92 items (Oryctolagus cuniculus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	MED12	Mediator complex subunit 12. (2142 aa)
	LMO4	LIM domain only 4. (214 aa)
	U3KP67_RABIT	Uncharacterized protein. (234 aa)
	TRAF6	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (552 aa)
	SUFU	SUFU negative regulator of hedgehog signaling. (578 aa)
	COBL	Cordon-bleu WH2 repeat protein. (1335 aa)
	SALL4	Spalt like transcription factor 4. (994 aa)
	G1U6A8_RABIT	40S ribosomal protein S7; Belongs to the eukaryotic ribosomal protein eS7 family. (194 aa)
	FZD3	Frizzled class receptor 3; Belongs to the G-protein coupled receptor Fz/Smo family. (603 aa)
	RPS7	40S ribosomal protein S7; Belongs to the eukaryotic ribosomal protein eS7 family. (231 aa)
	G1U106_RABIT	Uncharacterized protein. (312 aa)
	G1U0Z0_RABIT	40S ribosomal protein S7; Belongs to the eukaryotic ribosomal protein eS7 family. (177 aa)
	RALA-2	Uncharacterized protein. (206 aa)
	BBS4	Bardet-Biedl syndrome 4. (493 aa)
	TRIM71	Tripartite motif containing 71. (910 aa)
	RARA	Retinoic acid receptor alpha. (462 aa)
	ARHGAP35	Rho GTPase activating protein 35. (1415 aa)
	VANGL2	Vang-like protein. (521 aa)
	SFRP2	Secreted frizzled related protein 2. (295 aa)
	SPINT1	Serine peptidase inhibitor, Kunitz type 1. (506 aa)
	STIL	STIL centriolar assembly protein. (1207 aa)
	KAT2A	Histone acetyltransferase; Belongs to the acetyltransferase family. GCN5 subfamily. (795 aa)
	PAX2	Paired box 2. (448 aa)
	SHROOM3	ASD2 domain-containing protein. (137 aa)
	APAF1	Apoptotic peptidase activating factor 1. (1183 aa)
	MTHFD1	Methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1. (935 aa)
	BMP4	Bone morphogenetic protein 4; Induces cartilage and bone formation. Acts in concert with PTHLH/PTHRP to stimulate ductal outgrowth during embryonic mammary development and to inhibit hair follicle induction (By similarity). (409 aa)
	LRP2	Uncharacterized protein. (2726 aa)
	ADM	Adrenomedullin. (187 aa)
	ST14	Suppression of tumorigenicity 14. (774 aa)
	FZD6	Frizzled class receptor 6; Belongs to the G-protein coupled receptor Fz/Smo family. (712 aa)
	LIAS	Lipoyl synthase, mitochondrial; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. (374 aa)
	TEAD2	TEA domain transcription factor 2. (405 aa)
	ABL2	Tyrosine-protein kinase. (1146 aa)
	G1SV95_RABIT	Transforming growth factor beta; Belongs to the TGF-beta family. (387 aa)
	LHX2	LIM homeobox 2. (414 aa)
	MTHFR	Methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. (702 aa)
	DVL2	Dishevelled segment polarity protein 2. (783 aa)
	KDM2B	Lysine demethylase 2B. (1341 aa)
	TGFB2	Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
	GRHL2	Grainyhead like transcription factor 2. (728 aa)
	IFT172	Intraflagellar transport 172. (1749 aa)
	HECTD1	HECT domain E3 ubiquitin protein ligase 1. (2610 aa)
	TMED2	GOLD domain-containing protein. (116 aa)
	SEMA4C	Semaphorin 4C; Belongs to the semaphorin family. (832 aa)
	BRD2	Bromodomain containing 2. (802 aa)
	PTCH1	Patched 1. (1321 aa)
	PTK7	Protein tyrosine kinase 7 (inactive); Belongs to the protein kinase superfamily. Tyr protein kinase family. (978 aa)
	SETD2	Uncharacterized protein. (625 aa)
	MTHFD1L	Methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1 like. (979 aa)
	KIF20B	Kinesin family member 20B; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1758 aa)
	GLMN	Uncharacterized protein. (592 aa)
	G1SED3_RABIT	Uncharacterized protein. (590 aa)
	TBXT	T-box transcription factor T. (365 aa)
	WNT5A	Protein Wnt-5a; Ligand for members of the frizzled family of seven transmembrane receptors. Can activate or inhibit canonical Wnt signaling, depending on receptor context. In the presence of FZD4, activates beta-catenin signaling. In the presence of ROR2, inhibits the canonical Wnt pathway by promoting beta-catenin degradation through a GSK3-independent pathway which involves down-regulation of beta- catenin-induced reporter gene expression (By similarity). Suppression of the canonical pathway allows chondrogenesis to occur. Inhibits tumor formation. Stimulates cell migration. Decrease [...] (380 aa)
