STRINGSTRING
WNT2B WNT2B ENSOCUP00000049280 ENSOCUP00000049280 CXCL11 CXCL11 WNT3A WNT3A LOC100356937 LOC100356937 ENSOCUP00000047547 ENSOCUP00000047547 ENSOCUP00000046151 ENSOCUP00000046151 TNFSF14 TNFSF14 ENSOCUP00000045925 ENSOCUP00000045925 C10orf99 C10orf99 WNT9B WNT9B ENSOCUP00000044284 ENSOCUP00000044284 GRN GRN ENSOCUP00000041840 ENSOCUP00000041840 PF4 PF4 CCL25 CCL25 CMTM3 CMTM3 IFNG IFNG LOC100354910 LOC100354910 CCL19 CCL19 IL7 IL7 CCL7 CCL7 ENSOCUP00000037329 ENSOCUP00000037329 TNFSF12 TNFSF12 LOC100357452 LOC100357452 IL12A IL12A GPI GPI CCL4 CCL4 CLCF1 CLCF1 FAM3B FAM3B CKLF CKLF WNT3 WNT3 ENSOCUP00000033859 ENSOCUP00000033859 KITLG KITLG LOC103345451 LOC103345451 ENSOCUP00000030962 ENSOCUP00000030962 ENSOCUP00000030178 ENSOCUP00000030178 IL25 IL25 GRO-B GRO-B ENSOCUP00000029132 ENSOCUP00000029132 BMP1 BMP1 IFNE IFNE CXCL5 CXCL5 CXCL9 CXCL9 WNT7A WNT7A ALKAL2 ALKAL2 CMTM7 CMTM7 ALKAL1 ALKAL1 G1U9D6_RABIT G1U9D6_RABIT CSF1 CSF1 IL34 IL34 IL4 IL4 G1U5P7_RABIT G1U5P7_RABIT WNT1 WNT1 WNT16 WNT16 ENSOCUP00000023358 ENSOCUP00000023358 MIF MIF AIMP1 AIMP1 IL37 IL37 GDF11 GDF11 SCG2 SCG2 G1U0P1_RABIT G1U0P1_RABIT WNT9A WNT9A C1QTNF4 C1QTNF4 IFNK IFNK FASLG FASLG TSLP TSLP G1TYB9_RABIT G1TYB9_RABIT BMP7 BMP7 SPP1 SPP1 IL1B IL1B IL1RN IL1RN LOC100101568 LOC100101568 BMP15 BMP15 GREM1 GREM1 CCL21 CCL21 NDP NDP IFNB1 IFNB1 WNT4 WNT4 BMP5 BMP5 CXCL17 CXCL17 MSMP MSMP IL10 IL10 CXCL13 CXCL13 TNFSF13 TNFSF13 CCL17 CCL17 WNT6 WNT6 PPBP PPBP CXCL8 CXCL8 CCL14 CCL14 GDF7 GDF7 G1TN23_RABIT G1TN23_RABIT LOC100357194 LOC100357194 LOC100341360 LOC100341360 LOC100354654 LOC100354654 IL6 IL6 LOC100355669 LOC100355669 CXCL16 CXCL16 TNFSF18 TNFSF18 NTN1 NTN1 CMTM1 CMTM1 CCL2 CCL2 TNFSF11 TNFSF11 LOC100354804 LOC100354804 G1TE95_RABIT G1TE95_RABIT IL12B IL12B AREG AREG CXCL10 CXCL10 WNT2 WNT2 IL17B IL17B WNT10A WNT10A G1T9X6_RABIT G1T9X6_RABIT CCL22 CCL22 IL21 IL21 IL36A IL36A CMTM8 CMTM8 IL20 IL20 IL19 IL19 LOC100358223 LOC100358223 IL33 IL33 GDF3 GDF3 GDF2 GDF2 GDF9 GDF9 NAMPT NAMPT CCL1 CCL1 EDN1 EDN1 IL27 IL27 LOC100349255 LOC100349255 MSTN MSTN TNLG7A TNLG7A TNFSF15 TNFSF15 BMP2 BMP2 TGFB3 TGFB3 INHA INHA TNFRSF11B TNFRSF11B SCGB3A1 SCGB3A1 BMP4 BMP4 CMTM5 CMTM5 TIMP1 TIMP1 GDF5 GDF5 CER1 CER1 CCL28 CCL28 BMP10 BMP10 OSM OSM IL2 IL2 TNFSF8 TNFSF8 CSF3 CSF3 WNT10B WNT10B IL15 IL15 IL1A IL1A NODAL NODAL TNFSF4 TNFSF4 G1SV95_RABIT G1SV95_RABIT GDF6 GDF6 G1SU40_RABIT G1SU40_RABIT BMP8B BMP8B CX3CL1 CX3CL1 INHBE INHBE INHBC INHBC IL23A IL23A THPO THPO LTB LTB TNF TNF LTA LTA IL36G IL36G IL9 IL9 CCL11 CCL11 CTF1 CTF1 EPO EPO IL36RN IL36RN TGFB2 TGFB2 IL18 IL18 WNT8A WNT8A INHBB INHBB LOC100353137 LOC100353137 G1SLP9_RABIT G1SLP9_RABIT IL17F IL17F IL17A IL17A IL5 IL5 GDF10 GDF10 CD40LG CD40LG LIF LIF CD70 CD70 CSF2 CSF2 BMP6 BMP6 FAM3C FAM3C LOC100353390-2 LOC100353390-2 CCL5 CCL5 LOC100355421 LOC100355421 LOC100354397 LOC100354397 LOC100353390 LOC100353390 WNT11 WNT11 IL22 IL22 CCL27 CCL27 WNT8B WNT8B CCL20 CCL20 G1SE34_RABIT G1SE34_RABIT LOC100348776 LOC100348776 G1SDU7_RABIT G1SDU7_RABIT BMP3 BMP3 INHBA INHBA IL26 IL26 FGF2 FGF2 WNT5A WNT5A CCL24 CCL24 GREM2 GREM2 IL13 IL13
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
WNT2BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (397 aa)
ENSOCUP00000049280SCY domain-containing protein. (136 aa)
CXCL11C-X-C motif chemokine ligand 11. (110 aa)
WNT3AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (400 aa)
