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| | RGMB | Repulsive guidance molecule BMP co-receptor b. (474 aa) |
| | RGMA | Repulsive guidance molecule BMP co-receptor a. (325 aa) |
| | WNT5A | Protein Wnt-5a; Ligand for members of the frizzled family of seven transmembrane receptors. Can activate or inhibit canonical Wnt signaling, depending on receptor context. In the presence of FZD4, activates beta-catenin signaling. In the presence of ROR2, inhibits the canonical Wnt pathway by promoting beta-catenin degradation through a GSK3-independent pathway which involves down-regulation of beta- catenin-induced reporter gene expression (By similarity). Suppression of the canonical pathway allows chondrogenesis to occur. Inhibits tumor formation. Stimulates cell migration. Decrease [...] (380 aa) |
| | WFIKKN2 | WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2. (571 aa) |
| | INHBA | Inhibin subunit beta A. (424 aa) |
| | BMP3 | Bone morphogenetic protein 3; Belongs to the TGF-beta family. (475 aa) |
| | TBXT | T-box transcription factor T. (365 aa) |
| | ZFYVE9 | Zinc finger FYVE domain-containing protein. (1425 aa) |
| | TP53 | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...] (391 aa) |
| | LNPEP | Leucyl and cystinyl aminopeptidase. (1025 aa) |
| | MAP3K7 | Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. (606 aa) |
| | AKAP3 | A-kinase anchoring protein 3. (883 aa) |
| | PML | Promyelocytic leukemia. (860 aa) |
| | NUP93 | Nuclear pore complex protein Nup93; Plays a role in the nuclear pore complex (NPC) assembly and/or maintenance; Belongs to the nucleoporin interacting component (NIC) family. (819 aa) |
| | ACVR1 | Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (509 aa) |
| | SOST | Sclerostin. (257 aa) |
| | BMP6 | Bone morphogenetic protein 6. (411 aa) |
| | GLG1 | Golgi glycoprotein 1. (1225 aa) |
| | ATOH8 | Atonal bHLH transcription factor 8. (369 aa) |
| | SMAD4 | Mothers against decapentaplegic homolog. (552 aa) |
| | GDF10 | Bone morphogenetic protein 3; Belongs to the TGF-beta family. (472 aa) |
| | FUT8 | Alpha-(1,6)-fucosyltransferase; Catalyzes the addition of fucose in alpha 1-6 linkage to the first GlcNAc residue, next to the peptide chains in N-glycans. Belongs to the glycosyltransferase 23 family. (602 aa) |
| | FST | Follistatin. (310 aa) |
| | INHBB | Inhibin subunit beta B. (302 aa) |
| | TGFB2 | Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa) |
| | NCEH1 | Neutral cholesterol ester hydrolase 1. (439 aa) |
| | SMAD6 | MH2 domain-containing protein. (220 aa) |
| | HJV | Hemojuvelin BMP co-receptor. (427 aa) |
| | APPL1 | Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1. (708 aa) |
| | HNF4A | Hepatocyte nuclear factor 4 alpha. (468 aa) |
| | CHRD | Chordin. (636 aa) |
| | ENG | Endoglin. (758 aa) |
| | DSG4 | Desmoglein 4; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. (1039 aa) |
| | INHBC | Inhibin subunit beta C. (351 aa) |
| | INHBE | Inhibin subunit beta E. (352 aa) |
| | BMP8B | TGF_BETA_2 domain-containing protein. (374 aa) |
| | NLK | Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (527 aa) |
| | DLX3 | Distal-less homeobox 3. (287 aa) |
| | GDF6 | Growth differentiation factor 6. (427 aa) |
| | EGR1 | Early growth response protein; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Belongs to the EGR C2H2-type zinc-finger protein family. (700 aa) |
| | G1SV95_RABIT | Transforming growth factor beta; Belongs to the TGF-beta family. (387 aa) |
| | NODAL | Nodal growth differentiation factor. (348 aa) |
| | HEXA | Beta-hexosaminidase. (529 aa) |
| | ACVR1C | Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (493 aa) |
| | VIM | Vimentin; Belongs to the intermediate filament family. (466 aa) |
| | MTMR4 | Myotubularin related protein 4. (1195 aa) |
| | ZNF8 | Zinc finger protein 8. (571 aa) |
| | CDH5 | Cadherin 5; Cadherins are calcium-dependent cell adhesion proteins. (974 aa) |
| | BMP10 | Bone morphogenetic protein 10. (428 aa) |
| | GDF5 | Growth differentiation factor 5 preproprotein (Predicted). (500 aa) |
| | STAT3 | Signal transducer and activator of transcription. (770 aa) |
| | BMP4 | Bone morphogenetic protein 4; Induces cartilage and bone formation. Acts in concert with PTHLH/PTHRP to stimulate ductal outgrowth during embryonic mammary development and to inhibit hair follicle induction (By similarity). (409 aa) |
