STRINGSTRING
SLIT3 SLIT3 MEF2C MEF2C BMPR1A BMPR1A MTOR MTOR TBX5 TBX5 BMP4 BMP4 TIE1 TIE1 G1SV95_RABIT G1SV95_RABIT EMILIN1 EMILIN1 NFATC1 NFATC1 SMAD6 SMAD6 TGFB2 TGFB2 EFNA1 EFNA1 ROBO2 ROBO2 SMAD4 SMAD4 CCN1 CCN1 JAG1 JAG1 ROBO1 ROBO1 ACVR1 ACVR1 GATA4 GATA4 HEYL HEYL ADAMTS9 ADAMTS9 MDM4 MDM4 HEY1 HEY1 GATA3 GATA3 G1TLX8_RABIT G1TLX8_RABIT GJA5 GJA5 STRA6 STRA6 NOS3 NOS3 HEY2 HEY2 ENSOCUP00000029165 ENSOCUP00000029165 SLIT2 SLIT2 TBX20 TBX20 TGFBR2 TGFBR2 LOC103345451 LOC103345451 ENSOCUP00000035160 ENSOCUP00000035160 NOTCH2 NOTCH2 BMPR2 BMPR2 ENSOCUP00000037329 ENSOCUP00000037329 RB1 RB1 ENSOCUP00000041840 ENSOCUP00000041840 ENSOCUP00000044284 ENSOCUP00000044284 ENSOCUP00000045925 ENSOCUP00000045925
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SLIT3Slit guidance ligand 3. (1530 aa)
MEF2CMyocyte enhancer factor 2C. (483 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2547 aa)
TBX5T-box transcription factor 5. (518 aa)
BMP4Bone morphogenetic protein 4; Induces cartilage and bone formation. Acts in concert with PTHLH/PTHRP to stimulate ductal outgrowth during embryonic mammary development and to inhibit hair follicle induction (By similarity). (409 aa)
TIE1Tyrosine kinase with immunoglobulin like and EGF like domains 1. (732 aa)
G1SV95_RABITTransforming growth factor beta; Belongs to the TGF-beta family. (387 aa)
EMILIN1Elastin microfibril interfacer 1. (982 aa)
NFATC1RHD domain-containing protein. (672 aa)
SMAD6MH2 domain-containing protein. (220 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
EFNA1Ephrin A1; Belongs to the ephrin family. (205 aa)
ROBO2Roundabout guidance receptor 2. (1438 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
CCN1Cellular communication network factor 1. (386 aa)
JAG1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1218 aa)
ROBO1Roundabout guidance receptor 1. (1651 aa)
ACVR1Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (509 aa)
GATA4GATA binding protein 4. (444 aa)
HEYLHes related family bHLH transcription factor with YRPW motif like. (301 aa)
ADAMTS9ADAM metallopeptidase with thrombospondin type 1 motif 9. (2187 aa)
MDM4Protein Mdm4; Inhibits p53- and p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Belongs to the MDM2/MDM4 family. (491 aa)
HEY1Hes related family bHLH transcription factor with YRPW motif 1. (452 aa)
GATA3GATA binding protein 3. (444 aa)
G1TLX8_RABITRING-type domain-containing protein. (248 aa)
GJA5Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. (358 aa)
STRA6Stimulated by retinoic acid 6. (729 aa)
NOS3Nitric oxide synthase; Produces nitric oxide (NO). (1209 aa)
HEY2Hes related family bHLH transcription factor with YRPW motif 2. (338 aa)
ENSOCUP00000029165SWIB domain-containing protein. (260 aa)
SLIT2Slit guidance ligand 2. (1542 aa)
TBX20T-box transcription factor 20. (460 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (592 aa)
LOC103345451TGFb_propeptide domain-containing protein. (203 aa)
ENSOCUP00000035160Ig domain-containing protein. (246 aa)
NOTCH2Notch receptor 2. (2481 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1060 aa)
ENSOCUP00000037329TGFb_propeptide domain-containing protein. (263 aa)
RB1RB transcriptional corepressor 1. (943 aa)
ENSOCUP00000041840TGFb_propeptide domain-containing protein. (219 aa)
ENSOCUP00000044284TGFb_propeptide domain-containing protein. (260 aa)
ENSOCUP00000045925TGFb_propeptide domain-containing protein. (272 aa)
Your Current Organism:
Oryctolagus cuniculus
NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits
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