72 items (Oryctolagus cuniculus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	NOTCH4	Uncharacterized protein. (1854 aa)
	TCOF1	Treacle ribosome biogenesis factor 1. (1492 aa)
	SMAD4	Mothers against decapentaplegic homolog. (552 aa)
	EFNA1	Ephrin A1; Belongs to the ephrin family. (205 aa)
	AKNA	AT-hook transcription factor. (1421 aa)
	LEF1	Lymphoid enhancer binding factor 1. (414 aa)
	LOC100352102	Uncharacterized protein. (256 aa)
	ENSOCUP00000045925	TGFb_propeptide domain-containing protein. (272 aa)
	HNRNPAB	Heterogeneous nuclear ribonucleoprotein A/B. (269 aa)
	ENSOCUP00000044284	TGFb_propeptide domain-containing protein. (260 aa)
	DDX5	DEAD-box helicase 5; Belongs to the DEAD box helicase family. (614 aa)
	LOXL3	Lysyl oxidase like 3. (935 aa)
	ENSOCUP00000041840	TGFb_propeptide domain-containing protein. (219 aa)
	FGFR1	Fibroblast growth factor receptor. (823 aa)
	HIF1A	Uncharacterized protein. (851 aa)
	ENSOCUP00000037873	Uncharacterized protein. (411 aa)
	ENSOCUP00000037329	TGFb_propeptide domain-containing protein. (263 aa)
	LOXL4	Lysyl oxidase like 4. (803 aa)
	TGFBR1	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (486 aa)
	GSK3B	Glycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (433 aa)
	FGFR2	Fibroblast growth factor receptor. (894 aa)
	ENSOCUP00000031949	Uncharacterized protein. (217 aa)
	LOC103345451	TGFb_propeptide domain-containing protein. (203 aa)
	PDCD4	Programmed cell death 4. (491 aa)
	TGFBR3L	Transforming growth factor beta receptor 3 like. (313 aa)
	ENSOCUP00000029917	Uncharacterized protein. (169 aa)
	ENSOCUP00000028409	Uncharacterized protein. (64 aa)
	HEY2	Hes related family bHLH transcription factor with YRPW motif 2. (338 aa)
	KBTBD8	Uncharacterized protein. (153 aa)
	G1U373_RABIT	SRCR domain-containing protein; Belongs to the heparin-binding growth factors family. (200 aa)
	WNT16	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (365 aa)
	B7NZQ1_RABIT	FLNA protein (Predicted). (780 aa)
	HAS2	Uncharacterized protein. (556 aa)
	RFLNB	Refilin B. (214 aa)
	ROCK2	Rho associated coiled-coil containing protein kinase 2; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (1131 aa)
	DLG5	Discs large MAGUK scaffold protein 5; Belongs to the MAGUK family. (1112 aa)
	GSC	Goosecoid homeobox. (237 aa)
	PDCD6	Programmed cell death 6. (191 aa)
	WNT4	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (487 aa)
	TMEM100	Transmembrane protein 100. (134 aa)
	G1TTB9_RABIT	Uncharacterized protein. (200 aa)
	G1TQL7_RABIT	LisH domain-containing protein. (83 aa)
	SNAI1	Snail family transcriptional repressor 1. (238 aa)
	TRIM28	Tripartite motif containing 28. (857 aa)
	HEY1	Hes related family bHLH transcription factor with YRPW motif 1. (452 aa)
	DDX17	DEAD-box helicase 17; Belongs to the DEAD box helicase family. (716 aa)
	TGFB2	Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
	PEF1	Penta-EF-hand domain containing 1. (277 aa)
	POLR1B	DNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1135 aa)
	ADAM15	ADAM metallopeptidase domain 15. (881 aa)
	ENG	Endoglin. (758 aa)
	EPB41L5	Erythrocyte membrane protein band 4.1 like 5. (731 aa)
	G1SV95_RABIT	Transforming growth factor beta; Belongs to the TGF-beta family. (387 aa)
	KLHL12	Kelch like family member 12. (851 aa)
	BMP2	Bone morphogenetic protein 2; Induces cartilage and bone formation. Stimulates the differentiation of myoblasts into osteoblasts via the EIF2AK3- EIF2A- ATF4 pathway. BMP2 activation of EIF2AK3 stimulates phosphorylation of EIF2A which leads to increased expression of ATF4 which plays a central role in osteoblast differentiation. In addition stimulates TMEM119, which upregulates the expression of ATF4. (271 aa)
