STRINGSTRING
WNT5A WNT5A ACVR1 ACVR1 OTX2 OTX2 SRF SRF SMAD4 SMAD4 TENM4 TENM4 AMOT AMOT RNF2 RNF2 FOXA2 FOXA2 NODAL NODAL GDF3 GDF3 ACVR2A ACVR2A FRS2 FRS2 ZBTB17 ZBTB17 MEGF8 MEGF8 ZIC3 ZIC3 LDB1 LDB1 ETS2 ETS2 G1U8T4_RABIT G1U8T4_RABIT ENSOCUP00000031679 ENSOCUP00000031679 CTNNB1 CTNNB1 UGDH UGDH ENSOCUP00000036340 ENSOCUP00000036340 ENSOCUP00000038370 ENSOCUP00000038370 PLPP3 PLPP3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
WNT5AProtein Wnt-5a; Ligand for members of the frizzled family of seven transmembrane receptors. Can activate or inhibit canonical Wnt signaling, depending on receptor context. In the presence of FZD4, activates beta-catenin signaling. In the presence of ROR2, inhibits the canonical Wnt pathway by promoting beta-catenin degradation through a GSK3-independent pathway which involves down-regulation of beta- catenin-induced reporter gene expression (By similarity). Suppression of the canonical pathway allows chondrogenesis to occur. Inhibits tumor formation. Stimulates cell migration. Decrease [...] (380 aa)
ACVR1Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (509 aa)
OTX2Orthodenticle homeobox 2. (289 aa)
SRFSerum response factor. (685 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
TENM4Teneurin transmembrane protein 4. (2706 aa)
AMOTAngiomotin. (1091 aa)
RNF2RING-type domain-containing protein. (336 aa)
FOXA2Forkhead box A2. (471 aa)
NODALNodal growth differentiation factor. (348 aa)
GDF3Growth differentiation factor 3. (365 aa)
ACVR2ASerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (556 aa)
FRS2Fibroblast growth factor receptor substrate 2. (491 aa)
ZBTB17Zinc finger and BTB domain containing 17. (795 aa)
MEGF8Uncharacterized protein. (439 aa)
ZIC3Zic family member 3. (467 aa)
LDB1LIM domain binding 1. (410 aa)
ETS2ETS proto-oncogene 2, transcription factor; Transcription factor; Belongs to the ETS family. (468 aa)
G1U8T4_RABITUncharacterized protein. (139 aa)
ENSOCUP00000031679RING-type domain-containing protein. (249 aa)
CTNNB1Catenin beta 1. (741 aa)
UGDHUDP-glucose 6-dehydrogenase; Involved in the biosynthesis of glycosaminoglycans; hyaluronan, chondroitin sulfate, and heparan sulfate. Belongs to the UDP-glucose/GDP-mannose dehydrogenase family. (497 aa)
ENSOCUP00000036340EGF-like domain-containing protein. (81 aa)
ENSOCUP00000038370N-acetyltransferase domain-containing protein. (311 aa)
PLPP3acidPPc domain-containing protein. (331 aa)
Your Current Organism:
Oryctolagus cuniculus
NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits
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