STRINGSTRING
PSEN1 PSEN1 IL20 IL20 BATF2 BATF2 DHRS7B DHRS7B GPR68 GPR68 TCTA TCTA BMP4 BMP4 EIF2AK1 EIF2AK1 LBR LBR TSPAN2 TSPAN2 LTBR LTBR GPC3 GPC3 MITF MITF F2RL1 F2RL1 CSF2 CSF2 MYH9 MYH9 DCSTAMP DCSTAMP SNX10 SNX10 PIK3R1 PIK3R1 TNFRSF11A TNFRSF11A LOC100348108 LOC100348108 CD109 CD109 TNF TNF G1SSE7_RABIT G1SSE7_RABIT FOXP1 FOXP1 IL31RA IL31RA SRP54 SRP54 G1SV95_RABIT G1SV95_RABIT NF1 NF1 LRRK1 LRRK1 IL15 IL15 FARP2 FARP2 IRF4 IRF4 CSF3 CSF3 IREB2 IREB2 APP APP G1T067_RABIT G1T067_RABIT ENSOCUP00000041840 ENSOCUP00000041840 GLO1 GLO1 ENSOCUP00000044284 ENSOCUP00000044284 AP3B1 AP3B1 ENSOCUP00000045925 ENSOCUP00000045925 ENSOCUP00000046340 ENSOCUP00000046340 CITED2 CITED2 L3MBTL3 L3MBTL3 SP3 SP3 ENSOCUP00000049280 ENSOCUP00000049280 LEF1 LEF1 BAP1 BAP1 LOC100348748 LOC100348748 JUN JUN SH3PXD2A SH3PXD2A CCL19 CCL19 ENSOCUP00000037329 ENSOCUP00000037329 ENSOCUP00000037059 ENSOCUP00000037059 NOTCH2 NOTCH2 KIT KIT CSF1R CSF1R ENSOCUP00000034457 ENSOCUP00000034457 KITLG KITLG PDE1B PDE1B CTNNB1 CTNNB1 LOC103345451 LOC103345451 THOC5 THOC5 TGFBR2 TGFBR2 IL25 IL25 GAB3 GAB3 ENSOCUP00000029917 ENSOCUP00000029917 ITGB6 ITGB6 ENSOCUP00000027264 ENSOCUP00000027264 TRAF6 TRAF6 CSF1 CSF1 UBD UBD GATA1 GATA1 IL4 IL4 SIRT1 SIRT1 P2RY8 P2RY8 OSCAR OSCAR CEBPA CEBPA G1TXH1_RABIT G1TXH1_RABIT FOS FOS MED1 MED1 GPR183 GPR183 BATF BATF CALCR CALCR CASP10 CASP10 NRROS NRROS CAMK4 CAMK4 CEBPE CEBPE G1TLQ5_RABIT G1TLQ5_RABIT SPIB SPIB CCR7 CCR7 EPHA2 EPHA2 G1TH84_RABIT G1TH84_RABIT OCSTAMP OCSTAMP GAB2 GAB2 TNFSF11 TNFSF11 GATA3 GATA3 PIR PIR ATP6AP1 ATP6AP1 TFRC TFRC CCN4 CCN4 OSTM1 OSTM1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PSEN1Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (557 aa)
IL20Interleukin 20. (187 aa)
BATF2Basic leucine zipper ATF-like transcription factor 2. (274 aa)
DHRS7BDehydrogenase/reductase 7B; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (325 aa)
GPR68G protein-coupled receptor 68; Belongs to the G-protein coupled receptor 1 family. (375 aa)
TCTAT-cell leukemia translocation-altered gene protein homolog; May be required for cellular fusion during osteoclastogenesis; Belongs to the TCTA family. (106 aa)
BMP4Bone morphogenetic protein 4; Induces cartilage and bone formation. Acts in concert with PTHLH/PTHRP to stimulate ductal outgrowth during embryonic mammary development and to inhibit hair follicle induction (By similarity). (409 aa)
EIF2AK1Eukaryotic translation initiation factor 2-alpha kinase 1; Inhibits protein synthesis at the translation initiation level, in response to various stress conditions, including oxidative stress, heme deficiency, osmotic shock and heat shock. Exerts its function through the phosphorylation of EIF2S1 at 'Ser-48' and 'Ser- 51', thus preventing its recycling. Binds hemin forming a 1:1 complex through a cysteine thiolate and histidine nitrogenous coordination. This binding occurs with moderate affinity, allowing it to sense the heme concentration within the cell. Thanks to this unique heme-se [...] (618 aa)
LBRLamin B receptor. (627 aa)
TSPAN2Tetraspanin. (220 aa)
LTBRLymphotoxin beta receptor. (414 aa)
GPC3Glypican 3; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. (580 aa)
MITFMelanocyte inducing transcription factor. (526 aa)