LOC100356937Uncharacterized protein. (195 aa)
ENSOCUP00000047547annotation not available (190 aa)
ENSOCUP00000046151C-C motif chemokine. (119 aa)
TNFSF14TNF superfamily member 14. (241 aa)
ENSOCUP00000045925TGFb_propeptide domain-containing protein. (272 aa)
C10orf99Chromosome 10 open reading frame 99. (75 aa)
WNT9BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (431 aa)
ENSOCUP00000044284TGFb_propeptide domain-containing protein. (260 aa)
GRNGranulin precursor. (626 aa)
ENSOCUP00000041840TGFb_propeptide domain-containing protein. (219 aa)
PF4Platelet factor 4; Released during platelet aggregation. Neutralizes the anticoagulant effect of heparin because it binds more strongly to heparin than to the chondroitin-4-sulfate chains of the carrier molecule. Chemotactic for neutrophils and monocytes. Inhibits endothelial cell proliferation (By similarity); Belongs to the intercrine alpha (chemokine CxC) family. (105 aa)
CCL25SCY domain-containing protein. (159 aa)
CMTM3CKLF like MARVEL transmembrane domain containing 3. (252 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons; Belongs to the type II (or gamma) interferon family. (198 aa)
LOC100354910Uncharacterized protein. (187 aa)
CCL19C-C motif chemokine. (109 aa)
IL7Interleukin-7; Hematopoietic growth factor capable of stimulating the proliferation of lymphoid progenitors. It is important for proliferation during certain stages of B-cell maturation. Belongs to the IL-7/IL-9 family. (175 aa)
CCL7SCY domain-containing protein. (204 aa)
ENSOCUP00000037329TGFb_propeptide domain-containing protein. (263 aa)
TNFSF12TNF superfamily member 12; Belongs to the tumor necrosis factor family. (248 aa)
LOC100357452Uncharacterized protein. (190 aa)
IL12AInterleukin-12 subunit alpha; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated Killer cells, and stimulate the production of IFN-gamma by resting PBMC. (233 aa)
GPIGlucose-6-phosphate isomerase; In the cytoplasm, catalyzes the conversion of glucose-6- phosphate to fructose-6-phosphate, the second step in glycolysis, and the reverse reaction during gluconeogenesis (By similarity). Besides it's role as a glycolytic enzyme, also acts as a secreted cytokine: acts as an angiogenic factor (AMF) that stimulates endothelial cell motility. Acts as a neurotrophic factor, neuroleukin, for spinal and sensory neurons. It is secreted by lectin-stimulated T-cells and induces immunoglobulin secretion (By similarity). (588 aa)
CCL4C-C motif chemokine 4. (96 aa)
CLCF1Cardiotrophin like cytokine factor 1. (301 aa)
FAM3BUncharacterized protein. (380 aa)
CKLFChemokine like factor. (149 aa)
WNT3Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (358 aa)
ENSOCUP00000033859Uncharacterized protein. (176 aa)
KITLGKit ligand; Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. Belongs to the SCF family. (276 aa)
LOC103345451TGFb_propeptide domain-containing protein. (203 aa)
ENSOCUP00000030962Nicotinamide phosphoribosyltransferase; Belongs to the NAPRTase family. (455 aa)
ENSOCUP00000030178SCY domain-containing protein. (104 aa)
IL25Interleukin 25. (177 aa)
GRO-BPermeability factor 2; Has chemotactic activity for neutrophils; Belongs to the intercrine alpha (chemokine CxC) family. (145 aa)
ENSOCUP00000029132C-X-C motif chemokine. (111 aa)
BMP1Metalloendopeptidase. (984 aa)
IFNEInterferon epsilon. (212 aa)
