STRINGSTRING
PTPN3 PTPN3 ENSOCUP00000042987 ENSOCUP00000042987 MAN2A1 MAN2A1 ENSOCUP00000044284 ENSOCUP00000044284 UPB1 UPB1 LOC100348617 LOC100348617 ENSOCUP00000045925 ENSOCUP00000045925 PCSK9 PCSK9 ENSOCUP00000047510 ENSOCUP00000047510 CITED2 CITED2 SP3 SP3 CPS1 CPS1 ENSOCUP00000030170 ENSOCUP00000030170 CADM1 CADM1 CUL3 CUL3 LOC103345451 LOC103345451 CCDC39 CCDC39 FPGS FPGS RB1CC1 RB1CC1 NOTCH2 NOTCH2 CDK5RAP3 CDK5RAP3 LOC100357982 LOC100357982 ENSOCUP00000037329 ENSOCUP00000037329 SMARCB1 SMARCB1 LSR LSR IGF2R IGF2R JUN JUN RPS6KA1 RPS6KA1 ENSOCUP00000040784 ENSOCUP00000040784 PROX1 PROX1 EZH2 EZH2 ENSOCUP00000041840 ENSOCUP00000041840 ELK1 ELK1 ENSOCUP00000042760 ENSOCUP00000042760 ENSOCUP00000042867 ENSOCUP00000042867 MPST MPST E2F8 E2F8 PCNA PCNA HNF1B HNF1B PTCH1 PTCH1 ACAT1 ACAT1 PCK2 PCK2 PKD2 PKD2 RPGRIP1L RPGRIP1L ARF6 ARF6 HNRNPD HNRNPD C12H6orf58 C12H6orf58 ADA ADA JARID2 JARID2 LOC100350133 LOC100350133 SRSF5 SRSF5 LOC100349251 LOC100349251 NODAL NODAL TYMS TYMS NF1 NF1 G1SV95_RABIT G1SV95_RABIT XBP1 XBP1 HNF4A HNF4A TAF10 TAF10 UPF2 UPF2 HLX HLX HMGCS2 HMGCS2 E2F7 E2F7 PDX1 PDX1 FRZB FRZB HMOX1 HMOX1 CLDN1 CLDN1 ATF2 ATF2 CDKN2B CDKN2B UCP2 UCP2 PKD1 PKD1 ATP7A ATP7A NPHP3 NPHP3 TBX3 TBX3 FGL1 FGL1 LOC100350716 LOC100350716 ZMPSTE24 ZMPSTE24 TGFBR3 TGFBR3 CIT CIT ALDH1A2 ALDH1A2 SRD5A1 SRD5A1 CEBPG CEBPG AURKA AURKA PCK1 PCK1 CPB2 CPB2 ZIC3 ZIC3 DNAAF1 DNAAF1 CEBPB CEBPB RARA RARA IL6 IL6 RHBDD3 RHBDD3 WNT4 WNT4 ACO2 ACO2 MED1 MED1 GLI1 GLI1 SEC63 SEC63 HES1 HES1 G1U0P1_RABIT G1U0P1_RABIT WNT1 WNT1 IHH IHH ACADM ACADM PIK3CA PIK3CA U3KM51_RABIT U3KM51_RABIT COBL COBL SMAD3 SMAD3 U3KPP0_RABIT U3KPP0_RABIT ASS1 ASS1 ITGA2 ITGA2 OTC OTC
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PTPN3Tyrosine-protein phosphatase non-receptor type; May act at junctions between the membrane and the cytoskeleton. (1005 aa)
ENSOCUP00000042987Thymidylat_synt domain-containing protein. (98 aa)
MAN2A1Alpha-mannosidase. (1172 aa)
ENSOCUP00000044284TGFb_propeptide domain-containing protein. (260 aa)
UPB1Beta-ureidopropionase 1. (528 aa)
LOC100348617Uncharacterized protein. (420 aa)
ENSOCUP00000045925TGFb_propeptide domain-containing protein. (272 aa)
PCSK9Proprotein convertase subtilisin/kexin type 9; Belongs to the peptidase S8 family. (686 aa)
ENSOCUP00000047510Uncharacterized protein. (209 aa)
CITED2Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 2. (249 aa)
SP3Sp3 transcription factor. (715 aa)
CPS1Carbamoyl-phosphate synthase 1. (1506 aa)
ENSOCUP00000030170Uncharacterized protein. (353 aa)
CADM1Cell adhesion molecule 1. (511 aa)
CUL3Cullin 3; Belongs to the cullin family. (771 aa)
LOC103345451TGFb_propeptide domain-containing protein. (203 aa)
CCDC39Coiled-coil domain containing 39. (939 aa)
FPGSFolylpolyglutamate synthase. (642 aa)
RB1CC1RB1 inducible coiled-coil 1. (1606 aa)
NOTCH2Notch receptor 2. (2481 aa)
CDK5RAP3CDK5 regulatory subunit associated protein 3. (536 aa)
LOC100357982BZIP domain-containing protein. (301 aa)
ENSOCUP00000037329TGFb_propeptide domain-containing protein. (263 aa)
SMARCB1SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1. (327 aa)
LSRLipolysis stimulated lipoprotein receptor. (683 aa)
IGF2RInsulin like growth factor 2 receptor. (2697 aa)
JUNBZIP domain-containing protein; Belongs to the bZIP family. (352 aa)
RPS6KA1Ribosomal protein S6 kinase. (813 aa)
ENSOCUP00000040784Uncharacterized protein. (227 aa)
PROX1Prospero homeobox 1. (737 aa)
EZH2Enhancer of zeste 2 polycomb repressive complex 2 subunit. (769 aa)
ENSOCUP00000041840TGFb_propeptide domain-containing protein. (219 aa)
ELK1ETS transcription factor ELK1. (512 aa)
ENSOCUP00000042760HNF-1_N domain-containing protein. (109 aa)
ENSOCUP00000042867Uncharacterized protein. (340 aa)
MPSTUncharacterized protein. (541 aa)
E2F8E2F transcription factor 8. (867 aa)
PCNAProliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (261 aa)
HNF1BHNF1 homeobox B. (569 aa)
PTCH1Patched 1. (1321 aa)
ACAT1Acetyl-CoA acetyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family. (427 aa)
PCK2Phosphoenolpyruvate carboxykinase 2, mitochondrial. (640 aa)
PKD2Polycystin 2, transient receptor potential cation channel. (994 aa)
RPGRIP1LRPGRIP1 like. (1269 aa)
ARF6ADP ribosylation factor 6; Belongs to the small GTPase superfamily. Arf family. (175 aa)