F2RL1F2R like trypsin receptor 1. (397 aa)
CSF2Uncharacterized protein. (144 aa)
MYH9Myosin heavy chain 9; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1920 aa)
DCSTAMPDC_STAMP domain-containing protein. (283 aa)
SNX10Sorting nexin 10. (117 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
TNFRSF11ATNFR-Cys domain-containing protein. (349 aa)
LOC100348108AIG1-type G domain-containing protein. (312 aa)
CD109CD109 molecule. (1318 aa)
TNFTumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (234 aa)
G1SSE7_RABITUncharacterized protein; Belongs to the peptidase C14A family. (306 aa)
FOXP1Fork-head domain-containing protein. (714 aa)
IL31RAInterleukin 31 receptor A. (730 aa)
SRP54Signal recognition particle 54 kDa protein; Binds to the signal sequence of presecretory protein when they emerge from the ribosomes and transfers them to TRAM (translocating chain-associating membrane protein). Belongs to the GTP-binding SRP family. SRP54 subfamily. (499 aa)
G1SV95_RABITTransforming growth factor beta; Belongs to the TGF-beta family. (387 aa)
NF1Neurofibromin 1. (2841 aa)
LRRK1Leucine rich repeat kinase 1. (2013 aa)
IL15Interleukin-15; Cytokine that stimulates the proliferation of T-lymphocytes. Stimulation by IL15 requires interaction of IL15 with components of the IL2 receptor, including IL2RB and probably IL2RG but not IL2RA (By similarity). In neutrophils, stimulates phagocytosis probably by signaling through the IL15 receptor, which results in kinase SYK activation (By similarity). (162 aa)
FARP2FERM, ARH/RhoGEF and pleckstrin domain protein 2. (1013 aa)
IRF4Interferon regulatory factor 4. (451 aa)
CSF3Colony stimulating factor 3. (204 aa)
IREB2Iron responsive element binding protein 2; Belongs to the aconitase/IPM isomerase family. (956 aa)
APPGamma-secretase C-terminal fragment 57; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those medi [...] (769 aa)
G1T067_RABITFam20C domain-containing protein. (543 aa)
ENSOCUP00000041840TGFb_propeptide domain-containing protein. (219 aa)
GLO1Lactoylglutathione lyase; Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione. (206 aa)
ENSOCUP00000044284TGFb_propeptide domain-containing protein. (260 aa)
AP3B1AP-3 complex subunit beta; Belongs to the adaptor complexes large subunit family. (1187 aa)
ENSOCUP00000045925TGFb_propeptide domain-containing protein. (272 aa)
ENSOCUP00000046340RHD domain-containing protein. (343 aa)
CITED2Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 2. (249 aa)
L3MBTL3L3MBTL histone methyl-lysine binding protein 3. (780 aa)
SP3Sp3 transcription factor. (715 aa)
ENSOCUP00000049280SCY domain-containing protein. (136 aa)
LEF1Lymphoid enhancer binding factor 1. (414 aa)
BAP1BRCA1 associated protein 1. (731 aa)
LOC100348748IGv domain-containing protein. (604 aa)
JUNBZIP domain-containing protein; Belongs to the bZIP family. (352 aa)
SH3PXD2ASH3 and PX domains 2A. (1119 aa)
CCL19C-C motif chemokine. (109 aa)
ENSOCUP00000037329TGFb_propeptide domain-containing protein. (263 aa)
ENSOCUP00000037059Uncharacterized protein. (317 aa)
NOTCH2Notch receptor 2. (2481 aa)
KITMast/stem cell growth factor receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (970 aa)