	RGMA	Repulsive guidance molecule BMP co-receptor a. (325 aa)
	PHACTR4	Phosphatase and actin regulator. (781 aa)
	CITED2	Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 2. (249 aa)
	PRICKLE1	Prickle planar cell polarity protein 1. (814 aa)
	ENSOCUP00000045925	TGFb_propeptide domain-containing protein. (272 aa)
	ENSOCUP00000044284	TGFb_propeptide domain-containing protein. (260 aa)
	ENSOCUP00000044253	Uncharacterized protein. (465 aa)
	PRKACB	Protein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (398 aa)
	MKS1	MKS transition zone complex subunit 1. (667 aa)
	CECR2	CECR2 histone acetyl-lysine reader. (1315 aa)
	RALA	Uncharacterized protein. (263 aa)
	LRRC1	Leucine rich repeat containing 1. (458 aa)
	SPINT2	Serine peptidase inhibitor, Kunitz type 2. (252 aa)
	RARG	Uncharacterized protein. (415 aa)
	ENSOCUP00000041840	TGFb_propeptide domain-containing protein. (219 aa)
	TULP3	Tubby-like protein; Belongs to the TUB family. (614 aa)
	CLUAP1	Clusterin associated protein 1. (400 aa)
	IFT57	Intraflagellar transport 57. (452 aa)
	TSC1	Uncharacterized protein. (988 aa)
	ABL1	Tyrosine-protein kinase. (1118 aa)
	TSC2	TSC complex subunit 2. (1357 aa)
	ENSOCUP00000037329	TGFb_propeptide domain-containing protein. (263 aa)
	DVL3	Dishevelled segment polarity protein 3. (680 aa)
	IFT122	Intraflagellar transport 122. (1234 aa)
	KDM6A	Lysine demethylase 6A. (1401 aa)
	SDC4	Syndecan 4. (197 aa)
	GRHL3	Grainyhead like transcription factor 3. (619 aa)
	OPA1	OPA1 mitochondrial dynamin like GTPase; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (997 aa)
	LOC103345451	TGFb_propeptide domain-containing protein. (203 aa)
	ENSOCUP00000031621	Uncharacterized protein. (1225 aa)
	SEC24B	SEC24 homolog B, COPII coat complex component. (1229 aa)
	ENSOCUP00000029917	Uncharacterized protein. (169 aa)
	VASP	WH1 domain-containing protein. (147 aa)
	DLC1	DLC1 Rho GTPase activating protein. (1590 aa)
	ENSOCUP00000028636	40S ribosomal protein S7; Belongs to the eukaryotic ribosomal protein eS7 family. (116 aa)
	CC2D2A	Coiled-coil and C2 domain containing 2A. (1647 aa)
	ENSOCUP00000028121	GOLD domain-containing protein. (178 aa)

Your Current Organism:

Oryctolagus cuniculus

NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ABL1	ABL2	ENSOCUP00000038489	ENSOCUP00000007546	Tyrosine-protein kinase.	Tyrosine-protein kinase.	0.907
ABL1	VASP	ENSOCUP00000038489	ENSOCUP00000029878	Tyrosine-protein kinase.	WH1 domain-containing protein.	0.540
ABL2	ABL1	ENSOCUP00000007546	ENSOCUP00000038489	Tyrosine-protein kinase.	Tyrosine-protein kinase.	0.907
ABL2	VASP	ENSOCUP00000007546	ENSOCUP00000029878	Tyrosine-protein kinase.	WH1 domain-containing protein.	0.563
BBS4	CLUAP1	ENSOCUP00000020735	ENSOCUP00000040517	Bardet-Biedl syndrome 4.	Clusterin associated protein 1.	0.588
BBS4	IFT122	ENSOCUP00000020735	ENSOCUP00000035393	Bardet-Biedl syndrome 4.	Intraflagellar transport 122.	0.692
BBS4	IFT172	ENSOCUP00000020735	ENSOCUP00000003749	Bardet-Biedl syndrome 4.	Intraflagellar transport 172.	0.749
BBS4	IFT57	ENSOCUP00000020735	ENSOCUP00000040399	Bardet-Biedl syndrome 4.	Intraflagellar transport 57.	0.806
BMP4	ENSOCUP00000037329	ENSOCUP00000009545	ENSOCUP00000037329	Bone morphogenetic protein 4; Induces cartilage and bone formation. Acts in concert with PTHLH/PTHRP to stimulate ductal outgrowth during embryonic mammary development and to inhibit hair follicle induction (By similarity).	TGFb_propeptide domain-containing protein.	0.612
