeobox 5. (326 aa)
APLNRApelin receptor; Belongs to the G-protein coupled receptor 1 family. (380 aa)
RASIP1Ras interacting protein 1. (583 aa)
EPHA2EPH receptor A2. (1031 aa)
G1TGC0_RABITUncharacterized protein. (214 aa)
GJC1Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. (426 aa)
SHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (451 aa)
TGFBR3Transforming growth factor beta receptor 3. (851 aa)
MYO1EMyosin IE; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1107 aa)
GDF2Growth differentiation factor 2. (434 aa)
SOX17HMG box domain-containing protein. (165 aa)
WARS2Tryptophanyl tRNA synthetase 2, mitochondrial; Belongs to the class-I aminoacyl-tRNA synthetase family. (393 aa)
RTN4Reticulon. (1110 aa)
ACKR3Atypical chemokine receptor 3; Belongs to the G-protein coupled receptor 1 family. (336 aa)
ADMAdrenomedullin. (187 aa)
NTRK2Tyrosine-protein kinase receptor. (838 aa)
TIE1Tyrosine kinase with immunoglobulin like and EGF like domains 1. (732 aa)
TEAD2TEA domain transcription factor 2. (405 aa)
G1SV95_RABITTransforming growth factor beta; Belongs to the TGF-beta family. (387 aa)
FBXW7F-box and WD repeat domain containing 7. (780 aa)
ENGEndoglin. (758 aa)
MYO18BMyosin XVIIIB; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2502 aa)
ZFPM2Zinc finger protein, FOG family member 2. (1159 aa)
WT1WT1 transcription factor. (302 aa)
KDRUncharacterized protein; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1356 aa)
AMOTAngiomotin. (1091 aa)
Your Current Organism:
Oryctolagus cuniculus
NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits
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