STRINGSTRING
VAX1 VAX1 EPHB2 EPHB2 EGR2 EGR2 MYOT MYOT SEMA4B SEMA4B CNTN5 CNTN5 EPHA8 EPHA8 EVX1 EVX1 EXT1 EXT1 HOXA2 HOXA2 SCN1B SCN1B NFASC NFASC CNTN2 CNTN2 TTC8 TTC8 SLIT3 SLIT3 ENSOCUP00000046526 ENSOCUP00000046526 DPYSL5 DPYSL5 ENSOCUP00000047323 ENSOCUP00000047323 GLI2 GLI2 GFRA3 GFRA3 WNT3A WNT3A ENSOCUP00000049288 ENSOCUP00000049288 ENSOCUP00000049447 ENSOCUP00000049447 NTN5 NTN5 EFNA5 EFNA5 PLXNB3 PLXNB3 SHH SHH PLXNC1 PLXNC1 CCDC141 CCDC141 ARHGAP35 ARHGAP35 B3GNT2 B3GNT2 KIF5B KIF5B EPHA5 EPHA5 RHOG RHOG GATA3 GATA3 FEZF1 FEZF1 G1TH55_RABIT G1TH55_RABIT NTN1 NTN1 FLRT2 FLRT2 KIF5A KIF5A GDF7 GDF7 POU4F3 POU4F3 VSTM2L VSTM2L L1CAM L1CAM PAX6 PAX6 B4GAT1 B4GAT1 ARTN ARTN ISL1 ISL1 LAMA1 LAMA1 RYK RYK PLA2G10-2 PLA2G10-2 LHX9 LHX9 G1TXV5_RABIT G1TXV5_RABIT BMP7 BMP7 NTN3 NTN3 CDK5 CDK5 OR10A4 OR10A4 LRTM2 LRTM2 RHOH RHOH NEXN NEXN LRTM1 LRTM1 ARX ARX NOTCH3 NOTCH3 CRPPA CRPPA FZD3 FZD3 UNC5C UNC5C DPYSL2 DPYSL2 NTF3 NTF3 G1U9C3_RABIT G1U9C3_RABIT G1U9D6_RABIT G1U9D6_RABIT EPHA6 EPHA6 LOC103351908 LOC103351908 SMO SMO EFNB3 EFNB3 RNF165 RNF165 PLXNA4 PLXNA4 UNC5D UNC5D SLIT2 SLIT2 VASP VASP ENSOCUP00000030490 ENSOCUP00000030490 EPHA1 EPHA1 SEMA7A SEMA7A NFIB NFIB WNT3 WNT3 CSF1R CSF1R EPHB4 EPHB4 MYCBP2 MYCBP2 ENSOCUP00000035577 ENSOCUP00000035577 SEMA6A SEMA6A DLX5 DLX5 ECE1 ECE1 ETV1 ETV1 EFNB1 EFNB1 SEMA4A SEMA4A EFNA4 EFNA4 NEO1 NEO1 EMB EMB ENSOCUP00000039661 ENSOCUP00000039661 ENSOCUP00000041442 ENSOCUP00000041442 PLXNA3 PLXNA3 EFNA3 EFNA3 DCC DCC SEMA3C SEMA3C EFNB2 EFNB2 BMPR1B BMPR1B WNT5A WNT5A UNC5A UNC5A KALRN KALRN PLA2G10 PLA2G10 EPHA7 EPHA7 PTPRO PTPRO RPL24 RPL24 EDNRA EDNRA FLRT3 FLRT3 PLXNB1 PLXNB1 ENAH ENAH SEMA3B SEMA3B ROBO1 ROBO1 OTX2 OTX2 ROBO3 ROBO3 SEMA6C SEMA6C SEMA4G SEMA4G PTCH1 PTCH1 GDNF GDNF SEMA4C SEMA4C DAG1 DAG1 PLXNA2 PLXNA2 PLXNA1 PLXNA1 SLIT1 SLIT1 EPHB1 EPHB1 SMAD4 SMAD4 PTPRM PTPRM CHN1 CHN1 NRCAM NRCAM PALLD PALLD ENSOCUP00000046066 ENSOCUP00000046066 ANOS1 ANOS1 ISL2 ISL2 SEMA5A SEMA5A ROBO2 ROBO2 EFNA1 EFNA1 CHL1 CHL1 NRP1 NRP1 SEMA4F SEMA4F LAMB2 LAMB2 LHX4 LHX4 LMX1A LMX1A DRAXIN DRAXIN SEMA5B SEMA5B NCAM1 NCAM1 GLI3 GLI3 USP33 USP33 EPHA4 EPHA4 UNC5B UNC5B EPHB6 EPHB6 NGFR NGFR LGI1 LGI1 LHX2 LHX2 SEMA3G SEMA3G NRP2 NRP2 RELN RELN CNTN1 CNTN1 LAMA2 LAMA2 KIF5C KIF5C KLF7 KLF7 LAMA3 LAMA3 MYPN MYPN NPTN NPTN DSCAML1 DSCAML1 NECTIN1 NECTIN1 EPHA3 EPHA3 ERBB2 ERBB2 APP APP NTRK1 NTRK1 CYFIP1 CYFIP1 BOC BOC CNTN4 CNTN4 ALCAM ALCAM SEMA3F SEMA3F SEMA3A SEMA3A SEMA3D SEMA3D POU4F2 POU4F2 EPHB3 EPHB3 SEMA4D SEMA4D TRIO TRIO GBX2 GBX2 PLXND1 PLXND1 ATOH1 ATOH1 EDN1 EDN1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
VAX1Ventral anterior homeobox 1. (310 aa)
EPHB2EPH receptor B2. (966 aa)
EGR2Early growth response 2. (549 aa)
MYOTMyotilin. (806 aa)
SEMA4BSemaphorin 4B; Belongs to the semaphorin family. (832 aa)
CNTN5Contactin 5. (1099 aa)
EPHA8EPH receptor A8. (973 aa)
EVX1Even-skipped homeobox 1 (Predicted). (410 aa)
