STRINGSTRING
NKX2-5 NKX2-5 ATP1B3 ATP1B3 COMMD1 COMMD1 SLC9A3R1 SLC9A3R1 P2RX4 P2RX4 PRSS8 PRSS8 ATP1B2 ATP1B2 SPTBN4 SPTBN4 ANK3 ANK3 FGF11 FGF11 SERPINE2 SERPINE2 STOM STOM OSR1 OSR1 NEDD4 NEDD4 BPIFA1 BPIFA1 FGF12 FGF12 SCN5A SCN5A HECW1 HECW1 G1SV95_RABIT G1SV95_RABIT P2RX7 P2RX7 CNKSR3 CNKSR3 GRP GRP CNTN1 CNTN1 AHCYL1 AHCYL1 NKAIN3 NKAIN3 SCN3B SCN3B WNK3 WNK3 DRD2 DRD2 KLHL24 KLHL24 CHP1 CHP1 DMD DMD SCN1B SCN1B WNK4 WNK4 ADRB2 ADRB2 NETO2 NETO2 LOC100346323 LOC100346323 HECW2 HECW2 PER1 PER1 MLLT6 MLLT6 G1TQ93_RABIT G1TQ93_RABIT RANGRF RANGRF CAV3 CAV3 SLC9A1 SLC9A1 G1U4L1_RABIT G1U4L1_RABIT ATP1A1 ATP1A1 DRD3 DRD3 NOS3 NOS3 ATP1A2 ATP1A2 NETO1 NETO1 NKAIN2 NKAIN2 CHP2 CHP2 LOC103345451 LOC103345451 SLC8A1 SLC8A1 WNK1 WNK1 YWHAH YWHAH ENSOCUP00000037329 ENSOCUP00000037329 DNM2 DNM2 NEDD4L NEDD4L FGF14 FGF14 ENSOCUP00000041840 ENSOCUP00000041840 SCN2B SCN2B PTPN3 PTPN3 TESC TESC NKAIN1 NKAIN1 ENSOCUP00000044284 ENSOCUP00000044284 ENSOCUP00000045925 ENSOCUP00000045925 FGF13 FGF13 PCSK9 PCSK9 LOC103349229 LOC103349229
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
NKX2-5NK2 homeobox 5. (326 aa)
ATP1B3Sodium/potassium-transporting ATPase subunit beta-3; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. The exact function of the beta-3 subunit is not known (By similarity); Belongs to the X(+)/potassium ATPases subunit beta family. (274 aa)
COMMD1Copper metabolism domain containing 1. (188 aa)
SLC9A3R1Na(+)/H(+) exchange regulatory cofactor NHE-RF1; Scaffold protein that connects plasma membrane proteins with members of the ezrin/moesin/radixin family and thereby helps to link them to the actin cytoskeleton and to regulate their surface expression. Necessary for recycling of internalized ADRB2. Was first known to play a role in the regulation of the activity and subcellular location of SLC9A3. Necessary for cAMP-mediated phosphorylation and inhibition of SLC9A3. Involved in sperm capacitation. May participate in the regulation of the chloride and bicarbonate homeostasis in spermatoz [...] (356 aa)
P2RX4P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. (387 aa)
PRSS8Serine protease 8; Belongs to the peptidase S1 family. (342 aa)
ATP1B2Sodium/potassium-transporting ATPase subunit beta-2; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. The exact function of the beta-2 subunit is not known (By similarity). (290 aa)
SPTBN4Spectrin beta, non-erythrocytic 4. (1822 aa)
ANK3Ankyrin 3. (4364 aa)
FGF11Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (225 aa)
SERPINE2Serpin family E member 2; Belongs to the serpin family. (409 aa)
STOMStomatin. (284 aa)
OSR1Odd-skipped related transcription factor 1. (266 aa)
NEDD4NEDD4 E3 ubiquitin protein ligase. (1315 aa)
BPIFA1BPI fold containing family A member 1. (304 aa)
FGF12Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (243 aa)
SCN5ASodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (1847 aa)
HECW1HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1. (1588 aa)
G1SV95_RABITTransforming growth factor beta; Belongs to the TGF-beta family. (387 aa)
P2RX7P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. Belongs to the P2X receptor family. (595 aa)
CNKSR3CNKSR family member 3. (555 aa)
GRPGastrin releasing peptide. (130 aa)
CNTN1Contactin 1. (1018 aa)
AHCYL1Adenosylhomocysteinase like 1; Belongs to the adenosylhomocysteinase family. (530 aa)
NKAIN3Uncharacterized protein. (94 aa)
SCN3BSodium voltage-gated channel beta subunit 3. (215 aa)
WNK3WNK lysine deficient protein kinase 3. (1793 aa)
DRD2Dopamine receptor D2; Belongs to the G-protein coupled receptor 1 family. (443 aa)
