STRINGSTRING
mc1R mc1R ADCY8 ADCY8 ADCY4 ADCY4 PTGER2 PTGER2 ADGRF2 ADGRF2 UCN3 UCN3 PLN PLN CALCRL CALCRL ADGRF4 ADGRF4 S1PR2 S1PR2 ADGRB3 ADGRB3 ADCY6 ADCY6 GLP1R GLP1R PF4 PF4 PTH1R PTH1R CALCB CALCB AKAP13 AKAP13 ENSOCUP00000043322 ENSOCUP00000043322 ADGRG4 ADGRG4 ADGRL2 ADGRL2 S1PR5 S1PR5 ABCA1 ABCA1 ADM2 ADM2 GPR4 GPR4 ENSOCUP00000048460 ENSOCUP00000048460 ADCY7 ADCY7 RAMP2 RAMP2 ADGRF1 ADGRF1 CALCR CALCR MC5R MC5R PTGIR PTGIR CHGA CHGA ADGRG2 ADGRG2 TMEM116 TMEM116 ADGRD2 ADGRD2 GHRH GHRH ADGRD1 ADGRD1 GIP GIP ADRA1B ADRA1B RAPGEF4 RAPGEF4 ADCY5 ADCY5 S1PR3 S1PR3 GCG GCG ADCY1 ADCY1 PTRHD1 PTRHD1 ADCY3 ADCY3 S1PR1 S1PR1 LOC100356264 LOC100356264 GPR101 GPR101 MC3R MC3R ADGRF3 ADGRF3 ADGRE5 ADGRE5 GPER1 GPER1 GPR161 GPR161 LOC100346323 LOC100346323 GPR26 GPR26 G1TCA5_RABIT G1TCA5_RABIT CXCL10 CXCL10 ADCY2 ADCY2 ADORA2A ADORA2A ADCYAP1 ADCYAP1 RAPGEF2 RAPGEF2 GPR6 GPR6 ADM ADM DRD2 DRD2 GPR119 GPR119 LPAR1 LPAR1 CXCL11 CXCL11 RXFP2 RXFP2 GNAS GNAS GPR12 GPR12 ADRB2 ADRB2 GIPR GIPR ADGRG7 ADGRG7 GPHB5 GPHB5 ADGRE2 ADGRE2 DRD5 DRD5 ADGRG5 ADGRG5 TUBB3 TUBB3 ADGRL1 ADGRL1 GPR65 GPR65 ADORA2B ADORA2B CNR2 CNR2 MC4R MC4R LPAR3 LPAR3 MC2R MC2R ADRB3 ADRB3 ADCY9 ADCY9 GNA13 GNA13 ADGRG6 ADGRG6 PTGFR PTGFR CALCA CALCA SLC9A3R1 SLC9A3R1 TSHR TSHR RXFP1 RXFP1 VIP VIP LHCGR LHCGR ADGRL3 ADGRL3 ADGRL4 ADGRL4 ENSOCUP00000031759 ENSOCUP00000031759 ADGRG3 ADGRG3 GPR157 GPR157 ENSOCUP00000034349 ENSOCUP00000034349 CRHR1 CRHR1 ADGRG1 ADGRG1 ADGRF5 ADGRF5 RIT2 RIT2 CXCL9 CXCL9 HTR5A HTR5A GPR3 GPR3 DRD3 DRD3 DRD1 DRD1 GNAL GNAL
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
mc1RMelanocyte-stimulating hormone receptor; Receptor for MSH (alpha, beta and gamma) and ACTH. The activity of this receptor is mediated by G proteins which activate adenylate cyclase; Belongs to the G-protein coupled receptor 1 family. (307 aa)
ADCY8Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1251 aa)
ADCY4Adenylate cyclase type 4; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1082 aa)
PTGER2G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (361 aa)
ADGRF2Adhesion G protein-coupled receptor F2; Belongs to the G-protein coupled receptor 2 family. (670 aa)
UCN3Urocortin 3. (167 aa)
PLNCardiac phospholamban; Reversibly inhibits the activity of ATP2A2 in cardiac sarcoplasmic reticulum by decreasing the apparent affinity of the ATPase for Ca(2+). Modulates the contractility of the heart muscle in response to physiological stimuli via its effects on ATP2A2. Modulates calcium re-uptake during muscle relaxation and plays an important role in calcium homeostasis in the heart muscle. The degree of ATP2A2 inhibition depends on the oligomeric state of PLN. ATP2A2 inhibition is alleviated by PLN phosphorylation (By similarity). (52 aa)
CALCRLCalcitonin receptor like receptor; Belongs to the G-protein coupled receptor 2 family. (465 aa)
ADGRF4Adhesion G protein-coupled receptor F4; Belongs to the G-protein coupled receptor 2 family. (703 aa)
S1PR2G_PROTEIN_RECEP_F1_2 domain-containing protein. (353 aa)
ADGRB3Adhesion G protein-coupled receptor B3; Belongs to the G-protein coupled receptor 2 family. (1522 aa)
ADCY6Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1204 aa)
GLP1RGlucagon like peptide 1 receptor; Belongs to the G-protein coupled receptor 2 family. (488 aa)