EXT1Exostosin glycosyltransferase 1; Belongs to the glycosyltransferase 47 family. (746 aa)
HOXA2Homeobox domain-containing protein. (374 aa)
SCN1BSodium channel subunit beta-1; Regulatory subunit of multiple voltage-gated sodium channel complexes that play important roles in excitable membranes in brain, heart and skeletal muscle. Enhances the presence of the pore-forming alpha subunit at the cell surface and modulates channel gating characteristics and the rate of channel inactivation. Modulates the activity of a variety of pore-forming alpha subunits, such as SCN1A, SCN2A, SCN3A, SCN4A, SCN5A and SCN10A. (213 aa)
NFASCNeurofascin. (1331 aa)
CNTN2Contactin 2. (1040 aa)
TTC8Tetratricopeptide repeat domain 8. (515 aa)
SLIT3Slit guidance ligand 3. (1530 aa)
ENSOCUP00000046526Reelin domain-containing protein. (274 aa)
DPYSL5Dihydropyrimidinase like 5. (662 aa)
ENSOCUP00000047323Fork-head domain-containing protein. (261 aa)
GLI2GLI family zinc finger 2. (1575 aa)
GFRA3GDNF family receptor alpha 3. (378 aa)
WNT3AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (400 aa)
ENSOCUP00000049288annotation not available (67 aa)
ENSOCUP00000049447Uncharacterized protein. (168 aa)
NTN5Netrin 5. (580 aa)
EFNA5Ephrin A5; Belongs to the ephrin family. (228 aa)
PLXNB3Plexin B3. (1844 aa)
SHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (451 aa)
PLXNC1Plexin_cytopl domain-containing protein. (428 aa)
CCDC141Ig-like domain-containing protein. (1529 aa)
ARHGAP35Rho GTPase activating protein 35. (1415 aa)
B3GNT2Hexosyltransferase. (397 aa)
KIF5BKinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (921 aa)
EPHA5Uncharacterized protein. (958 aa)
RHOGRas homolog family member G. (191 aa)
GATA3GATA binding protein 3. (444 aa)
FEZF1FEZ family zinc finger 1. (463 aa)
G1TH55_RABITTRASH domain-containing protein. (157 aa)
NTN1Netrin 1. (533 aa)
FLRT2Fibronectin leucine rich transmembrane protein 2. (660 aa)
KIF5AKinesin family member 5A; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1032 aa)
GDF7Growth differentiation factor 7. (546 aa)
POU4F3POU domain protein. (166 aa)
VSTM2LV-set and transmembrane domain containing 2 like. (314 aa)
L1CAMUncharacterized protein. (1256 aa)
PAX6Uncharacterized protein. (436 aa)
B4GAT1Beta-1,4-glucuronyltransferase 1. (415 aa)
ARTNArtemin. (218 aa)
ISL1ISL LIM homeobox 1. (349 aa)
LAMA1Laminin subunit alpha 1. (3030 aa)
RYKReceptor like tyrosine kinase. (553 aa)
PLA2G10-2Phospholipase A(2). (152 aa)
LHX9LIM homeobox 9. (388 aa)
G1TXV5_RABITEph LBD domain-containing protein. (259 aa)
BMP7TGF_BETA_2 domain-containing protein. (170 aa)
NTN3Netrin 3. (393 aa)
CDK5Cyclin dependent kinase 5; Belongs to the protein kinase superfamily. (292 aa)
OR10A4Olfactory receptor. (315 aa)
LRTM2Leucine rich repeats and transmembrane domains 2. (384 aa)
RHOHRas homolog family member H. (191 aa)
NEXNNexilin F-actin binding protein. (696 aa)
LRTM1Leucine rich repeats and transmembrane domains 1. (386 aa)
ARXAristaless related homeobox. (518 aa)