	RTN4	Reticulon. (1110 aa)
	SNAI2	Uncharacterized protein. (268 aa)
	TASOR	Transcription activation suppressor. (1672 aa)
	EDN1	Big endothelin-1; Endothelins are endothelium-derived vasoconstrictor peptides (By similarity). Probable ligand for G-protein coupled receptors EDNRA and EDNRB which activates PTK2B, BCAR1, BCAR3 and, GTPases RAP1 and RHOA cascade in glomerular mesangial cells (By similarity). Belongs to the endothelin/sarafotoxin family. (202 aa)
	TBX3	Uncharacterized protein. (242 aa)
	SPRY1	Sprouty RTK signaling antagonist 1. (319 aa)
	TGFBR3	Transforming growth factor beta receptor 3. (851 aa)
	WNT2	Protein Wnt-2; Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters (By similarity). (360 aa)
	WNT5A	Protein Wnt-5a; Ligand for members of the frizzled family of seven transmembrane receptors. Can activate or inhibit canonical Wnt signaling, depending on receptor context. In the presence of FZD4, activates beta-catenin signaling. In the presence of ROR2, inhibits the canonical Wnt pathway by promoting beta-catenin degradation through a GSK3-independent pathway which involves down-regulation of beta- catenin-induced reporter gene expression (By similarity). Suppression of the canonical pathway allows chondrogenesis to occur. Inhibits tumor formation. Stimulates cell migration. Decrease [...] (380 aa)
	EOMES	Eomesodermin. (410 aa)
	NOLC1	LisH domain-containing protein. (702 aa)
	HEYL	Hes related family bHLH transcription factor with YRPW motif like. (301 aa)
	FLNA	Uncharacterized protein. (2617 aa)
	EDNRA	Endothelin receptor type A; Belongs to the G-protein coupled receptor 1 family. (427 aa)
	CUL7	Cullin 7; Belongs to the cullin family. (1728 aa)
	WNT11	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
	LRP6	Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1613 aa)

Your Current Organism:

Oryctolagus cuniculus

NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BMP2	EDN1	ENSOCUP00000010036	ENSOCUP00000011526	Bone morphogenetic protein 2; Induces cartilage and bone formation. Stimulates the differentiation of myoblasts into osteoblasts via the EIF2AK3- EIF2A- ATF4 pathway. BMP2 activation of EIF2AK3 stimulates phosphorylation of EIF2A which leads to increased expression of ATF4 which plays a central role in osteoblast differentiation. In addition stimulates TMEM119, which upregulates the expression of ATF4.	Big endothelin-1; Endothelins are endothelium-derived vasoconstrictor peptides (By similarity). Probable ligand for G-protein coupled receptors EDNRA and EDNRB which activates PTK2B, BCAR1, BCAR3 and, GTPases RAP1 and RHOA cascade in glomerular mesangial cells (By similarity). Belongs to the endothelin/sarafotoxin family.	0.404
BMP2	ENG	ENSOCUP00000010036	ENSOCUP00000006169	Bone morphogenetic protein 2; Induces cartilage and bone formation. Stimulates the differentiation of myoblasts into osteoblasts via the EIF2AK3- EIF2A- ATF4 pathway. BMP2 activation of EIF2AK3 stimulates phosphorylation of EIF2A which leads to increased expression of ATF4 which plays a central role in osteoblast differentiation. In addition stimulates TMEM119, which upregulates the expression of ATF4.	Endoglin.	0.418