PF4Platelet factor 4; Released during platelet aggregation. Neutralizes the anticoagulant effect of heparin because it binds more strongly to heparin than to the chondroitin-4-sulfate chains of the carrier molecule. Chemotactic for neutrophils and monocytes. Inhibits endothelial cell proliferation (By similarity); Belongs to the intercrine alpha (chemokine CxC) family. (105 aa)
PTH1RUncharacterized protein; Belongs to the G-protein coupled receptor 2 family. (619 aa)
CALCBCalcitonin related polypeptide beta. (174 aa)
AKAP13Uncharacterized protein. (1454 aa)
ENSOCUP00000043322Uncharacterized protein. (234 aa)
ADGRG4Adhesion G protein-coupled receptor G4; Belongs to the G-protein coupled receptor 2 family. (2963 aa)
ADGRL2Adhesion G protein-coupled receptor L2; Belongs to the G-protein coupled receptor 2 family. (1494 aa)
S1PR5Sphingosine-1-phosphate receptor 5; Belongs to the G-protein coupled receptor 1 family. (399 aa)
ABCA1ATP binding cassette subfamily A member 1. (2261 aa)
ADM2Adrenomedullin 2. (178 aa)
GPR4G protein-coupled receptor 4; Belongs to the G-protein coupled receptor 1 family. (361 aa)
ENSOCUP00000048460Uncharacterized protein. (176 aa)
ADCY7Adenylate cyclase type 7; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1080 aa)
RAMP2Receptor activity modifying protein 2. (100 aa)
ADGRF1Adhesion G protein-coupled receptor F1; Belongs to the G-protein coupled receptor 2 family. (915 aa)
CALCRCalcitonin receptor; This is a receptor for calcitonin. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. The calcitonin receptor is thought to couple to the heterotrimeric guanosine triphosphate-binding protein that is sensitive to cholera toxin. Isoform 2 has altered ligand binding and abolished coupling to phospholipase C. (491 aa)
MC5RMelanocortin 5 receptor. (412 aa)
PTGIRProstaglandin I2 receptor; Belongs to the G-protein coupled receptor 1 family. (375 aa)
CHGAUncharacterized protein. (289 aa)
ADGRG2Adhesion G protein-coupled receptor G2; Belongs to the G-protein coupled receptor 2 family. (1002 aa)
TMEM116Transmembrane protein 116. (364 aa)
ADGRD2Adhesion G protein-coupled receptor D2; Belongs to the G-protein coupled receptor 2 family. (846 aa)
GHRHGrowth hormone releasing hormone. (106 aa)
ADGRD1Adhesion G protein-coupled receptor D1; Belongs to the G-protein coupled receptor 2 family. (851 aa)
GIPGastric inhibitory polypeptide. (153 aa)
ADRA1BG_PROTEIN_RECEP_F1_2 domain-containing protein. (494 aa)
RAPGEF4Rap guanine nucleotide exchange factor 4. (1011 aa)
ADCY5Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. Mediates signaling downstream of ADRB1. Regulates the increase of free cytosolic Ca(2+) in response to increased blood glucose levels and contributes to the regulation of Ca(2+)-dependent insulin secretion; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1010 aa)
S1PR3Sphingosine-1-phosphate receptor 3; Belongs to the G-protein coupled receptor 1 family. (367 aa)
GCGGlucagon; Glucagon plays a key role in glucose metabolism and homeostasis. Regulates blood glucose by increasing gluconeogenesis and decreasing glycolysis (By similarity). (180 aa)
ADCY1Guanylate cyclase domain-containing protein. (266 aa)
PTRHD1Peptidyl-tRNA hydrolase domain containing 1. (140 aa)
