STRINGSTRING
CA9 CA9 ADA ADA LMNA LMNA NOL3 NOL3 AK4 AK4 ADM ADM PPARA PPARA ALKBH5 ALKBH5 SCFD1 SCFD1 SLC11A2 SLC11A2 G1SSI4_RABIT G1SSI4_RABIT ENG ENG ADAM15 ADAM15 BRIP1 BRIP1 PINK1 PINK1 WDR83 WDR83 STC1 STC1 EPO EPO PTEN PTEN TGFB2 TGFB2 IL18 IL18 NKX3-1 NKX3-1 HYOU1 HYOU1 KCND2 KCND2 SMAD4 SMAD4 AGTRAP AGTRAP SLC29A1 SLC29A1 SCAP SCAP SRF SRF STOX1 STOX1 FAM162A FAM162A CHRNA7 CHRNA7 BNIP3 BNIP3 RYR2 RYR2 PML PML NDNF NDNF TIGAR TIGAR CXCR4 CXCR4 NOS2 NOS2 TBL2 TBL2 REST REST PAM PAM PLOD2 PLOD2 EDNRA EDNRA TP53 TP53 LOC100347410 LOC100347410 OPRD1 OPRD1 PRKAA1 PRKAA1 PDK1 PDK1 G1SCK7_RABIT G1SCK7_RABIT MDM4 MDM4 NF1 NF1 EGLN3 EGLN3 G1SV95_RABIT G1SV95_RABIT EGR1 EGR1 G1SV48_RABIT G1SV48_RABIT SLC2A8 SLC2A8 CAMK2G CAMK2G ENSOCUP00000048569 ENSOCUP00000048569 MECP2 MECP2 CITED2 CITED2 CPEB2 CPEB2 ABAT ABAT LOC100341256 LOC100341256 PIN1 PIN1 PDK3 PDK3 SLC8A3 SLC8A3 ENSOCUP00000045925 ENSOCUP00000045925 ADAM8 ADAM8 ENSOCUP00000045399 ENSOCUP00000045399 NDRG1 NDRG1 BACH1 BACH1 ENSOCUP00000044284 ENSOCUP00000044284 USF1 USF1 MPL MPL FABP1 FABP1 ENSOCUP00000043082 ENSOCUP00000043082 LOXL3 LOXL3 XRCC1 XRCC1 PLAT PLAT ITPR2 ITPR2 ENSOCUP00000041840 ENSOCUP00000041840 ENSOCUP00000041723 ENSOCUP00000041723 HIF1A HIF1A NR4A2 NR4A2 ENSOCUP00000040050 ENSOCUP00000040050 SIRT2 SIRT2 EGLN2 EGLN2 GHRHR GHRHR ENSOCUP00000038975 ENSOCUP00000038975 HP1BP3 HP1BP3 PSEN2 PSEN2 HK2 HK2 ENSOCUP00000037329 ENSOCUP00000037329 LOXL4 LOXL4 TXN2 TXN2 HIF1AN HIF1AN BCL2 BCL2 KCNK2 KCNK2 CYBB CYBB CHRNA4 CHRNA4 ENSOCUP00000034930 ENSOCUP00000034930 MIEF1 MIEF1 SLC2A4 SLC2A4 SLC8A1 SLC8A1 RORA RORA HSF1 HSF1 LOC103345451 LOC103345451 ENSOCUP00000031376 ENSOCUP00000031376 RBPJ RBPJ ENSOCUP00000030729 ENSOCUP00000030729 LIMD1 LIMD1 ENSOCUP00000030584 ENSOCUP00000030584 TGFBR2 TGFBR2 ITPR1 ITPR1 IRAK1 IRAK1 ENSOCUP00000029917 ENSOCUP00000029917 ITGA2 ITGA2 ENSOCUP00000029165 ENSOCUP00000029165 CPEB1 CPEB1 ENSOCUP00000028473 ENSOCUP00000028473 P2RX3 P2RX3 PPARD PPARD UCP3 UCP3 VHL VHL MST1 MST1 ACAA2 ACAA2 SMAD3 SMAD3 FUNDC1 FUNDC1 NFE2L2 NFE2L2 G1U9D6_RABIT G1U9D6_RABIT G1U940_RABIT G1U940_RABIT SCN2A SCN2A RYR1 RYR1 DNMT3A DNMT3A NARF NARF MYOCD MYOCD NPEPPS NPEPPS PHB2 PHB2 G1U2E4_RABIT G1U2E4_RABIT ARNT2 ARNT2 PLAU PLAU SIRT1 SIRT1 ANGPT4 ANGPT4 CAV3 CAV3 EPAS1 EPAS1 FOS FOS ADIPOQ ADIPOQ LOC100346169 LOC100346169 PGF PGF DIO3 DIO3 KCNK3 KCNK3 PTK2B PTK2B G1TLX8_RABIT G1TLX8_RABIT G1TLX0_RABIT G1TLX0_RABIT MGARP MGARP AGER AGER PLOD1 PLOD1 ADO ADO ACVRL1 ACVRL1 AJUBA AJUBA VEGFC VEGFC AQP3 AQP3 VEGFD VEGFD P2RX2 P2RX2 TFRC TFRC GNGT1 GNGT1 PTGS2 PTGS2 DDIT4 DDIT4 ANGPTL4 ANGPTL4 HSP90B1 HSP90B1 TGFBR3 TGFBR3 ANGPT2 ANGPT2 SUV39H2 SUV39H2 FNDC1 FNDC1 PKLR PKLR G1T8C0_RABIT G1T8C0_RABIT ATM ATM CAV1 CAV1 NPPC NPPC ATP7A ATP7A CDKN1B CDKN1B PRKCE PRKCE UCN3 UCN3 PDLIM1 PDLIM1 ALAS2 ALAS2 TM9SF4 TM9SF4 EDN1 EDN1 EGLN1 EGLN1 MTOR MTOR CRYAB CRYAB ERO1A ERO1A UCP2 UCP2 ATF2 ATF2 RTN4 RTN4 APAF1 APAF1 HILPDA HILPDA DRD2 DRD2 DDR2 DDR2 EP300 EP300 TGFB3 TGFB3 SIRT4 SIRT4 FAM167A FAM167A HMOX1 HMOX1 BNIP3L BNIP3L ADAM17 ADAM17
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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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CA9Carbonic anhydrase 9; Belongs to the alpha-carbonic anhydrase family. (435 aa)
ADAAdenosine deaminase. (363 aa)
LMNALamin A/C; Belongs to the intermediate filament family. (704 aa)
NOL3Nucleolar protein 3. (212 aa)
AK4Adenylate kinase 4, mitochondrial; Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates. Efficiently phosphorylates AMP and dAMP using ATP as phosphate donor, but phosphorylates only AMP when using GTP as phosphate donor. Also displays broad nucleoside diphosphate kinase activity. (223 aa)
