STRINGSTRING
SPEN SPEN CDK6 CDK6 ENSOCUP00000040050 ENSOCUP00000040050 PTP4A3 PTP4A3 PGAM2 PGAM2 G1U7N5_RABIT G1U7N5_RABIT NOTCH3 NOTCH3 SUSD5 SUSD5 HEY2 HEY2 G1U4G3_RABIT G1U4G3_RABIT RITA1 RITA1 HES3 HES3 DTX3L DTX3L ANGPT4 ANGPT4 TBX2 TBX2 HES1 HES1 HOXD3 HOXD3 TMEM100 TMEM100 GRIP2 GRIP2 NRIP2 NRIP2 KCNA5 KCNA5 SNAI1 SNAI1 G1TGC0_RABIT G1TGC0_RABIT DNER DNER HEY1 HEY1 NOTCH4 NOTCH4 TIMP4 TIMP4 ANXA4 ANXA4 S1PR3 S1PR3 GMDS GMDS MAML1 MAML1 PSEN1 PSEN1 NCSTN NCSTN NLE1 NLE1 CDKN1B CDKN1B PLN PLN PSENEN PSENEN ATOH1 ATOH1 CNTN6 CNTN6 SNAI2 SNAI2 SEL1L SEL1L MAML2 MAML2 DLL4 DLL4 APP APP ADAM17 ADAM17 CNTN1 CNTN1 MAML3 MAML3 APH1A APH1A CFAP58 CFAP58 G1SV95_RABIT G1SV95_RABIT FBXW7 FBXW7 DLL3 DLL3 NR1H4 NR1H4 G1SSE9_RABIT G1SSE9_RABIT NR0B2 NR0B2 MIB1 MIB1 G1SPA3_RABIT G1SPA3_RABIT APH1B APH1B IFT172 IFT172 IL17A IL17A PERP PERP GSX2 GSX2 ITGB1BP1 ITGB1BP1 DLX1 DLX1 WDR12 WDR12 JAG1 JAG1 HES7 HES7 IFT74 IFT74 HEYL HEYL CDH6 CDH6 DLL1 DLL1 ENSOCUP00000041840 ENSOCUP00000041840 TSPEAR TSPEAR ENSOCUP00000044284 ENSOCUP00000044284 LOC100338113 LOC100338113 ENSOCUP00000045925 ENSOCUP00000045925 GALNT11 GALNT11 LOC100352102 LOC100352102 DTX2 DTX2 MECP2 MECP2 TP63 TP63 SORBS2 SORBS2 NEURL1B NEURL1B TGFBR2 TGFBR2 ENSOCUP00000030729 ENSOCUP00000030729 RBPJ RBPJ LOC103345451 LOC103345451 ZNF423 ZNF423 EPN2 EPN2 GOT1 GOT1 NOTCH2 NOTCH2 NEURL1 NEURL1 ENSOCUP00000037329 ENSOCUP00000037329 DTX4 DTX4 ADAM10 ADAM10 CHAC1 CHAC1 PSEN2 PSEN2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SPENSpen family transcriptional repressor. (3600 aa)
CDK6Cyclin dependent kinase 6; Belongs to the protein kinase superfamily. (349 aa)
ENSOCUP00000040050LAG1_DNAbind domain-containing protein. (92 aa)
PTP4A3Protein tyrosine phosphatase 4A3. (181 aa)
PGAM2Phosphoglycerate mutase; Belongs to the phosphoglycerate mutase family. BPG- dependent PGAM subfamily. (253 aa)
G1U7N5_RABITPID domain-containing protein. (200 aa)
NOTCH3Notch receptor 3. (2262 aa)
SUSD5Sushi domain containing 5. (626 aa)
HEY2Hes related family bHLH transcription factor with YRPW motif 2. (338 aa)
G1U4G3_RABITUncharacterized protein. (258 aa)
RITA1RBPJ interacting and tubulin associated 1. (282 aa)
HES3BHLH domain-containing protein. (170 aa)
DTX3LDeltex E3 ubiquitin ligase 3L. (857 aa)
ANGPT4Angiopoietin 4. (487 aa)
TBX2T-box transcription factor 2. (662 aa)
HES1Hes family bHLH transcription factor 1. (279 aa)
HOXD3Homeobox D3. (498 aa)
TMEM100Transmembrane protein 100. (134 aa)
GRIP2Glutamate receptor interacting protein 2. (995 aa)
NRIP2Nuclear receptor interacting protein 2. (314 aa)
KCNA5Potassium voltage-gated channel subfamily A member 5; Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes. Forms tetrameric potassium- selective channels through which potassium ions pass in accordance with their electrochemical gradient. The channel alternates between opened and closed conformations in response to the voltage difference across the membrane. Can form functional homotetrameric channels and heterotetrameric channels that contain variable proportions of KCNA1, KCNA2, KCNA4, KCNA5, and possibly other family members as well [...] (598 aa)
SNAI1Snail family transcriptional repressor 1. (238 aa)
G1TGC0_RABITUncharacterized protein. (214 aa)
DNERDelta/notch like EGF repeat containing. (719 aa)
HEY1Hes related family bHLH transcription factor with YRPW motif 1. (452 aa)
NOTCH4Uncharacterized protein. (1854 aa)
TIMP4Metalloproteinase inhibitor 4; Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor; Belongs to the protease inhibitor I35 (TIMP) family. (224 aa)
ANXA4Annexin. (321 aa)
S1PR3Sphingosine-1-phosphate receptor 3; Belongs to the G-protein coupled receptor 1 family. (367 aa)
GMDSGDP-mannose 4,6-dehydratase. (358 aa)
MAML1Mastermind like transcriptional coactivator 1. (932 aa)
PSEN1Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (557 aa)
NCSTNNicastrin. (667 aa)
NLE1Notchless homolog 1. (485 aa)
CDKN1BCyclin dependent kinase inhibitor 1B. (198 aa)
PLNCardiac phospholamban; Reversibly inhibits the activity of ATP2A2 in cardiac sarcoplasmic reticulum by decreasing the apparent affinity of the ATPase for Ca(2+). Modulates the contractility of the heart muscle in response to physiological stimuli via its effects on ATP2A2. Modulates calcium re-uptake during muscle relaxation and plays an important role in calcium homeostasis in the heart muscle. The degree of ATP2A2 inhibition depends on the oligomeric state of PLN. ATP2A2 inhibition is alleviated by PLN phosphorylation (By similarity). (52 aa)
