STRINGSTRING
WNT5A WNT5A FGF2 FGF2 RARB RARB CBFA2T2 CBFA2T2 PAX4 PAX4 WNT11 WNT11 TIGAR TIGAR PDPK1 PDPK1 GATA4 GATA4 JAG1 JAG1 BMP6 BMP6 FST FST RBM4 RBM4 PDX1 PDX1 CDX2 CDX2 SLC9A4 SLC9A4 NR5A2 NR5A2 ENAM ENAM HNF4A HNF4A CLCN2 CLCN2 DLX3 DLX3 IL31RA IL31RA IL6ST IL6ST G1SV95_RABIT G1SV95_RABIT TYMS TYMS TMEM231 TMEM231 ABL2 ABL2 BCCIP BCCIP NKX3-2 NKX3-2 G1T067_RABIT G1T067_RABIT BMP4 BMP4 KLF5 KLF5 RFX6 RFX6 VAX1 VAX1 CAV1 CAV1 PGR PGR EXT1 EXT1 DSPP DSPP SOX11 SOX11 B9D1 B9D1 RARA RARA EMX1 EMX1 NKX6-3 NKX6-3 C1GALT1 C1GALT1 CDH2 CDH2 PAX6 PAX6 NKX6-1 NKX6-1 BMP5 BMP5 SIDT2 SIDT2 WNT4 WNT4 G1TVI4_RABIT G1TVI4_RABIT HES1 HES1 BMP7 BMP7 GDF11 GDF11 HOXA5 HOXA5 G1U373_RABIT G1U373_RABIT ENSOCUP00000024205 ENSOCUP00000024205 SMO SMO PRDM1 PRDM1 YIPF6 YIPF6 ENSOCUP00000027514 ENSOCUP00000027514 ROS1 ROS1 RFX3 RFX3 SAV1 SAV1 LOC103345451 LOC103345451 WDR77 WDR77 NFIB NFIB FGFR2 FGFR2 ENSOCUP00000037329 ENSOCUP00000037329 ABL1 ABL1 CDK6 CDK6 HIF1A HIF1A PROX1 PROX1 DLL1 DLL1 ENSOCUP00000041840 ENSOCUP00000041840 RARG RARG ENSOCUP00000042987 ENSOCUP00000042987 ENSOCUP00000044284 ENSOCUP00000044284 ENSOCUP00000045093 ENSOCUP00000045093 ENSOCUP00000045925 ENSOCUP00000045925 MAP1B MAP1B TP63 TP63
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
WNT5AProtein Wnt-5a; Ligand for members of the frizzled family of seven transmembrane receptors. Can activate or inhibit canonical Wnt signaling, depending on receptor context. In the presence of FZD4, activates beta-catenin signaling. In the presence of ROR2, inhibits the canonical Wnt pathway by promoting beta-catenin degradation through a GSK3-independent pathway which involves down-regulation of beta- catenin-induced reporter gene expression (By similarity). Suppression of the canonical pathway allows chondrogenesis to occur. Inhibits tumor formation. Stimulates cell migration. Decrease [...] (380 aa)
FGF2Fibroblast growth factor 2; Acts as a ligand for FGFR1, FGFR2, FGFR3 and FGFR4. Also acts as an integrin ligand which is required for FGF2 signaling. Binds to integrin ITGAV:ITGB3. Plays an important role in the regulation of cell survival, cell division, cell differentiation and cell migration. Functions as a potent mitogen in vitro. Can induce angiogenesis. Belongs to the heparin-binding growth factors family. (155 aa)
RARBRetinoic acid receptor beta. (448 aa)
CBFA2T2CBFA2/RUNX1 partner transcriptional co-repressor 2. (630 aa)
PAX4Paired box 4. (350 aa)
WNT11Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
TIGARTP53 induced glycolysis regulatory phosphatase. (265 aa)
PDPK13-phosphoinositide dependent protein kinase 1; Belongs to the protein kinase superfamily. (325 aa)
GATA4GATA binding protein 4. (444 aa)
JAG1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1218 aa)
BMP6Bone morphogenetic protein 6. (411 aa)
FSTFollistatin. (310 aa)
RBM4RNA-binding protein 4; RNA-binding factor involved in multiple aspects of cellular processes like alternative splicing of pre-mRNA and translation regulation. Modulates alternative 5'-splice site and exon selection. Acts as a muscle cell differentiation-promoting factor. Activates exon skipping of the PTB pre-mRNA during muscle cell differentiation. Antagonizes the activity of the splicing factor PTBP1 to modulate muscle cell-specific exon selection of alpha tropomyosin. Binds to intronic pyrimidine-rich sequence of the TPM1 and MAPT pre-mRNAs. Required for the translational activation [...] (365 aa)
PDX1Pancreatic and duodenal homeobox 1. (336 aa)
CDX2Caudal type homeobox 2. (314 aa)
SLC9A4Sodium/hydrogen exchanger; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. (803 aa)
NR5A2Uncharacterized protein. (541 aa)
ENAMEnamelin. (1134 aa)
HNF4AHepatocyte nuclear factor 4 alpha. (468 aa)
CLCN2Chloride channel protein 2; Voltage-gated chloride channel. Chloride channels have several functions including the regulation of cell volume, membrane potential stabilization, signal transduction and transepithelial transport (By similarity). Involved in the regulation of aldosterone production. The opening of CLCN2 channels at hyperpolarized membrane potentials in the glomerulosa causes cell membrane depolarization, activation of voltage-gated Ca2+ channels and increased expression of aldosterone synthase, the rate-limiting enzyme for aldosterone biosynthesis (By similarity). (898 aa)
DLX3Distal-less homeobox 3. (287 aa)
IL31RAInterleukin 31 receptor A. (730 aa)
IL6STInterleukin 6 signal transducer. (918 aa)
G1SV95_RABITTransforming growth factor beta; Belongs to the TGF-beta family. (387 aa)
TYMSThymidylate synthetase. (310 aa)