| | SMAD2 | Mothers against decapentaplegic homolog. (467 aa) |
| | INHA | Inhibin alpha chain; Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition; Belongs to the TGF-beta family. (364 aa) |
| | TGFB3 | Transforming growth factor beta 3. (458 aa) |
| | SMPD3 | Sphingomyelin phosphodiesterase 3. (657 aa) |
| | BMP2 | Bone morphogenetic protein 2; Induces cartilage and bone formation. Stimulates the differentiation of myoblasts into osteoblasts via the EIF2AK3- EIF2A- ATF4 pathway. BMP2 activation of EIF2AK3 stimulates phosphorylation of EIF2A which leads to increased expression of ATF4 which plays a central role in osteoblast differentiation. In addition stimulates TMEM119, which upregulates the expression of ATF4. (271 aa) |
| | ATF2 | Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. (498 aa) |
| | COL1A2 | Collagen alpha-2(I) chain; Type I collagen is a member of group I collagen (fibrillar forming collagen); Belongs to the fibrillar collagen family. (1364 aa) |
| | HIVEP1 | Human immunodeficiency virus type I enhancer binding protein 1. (2651 aa) |
| | SOSTDC1 | Sclerostin domain containing 1. (206 aa) |
| | MSTN | Myostatin. (375 aa) |
| | SMURF2 | E3 ubiquitin-protein ligase. (747 aa) |
| | SKIL | SKI like proto-oncogene. (683 aa) |
| | GDF2 | Growth differentiation factor 2. (434 aa) |
| | GDF3 | Growth differentiation factor 3. (365 aa) |
| | HFE | Homeostatic iron regulator; Belongs to the MHC class I family. (356 aa) |
| | CAV2 | Caveolin-2; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity. Acts as an accessory protein in conjunction with CAV1 in targeting to lipid rafts and driving caveolae formation. Positive regulator of cellular mitogenesis of the MAPK signaling pathway. Required for the insulin-stimulated nuclear translocation and activation of MAPK1 and STAT3, and the subsequent regulation of cell cycle progression (By similarity); Belongs to the caveolin family. (162 aa) |
| | ITGB5 | Integrin beta; Belongs to the integrin beta chain family. (799 aa) |
| | COL3A1 | Collagen type III alpha 1 chain. (1462 aa) |
| | EXT1 | Exostosin glycosyltransferase 1; Belongs to the glycosyltransferase 47 family. (746 aa) |
| | LRRC32 | Leucine rich repeat containing 32. (664 aa) |
| | FAM83G | Family with sequence similarity 83 member G. (812 aa) |
| | TGFBR3 | Transforming growth factor beta receptor 3. (851 aa) |
| | HPGD | 15-hydroxyprostaglandin dehydrogenase; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (262 aa) |
| | SMURF1 | E3 ubiquitin-protein ligase. (737 aa) |
| | ACVR2A | Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (556 aa) |
| | SFRP2 | Secreted frizzled related protein 2. (295 aa) |
| | G1TC56_RABIT | TGFb_propeptide domain-containing protein. (168 aa) |
| | ZNF831 | Zinc finger protein 831. (1601 aa) |
| | BMPR1A | Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa) |
| | TWSG1 | Twisted gastrulation BMP signaling modulator 1. (202 aa) |
| | SPART | Spartin. (679 aa) |
| | FLCN | Folliculin. (579 aa) |
| | PARP1 | Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair. (1013 aa) |
| | ACVR1B | Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (474 aa) |
| | USP9X | Ubiquitin specific peptidase 9 X-linked; Belongs to the peptidase C19 family. (2575 aa) |
| | MEGF8 | Uncharacterized protein. (439 aa) |
| | ACVRL1 | Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (327 aa) |
| | FSHB | Follitropin subunit beta; Together with the alpha chain CGA constitutes follitropin, the follicle-stimulating hormone, and provides its biological specificity to the hormone heterodimer. Binds FSHR, a G protein-coupled receptor, on target cells to activate downstream signaling pathways. Follitropin is involved in follicle development and spermatogenesis in reproductive organs. (129 aa) |
| | LOC100341360 | TGF_BETA_2 domain-containing protein. (566 aa) |
| | CCDC142 | Coiled-coil domain containing 142. (762 aa) |
| | SMAD7 | Mothers against decapentaplegic homolog. (549 aa) |
| | GDF7 | Growth differentiation factor 7. (546 aa) |
| | ZYX | Zyxin. (572 aa) |
| | G1TQE3_RABIT | Fork-head domain-containing protein. (520 aa) |
| | JADE2 | Jade family PHD finger 2. (834 aa) |
| | RBM14 | RRM domain-containing protein. (119 aa) |