ADMAdrenomedullin. (187 aa)
PPARAPeroxisome proliferator activated receptor alpha. (503 aa)
ALKBH5AlkB homolog 5, RNA demethylase. (393 aa)
SCFD1Sec1 family domain containing 1; Belongs to the STXBP/unc-18/SEC1 family. (619 aa)
SLC11A2Solute carrier family 11 member 2. (589 aa)
G1SSI4_RABITGLOBIN domain-containing protein; Belongs to the globin family. (482 aa)
ENGEndoglin. (758 aa)
ADAM15ADAM metallopeptidase domain 15. (881 aa)
BRIP1BRCA1 interacting protein C-terminal helicase 1. (1212 aa)
PINK1PTEN induced kinase 1. (569 aa)
WDR83WD repeat domain 83. (315 aa)
STC1Stanniocalcin 1. (247 aa)
EPOErythropoietin; Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Binds to EPOR leading to EPOR dimerization and JAK2 activation thereby activating specific downstream effectors, including STAT1 and STAT3. Belongs to the EPO/TPO family. (195 aa)
PTENPhosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (403 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
IL18Uncharacterized protein. (408 aa)
NKX3-1NK3 homeobox 1. (159 aa)
HYOU1Hypoxia up-regulated 1. (999 aa)
KCND2Potassium voltage-gated channel subfamily D member 2; Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes, primarily in the brain, but also in rodent heart. Mediates the major part of the dendritic A-type current I(SA) in brain neurons (By similarity). This current is activated at membrane potentials that are below the threshold for action potentials. It regulates neuronal excitability, prolongs the latency before the first spike in a series of action potentials, regulates the frequency of repetitive action potential firing, shortens t [...] (630 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
AGTRAPAngiotensin II receptor associated protein. (159 aa)
SLC29A1Solute carrier family 29 member 1 (Augustine blood group). (456 aa)
SCAPSREBF chaperone. (1279 aa)
SRFSerum response factor. (685 aa)
STOX1Storkhead box 1. (977 aa)
FAM162AFamily with sequence similarity 162 member A. (155 aa)
CHRNA7Uncharacterized protein. (513 aa)
BNIP3BCL2 interacting protein 3. (218 aa)
RYR2Ryanodine receptor 2; Calcium channel that mediates the release of Ca(2+) from the sarcoplasmic reticulum into the cytoplasm and thereby plays a key role in triggering cardiac muscle contraction. Aberrant channel activation can lead to cardiac arrhythmia. In cardiac myocytes, calcium release is triggered by increased Ca(2+) levels due to activation of the L-type calcium channel CACNA1C. Required for cellular calcium ion homeostasis. Required for embryonic heart development (By similarity). The calcium channel activity is modulated by formation of heterotetramers with RYR3; Belongs to t [...] (4965 aa)
PMLPromyelocytic leukemia. (860 aa)
NDNFNeuron derived neurotrophic factor. (643 aa)
TIGARTP53 induced glycolysis regulatory phosphatase. (265 aa)
CXCR4C-X-C motif chemokine receptor 4; Belongs to the G-protein coupled receptor 1 family. (366 aa)
NOS2Nitric oxide synthase, inducible; Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. In macrophages, NO mediates tumoricidal and bactericidal actions. Also has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such PTGS2/COX2. As component of the iNOS-S100A8/9 transnitrosylase complex involved in the selective inflammatory stimulus-dependent S- nitrosylation of GAPDH implicated in regulation of the GAIT complex activity and probably multiple targets including ANXA5, EZR, MSN and VIM. Involved in i [...] (1146 aa)