CXCL5Alveolar macrophage chemotactic factor; Has chemotactic activity for neutrophils. Belongs to the intercrine alpha (chemokine CxC) family. (148 aa)
CXCL9C-X-C motif chemokine. (153 aa)
WNT7AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (325 aa)
ALKAL2ALK and LTK ligand 2. (152 aa)
CMTM7CKLF like MARVEL transmembrane domain containing 7. (225 aa)
ALKAL1ALK and LTK ligand 1. (129 aa)
G1U9D6_RABITUncharacterized protein. (105 aa)
CSF1Colony stimulating factor 1. (535 aa)
IL34Interleukin 34. (200 aa)
IL4Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Positively regulates IL31RA expression in macrophages. Stimulates autophagy in dendritic cells by interfering with mTORC1 signaling and through the induction of RUFY4; Belongs to the IL- [...] (144 aa)
G1U5P7_RABITUncharacterized protein. (204 aa)
WNT1Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (370 aa)
WNT16Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (365 aa)
ENSOCUP00000023358annotation not available (195 aa)
MIFMacrophage migration inhibitory factor. (115 aa)
AIMP1Aminoacyl tRNA synthetase complex interacting multifunctional protein 1. (334 aa)
IL37Interleukin-1. (280 aa)
GDF11Growth differentiation factor 11. (395 aa)
SCG2Secretogranin II. (621 aa)
G1U0P1_RABITUncharacterized protein. (209 aa)
WNT9AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (538 aa)
C1QTNF4C1q and TNF related 4. (173 aa)
IFNKInterferon kappa. (198 aa)
FASLGFas ligand; Belongs to the tumor necrosis factor family. (259 aa)
TSLPUncharacterized protein. (149 aa)
G1TYB9_RABITTGF_BETA_2 domain-containing protein. (358 aa)
BMP7TGF_BETA_2 domain-containing protein. (170 aa)
SPP1Osteopontin; Binds tightly to hydroxyapatite. Appears to form an integral part of the mineralized matrix. Probably important to cell-matrix interaction; Belongs to the osteopontin family. (311 aa)
IL1BInterleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. (234 aa)
IL1RNInterleukin-1 receptor antagonist protein; Inhibits the activity of interleukin-1 by binding to receptor IL1R1 and preventing its association with the coreceptor IL1RAP for signaling. Has no interleukin-1 like activity; Belongs to the IL-1 family. (221 aa)
LOC100101568Left-right determination factor. (368 aa)
BMP15TGF_BETA_2 domain-containing protein. (393 aa)
GREM1Gremlin 1, DAN family BMP antagonist. (240 aa)
CCL21C-C motif chemokine ligand 21. (131 aa)
NDPNorrin cystine knot growth factor NDP. (133 aa)
IFNB1Interferon beta 1. (180 aa)
WNT4Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (487 aa)
BMP5Bone morphogenetic protein 5. (454 aa)
CXCL17C-X-C motif chemokine ligand 17. (122 aa)
MSMPBeta-microseminoprotein. (139 aa)
IL10Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...] (304 aa)
CXCL13C-X-C motif chemokine ligand 13. (105 aa)
TNFSF13TNF_2 domain-containing protein; Belongs to the tumor necrosis factor family. (250 aa)
CCL17SCY domain-containing protein. (106 aa)
WNT6Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (338 aa)
PPBPUncharacterized protein. (82 aa)
CXCL8Interleukin-8; IL-8 is a chemotactic factor that attracts neutrophils, basophils, and T-cells, but not monocytes. It is also involved in neutrophil activation. It is released from several cell types in response to an inflammatory stimulus; Belongs to the intercrine alpha (chemokine CxC) family. (101 aa)
CCL14C-C motif chemokine ligand 14. (94 aa)
