STRINGSTRING
ENG ENG NLK NLK MTMR4 MTMR4 G1SV95_RABIT G1SV95_RABIT NODAL NODAL CDH5 CDH5 STAT3 STAT3 SMAD2 SMAD2 TGFB3 TGFB3 COL1A2 COL1A2 MSTN MSTN SKIL SKIL CAV2 CAV2 ITGB5 ITGB5 COL3A1 COL3A1 LRRC32 LRRC32 TGFBR3 TGFBR3 HPGD HPGD TWSG1 TWSG1 FLCN FLCN PARP1 PARP1 USP9X USP9X ACVRL1 ACVRL1 FSHB FSHB SMAD7 SMAD7 ZYX ZYX G1TQE3_RABIT G1TQE3_RABIT NRROS NRROS FOS FOS SIRT1 SIRT1 G1U940_RABIT G1U940_RABIT SMAD3 SMAD3 CITED2 CITED2 SMAD5 SMAD5 ZMIZ1 ZMIZ1 ITGA8 ITGA8 ENSOCUP00000045925 ENSOCUP00000045925 ENSOCUP00000044284 ENSOCUP00000044284 PTPRK PTPRK USP15 USP15 ENSOCUP00000041840 ENSOCUP00000041840 JUN JUN PTK2-2 PTK2-2 ENSOCUP00000037329 ENSOCUP00000037329 ENSOCUP00000036823 ENSOCUP00000036823 TGFBR1 TGFBR1 PXN PXN SMAD1 SMAD1 APPL2 APPL2 GCNT2 GCNT2 ENSOCUP00000032400 ENSOCUP00000032400 LOC103345451 LOC103345451 TGFBR2 TGFBR2 TGFBR3L TGFBR3L PTK2 PTK2 ITGB6 ITGB6 DUSP22 DUSP22 CITED1 CITED1 FERMT2 FERMT2 WFIKKN2 WFIKKN2 ZFYVE9 ZFYVE9 TP53 TP53 MAP3K7 MAP3K7 PML PML ACVR1 ACVR1 GLG1 GLG1 SMAD4 SMAD4 FUT8 FUT8 TGFB2 TGFB2 SMAD6 SMAD6 APPL1 APPL1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ENGEndoglin. (758 aa)
NLKMitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (527 aa)
MTMR4Myotubularin related protein 4. (1195 aa)
G1SV95_RABITTransforming growth factor beta; Belongs to the TGF-beta family. (387 aa)
NODALNodal growth differentiation factor. (348 aa)
CDH5Cadherin 5; Cadherins are calcium-dependent cell adhesion proteins. (974 aa)
STAT3Signal transducer and activator of transcription. (770 aa)
SMAD2Mothers against decapentaplegic homolog. (467 aa)
TGFB3Transforming growth factor beta 3. (458 aa)
COL1A2Collagen alpha-2(I) chain; Type I collagen is a member of group I collagen (fibrillar forming collagen); Belongs to the fibrillar collagen family. (1364 aa)
MSTNMyostatin. (375 aa)
SKILSKI like proto-oncogene. (683 aa)
CAV2Caveolin-2; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity. Acts as an accessory protein in conjunction with CAV1 in targeting to lipid rafts and driving caveolae formation. Positive regulator of cellular mitogenesis of the MAPK signaling pathway. Required for the insulin-stimulated nuclear translocation and activation of MAPK1 and STAT3, and the subsequent regulation of cell cycle progression (By similarity); Belongs to the caveolin family. (162 aa)
ITGB5Integrin beta; Belongs to the integrin beta chain family. (799 aa)
COL3A1Collagen type III alpha 1 chain. (1462 aa)
LRRC32Leucine rich repeat containing 32. (664 aa)
TGFBR3Transforming growth factor beta receptor 3. (851 aa)
HPGD15-hydroxyprostaglandin dehydrogenase; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (262 aa)
TWSG1Twisted gastrulation BMP signaling modulator 1. (202 aa)
FLCNFolliculin. (579 aa)
PARP1Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair. (1013 aa)
USP9XUbiquitin specific peptidase 9 X-linked; Belongs to the peptidase C19 family. (2575 aa)
ACVRL1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (327 aa)
FSHBFollitropin subunit beta; Together with the alpha chain CGA constitutes follitropin, the follicle-stimulating hormone, and provides its biological specificity to the hormone heterodimer. Binds FSHR, a G protein-coupled receptor, on target cells to activate downstream signaling pathways. Follitropin is involved in follicle development and spermatogenesis in reproductive organs. (129 aa)
SMAD7Mothers against decapentaplegic homolog. (549 aa)
ZYXZyxin. (572 aa)
G1TQE3_RABITFork-head domain-containing protein. (520 aa)
NRROSNegative regulator of reactive oxygen species. (692 aa)
FOSFos proto-oncogene, AP-1 transcription factor subunit. (380 aa)
SIRT1Sirtuin 1. (748 aa)
G1U940_RABITCellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (178 aa)
SMAD3SMAD family member 3. (230 aa)
CITED2Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 2. (249 aa)
SMAD5Mothers against decapentaplegic homolog. (465 aa)
ZMIZ1Zinc finger MIZ-type containing 1. (1060 aa)
ITGA8Integrin subunit alpha 8; Belongs to the integrin alpha chain family. (1100 aa)
ENSOCUP00000045925TGFb_propeptide domain-containing protein. (272 aa)
ENSOCUP00000044284TGFb_propeptide domain-containing protein. (260 aa)
PTPRKProtein tyrosine phosphatase receptor type K. (1472 aa)
USP15Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (997 aa)
ENSOCUP00000041840TGFb_propeptide domain-containing protein. (219 aa)
JUNBZIP domain-containing protein; Belongs to the bZIP family. (352 aa)
PTK2-2FERM_N_2 domain-containing protein. (121 aa)
ENSOCUP00000037329TGFb_propeptide domain-containing protein. (263 aa)
ENSOCUP00000036823Mitogen-activated protein kinase. (254 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (486 aa)
PXNPaxillin. (1072 aa)
SMAD1Mothers against decapentaplegic homolog. (465 aa)
APPL2Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2. (666 aa)
GCNT2Uncharacterized protein. (402 aa)
ENSOCUP00000032400Uncharacterized protein. (531 aa)
LOC103345451TGFb_propeptide domain-containing protein. (203 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (592 aa)
TGFBR3LTransforming growth factor beta receptor 3 like. (313 aa)
PTK2Uncharacterized protein; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1041 aa)
ITGB6Integrin beta; Belongs to the integrin beta chain family. (787 aa)
DUSP22Uncharacterized protein. (319 aa)
CITED1Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 1. (360 aa)
FERMT2Fermitin family member 2. (696 aa)
WFIKKN2WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2. (571 aa)
ZFYVE9Zinc finger FYVE domain-containing protein. (1425 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...] (391 aa)
MAP3K7Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. (606 aa)
PMLPromyelocytic leukemia. (860 aa)
ACVR1Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (509 aa)
GLG1Golgi glycoprotein 1. (1225 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
FUT8Alpha-(1,6)-fucosyltransferase; Catalyzes the addition of fucose in alpha 1-6 linkage to the first GlcNAc residue, next to the peptide chains in N-glycans. Belongs to the glycosyltransferase 23 family. (602 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
SMAD6MH2 domain-containing protein. (220 aa)
APPL1Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1. (708 aa)
Your Current Organism:
Oryctolagus cuniculus
NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits
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