STRINGSTRING
SOSTDC1 SOSTDC1 NGFR NGFR LHX2 LHX2 DLX3 DLX3 FGF10 FGF10 NF1 NF1 KRT25 KRT25 FZD6 FZD6 ZDHHC21 ZDHHC21 DKK1 DKK1 FOXN1 FOXN1 ATP7A ATP7A KRT28 KRT28 EXT1 EXT1 EDA EDA ZMPSTE24 ZMPSTE24 WNT10A WNT10A SHH SHH PUM2 PUM2 ACVR1B ACVR1B GORAB GORAB LOC100346323 LOC100346323 EDAR EDAR SNAI1 SNAI1 LDB1 LDB1 SOS1 SOS1 PLA2G10-2 PLA2G10-2 G1U106_RABIT G1U106_RABIT IGFBP5 IGFBP5 FZD3 FZD3 KRT71 KRT71 LOC108177930 LOC108177930 SMO SMO ERCC2 ERCC2 TMEM79 TMEM79 SAV1 SAV1 CTNNB1 CTNNB1 LDB2 LDB2 NSUN2 NSUN2 FGFR2 FGFR2 ENSOCUP00000034349 ENSOCUP00000034349 ENSOCUP00000034777 ENSOCUP00000034777 BCL2 BCL2 LGR5 LGR5 FGF7 FGF7 HDAC1 HDAC1 NOM1 NOM1 TRPC4AP TRPC4AP TNFRSF19 TNFRSF19 NSDHL NSDHL HDAC2 HDAC2 GLI2 GLI2 LOC100352102 LOC100352102 TP63 TP63 GNAS GNAS ALX4 ALX4 DSG4 DSG4 CD109 CD109 TGFB2 TGFB2 FST FST LGR4 LGR4 LRP4 LRP4 INTU INTU INHBA INHBA PLA2G10 PLA2G10
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SOSTDC1Sclerostin domain containing 1. (206 aa)
NGFRNerve growth factor receptor. (407 aa)
LHX2LIM homeobox 2. (414 aa)
DLX3Distal-less homeobox 3. (287 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (220 aa)
NF1Neurofibromin 1. (2841 aa)
KRT25Keratin 25; Belongs to the intermediate filament family. (450 aa)
FZD6Frizzled class receptor 6; Belongs to the G-protein coupled receptor Fz/Smo family. (712 aa)
ZDHHC21Palmitoyltransferase; Belongs to the DHHC palmitoyltransferase family. (265 aa)
DKK1Dickkopf-like protein 1. (268 aa)
FOXN1Forkhead box N1. (648 aa)
ATP7AATPase copper transporting alpha. (1499 aa)
KRT28Keratin 28; Belongs to the intermediate filament family. (459 aa)
EXT1Exostosin glycosyltransferase 1; Belongs to the glycosyltransferase 47 family. (746 aa)
EDAEctodysplasin A; Belongs to the tumor necrosis factor family. (386 aa)
ZMPSTE24CAAX prenyl protease; Proteolytically removes the C-terminal three residues of farnesylated proteins; Belongs to the peptidase M48A family. (475 aa)
WNT10AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (417 aa)
SHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (451 aa)
PUM2Pumilio RNA binding family member 2. (1066 aa)
ACVR1BReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (474 aa)
GORABGolgin, RAB6 interacting. (394 aa)
LOC100346323Uncharacterized protein. (240 aa)
EDAREctodysplasin A receptor. (449 aa)
SNAI1Snail family transcriptional repressor 1. (238 aa)
LDB1LIM domain binding 1. (410 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1304 aa)
PLA2G10-2Phospholipase A(2). (152 aa)
G1U106_RABITUncharacterized protein. (312 aa)
IGFBP5Insulin like growth factor binding protein 5. (271 aa)
FZD3Frizzled class receptor 3; Belongs to the G-protein coupled receptor Fz/Smo family. (603 aa)
KRT71Keratin 71; Belongs to the intermediate filament family. (523 aa)
LOC108177930Uncharacterized protein. (102 aa)
SMOSmoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (787 aa)
ERCC2ERCC excision repair 2, TFIIH core complex helicase subunit. (805 aa)
TMEM79Uncharacterized protein. (504 aa)
SAV1Salvador family WW domain containing protein 1. (392 aa)
CTNNB1Catenin beta 1. (741 aa)
LDB2LIM domain binding 2. (387 aa)
NSUN2NOP2/Sun RNA methyltransferase 2; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. (1007 aa)
FGFR2Fibroblast growth factor receptor. (894 aa)
ENSOCUP00000034349Uncharacterized protein. (160 aa)
ENSOCUP00000034777Uncharacterized protein. (55 aa)
BCL2BH4_2 domain-containing protein. (389 aa)
LGR5Leucine rich repeat containing G protein-coupled receptor 5. (1006 aa)
FGF7Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (194 aa)
HDAC1Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (550 aa)
NOM1Nucleolar protein with MIF4G domain 1. (848 aa)
TRPC4APTransient receptor potential cation channel subfamily C member 4 associated protein. (882 aa)
TNFRSF19TNF receptor superfamily member 19. (481 aa)
NSDHLNAD(P) dependent steroid dehydrogenase-like; Belongs to the 3-beta-HSD family. (383 aa)
HDAC2Histone deacetylase 2. (581 aa)
GLI2GLI family zinc finger 2. (1575 aa)
LOC100352102Uncharacterized protein. (256 aa)
TP63Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. (680 aa)
GNASGNAS complex locus. (977 aa)
ALX4ALX homeobox 4. (397 aa)
DSG4Desmoglein 4; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. (1039 aa)
CD109CD109 molecule. (1318 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
FSTFollistatin. (310 aa)
LGR4Leucine rich repeat containing G protein-coupled receptor 4. (951 aa)
LRP4LDL receptor related protein 4. (1899 aa)
INTUInturned planar cell polarity protein. (944 aa)
INHBAInhibin subunit beta A. (424 aa)
PLA2G10Phospholipase A(2). (163 aa)
Your Current Organism:
Oryctolagus cuniculus
NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits
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