ADCY3Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1138 aa)
S1PR1Uncharacterized protein. (356 aa)
LOC100356264Uncharacterized protein; Belongs to the G-protein coupled receptor 2 family. (630 aa)
GPR101G protein-coupled receptor 101; Belongs to the G-protein coupled receptor 1 family. (505 aa)
MC3RMelanocortin 3 receptor. (323 aa)
ADGRF3Adhesion G protein-coupled receptor F3; Belongs to the G-protein coupled receptor 2 family. (987 aa)
ADGRE5Adhesion G protein-coupled receptor E5; Belongs to the G-protein coupled receptor 2 family. (720 aa)
GPER1G protein-coupled estrogen receptor 1; Belongs to the G-protein coupled receptor 1 family. (361 aa)
GPR161G protein-coupled receptor 161; Belongs to the G-protein coupled receptor 1 family. (546 aa)
LOC100346323Uncharacterized protein. (240 aa)
GPR26G protein-coupled receptor 26. (325 aa)
G1TCA5_RABITUncharacterized protein. (186 aa)
CXCL10C-X-C motif chemokine. (98 aa)
ADCY2Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1040 aa)
ADORA2AAdenosine receptor A2; Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family. (409 aa)
ADCYAP1Adenylate cyclase activating polypeptide 1. (176 aa)
RAPGEF2Rap guanine nucleotide exchange factor 2. (1659 aa)
GPR6G protein-coupled receptor 6; Belongs to the G-protein coupled receptor 1 family. (378 aa)
ADMAdrenomedullin. (187 aa)
DRD2Dopamine receptor D2; Belongs to the G-protein coupled receptor 1 family. (443 aa)
GPR119G protein-coupled receptor 119; Belongs to the G-protein coupled receptor 1 family. (336 aa)
LPAR1Lysophosphatidic acid receptor 1; Belongs to the G-protein coupled receptor 1 family. (391 aa)
CXCL11C-X-C motif chemokine ligand 11. (110 aa)
RXFP2Relaxin family peptide receptor 2. (745 aa)
GNASGNAS complex locus. (977 aa)
GPR12G protein-coupled receptor 12; Belongs to the G-protein coupled receptor 1 family. (375 aa)
ADRB2Adrenoceptor beta 2. (437 aa)
GIPRGastric inhibitory polypeptide receptor; Belongs to the G-protein coupled receptor 2 family. (468 aa)
ADGRG7Adhesion G protein-coupled receptor G7; Belongs to the G-protein coupled receptor 2 family. (796 aa)
GPHB5Glycoprotein hormone subunit beta 5. (130 aa)
ADGRE2Adhesion G protein-coupled receptor E2; Belongs to the G-protein coupled receptor 2 family. (844 aa)
DRD5Dopamine receptor D5; Belongs to the G-protein coupled receptor 1 family. (483 aa)
ADGRG5Uncharacterized protein. (362 aa)
TUBB3Tubulin beta chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. Belongs to the tubulin family. (502 aa)
ADGRL1Adhesion G protein-coupled receptor L1; Belongs to the G-protein coupled receptor 2 family. (1550 aa)
GPR65G protein-coupled receptor 65; Belongs to the G-protein coupled receptor 1 family. (336 aa)
ADORA2BAdenosine receptor A2b; Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase (By similarity). Belongs to the G-protein coupled receptor 1 family. (444 aa)
CNR2Cannabinoid receptor 2; Belongs to the G-protein coupled receptor 1 family. (517 aa)
MC4RMelanocortin 4 receptor. (333 aa)
LPAR3Lysophosphatidic acid receptor 3; Belongs to the G-protein coupled receptor 1 family. (401 aa)
MC2RMelanocortin 2 receptor. (372 aa)
ADRB3G_PROTEIN_RECEP_F1_2 domain-containing protein. (407 aa)
ADCY9Adenylate cyclase 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1236 aa)