TBL2Transducin beta like 2. (446 aa)
RESTRE1 silencing transcription factor. (930 aa)
PAMPeptidylglycine alpha-amidating monooxygenase. (975 aa)
PLOD2Procollagen-lysine,2-oxoglutarate 5-dioxygenase 2. (762 aa)
EDNRAEndothelin receptor type A; Belongs to the G-protein coupled receptor 1 family. (427 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...] (391 aa)
LOC100347410Uncharacterized protein. (155 aa)
OPRD1Opioid receptor delta 1; Belongs to the G-protein coupled receptor 1 family. (373 aa)
PRKAA1Non-specific serine/threonine protein kinase. (656 aa)
PDK1Protein-serine/threonine kinase. (396 aa)
G1SCK7_RABITUncharacterized protein; Belongs to the cytochrome P450 family. (765 aa)
MDM4Protein Mdm4; Inhibits p53- and p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Belongs to the MDM2/MDM4 family. (491 aa)
NF1Neurofibromin 1. (2841 aa)
EGLN3Fe2OG dioxygenase domain-containing protein. (456 aa)
G1SV95_RABITTransforming growth factor beta; Belongs to the TGF-beta family. (387 aa)
EGR1Early growth response protein; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Belongs to the EGR C2H2-type zinc-finger protein family. (700 aa)
G1SV48_RABITUncharacterized protein. (80 aa)
SLC2A8Solute carrier family 2 member 8; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (477 aa)
CAMK2GProtein kinase domain-containing protein. (592 aa)
ENSOCUP00000048569Uncharacterized protein. (108 aa)
MECP2Methyl-CpG-binding protein 2; Chromosomal protein that binds to methylated DNA. It can bind specifically to a single methyl-CpG pair. It is not influenced by sequences flanking the methyl-CpGs. Binds both 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC)-containing DNA, with a preference for 5-methylcytosine (5mC). (485 aa)
CITED2Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 2. (249 aa)
CPEB2Cytoplasmic polyadenylation element binding protein 2. (698 aa)
ABAT4-aminobutyrate aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (549 aa)
LOC100341256Succinate dehydrogenase [ubiquinone] cytochrome b small subunit; Membrane-anchoring subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q); Belongs to the CybS family. (85 aa)
PIN1Peptidyl-prolyl cis-trans isomerase. (224 aa)
PDK3Protein-serine/threonine kinase. (439 aa)
SLC8A3Solute carrier family 8 member A3; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (958 aa)
ENSOCUP00000045925TGFb_propeptide domain-containing protein. (272 aa)
ADAM8ADAM metallopeptidase domain 8. (978 aa)
ENSOCUP00000045399Uncharacterized protein. (182 aa)
NDRG1N-myc downstream regulated 1. (438 aa)
BACH1BTB domain and CNC homolog 1. (719 aa)
ENSOCUP00000044284TGFb_propeptide domain-containing protein. (260 aa)
USF1Upstream stimulatory factor 1; Transcription factor that binds to a symmetrical DNA sequence (E-boxes) (5'-CACGTG-3') that is found in a variety of viral and cellular promoters. Regulates the expression of the surfactant protein- A (SP-A) gene. (326 aa)
MPLMPL proto-oncogene, thrombopoietin receptor. (635 aa)
FABP1FABP domain-containing protein. (194 aa)
ENSOCUP00000043082Uncharacterized protein. (319 aa)
LOXL3Lysyl oxidase like 3. (935 aa)
XRCC1X-ray repair cross complementing 1. (610 aa)
PLATUncharacterized protein. (594 aa)
ITPR2Inositol 1,4,5-trisphosphate receptor type 2. (2735 aa)
ENSOCUP00000041840TGFb_propeptide domain-containing protein. (219 aa)
ENSOCUP00000041723Succinate dehydrogenase [ubiquinone] cytochrome b small subunit; Membrane-anchoring subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q); Belongs to the CybS family. (145 aa)
HIF1AUncharacterized protein. (851 aa)