GDF7Growth differentiation factor 7. (546 aa)
G1TN23_RABITSCY domain-containing protein. (116 aa)
LOC100357194Uncharacterized protein. (189 aa)
LOC100341360TGF_BETA_2 domain-containing protein. (566 aa)
LOC100354654Uncharacterized protein. (189 aa)
IL6Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...] (241 aa)
LOC100355669Uncharacterized protein. (190 aa)
CXCL16Uncharacterized protein. (227 aa)
TNFSF18TNF superfamily member 18. (217 aa)
NTN1Netrin 1. (533 aa)
CMTM1MARVEL domain-containing protein. (373 aa)
CCL2C-C motif chemokine 2; Acts as a ligand for C-C chemokine receptor CCR2 (By similarity). Signals through binding and activation of CCR2 and induces a strong chemotactic response and mobilization of intracellular calcium ions (By similarity). Exhibits a chemotactic activity for monocytes and basophils but not neutrophils or eosinophils (By similarity). Plays an important role in mediating peripheral nerve injury-induced neuropathic pain (By similarity). Increases NMDA-mediated synaptic transmission in both dopamine D1 and D2 receptor-containing neurons, which may be caused by MAPK/ERK-d [...] (125 aa)
TNFSF11TNF superfamily member 11; Belongs to the tumor necrosis factor family. (322 aa)
LOC100354804C-X-C motif chemokine. (103 aa)
G1TE95_RABITUncharacterized protein. (178 aa)
IL12BInterleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. (324 aa)
AREGAmphiregulin. (275 aa)
CXCL10C-X-C motif chemokine. (98 aa)
WNT2Protein Wnt-2; Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters (By similarity). (360 aa)
IL17BInterleukin 17B. (175 aa)
WNT10AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (417 aa)
G1T9X6_RABITUncharacterized protein. (188 aa)
CCL22C-C motif chemokine. (93 aa)
IL21Interleukin; Belongs to the IL-15/IL-21 family. (154 aa)
IL36AInterleukin-1. (156 aa)
CMTM8CKLF like MARVEL transmembrane domain containing 8. (173 aa)
IL20Interleukin 20. (187 aa)
IL19Interleukin 19. (233 aa)
LOC100358223Uncharacterized protein. (195 aa)
IL33Uncharacterized protein. (142 aa)
GDF3Growth differentiation factor 3. (365 aa)
GDF2Growth differentiation factor 2. (434 aa)
GDF9TGF_BETA_2 domain-containing protein. (449 aa)
NAMPTNicotinamide phosphoribosyltransferase; Belongs to the NAPRTase family. (491 aa)
CCL1C-C motif chemokine. (190 aa)
EDN1Big endothelin-1; Endothelins are endothelium-derived vasoconstrictor peptides (By similarity). Probable ligand for G-protein coupled receptors EDNRA and EDNRB which activates PTK2B, BCAR1, BCAR3 and, GTPases RAP1 and RHOA cascade in glomerular mesangial cells (By similarity). Belongs to the endothelin/sarafotoxin family. (202 aa)
IL27Uncharacterized protein. (142 aa)
LOC100349255SCY domain-containing protein. (114 aa)
MSTNMyostatin. (375 aa)
TNLG7ATumor necrosis factor ligand 7A; Belongs to the tumor necrosis factor family. (362 aa)
TNFSF15TNF superfamily member 15. (340 aa)
BMP2Bone morphogenetic protein 2; Induces cartilage and bone formation. Stimulates the differentiation of myoblasts into osteoblasts via the EIF2AK3- EIF2A- ATF4 pathway. BMP2 activation of EIF2AK3 stimulates phosphorylation of EIF2A which leads to increased expression of ATF4 which plays a central role in osteoblast differentiation. In addition stimulates TMEM119, which upregulates the expression of ATF4. (271 aa)
TGFB3Transforming growth factor beta 3. (458 aa)