BMP2	ENSOCUP00000037329	ENSOCUP00000010036	ENSOCUP00000037329	Bone morphogenetic protein 2; Induces cartilage and bone formation. Stimulates the differentiation of myoblasts into osteoblasts via the EIF2AK3- EIF2A- ATF4 pathway. BMP2 activation of EIF2AK3 stimulates phosphorylation of EIF2A which leads to increased expression of ATF4 which plays a central role in osteoblast differentiation. In addition stimulates TMEM119, which upregulates the expression of ATF4.	TGFb_propeptide domain-containing protein.	0.730
BMP2	ENSOCUP00000044284	ENSOCUP00000010036	ENSOCUP00000044284	Bone morphogenetic protein 2; Induces cartilage and bone formation. Stimulates the differentiation of myoblasts into osteoblasts via the EIF2AK3- EIF2A- ATF4 pathway. BMP2 activation of EIF2AK3 stimulates phosphorylation of EIF2A which leads to increased expression of ATF4 which plays a central role in osteoblast differentiation. In addition stimulates TMEM119, which upregulates the expression of ATF4.	TGFb_propeptide domain-containing protein.	0.730
BMP2	G1U373_RABIT	ENSOCUP00000010036	ENSOCUP00000023832	Bone morphogenetic protein 2; Induces cartilage and bone formation. Stimulates the differentiation of myoblasts into osteoblasts via the EIF2AK3- EIF2A- ATF4 pathway. BMP2 activation of EIF2AK3 stimulates phosphorylation of EIF2A which leads to increased expression of ATF4 which plays a central role in osteoblast differentiation. In addition stimulates TMEM119, which upregulates the expression of ATF4.	SRCR domain-containing protein; Belongs to the heparin-binding growth factors family.	0.429
BMP2	HIF1A	ENSOCUP00000010036	ENSOCUP00000041090	Bone morphogenetic protein 2; Induces cartilage and bone formation. Stimulates the differentiation of myoblasts into osteoblasts via the EIF2AK3- EIF2A- ATF4 pathway. BMP2 activation of EIF2AK3 stimulates phosphorylation of EIF2A which leads to increased expression of ATF4 which plays a central role in osteoblast differentiation. In addition stimulates TMEM119, which upregulates the expression of ATF4.	Uncharacterized protein.	0.452
BMP2	LOC103345451	ENSOCUP00000010036	ENSOCUP00000031740	Bone morphogenetic protein 2; Induces cartilage and bone formation. Stimulates the differentiation of myoblasts into osteoblasts via the EIF2AK3- EIF2A- ATF4 pathway. BMP2 activation of EIF2AK3 stimulates phosphorylation of EIF2A which leads to increased expression of ATF4 which plays a central role in osteoblast differentiation. In addition stimulates TMEM119, which upregulates the expression of ATF4.	TGFb_propeptide domain-containing protein.	0.730
BMP2	LRP6	ENSOCUP00000010036	ENSOCUP00000002615	Bone morphogenetic protein 2; Induces cartilage and bone formation. Stimulates the differentiation of myoblasts into osteoblasts via the EIF2AK3- EIF2A- ATF4 pathway. BMP2 activation of EIF2AK3 stimulates phosphorylation of EIF2A which leads to increased expression of ATF4 which plays a central role in osteoblast differentiation. In addition stimulates TMEM119, which upregulates the expression of ATF4.	Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family.	0.414
BMP2	SMAD4	ENSOCUP00000010036	ENSOCUP00000003411	Bone morphogenetic protein 2; Induces cartilage and bone formation. Stimulates the differentiation of myoblasts into osteoblasts via the EIF2AK3- EIF2A- ATF4 pathway. BMP2 activation of EIF2AK3 stimulates phosphorylation of EIF2A which leads to increased expression of ATF4 which plays a central role in osteoblast differentiation. In addition stimulates TMEM119, which upregulates the expression of ATF4.	Mothers against decapentaplegic homolog.	0.893