NR4A2Nuclear receptor subfamily 4 group A member 2. (609 aa)
ENSOCUP00000040050LAG1_DNAbind domain-containing protein. (92 aa)
SIRT2Sirtuin 2. (509 aa)
EGLN2Egl-9 family hypoxia inducible factor 2. (501 aa)
GHRHRUncharacterized protein; Belongs to the MIP/aquaporin (TC 1.A.8) family. (524 aa)
ENSOCUP00000038975Succinate dehydrogenase [ubiquinone] cytochrome b small subunit; Membrane-anchoring subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q); Belongs to the CybS family. (85 aa)
HP1BP3Heterochromatin protein 1 binding protein 3. (570 aa)
PSEN2Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (539 aa)
HK2Hexokinase 2. (957 aa)
ENSOCUP00000037329TGFb_propeptide domain-containing protein. (263 aa)
LOXL4Lysyl oxidase like 4. (803 aa)
TXN2Thioredoxin 2. (166 aa)
HIF1ANHypoxia inducible factor 1 subunit alpha inhibitor. (371 aa)
BCL2BH4_2 domain-containing protein. (389 aa)
KCNK2Potassium two pore domain channel subfamily K member 2; Belongs to the two pore domain potassium channel (TC 1.A.1.8) family. (469 aa)
CYBBFAD-binding FR-type domain-containing protein. (570 aa)
CHRNA4Cholinergic receptor nicotinic alpha 4 subunit. (620 aa)
ENSOCUP00000034930Protein-serine/threonine kinase. (195 aa)
MIEF1Mab-21 domain-containing protein. (600 aa)
SLC2A4MFS domain-containing protein; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (574 aa)
SLC8A1J domain-containing protein; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (973 aa)
RORARAR related orphan receptor A. (512 aa)
HSF1Heat shock transcription factor 1. (680 aa)
LOC103345451TGFb_propeptide domain-containing protein. (203 aa)
ENSOCUP00000031376Uncharacterized protein. (95 aa)
RBPJRecombination signal binding protein for immunoglobulin kappa J region. (499 aa)
ENSOCUP00000030729Uncharacterized protein. (69 aa)
LIMD1LIM domains containing 1. (693 aa)
ENSOCUP00000030584Uncharacterized protein. (513 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (592 aa)
ITPR1Inositol 1,4,5-trisphosphate receptor type 1. (2756 aa)
IRAK1Interleukin 1 receptor associated kinase 1. (534 aa)
ENSOCUP00000029917Uncharacterized protein. (169 aa)
ITGA2Integrin subunit alpha 2; Belongs to the integrin alpha chain family. (1202 aa)
ENSOCUP00000029165SWIB domain-containing protein. (260 aa)
CPEB1RRM domain-containing protein. (653 aa)
ENSOCUP00000028473Mab-21 domain-containing protein. (169 aa)
P2RX3P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. (410 aa)
PPARDUncharacterized protein. (420 aa)
UCP3Uncoupling protein 3; Belongs to the mitochondrial carrier (TC 2.A.29) family. (309 aa)
VHLUncharacterized protein. (191 aa)
MST1Macrophage stimulating 1; Belongs to the peptidase S1 family. (773 aa)
ACAA2Acetyl-CoA acyltransferase 2; Belongs to the thiolase-like superfamily. Thiolase family. (397 aa)
SMAD3SMAD family member 3. (230 aa)
FUNDC1Uncharacterized protein. (155 aa)
NFE2L2Nuclear factor, erythroid 2 like 2. (677 aa)
G1U9D6_RABITUncharacterized protein. (105 aa)
G1U940_RABITCellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (178 aa)
SCN2ASodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (2006 aa)
RYR1Ryanodine receptor 1; Calcium channel that mediates the release of Ca(2+) from the sarcoplasmic reticulum into the cytoplasm and thereby plays a key role in triggering muscle contraction following depolarization of T-tubules. Repeated very high- level exercise increases the open probability of the channel and leads to Ca(2+) leaking into the cytoplasm (By similarity). Can also mediate the release of Ca(2+) from intracellular stores in neurons, and may thereby promote prolonged Ca(2+) signaling in the brain. Required for normal embryonic development of muscle fibers and skeletal muscle. [...] (4598 aa)