INHAInhibin alpha chain; Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition; Belongs to the TGF-beta family. (364 aa)
TNFRSF11BTumor necrosis factor receptor superfamily member 11B; Acts as decoy receptor for TNFSF11/RANKL and thereby neutralizes its function in osteoclastogenesis. (401 aa)
SCGB3A1Secretoglobin family 3A member 1. (104 aa)
BMP4Bone morphogenetic protein 4; Induces cartilage and bone formation. Acts in concert with PTHLH/PTHRP to stimulate ductal outgrowth during embryonic mammary development and to inhibit hair follicle induction (By similarity). (409 aa)
CMTM5CKLF like MARVEL transmembrane domain containing 5. (156 aa)
TIMP1Metalloproteinase inhibitor 1; Metalloproteinase inhibitor that functions by forming one to one complexes with target metalloproteinases, such as collagenases, and irreversibly inactivates them by binding to their catalytic zinc cofactor. Acts on MMP1, MMP2, MMP3, MMP7, MMP8, MMP9, MMP10, MMP11, MMP12, MMP13 and MMP16. Does not act on MMP14. Also functions as a growth factor that regulates cell differentiation, migration and cell death and activates cellular signaling cascades via CD63 and ITGB1. Plays a role in integrin signaling (By similarity). (256 aa)
GDF5Growth differentiation factor 5 preproprotein (Predicted). (500 aa)
CER1Cerberus 1, DAN family BMP antagonist. (267 aa)
CCL28SCY domain-containing protein. (130 aa)
BMP10Bone morphogenetic protein 10. (428 aa)
OSMUncharacterized protein. (333 aa)
IL2Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells; Belongs to the IL-2 family. (153 aa)
TNFSF8TNF superfamily member 8; Belongs to the tumor necrosis factor family. (234 aa)
CSF3Colony stimulating factor 3. (204 aa)
WNT10BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (389 aa)
IL15Interleukin-15; Cytokine that stimulates the proliferation of T-lymphocytes. Stimulation by IL15 requires interaction of IL15 with components of the IL2 receptor, including IL2RB and probably IL2RG but not IL2RA (By similarity). In neutrophils, stimulates phagocytosis probably by signaling through the IL15 receptor, which results in kinase SYK activation (By similarity). (162 aa)
IL1AInterleukin-1 alpha; Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells. (267 aa)
NODALNodal growth differentiation factor. (348 aa)
TNFSF4Tumor necrosis factor ligand superfamily member 4; Cytokine that binds to TNFRSF4. Co-stimulates T-cell proliferation and cytokine production. (216 aa)
G1SV95_RABITTransforming growth factor beta; Belongs to the TGF-beta family. (387 aa)
GDF6Growth differentiation factor 6. (427 aa)
G1SU40_RABITUncharacterized protein. (129 aa)
BMP8BTGF_BETA_2 domain-containing protein. (374 aa)
CX3CL1C-X3-C motif chemokine ligand 1. (404 aa)
INHBEInhibin subunit beta E. (352 aa)
INHBCInhibin subunit beta C. (351 aa)
IL23AInterleukin 23 subunit alpha. (191 aa)
THPOThrombopoietin. (348 aa)
LTBLymphotoxin beta; Belongs to the tumor necrosis factor family. (247 aa)
TNFTumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (234 aa)
LTALymphotoxin-alpha; Cytokine that in its homotrimeric form binds to TNFRSF1A/TNFR1, TNFRSF1B/TNFBR and TNFRSF14/HVEM (By similarity). In its heterotrimeric form with LTB binds to TNFRSF3/LTBR. Lymphotoxin is produced by lymphocytes and is cytotoxic for a wide range of tumor cells in vitro and in vivo. (197 aa)
IL36GInterleukin-1. (170 aa)
IL9Interleukin 9. (143 aa)
CCL11SCY domain-containing protein. (96 aa)