NOTCH3Notch receptor 3. (2262 aa)
CRPPACDP-L-ribitol pyrophosphorylase A. (440 aa)
FZD3Frizzled class receptor 3; Belongs to the G-protein coupled receptor Fz/Smo family. (603 aa)
UNC5CUnc-5 netrin receptor C. (931 aa)
DPYSL2Dihydropyrimidinase like 2. (572 aa)
NTF3Neurotrophin-3; Seems to promote the survival of visceral and proprioceptive sensory neurons; Belongs to the NGF-beta family. (270 aa)
G1U9C3_RABITFibronectin type-III domain-containing protein. (166 aa)
G1U9D6_RABITUncharacterized protein. (105 aa)
EPHA6EPH receptor A6. (1130 aa)
LOC103351908Homeobox domain-containing protein. (408 aa)
SMOSmoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (787 aa)
EFNB3Ephrin B3; Belongs to the ephrin family. (486 aa)
RNF165Ring finger protein 165. (364 aa)
PLXNA4Plexin A4. (1912 aa)
UNC5DUnc-5 netrin receptor D. (958 aa)
SLIT2Slit guidance ligand 2. (1542 aa)
VASPWH1 domain-containing protein. (147 aa)
ENSOCUP00000030490Eph LBD domain-containing protein. (294 aa)
EPHA1EPH receptor A1. (948 aa)
SEMA7ASema domain-containing protein; Belongs to the semaphorin family. (408 aa)
NFIBNuclear factor 1; Recognizes and binds the palindromic sequence 5'- TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication. (586 aa)
WNT3Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (358 aa)
CSF1RColony stimulating factor 1 receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (973 aa)
EPHB4EPH receptor B4. (1011 aa)
MYCBP2RING-type domain-containing protein. (275 aa)
ENSOCUP00000035577Uncharacterized protein. (517 aa)
SEMA6ASemaphorin 6A; Belongs to the semaphorin family. (1038 aa)
DLX5Distal-less homeobox 5. (313 aa)
ECE1Endothelin converting enzyme 1. (783 aa)
ETV1ETS variant 1. (471 aa)
EFNB1Ephrin B1; Belongs to the ephrin family. (370 aa)
SEMA4ASemaphorin 4A; Belongs to the semaphorin family. (977 aa)
EFNA4Ephrin A4; Belongs to the ephrin family. (204 aa)
NEO1Neogenin 1. (1424 aa)
EMBEmbigin. (365 aa)
ENSOCUP00000039661Protein kinase domain-containing protein. (664 aa)
ENSOCUP00000041442Uncharacterized protein. (128 aa)
PLXNA3Sema domain-containing protein. (1995 aa)
EFNA3Ephrin RBD domain-containing protein; Belongs to the ephrin family. (330 aa)
DCCDCC netrin 1 receptor. (1425 aa)
SEMA3CSemaphorin 3C; Belongs to the semaphorin family. (751 aa)
EFNB2Ephrin B2; Belongs to the ephrin family. (332 aa)
BMPR1BSerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (543 aa)
WNT5AProtein Wnt-5a; Ligand for members of the frizzled family of seven transmembrane receptors. Can activate or inhibit canonical Wnt signaling, depending on receptor context. In the presence of FZD4, activates beta-catenin signaling. In the presence of ROR2, inhibits the canonical Wnt pathway by promoting beta-catenin degradation through a GSK3-independent pathway which involves down-regulation of beta- catenin-induced reporter gene expression (By similarity). Suppression of the canonical pathway allows chondrogenesis to occur. Inhibits tumor formation. Stimulates cell migration. Decrease [...] (380 aa)