GNA13G protein subunit alpha 13. (377 aa)
ADGRG6Adhesion G protein-coupled receptor G6; Belongs to the G-protein coupled receptor 2 family. (1250 aa)
PTGFRProstaglandin F receptor; Belongs to the G-protein coupled receptor 1 family. (366 aa)
CALCACalcitonin related polypeptide alpha. (140 aa)
SLC9A3R1Na(+)/H(+) exchange regulatory cofactor NHE-RF1; Scaffold protein that connects plasma membrane proteins with members of the ezrin/moesin/radixin family and thereby helps to link them to the actin cytoskeleton and to regulate their surface expression. Necessary for recycling of internalized ADRB2. Was first known to play a role in the regulation of the activity and subcellular location of SLC9A3. Necessary for cAMP-mediated phosphorylation and inhibition of SLC9A3. Involved in sperm capacitation. May participate in the regulation of the chloride and bicarbonate homeostasis in spermatoz [...] (356 aa)
TSHRThyrotropin receptor; Receptor for the thyroid-stimulating hormone (TSH) or thyrotropin. Also acts as a receptor for the heterodimeric glycoprotein hormone (GPHA2:GPHB5) or thyrostimulin. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Plays a central role in controlling thyroid cell metabolism. Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily. (764 aa)
RXFP1Relaxin family peptide receptor 1. (714 aa)
VIPVasoactive intestinal peptide; VIP causes vasodilation, lowers arterial blood pressure, stimulates myocardial contractility, increases glycogenolysis and relaxes the smooth muscle of trachea, stomach and gall bladder; Belongs to the glucagon family. (166 aa)
LHCGRLutropin-choriogonadotropic hormone receptor; Receptor for lutropin-choriogonadotropic hormone. The activity of this receptor is mediated by G proteins which activate adenylate cyclase; Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily. (732 aa)
ADGRL3Adhesion G protein-coupled receptor L3; Belongs to the G-protein coupled receptor 2 family. (1450 aa)
ADGRL4Adhesion G protein-coupled receptor L4; Belongs to the G-protein coupled receptor 2 family. (740 aa)
ENSOCUP00000031759Guanylate cyclase domain-containing protein. (312 aa)
ADGRG3Uncharacterized protein; Belongs to the G-protein coupled receptor 2 family. (868 aa)
GPR157Uncharacterized protein. (489 aa)
ENSOCUP00000034349Uncharacterized protein. (160 aa)
CRHR1Uncharacterized protein; Belongs to the G-protein coupled receptor 2 family. (429 aa)
ADGRG1Adhesion G protein-coupled receptor G1; Belongs to the G-protein coupled receptor 2 family. (888 aa)
ADGRF5Adhesion G protein-coupled receptor F5; Belongs to the G-protein coupled receptor 2 family. (1405 aa)
RIT2Ras-like GTP binding protein. (217 aa)
CXCL9C-X-C motif chemokine. (153 aa)
HTR5A5-hydroxytryptamine receptor 5A. (358 aa)
GPR3G protein-coupled receptor 3; Belongs to the G-protein coupled receptor 1 family. (367 aa)
DRD3Dopamine receptor D3; Belongs to the G-protein coupled receptor 1 family. (399 aa)
DRD1D(1A) dopamine receptor; Dopamine receptor whose activity is mediated by G proteins which activate adenylyl cyclase. (448 aa)
GNALG protein subunit alpha L. (464 aa)
Your Current Organism:
Oryctolagus cuniculus
NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits
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