PSENENUncharacterized protein. (101 aa)
ATOH1Atonal bHLH transcription factor 1. (359 aa)
CNTN6Contactin 6. (1029 aa)
SNAI2Uncharacterized protein. (268 aa)
SEL1LSEL1L adaptor subunit of ERAD E3 ubiquitin ligase. (873 aa)
MAML2Mastermind like transcriptional coactivator 2. (1137 aa)
DLL4Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (685 aa)
APPGamma-secretase C-terminal fragment 57; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those medi [...] (769 aa)
ADAM17ADAM metallopeptidase domain 17. (827 aa)
CNTN1Contactin 1. (1018 aa)
MAML3Mastermind like transcriptional coactivator 3. (1124 aa)
APH1AAph-1 homolog A, gamma-secretase subunit. (265 aa)
CFAP58Cilia and flagella associated protein 58. (873 aa)
G1SV95_RABITTransforming growth factor beta; Belongs to the TGF-beta family. (387 aa)
FBXW7F-box and WD repeat domain containing 7. (780 aa)
DLL3Delta like canonical Notch ligand 3. (605 aa)
NR1H4Uncharacterized protein. (486 aa)
G1SSE9_RABITUncharacterized protein. (296 aa)
NR0B2Nuclear receptor subfamily 0 group B member 2. (260 aa)
MIB1Mindbomb E3 ubiquitin protein ligase 1. (1006 aa)
G1SPA3_RABITUncharacterized protein. (226 aa)
APH1BAph-1 homolog B, gamma-secretase subunit. (240 aa)
IFT172Intraflagellar transport 172. (1749 aa)
IL17AInterleukin 17A. (153 aa)
PERPUncharacterized protein. (193 aa)
GSX2GS homeobox 2. (291 aa)
ITGB1BP1PID domain-containing protein. (200 aa)
DLX1Distal-less homeobox 1. (255 aa)
WDR12Ribosome biogenesis protein WDR12; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome. (423 aa)
JAG1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1218 aa)
HES7Hes family bHLH transcription factor 7. (217 aa)
IFT74Intraflagellar transport 74. (600 aa)
HEYLHes related family bHLH transcription factor with YRPW motif like. (301 aa)
CDH6Cadherin 6; Cadherins are calcium-dependent cell adhesion proteins. (790 aa)
DLL1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (754 aa)
ENSOCUP00000041840TGFb_propeptide domain-containing protein. (219 aa)
TSPEARThrombospondin type laminin G domain and EAR repeats. (667 aa)
ENSOCUP00000044284TGFb_propeptide domain-containing protein. (260 aa)
LOC100338113Uncharacterized protein. (282 aa)
ENSOCUP00000045925TGFb_propeptide domain-containing protein. (272 aa)
GALNT11Polypeptide N-acetylgalactosaminyltransferase 11; Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily. (647 aa)
LOC100352102Uncharacterized protein. (256 aa)
DTX2Deltex E3 ubiquitin ligase 2. (619 aa)
MECP2Methyl-CpG-binding protein 2; Chromosomal protein that binds to methylated DNA. It can bind specifically to a single methyl-CpG pair. It is not influenced by sequences flanking the methyl-CpGs. Binds both 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC)-containing DNA, with a preference for 5-methylcytosine (5mC). (485 aa)
TP63Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. (680 aa)
SORBS2Sorbin and SH3 domain containing 2. (1230 aa)
NEURL1BNeuralized E3 ubiquitin protein ligase 1B. (315 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (592 aa)
ENSOCUP00000030729Uncharacterized protein. (69 aa)
RBPJRecombination signal binding protein for immunoglobulin kappa J region. (499 aa)
LOC103345451TGFb_propeptide domain-containing protein. (203 aa)
ZNF423Zinc finger protein 423. (1421 aa)
EPN2Epsin 2. (576 aa)
GOT1Aspartate aminotransferase. (442 aa)
NOTCH2Notch receptor 2. (2481 aa)
NEURL1Neuralized E3 ubiquitin protein ligase 1. (591 aa)
ENSOCUP00000037329TGFb_propeptide domain-containing protein. (263 aa)
DTX4Deltex E3 ubiquitin ligase 4. (513 aa)
ADAM10ADAM metallopeptidase domain 10. (748 aa)
CHAC1Gamma-glutamylcyclotransferase; Catalyzes the cleavage of glutathione into 5-oxo-L-proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides; Belongs to the gamma-glutamylcyclotransferase family. (347 aa)
PSEN2Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (539 aa)
Your Current Organism:
Oryctolagus cuniculus
NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits
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