UNC5AUnc-5 netrin receptor A. (819 aa)
KALRNKalirin RhoGEF kinase. (2988 aa)
PLA2G10Phospholipase A(2). (163 aa)
EPHA7EPH receptor A7. (998 aa)
PTPROUncharacterized protein. (1215 aa)
RPL24Ribosomal protein L24. (157 aa)
EDNRAEndothelin receptor type A; Belongs to the G-protein coupled receptor 1 family. (427 aa)
FLRT3Fibronectin leucine rich transmembrane protein 3. (649 aa)
PLXNB1Plexin B1. (2118 aa)
ENAHENAH actin regulator. (483 aa)
SEMA3BSemaphorin 3B; Belongs to the semaphorin family. (757 aa)
ROBO1Roundabout guidance receptor 1. (1651 aa)
OTX2Orthodenticle homeobox 2. (289 aa)
ROBO3Roundabout guidance receptor 3. (1397 aa)
SEMA6CSema domain-containing protein; Belongs to the semaphorin family. (948 aa)
SEMA4GSemaphorin 4G; Belongs to the semaphorin family. (843 aa)
PTCH1Patched 1. (1321 aa)
GDNFGlial cell derived neurotrophic factor. (159 aa)
SEMA4CSemaphorin 4C; Belongs to the semaphorin family. (832 aa)
DAG1Alpha-dystroglycan; The dystroglycan complex is involved in a number of processes including laminin and basement membrane assembly, sacrolemmal stability, cell survival, peripheral nerve myelination, nodal structure, cell migration, and epithelial polarization. Beta-dystroglycan is a transmembrane protein that plays important roles in connecting the extracellular matrix to the cytoskeleton. Acts as a cell adhesion receptor in both muscle and non- muscle tissues. Receptor for both DMD and UTRN and, through these interactions, scaffolds axin to the cytoskeleton. Also functions in cell ad [...] (895 aa)
PLXNA2Plexin A2. (1897 aa)
PLXNA1Plexin A1. (1772 aa)
SLIT1Slit guidance ligand 1. (1452 aa)
EPHB1Receptor protein-tyrosine kinase. (984 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
PTPRMProtein tyrosine phosphatase receptor type M. (1549 aa)
CHN1Chimerin 1. (531 aa)
NRCAMNeuronal cell adhesion molecule. (1305 aa)
PALLDPalladin, cytoskeletal associated protein. (1429 aa)
ENSOCUP00000046066EGF-like domain-containing protein. (561 aa)
ANOS1Uncharacterized protein. (342 aa)
ISL2ISL LIM homeobox 2. (440 aa)
SEMA5ASemaphorin 5A. (978 aa)
ROBO2Roundabout guidance receptor 2. (1438 aa)
EFNA1Ephrin A1; Belongs to the ephrin family. (205 aa)
CHL1Cell adhesion molecule L1 like. (1227 aa)
NRP1Neuropilin; Belongs to the neuropilin family. (950 aa)
SEMA4FSsemaphorin 4F; Belongs to the semaphorin family. (721 aa)
LAMB2Laminin subunit beta 2. (1802 aa)
LHX4LIM homeobox 4. (390 aa)
LMX1ALIM homeobox transcription factor 1 alpha. (382 aa)
DRAXINDraxin; Chemorepulsive axon guidance protein required for the development of spinal cord and forebrain commissures. Acts as a chemorepulsive guidance protein for commissural axons during development. Able to inhibit or repel neurite outgrowth from dorsal spinal cord. Inhibits the stabilization of cytosolic beta-catenin (CTNNB1) via its interaction with LRP6, thereby acting as an antagonist of Wnt signaling pathway. (337 aa)