BMP2	TGFBR1	ENSOCUP00000010036	ENSOCUP00000035624	Bone morphogenetic protein 2; Induces cartilage and bone formation. Stimulates the differentiation of myoblasts into osteoblasts via the EIF2AK3- EIF2A- ATF4 pathway. BMP2 activation of EIF2AK3 stimulates phosphorylation of EIF2A which leads to increased expression of ATF4 which plays a central role in osteoblast differentiation. In addition stimulates TMEM119, which upregulates the expression of ATF4.	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily.	0.758
BMP2	TGFBR3	ENSOCUP00000010036	ENSOCUP00000013829	Bone morphogenetic protein 2; Induces cartilage and bone formation. Stimulates the differentiation of myoblasts into osteoblasts via the EIF2AK3- EIF2A- ATF4 pathway. BMP2 activation of EIF2AK3 stimulates phosphorylation of EIF2A which leads to increased expression of ATF4 which plays a central role in osteoblast differentiation. In addition stimulates TMEM119, which upregulates the expression of ATF4.	Transforming growth factor beta receptor 3.	0.442
BMP2	WNT4	ENSOCUP00000010036	ENSOCUP00000020454	Bone morphogenetic protein 2; Induces cartilage and bone formation. Stimulates the differentiation of myoblasts into osteoblasts via the EIF2AK3- EIF2A- ATF4 pathway. BMP2 activation of EIF2AK3 stimulates phosphorylation of EIF2A which leads to increased expression of ATF4 which plays a central role in osteoblast differentiation. In addition stimulates TMEM119, which upregulates the expression of ATF4.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.427
BMP2	WNT5A	ENSOCUP00000010036	ENSOCUP00000000333	Bone morphogenetic protein 2; Induces cartilage and bone formation. Stimulates the differentiation of myoblasts into osteoblasts via the EIF2AK3- EIF2A- ATF4 pathway. BMP2 activation of EIF2AK3 stimulates phosphorylation of EIF2A which leads to increased expression of ATF4 which plays a central role in osteoblast differentiation. In addition stimulates TMEM119, which upregulates the expression of ATF4.	Protein Wnt-5a; Ligand for members of the frizzled family of seven transmembrane receptors. Can activate or inhibit canonical Wnt signaling, depending on receptor context. In the presence of FZD4, activates beta-catenin signaling. In the presence of ROR2, inhibits the canonical Wnt pathway by promoting beta-catenin degradation through a GSK3-independent pathway which involves down-regulation of beta- catenin-induced reporter gene expression (By similarity). Suppression of the canonical pathway allows chondrogenesis to occur. Inhibits tumor formation. Stimulates cell migration. Decrease [...]	0.427
CUL7	KLHL12	ENSOCUP00000001360	ENSOCUP00000007958	Cullin 7; Belongs to the cullin family.	Kelch like family member 12.	0.552
CUL7	POLR1B	ENSOCUP00000001360	ENSOCUP00000005249	Cullin 7; Belongs to the cullin family.	DNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.	0.809
DDX17	DDX5	ENSOCUP00000004311	ENSOCUP00000043262	DEAD-box helicase 17; Belongs to the DEAD box helicase family.	DEAD-box helicase 5; Belongs to the DEAD box helicase family.	0.924
DDX17	PDCD4	ENSOCUP00000004311	ENSOCUP00000030567	DEAD-box helicase 17; Belongs to the DEAD box helicase family.	Programmed cell death 4.	0.403
DDX17	POLR1B	ENSOCUP00000004311	ENSOCUP00000005249	DEAD-box helicase 17; Belongs to the DEAD box helicase family.	DNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.	0.608
DDX5	DDX17	ENSOCUP00000043262	ENSOCUP00000004311	DEAD-box helicase 5; Belongs to the DEAD box helicase family.	DEAD-box helicase 17; Belongs to the DEAD box helicase family.	0.924
DDX5	PDCD4	ENSOCUP00000043262	ENSOCUP00000030567	DEAD-box helicase 5; Belongs to the DEAD box helicase family.	Programmed cell death 4.	0.496