(31 nodes) Cell fate determination network (Oryctolagus cuniculus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	BMP4	Bone morphogenetic protein 4; Induces cartilage and bone formation. Acts in concert with PTHLH/PTHRP to stimulate ductal outgrowth during embryonic mammary development and to inhibit hair follicle induction (By similarity). (409 aa)
	BARHL2	BarH like homeobox 2. (387 aa)
	PTCH1	Patched 1. (1321 aa)
	FEZF2	FEZ family zinc finger 2. (460 aa)
	CYP26B1	Cytochrome P450 family 26 subfamily B member 1; Belongs to the cytochrome P450 family. (709 aa)
	PTCH2	Patched 2. (1198 aa)
	PRRX1	Paired related homeobox 1. (278 aa)
	SOX17	HMG box domain-containing protein. (165 aa)
	PAX2	Paired box 2. (448 aa)
	LBX1	Ladybird homeobox 1. (260 aa)
	ATOH1	Atonal bHLH transcription factor 1. (359 aa)
	HOXA2	Homeobox domain-containing protein. (374 aa)
	GATA3	GATA binding protein 3. (444 aa)
	NKX6-3	Homeobox domain-containing protein. (263 aa)
	PAX6	Uncharacterized protein. (436 aa)
	ISL1	ISL LIM homeobox 1. (349 aa)
	NTF4	Neurotrophin 4; Belongs to the NGF-beta family. (205 aa)
	HES1	Hes family bHLH transcription factor 1. (279 aa)
	TBX2	T-box transcription factor 2. (662 aa)
	MYOD1	Myogenic factor; Induces fibroblasts to differentiate into myoblasts. Acts as a transcriptional activator that promotes transcription of muscle- specific target genes and plays a role in muscle differentiation. (323 aa)
	WNT1	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (370 aa)
	CDC42-2	Uncharacterized protein. (222 aa)
	NTF3	Neurotrophin-3; Seems to promote the survival of visceral and proprioceptive sensory neurons; Belongs to the NGF-beta family. (270 aa)
	CTNNB1	Catenin beta 1. (741 aa)
	MEF2C	Myocyte enhancer factor 2C. (483 aa)
	ENSOCUP00000047323	Fork-head domain-containing protein. (261 aa)
	EBF2	EBF transcription factor 2. (609 aa)
	PROX1	Prospero homeobox 1. (737 aa)
	NOTCH2	Notch receptor 2. (2481 aa)
	PRADC1	Protease associated domain containing 1. (244 aa)
	CDC42	Uncharacterized protein. (191 aa)

Your Current Organism:

Oryctolagus cuniculus

NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ATOH1	BARHL2	ENSOCUP00000011321	ENSOCUP00000003642	Atonal bHLH transcription factor 1.	BarH like homeobox 2.	0.529
ATOH1	BMP4	ENSOCUP00000011321	ENSOCUP00000009545	Atonal bHLH transcription factor 1.	Bone morphogenetic protein 4; Induces cartilage and bone formation. Acts in concert with PTHLH/PTHRP to stimulate ductal outgrowth during embryonic mammary development and to inhibit hair follicle induction (By similarity).	0.448
ATOH1	GATA3	ENSOCUP00000011321	ENSOCUP00000015302	Atonal bHLH transcription factor 1.	GATA binding protein 3.	0.457
ATOH1	HES1	ENSOCUP00000011321	ENSOCUP00000022035	Atonal bHLH transcription factor 1.	Hes family bHLH transcription factor 1.	0.700
ATOH1	HOXA2	ENSOCUP00000011321	ENSOCUP00000013067	Atonal bHLH transcription factor 1.	Homeobox domain-containing protein.	0.436
ATOH1	ISL1	ENSOCUP00000011321	ENSOCUP00000020036	Atonal bHLH transcription factor 1.	ISL LIM homeobox 1.	0.505
ATOH1	PAX2	ENSOCUP00000011321	ENSOCUP00000011064	Atonal bHLH transcription factor 1.	Paired box 2.	0.730
ATOH1	PAX6	ENSOCUP00000011321	ENSOCUP00000019685	Atonal bHLH transcription factor 1.	Uncharacterized protein.	0.677
ATOH1	PTCH1	ENSOCUP00000011321	ENSOCUP00000002587	Atonal bHLH transcription factor 1.	Patched 1.	0.482
BARHL2	ATOH1	ENSOCUP00000003642	ENSOCUP00000011321	BarH like homeobox 2.	Atonal bHLH transcription factor 1.	0.529
BARHL2	ISL1	ENSOCUP00000003642	ENSOCUP00000020036	BarH like homeobox 2.	ISL LIM homeobox 1.	0.671
BMP4	ATOH1	ENSOCUP00000009545	ENSOCUP00000011321	Bone morphogenetic protein 4; Induces cartilage and bone formation. Acts in concert with PTHLH/PTHRP to stimulate ductal outgrowth during embryonic mammary development and to inhibit hair follicle induction (By similarity).	Atonal bHLH transcription factor 1.	0.448
BMP4	CTNNB1	ENSOCUP00000009545	ENSOCUP00000032985	Bone morphogenetic protein 4; Induces cartilage and bone formation. Acts in concert with PTHLH/PTHRP to stimulate ductal outgrowth during embryonic mammary development and to inhibit hair follicle induction (By similarity).	Catenin beta 1.	0.475
BMP4	GATA3	ENSOCUP00000009545	ENSOCUP00000015302	Bone morphogenetic protein 4; Induces cartilage and bone formation. Acts in concert with PTHLH/PTHRP to stimulate ductal outgrowth during embryonic mammary development and to inhibit hair follicle induction (By similarity).	GATA binding protein 3.	0.505
BMP4	ISL1	ENSOCUP00000009545	ENSOCUP00000020036	Bone morphogenetic protein 4; Induces cartilage and bone formation. Acts in concert with PTHLH/PTHRP to stimulate ductal outgrowth during embryonic mammary development and to inhibit hair follicle induction (By similarity).	ISL LIM homeobox 1.	0.737
BMP4	MEF2C	ENSOCUP00000009545	ENSOCUP00000047636	Bone morphogenetic protein 4; Induces cartilage and bone formation. Acts in concert with PTHLH/PTHRP to stimulate ductal outgrowth during embryonic mammary development and to inhibit hair follicle induction (By similarity).	Myocyte enhancer factor 2C.	0.551
BMP4	NOTCH2	ENSOCUP00000009545	ENSOCUP00000035735	Bone morphogenetic protein 4; Induces cartilage and bone formation. Acts in concert with PTHLH/PTHRP to stimulate ductal outgrowth during embryonic mammary development and to inhibit hair follicle induction (By similarity).	Notch receptor 2.	0.403
BMP4	PAX2	ENSOCUP00000009545	ENSOCUP00000011064	Bone morphogenetic protein 4; Induces cartilage and bone formation. Acts in concert with PTHLH/PTHRP to stimulate ductal outgrowth during embryonic mammary development and to inhibit hair follicle induction (By similarity).	Paired box 2.	0.626
BMP4	PAX6	ENSOCUP00000009545	ENSOCUP00000019685	Bone morphogenetic protein 4; Induces cartilage and bone formation. Acts in concert with PTHLH/PTHRP to stimulate ductal outgrowth during embryonic mammary development and to inhibit hair follicle induction (By similarity).	Uncharacterized protein.	0.730
BMP4	PTCH1	ENSOCUP00000009545	ENSOCUP00000002587	Bone morphogenetic protein 4; Induces cartilage and bone formation. Acts in concert with PTHLH/PTHRP to stimulate ductal outgrowth during embryonic mammary development and to inhibit hair follicle induction (By similarity).	Patched 1.	0.724