SEMA5BSemaphorin 5B. (1077 aa)
NCAM1Neural cell adhesion molecule 1. (1121 aa)
GLI3GLI family zinc finger 3. (1575 aa)
USP33Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (876 aa)
EPHA4EPH receptor A4. (986 aa)
UNC5BUnc-5 netrin receptor B. (946 aa)
EPHB6EPH receptor B6. (1015 aa)
NGFRNerve growth factor receptor. (407 aa)
LGI1Leucine rich glioma inactivated 1. (557 aa)
LHX2LIM homeobox 2. (414 aa)
SEMA3GSemaphorin 3G; Belongs to the semaphorin family. (777 aa)
NRP2Neuropilin; Belongs to the neuropilin family. (931 aa)
RELNUncharacterized protein. (1813 aa)
CNTN1Contactin 1. (1018 aa)
LAMA2Laminin subunit alpha 2. (3126 aa)
KIF5CKinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (946 aa)
KLF7Kruppel like factor 7. (302 aa)
LAMA3Laminin subunit alpha 3. (3340 aa)
MYPNMyopalladin. (1381 aa)
NPTNNeuroplastin. (367 aa)
DSCAML1DS cell adhesion molecule like 1. (2112 aa)
NECTIN1Nectin cell adhesion molecule 1. (514 aa)
EPHA3EPH receptor A3. (984 aa)
ERBB2Receptor protein-tyrosine kinase. (1255 aa)
APPGamma-secretase C-terminal fragment 57; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those medi [...] (769 aa)
NTRK1Tyrosine-protein kinase receptor. (823 aa)
CYFIP1Cytoplasmic FMR1-interacting protein; Belongs to the CYFIP family. (1272 aa)
BOCBOC cell adhesion associated, oncogene regulated. (1111 aa)
CNTN4Contactin 4. (1026 aa)
ALCAMCD166 antigen; Cell adhesion molecule that mediates both heterotypic cell- cell contacts via its interaction with CD6, as well as homotypic cell- cell contacts. Promotes T-cell activation and proliferation via its interactions with CD6 (By similarity). Contributes to the formation and maturation of the immunological synapse via its interactions with CD6 (By similarity). Mediates homotypic interactions with cells that express ALCAM. Mediates attachment of dendritic cells onto endothelial cells via homotypic interaction. Inhibits endothelial cell migration and promotes endothelial tube f [...] (583 aa)
SEMA3FSemaphorin 3F; Belongs to the semaphorin family. (784 aa)
SEMA3ASemaphorin 3A; Belongs to the semaphorin family. (770 aa)
SEMA3DSemaphorin 3D; Belongs to the semaphorin family. (777 aa)
POU4F2POU domain protein. (392 aa)
EPHB3EPH receptor B3. (1075 aa)
SEMA4DSemaphorin 4D; Belongs to the semaphorin family. (864 aa)
TRIOTrio Rho guanine nucleotide exchange factor. (3040 aa)
GBX2Gastrulation brain homeobox 2. (344 aa)
PLXND1Plexin D1. (1886 aa)
ATOH1Atonal bHLH transcription factor 1. (359 aa)
EDN1Big endothelin-1; Endothelins are endothelium-derived vasoconstrictor peptides (By similarity). Probable ligand for G-protein coupled receptors EDNRA and EDNRB which activates PTK2B, BCAR1, BCAR3 and, GTPases RAP1 and RHOA cascade in glomerular mesangial cells (By similarity). Belongs to the endothelin/sarafotoxin family. (202 aa)
Your Current Organism:
Oryctolagus cuniculus
NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits
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