BMP4	ENSOCUP00000044284	ENSOCUP00000009545	ENSOCUP00000044284	Bone morphogenetic protein 4; Induces cartilage and bone formation. Acts in concert with PTHLH/PTHRP to stimulate ductal outgrowth during embryonic mammary development and to inhibit hair follicle induction (By similarity).	TGFb_propeptide domain-containing protein.	0.612
BMP4	LHX2	ENSOCUP00000009545	ENSOCUP00000006701	Bone morphogenetic protein 4; Induces cartilage and bone formation. Acts in concert with PTHLH/PTHRP to stimulate ductal outgrowth during embryonic mammary development and to inhibit hair follicle induction (By similarity).	LIM homeobox 2.	0.493
BMP4	LOC103345451	ENSOCUP00000009545	ENSOCUP00000031740	Bone morphogenetic protein 4; Induces cartilage and bone formation. Acts in concert with PTHLH/PTHRP to stimulate ductal outgrowth during embryonic mammary development and to inhibit hair follicle induction (By similarity).	TGFb_propeptide domain-containing protein.	0.612
BMP4	LRP2	ENSOCUP00000009545	ENSOCUP00000009497	Bone morphogenetic protein 4; Induces cartilage and bone formation. Acts in concert with PTHLH/PTHRP to stimulate ductal outgrowth during embryonic mammary development and to inhibit hair follicle induction (By similarity).	Uncharacterized protein.	0.402
BMP4	PAX2	ENSOCUP00000009545	ENSOCUP00000011064	Bone morphogenetic protein 4; Induces cartilage and bone formation. Acts in concert with PTHLH/PTHRP to stimulate ductal outgrowth during embryonic mammary development and to inhibit hair follicle induction (By similarity).	Paired box 2.	0.626
BMP4	PTCH1	ENSOCUP00000009545	ENSOCUP00000002587	Bone morphogenetic protein 4; Induces cartilage and bone formation. Acts in concert with PTHLH/PTHRP to stimulate ductal outgrowth during embryonic mammary development and to inhibit hair follicle induction (By similarity).	Patched 1.	0.724
BMP4	RGMA	ENSOCUP00000009545	ENSOCUP00000000208	Bone morphogenetic protein 4; Induces cartilage and bone formation. Acts in concert with PTHLH/PTHRP to stimulate ductal outgrowth during embryonic mammary development and to inhibit hair follicle induction (By similarity).	Repulsive guidance molecule BMP co-receptor a.	0.855
BMP4	SALL4	ENSOCUP00000009545	ENSOCUP00000025620	Bone morphogenetic protein 4; Induces cartilage and bone formation. Acts in concert with PTHLH/PTHRP to stimulate ductal outgrowth during embryonic mammary development and to inhibit hair follicle induction (By similarity).	Spalt like transcription factor 4.	0.427
BMP4	SFRP2	ENSOCUP00000009545	ENSOCUP00000014323	Bone morphogenetic protein 4; Induces cartilage and bone formation. Acts in concert with PTHLH/PTHRP to stimulate ductal outgrowth during embryonic mammary development and to inhibit hair follicle induction (By similarity).	Secreted frizzled related protein 2.	0.509
BMP4	TBXT	ENSOCUP00000009545	ENSOCUP00000000574	Bone morphogenetic protein 4; Induces cartilage and bone formation. Acts in concert with PTHLH/PTHRP to stimulate ductal outgrowth during embryonic mammary development and to inhibit hair follicle induction (By similarity).	T-box transcription factor T.	0.819
BMP4	WNT5A	ENSOCUP00000009545	ENSOCUP00000000333	Bone morphogenetic protein 4; Induces cartilage and bone formation. Acts in concert with PTHLH/PTHRP to stimulate ductal outgrowth during embryonic mammary development and to inhibit hair follicle induction (By similarity).	Protein Wnt-5a; Ligand for members of the frizzled family of seven transmembrane receptors. Can activate or inhibit canonical Wnt signaling, depending on receptor context. In the presence of FZD4, activates beta-catenin signaling. In the presence of ROR2, inhibits the canonical Wnt pathway by promoting beta-catenin degradation through a GSK3-independent pathway which involves down-regulation of beta- catenin-induced reporter gene expression (By similarity). Suppression of the canonical pathway allows chondrogenesis to occur. Inhibits tumor formation. Stimulates cell migration. Decrease [...]	0.750