| | NRROS | Negative regulator of reactive oxygen species. (692 aa) |
| | BMP5 | Bone morphogenetic protein 5. (454 aa) |
| | TMEM100 | Transmembrane protein 100. (134 aa) |
| | BMP15 | TGF_BETA_2 domain-containing protein. (393 aa) |
| | LOC100101568 | Left-right determination factor. (368 aa) |
| | FOS | Fos proto-oncogene, AP-1 transcription factor subunit. (380 aa) |
| | HES1 | Hes family bHLH transcription factor 1. (279 aa) |
| | BMP7 | TGF_BETA_2 domain-containing protein. (170 aa) |
| | G1TYB9_RABIT | TGF_BETA_2 domain-containing protein. (358 aa) |
| | SIRT1 | Sirtuin 1. (748 aa) |
| | GDF11 | Growth differentiation factor 11. (395 aa) |
| | WNT1 | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (370 aa) |
| | ZCCHC12 | Zinc finger CCHC-type containing 12. (394 aa) |
| | ID1 | Inhibitor of DNA binding 1, HLH protein. (154 aa) |
| | G1U940_RABIT | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (178 aa) |
| | BMPER | BMP binding endothelial regulator. (685 aa) |
| | SLC33A1 | Solute carrier family 33 member 1. (568 aa) |
| | SMAD3 | SMAD family member 3. (230 aa) |
| | ENSOCUP00000027223 | Uncharacterized protein. (67 aa) |
| | FERMT2 | Fermitin family member 2. (696 aa) |
| | PPM1L | Protein phosphatase, Mg2+/Mn2+ dependent 1L. (360 aa) |
| | CITED1 | Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 1. (360 aa) |
| | DUSP22 | Uncharacterized protein. (319 aa) |
| | ITGB6 | Integrin beta; Belongs to the integrin beta chain family. (787 aa) |
| | ENSOCUP00000029917 | Uncharacterized protein. (169 aa) |
| | PTK2 | Uncharacterized protein; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1041 aa) |
| | TGFBR3L | Transforming growth factor beta receptor 3 like. (313 aa) |
| | TGFBR2 | TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (592 aa) |
| | PDCD4 | Programmed cell death 4. (491 aa) |
| | LOC103345451 | TGFb_propeptide domain-containing protein. (203 aa) |
| | ENSOCUP00000032400 | Uncharacterized protein. (531 aa) |
| | GCNT2 | Uncharacterized protein. (402 aa) |
| | APPL2 | Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2. (666 aa) |
| | SMAD1 | Mothers against decapentaplegic homolog. (465 aa) |
| | BTBD11 | BTB domain containing 11. (1051 aa) |
| | PXN | Paxillin. (1072 aa) |
| | MAGI2 | Membrane associated guanylate kinase, WW and PDZ domain containing 2. (1449 aa) |
| | CHRDL1 | Chordin like 1. (578 aa) |
| | TGFBR1 | Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (486 aa) |
| | NOTCH2 | Notch receptor 2. (2481 aa) |
| | SMAD9 | Mothers against decapentaplegic homolog. (441 aa) |
| | BMPR2 | Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1060 aa) |
| | ENSOCUP00000036823 | Mitogen-activated protein kinase. (254 aa) |
| | DLX5 | Distal-less homeobox 5. (313 aa) |
| | ENSOCUP00000037329 | TGFb_propeptide domain-containing protein. (263 aa) |
| | PTK2-2 | FERM_N_2 domain-containing protein. (121 aa) |
| | SLC39A5 | Solute carrier family 39 member 5. (549 aa) |
| | RNF111 | Ring finger protein 111. (993 aa) |
| | JUN | BZIP domain-containing protein; Belongs to the bZIP family. (352 aa) |
| | ENSOCUP00000040784 | Uncharacterized protein. (227 aa) |
| | AFP | Alpha fetoprotein. (611 aa) |
| | AMHR2 | Anti-Muellerian hormone type-2 receptor; On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for anti-Muellerian hormone. (569 aa) |
| | ENSOCUP00000041840 | TGFb_propeptide domain-containing protein. (219 aa) |
| | USP15 | Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (997 aa) |
| | TDGF1 | EGF-like domain-containing protein. (259 aa) |
| | DDX5 | DEAD-box helicase 5; Belongs to the DEAD box helicase family. (614 aa) |
| | PTPRK | Protein tyrosine phosphatase receptor type K. (1472 aa) |
| | BMPR1B | Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (543 aa) |
| | ENSOCUP00000044284 | TGFb_propeptide domain-containing protein. (260 aa) |
| | ENSOCUP00000045925 | TGFb_propeptide domain-containing protein. (272 aa) |
| | ITGA8 | Integrin subunit alpha 8; Belongs to the integrin alpha chain family. (1100 aa) |
| | ZMIZ1 | Zinc finger MIZ-type containing 1. (1060 aa) |
| | SMAD5 | Mothers against decapentaplegic homolog. (465 aa) |
| | CITED2 | Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 2. (249 aa) |
| | LEF1 | Lymphoid enhancer binding factor 1. (414 aa) |