CSF1RColony stimulating factor 1 receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (973 aa)
ENSOCUP00000034457VOC domain-containing protein. (185 aa)
KITLGKit ligand; Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. Belongs to the SCF family. (276 aa)
PDE1BPhosphodiesterase. (563 aa)
CTNNB1Catenin beta 1. (741 aa)
LOC103345451TGFb_propeptide domain-containing protein. (203 aa)
THOC5THO complex 5. (748 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (592 aa)
IL25Interleukin 25. (177 aa)
GAB3PH domain-containing protein. (724 aa)
ENSOCUP00000029917Uncharacterized protein. (169 aa)
ITGB6Integrin beta; Belongs to the integrin beta chain family. (787 aa)
ENSOCUP00000027264Protein kinase domain-containing protein. (77 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (552 aa)
CSF1Colony stimulating factor 1. (535 aa)
UBDUbiquitin D. (182 aa)
GATA1GATA binding protein 1. (413 aa)
IL4Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Positively regulates IL31RA expression in macrophages. Stimulates autophagy in dendritic cells by interfering with mTORC1 signaling and through the induction of RUFY4; Belongs to the IL- [...] (144 aa)
SIRT1Sirtuin 1. (748 aa)
P2RY8P2Y receptor family member 8; Belongs to the G-protein coupled receptor 1 family. (382 aa)
OSCARIg-like domain-containing protein. (323 aa)
CEBPACCAAT enhancer binding protein alpha. (402 aa)
G1TXH1_RABITBTB domain-containing protein. (421 aa)
FOSFos proto-oncogene, AP-1 transcription factor subunit. (380 aa)
MED1Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1580 aa)
GPR183G protein-coupled receptor 183; Belongs to the G-protein coupled receptor 1 family. (327 aa)
BATFBasic leucine zipper ATF-like transcription factor. (125 aa)
CALCRCalcitonin receptor; This is a receptor for calcitonin. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. The calcitonin receptor is thought to couple to the heterotrimeric guanosine triphosphate-binding protein that is sensitive to cholera toxin. Isoform 2 has altered ligand binding and abolished coupling to phospholipase C. (491 aa)
CASP10Caspase-10; Belongs to the peptidase C14A family. (469 aa)
NRROSNegative regulator of reactive oxygen species. (692 aa)
CAMK4Protein kinase domain-containing protein. (264 aa)
CEBPECCAAT/enhancer-binding protein. (281 aa)
G1TLQ5_RABITUncharacterized protein; Belongs to the tetraspanin (TM4SF) family. (245 aa)
SPIBETS domain-containing protein. (158 aa)
CCR7C-C motif chemokine receptor 7; Belongs to the G-protein coupled receptor 1 family. (378 aa)
EPHA2EPH receptor A2. (1031 aa)
G1TH84_RABITAIG1-type G domain-containing protein. (194 aa)
OCSTAMPOsteoclast stimulatory transmembrane protein. (481 aa)
GAB2GRB2 associated binding protein 2. (679 aa)
TNFSF11TNF superfamily member 11; Belongs to the tumor necrosis factor family. (322 aa)
GATA3GATA binding protein 3. (444 aa)
PIRPirin; Belongs to the pirin family. (473 aa)
ATP6AP1Uncharacterized protein. (470 aa)
TFRCTransferrin receptor. (763 aa)
CCN4Cellular communication network factor 4. (337 aa)
OSTM1Uncharacterized protein. (331 aa)
Your Current Organism:
Oryctolagus cuniculus
NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits
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