DNMT3ADNA methyltransferase 3 alpha; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. (843 aa)
NARFNuclear prelamin A recognition factor; Belongs to the NARF family. (409 aa)
MYOCDMyocardin. (989 aa)
NPEPPSAminopeptidase. (921 aa)
PHB2Prohibitin. (299 aa)
G1U2E4_RABITUncharacterized protein. (147 aa)
ARNT2Aryl hydrocarbon receptor nuclear translocator 2. (668 aa)
PLAUUrokinase-type plasminogen activator short chain A; Specifically cleaves the zymogen plasminogen to form the active enzyme plasmin; Belongs to the peptidase S1 family. (433 aa)
SIRT1Sirtuin 1. (748 aa)
ANGPT4Angiopoietin 4. (487 aa)
CAV3Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (151 aa)
EPAS1Endothelial PAS domain protein 1. (902 aa)
FOSFos proto-oncogene, AP-1 transcription factor subunit. (380 aa)
ADIPOQC1q domain-containing protein. (244 aa)
LOC100346169Succinate dehydrogenase [ubiquinone] cytochrome b small subunit; Membrane-anchoring subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q); Belongs to the CybS family. (159 aa)
PGFPlacental growth factor; Belongs to the PDGF/VEGF growth factor family. (170 aa)
DIO3Iodothyronine deiodinase; Responsible for the deiodination of T4 (3,5,3',5'- tetraiodothyronine). (342 aa)
KCNK3Potassium channel subfamily K member. (347 aa)
PTK2BProtein tyrosine kinase 2 beta; Belongs to the protein kinase superfamily. Tyr protein kinase family. (996 aa)
G1TLX8_RABITRING-type domain-containing protein. (248 aa)
G1TLX0_RABITProtein-serine/threonine kinase. (145 aa)
MGARPMitochondria localized glutamic acid rich protein. (312 aa)
AGERAdvanced glycosylation end-product specific receptor. (401 aa)
PLOD1Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1. (727 aa)
ADO2-aminoethanethiol dioxygenase. (247 aa)
ACVRL1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (327 aa)
AJUBAUncharacterized protein. (122 aa)
VEGFCVascular endothelial growth factor C; Belongs to the PDGF/VEGF growth factor family. (418 aa)
AQP3Aquaporin 3 (Gill blood group); Belongs to the MIP/aquaporin (TC 1.A.8) family. (292 aa)
VEGFDVascular endothelial growth factor D; Belongs to the PDGF/VEGF growth factor family. (354 aa)
P2RX2P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. Belongs to the P2X receptor family. (511 aa)
TFRCTransferrin receptor. (763 aa)
GNGT1Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (74 aa)
PTGS2Prostaglandin G/H synthase 2; Converts arachidonate to prostaglandin H2 (PGH2), a committed step in prostanoid synthesis. Constitutively expressed in some tissues in physiological conditions, such as the endothelium, kidney and brain, and in pathological conditions, such as in cancer. PTGS2 is responsible for production of inflammatory prostaglandins. Up-regulation of PTGS2 is also associated with increased cell adhesion, phenotypic changes, resistance to apoptosis and tumor angiogenesis. In cancer cells, PTGS2 is a key step in the production of prostaglandin E2 (PGE2), which plays imp [...] (604 aa)
DDIT4DNA damage inducible transcript 4. (229 aa)
ANGPTL4Angiopoietin like 4. (411 aa)
HSP90B1Endoplasmin; Molecular chaperone that functions in the processing and transport of secreted proteins. When associated with CNPY3, required for proper folding of Toll-like receptors. Functions in endoplasmic reticulum associated degradation (ERAD). Has ATPase activity. (802 aa)
TGFBR3Transforming growth factor beta receptor 3. (851 aa)
ANGPT2Angiopoietin 2. (496 aa)