HNRNPDHeterogeneous nuclear ribonucleoprotein D. (286 aa)
C12H6orf58Uncharacterized protein. (321 aa)
ADAAdenosine deaminase. (363 aa)
JARID2Jumonji and AT-rich interaction domain containing 2. (1242 aa)
LOC100350133Uncharacterized protein. (422 aa)
SRSF5Serine and arginine rich splicing factor 5. (276 aa)
LOC100349251Uncharacterized protein. (341 aa)
NODALNodal growth differentiation factor. (348 aa)
TYMSThymidylate synthetase. (310 aa)
NF1Neurofibromin 1. (2841 aa)
G1SV95_RABITTransforming growth factor beta; Belongs to the TGF-beta family. (387 aa)
XBP1X-box binding protein 1. (208 aa)
HNF4AHepatocyte nuclear factor 4 alpha. (468 aa)
TAF10Transcription initiation factor TFIID subunit 10; TFIID is a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors; Belongs to the TAF10 family. (218 aa)
UPF2UPF2 regulator of nonsense mediated mRNA decay. (1264 aa)
HLXH2.0 like homeobox. (682 aa)
HMGCS23-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase. (534 aa)
E2F7E2F transcription factor 7. (959 aa)
PDX1Pancreatic and duodenal homeobox 1. (336 aa)
FRZBFrizzled related protein. (318 aa)
HMOX1Heme oxygenase 1. (288 aa)
CLDN1Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (211 aa)
ATF2Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. (498 aa)
CDKN2BCyclin dependent kinase inhibitor 2B. (138 aa)
UCP2Uncoupling protein 2; Belongs to the mitochondrial carrier (TC 2.A.29) family. (309 aa)
PKD1Uncharacterized protein. (2465 aa)
ATP7AATPase copper transporting alpha. (1499 aa)
NPHP3TPR_REGION domain-containing protein. (1218 aa)
TBX3Uncharacterized protein. (242 aa)
FGL1Fibrinogen like 1. (323 aa)
LOC100350716Carn_acyltransf domain-containing protein; Belongs to the carnitine/choline acetyltransferase family. (808 aa)
ZMPSTE24CAAX prenyl protease; Proteolytically removes the C-terminal three residues of farnesylated proteins; Belongs to the peptidase M48A family. (475 aa)
TGFBR3Transforming growth factor beta receptor 3. (851 aa)
CITCitron Rho-interacting kinase; Plays a role in cytokinesis. Displays serine/threonine protein kinase activity; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (2070 aa)
ALDH1A2Aldehyde dehydrogenase 1 family member A2; Belongs to the aldehyde dehydrogenase family. (590 aa)
SRD5A13-oxo-5-alpha-steroid 4-dehydrogenase; Converts testosterone into 5-alpha-dihydrotestosterone and progesterone or corticosterone into their corresponding 5-alpha-3- oxosteroids. It plays a central role in sexual differentiation and androgen physiology. (255 aa)
CEBPGCCAAT enhancer binding protein gamma. (150 aa)
AURKAAurora kinase A; Belongs to the protein kinase superfamily. (402 aa)
PCK1Phosphoenolpyruvate carboxykinase 1. (622 aa)
CPB2Carboxypeptidase B2. (424 aa)
ZIC3Zic family member 3. (467 aa)
DNAAF1Dynein assembly factor 1, axonemal. (368 aa)
CEBPBCCAAT enhancer binding protein beta. (353 aa)
RARARetinoic acid receptor alpha. (462 aa)
IL6Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...] (241 aa)
RHBDD3Rhomboid domain containing 3. (375 aa)
WNT4Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (487 aa)
ACO2Aconitate hydratase, mitochondrial; Belongs to the aconitase/IPM isomerase family. (798 aa)
MED1Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1580 aa)
GLI1GLI family zinc finger 1. (1103 aa)
SEC63J domain-containing protein. (716 aa)
HES1Hes family bHLH transcription factor 1. (279 aa)
G1U0P1_RABITUncharacterized protein. (209 aa)
WNT1Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (370 aa)
IHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (410 aa)
ACADMAcyl-CoA dehydrogenase medium chain. (474 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
U3KM51_RABITUncharacterized protein; Belongs to the carnitine/choline acetyltransferase family. (794 aa)
COBLCordon-bleu WH2 repeat protein. (1335 aa)
SMAD3SMAD family member 3. (230 aa)
U3KPP0_RABITUncharacterized protein. (350 aa)
ASS1Uncharacterized protein. (251 aa)
ITGA2Integrin subunit alpha 2; Belongs to the integrin alpha chain family. (1202 aa)
OTCOrnithine carbamoyltransferase; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. (360 aa)
Your Current Organism:
Oryctolagus cuniculus
NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits
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