CTF1Cardiotrophin 1. (190 aa)
EPOErythropoietin; Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Binds to EPOR leading to EPOR dimerization and JAK2 activation thereby activating specific downstream effectors, including STAT1 and STAT3. Belongs to the EPO/TPO family. (195 aa)
IL36RNInterleukin-1. (296 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
IL18Uncharacterized protein. (408 aa)
WNT8AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (352 aa)
INHBBInhibin subunit beta B. (302 aa)
LOC100353137Uncharacterized protein. (195 aa)
G1SLP9_RABITIg-like domain-containing protein. (215 aa)
IL17FInterleukin 17F. (163 aa)
IL17AInterleukin 17A. (153 aa)
IL5Interleukin-5; Factor that induces terminal differentiation of late- developing B-cells to immunoglobulin secreting cells. (134 aa)
GDF10Bone morphogenetic protein 3; Belongs to the TGF-beta family. (472 aa)
CD40LGCD40 ligand; Cytokine that acts as a ligand to CD40/TNFRSF5. Costimulates T-cell proliferation and cytokine production. Involved in immunoglobulin class switching. (261 aa)
LIFLIF interleukin 6 family cytokine. (203 aa)
CD70TNF_2 domain-containing protein; Belongs to the tumor necrosis factor family. (297 aa)
CSF2Uncharacterized protein. (144 aa)
BMP6Bone morphogenetic protein 6. (411 aa)
FAM3CFamily with sequence similarity 3 member C. (205 aa)
LOC100353390-2Uncharacterized protein. (190 aa)
CCL5C-C motif chemokine. (91 aa)
LOC100355421Uncharacterized protein. (195 aa)
LOC100354397Uncharacterized protein. (195 aa)
LOC100353390Uncharacterized protein. (189 aa)
WNT11Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
IL22Interleukin 22. (187 aa)
CCL27Uncharacterized protein. (257 aa)
WNT8BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (351 aa)
CCL20C-C motif chemokine. (96 aa)
G1SE34_RABITIg-like domain-containing protein. (276 aa)
LOC100348776C-C motif chemokine. (93 aa)
G1SDU7_RABITC-C motif chemokine. (104 aa)
BMP3Bone morphogenetic protein 3; Belongs to the TGF-beta family. (475 aa)
INHBAInhibin subunit beta A. (424 aa)
IL26Interleukin 26. (180 aa)
FGF2Fibroblast growth factor 2; Acts as a ligand for FGFR1, FGFR2, FGFR3 and FGFR4. Also acts as an integrin ligand which is required for FGF2 signaling. Binds to integrin ITGAV:ITGB3. Plays an important role in the regulation of cell survival, cell division, cell differentiation and cell migration. Functions as a potent mitogen in vitro. Can induce angiogenesis. Belongs to the heparin-binding growth factors family. (155 aa)
WNT5AProtein Wnt-5a; Ligand for members of the frizzled family of seven transmembrane receptors. Can activate or inhibit canonical Wnt signaling, depending on receptor context. In the presence of FZD4, activates beta-catenin signaling. In the presence of ROR2, inhibits the canonical Wnt pathway by promoting beta-catenin degradation through a GSK3-independent pathway which involves down-regulation of beta- catenin-induced reporter gene expression (By similarity). Suppression of the canonical pathway allows chondrogenesis to occur. Inhibits tumor formation. Stimulates cell migration. Decrease [...] (380 aa)
CCL24SCY domain-containing protein. (113 aa)
GREM2Gremlin 2, DAN family BMP antagonist. (184 aa)
IL13Interleukin 13. (138 aa)
Your Current Organism:
Oryctolagus cuniculus
NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits
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