SUV39H2Histone-lysine N-methyltransferase; Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. Suvar3-9 subfamily. (410 aa)
FNDC1Fibronectin type III domain containing 1. (1636 aa)
PKLRPyruvate kinase; Belongs to the pyruvate kinase family. (574 aa)
G1T8C0_RABITUncharacterized protein. (311 aa)
ATMSerine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3056 aa)
CAV1Caveolin-1; May act as a scaffolding protein within caveolar membranes. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (By similarity). Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependen [...] (178 aa)
NPPCUncharacterized protein. (351 aa)
ATP7AATPase copper transporting alpha. (1499 aa)
CDKN1BCyclin dependent kinase inhibitor 1B. (198 aa)
PRKCEProtein kinase C epsilon type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays essential roles in the regulation of multiple cellular processes linked to cytoskeletal proteins, such as cell adhesion, motility, migration and cell cycle, functions in neuron growth and ion channel regulation, and is involved in immune response, cancer cell invasion and regulation of apoptosis. Mediates cell adhesion to the extracellular matrix via integrin- dependent signaling, by mediating angiotensin-2-induced activation of integrin beta- [...] (744 aa)
UCN3Urocortin 3. (167 aa)
PDLIM1PDZ and LIM domain 1. (330 aa)
ALAS25-aminolevulinate synthase. (613 aa)
TM9SF4Transmembrane 9 superfamily member; Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family. (654 aa)
EDN1Big endothelin-1; Endothelins are endothelium-derived vasoconstrictor peptides (By similarity). Probable ligand for G-protein coupled receptors EDNRA and EDNRB which activates PTK2B, BCAR1, BCAR3 and, GTPases RAP1 and RHOA cascade in glomerular mesangial cells (By similarity). Belongs to the endothelin/sarafotoxin family. (202 aa)
EGLN1Uncharacterized protein. (457 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2547 aa)
CRYABAlpha-crystallin B chain; May contribute to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions; Belongs to the small heat shock protein (HSP20) family. (175 aa)
ERO1AEndoplasmic reticulum oxidoreductase 1 alpha. (492 aa)
UCP2Uncoupling protein 2; Belongs to the mitochondrial carrier (TC 2.A.29) family. (309 aa)
ATF2Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. (498 aa)
RTN4Reticulon. (1110 aa)
APAF1Apoptotic peptidase activating factor 1. (1183 aa)
HILPDAHypoxia inducible lipid droplet associated. (64 aa)
DRD2Dopamine receptor D2; Belongs to the G-protein coupled receptor 1 family. (443 aa)
DDR2Discoidin domain receptor tyrosine kinase 2. (848 aa)
EP300E1A binding protein p300. (2418 aa)
TGFB3Transforming growth factor beta 3. (458 aa)
SIRT4NAD-dependent protein lipoamidase sirtuin-4, mitochondrial; Acts as NAD-dependent protein lipoamidase, ADP-ribosyl transferase and deacetylase. Catalyzes more efficiently removal of lipoyl- and biotinyl- than acetyl-lysine modifications. Inhibits the pyruvate dehydrogenase complex (PDH) activity via the enzymatic hydrolysis of the lipoamide cofactor from the E2 component, DLAT, in a phosphorylation-independent manner. Catalyzes the transfer of ADP- ribosyl groups onto target proteins, including mitochondrial GLUD1, inhibiting GLUD1 enzyme activity. Acts as a negative regulator of mitoc [...] (331 aa)
FAM167AFamily with sequence similarity 167 member A. (217 aa)
HMOX1Heme oxygenase 1. (288 aa)
BNIP3LBCL2 interacting protein 3 like. (219 aa)
ADAM17ADAM metallopeptidase domain 17. (827 aa)
Your Current Organism:
Oryctolagus cuniculus
NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits
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