KLHL24Kelch like family member 24. (600 aa)
CHP1Calcineurin like EF-hand protein 1. (194 aa)
DMDUncharacterized protein. (956 aa)
SCN1BSodium channel subunit beta-1; Regulatory subunit of multiple voltage-gated sodium channel complexes that play important roles in excitable membranes in brain, heart and skeletal muscle. Enhances the presence of the pore-forming alpha subunit at the cell surface and modulates channel gating characteristics and the rate of channel inactivation. Modulates the activity of a variety of pore-forming alpha subunits, such as SCN1A, SCN2A, SCN3A, SCN4A, SCN5A and SCN10A. (213 aa)
WNK4WNK lysine deficient protein kinase 4. (1266 aa)
ADRB2Adrenoceptor beta 2. (437 aa)
NETO2Neuropilin and tolloid like 2. (525 aa)
LOC100346323Uncharacterized protein. (240 aa)
HECW2HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2. (1536 aa)
PER1Period circadian regulator 1. (1203 aa)
MLLT6MLLT6, PHD finger containing. (1040 aa)
G1TQ93_RABITUncharacterized protein. (772 aa)
RANGRFRAN guanine nucleotide release factor. (186 aa)
CAV3Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (151 aa)
SLC9A1Sodium/hydrogen exchanger 1; Involved in pH regulation to eliminate acids generated by active metabolism or to counter adverse environmental conditions. Major proton extruding system driven by the inward sodium ion chemical gradient. Plays an important role in signal transduction; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. (816 aa)
G1U4L1_RABITUncharacterized protein. (195 aa)
ATP1A1Sodium/potassium-transporting ATPase subunit alpha-1; This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients (By similarity). May contribute to blood-heart barrier properties of endocardial endothelium and may control cardiac performance via endothelial Na(+)/H(+) exchange. (956 aa)
DRD3Dopamine receptor D3; Belongs to the G-protein coupled receptor 1 family. (399 aa)
NOS3Nitric oxide synthase; Produces nitric oxide (NO). (1209 aa)
ATP1A2Sodium/potassium-transporting ATPase subunit alpha. (1019 aa)
NETO1Neuropilin and tolloid like 1. (547 aa)
NKAIN2Sodium/potassium transporting ATPase interacting 2. (208 aa)
CHP2Calcineurin like EF-hand protein 2. (229 aa)
LOC103345451TGFb_propeptide domain-containing protein. (203 aa)
SLC8A1J domain-containing protein; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (973 aa)
WNK1WNK lysine deficient protein kinase 1. (2853 aa)
YWHAH14_3_3 domain-containing protein; Belongs to the 14-3-3 family. (309 aa)
ENSOCUP00000037329TGFb_propeptide domain-containing protein. (263 aa)
DNM2Dynamin 2; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (846 aa)
NEDD4LNEDD4 like E3 ubiquitin protein ligase. (1239 aa)
FGF14Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (252 aa)
ENSOCUP00000041840TGFb_propeptide domain-containing protein. (219 aa)
SCN2BSodium voltage-gated channel beta subunit 2. (288 aa)
PTPN3Tyrosine-protein phosphatase non-receptor type; May act at junctions between the membrane and the cytoskeleton. (1005 aa)
TESCTescalcin. (240 aa)
NKAIN1Uncharacterized protein. (440 aa)
ENSOCUP00000044284TGFb_propeptide domain-containing protein. (260 aa)
ENSOCUP00000045925TGFb_propeptide domain-containing protein. (272 aa)
FGF13Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (271 aa)
PCSK9Proprotein convertase subtilisin/kexin type 9; Belongs to the peptidase S8 family. (686 aa)
LOC103349229FXYD domain-containing ion transport regulator; Belongs to the FXYD family. (64 aa)
Your Current Organism:
Oryctolagus cuniculus
NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits
Server load: low (20%) [HD]