TMEM231Transmembrane protein 231. (316 aa)
ABL2Tyrosine-protein kinase. (1146 aa)
BCCIPBRCA2 and CDKN1A-interacting protein; May promote cell cycle arrest by enhancing the inhibition of CDK2 activity by CDKN1A. May be required for repair of DNA damage by homologous recombination in conjunction with BRCA2. May not be involved in non-homologous end joining (NHEJ); Belongs to the BCP1 family. (315 aa)
NKX3-2NK3 homeobox 2. (333 aa)
G1T067_RABITFam20C domain-containing protein. (543 aa)
BMP4Bone morphogenetic protein 4; Induces cartilage and bone formation. Acts in concert with PTHLH/PTHRP to stimulate ductal outgrowth during embryonic mammary development and to inhibit hair follicle induction (By similarity). (409 aa)
KLF5Uncharacterized protein. (457 aa)
RFX6Regulatory factor X6. (928 aa)
VAX1Ventral anterior homeobox 1. (310 aa)
CAV1Caveolin-1; May act as a scaffolding protein within caveolar membranes. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (By similarity). Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependen [...] (178 aa)
PGRProgesterone receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcriptional activator of several progesteron-dependent promoters in a variety of cell types. Involved in activation of SRC-dependent MAPK signaling on hormone stimulation; Belongs to the nuclear hormone receptor family. NR3 subfamily. (930 aa)
EXT1Exostosin glycosyltransferase 1; Belongs to the glycosyltransferase 47 family. (746 aa)
DSPPUncharacterized protein. (657 aa)
SOX11Transcription factor SOX. (446 aa)
B9D1B9 domain containing 1. (203 aa)
RARARetinoic acid receptor alpha. (462 aa)
EMX1Empty spiracles homeobox 1. (241 aa)
NKX6-3Homeobox domain-containing protein. (263 aa)
C1GALT1Glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1; Glycosyltransferase that generates the core 1 O-glycan Gal- beta1-3GalNAc-alpha1-Ser/Thr (T antigen), which is a precursor for many extended O-glycans in glycoproteins; Belongs to the glycosyltransferase 31 family. Beta3-Gal-T subfamily. (389 aa)
CDH2Cadherin 2; Cadherins are calcium-dependent cell adhesion proteins. (854 aa)
PAX6Uncharacterized protein. (436 aa)
NKX6-1NK6 homeobox 1. (369 aa)
BMP5Bone morphogenetic protein 5. (454 aa)
SIDT2SID1 transmembrane family member 2. (853 aa)
WNT4Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (487 aa)
G1TVI4_RABITNR LBD domain-containing protein. (321 aa)
HES1Hes family bHLH transcription factor 1. (279 aa)
BMP7TGF_BETA_2 domain-containing protein. (170 aa)
GDF11Growth differentiation factor 11. (395 aa)
HOXA5Homeobox A5. (381 aa)
G1U373_RABITSRCR domain-containing protein; Belongs to the heparin-binding growth factors family. (200 aa)
ENSOCUP00000024205annotation not available (363 aa)
SMOSmoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (787 aa)
PRDM1PR/SET domain 1. (889 aa)
YIPF6Protein YIPF. (292 aa)
ENSOCUP00000027514Uncharacterized protein. (592 aa)
ROS1Tyrosine-protein kinase receptor. (2288 aa)
RFX3Regulatory factor X3. (780 aa)
SAV1Salvador family WW domain containing protein 1. (392 aa)
LOC103345451TGFb_propeptide domain-containing protein. (203 aa)
WDR77WD repeat domain 77. (424 aa)
NFIBNuclear factor 1; Recognizes and binds the palindromic sequence 5'- TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication. (586 aa)
FGFR2Fibroblast growth factor receptor. (894 aa)
ENSOCUP00000037329TGFb_propeptide domain-containing protein. (263 aa)
ABL1Tyrosine-protein kinase. (1118 aa)
CDK6Cyclin dependent kinase 6; Belongs to the protein kinase superfamily. (349 aa)
HIF1AUncharacterized protein. (851 aa)
PROX1Prospero homeobox 1. (737 aa)
DLL1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (754 aa)
ENSOCUP00000041840TGFb_propeptide domain-containing protein. (219 aa)
RARGUncharacterized protein. (415 aa)
ENSOCUP00000042987Thymidylat_synt domain-containing protein. (98 aa)
ENSOCUP00000044284TGFb_propeptide domain-containing protein. (260 aa)
ENSOCUP00000045093BRCA2 and CDKN1A-interacting protein; May promote cell cycle arrest by enhancing the inhibition of CDK2 activity by CDKN1A. May be required for repair of DNA damage by homologous recombination in conjunction with BRCA2. May not be involved in non-homologous end joining (NHEJ); Belongs to the BCP1 family. (315 aa)
ENSOCUP00000045925TGFb_propeptide domain-containing protein. (272 aa)
MAP1BMicrotubule associated protein 1B. (2355 aa)
TP63Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. (680 aa)
Your Current Organism:
Oryctolagus cuniculus
NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits
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