STRINGSTRING
PELO PELO ITGA4 ITGA4 RTF1 RTF1 COL8A1 COL8A1 G1U373_RABIT G1U373_RABIT VTN VTN PINX1 PINX1 MMP9 MMP9 SMAD3 SMAD3 LOC103345451 LOC103345451 PAF1 PAF1 COL11A1 COL11A1 CTNNB1 CTNNB1 APELA APELA ENSOCUP00000034777 ENSOCUP00000034777 ENSOCUP00000037329 ENSOCUP00000037329 ENSOCUP00000037873 ENSOCUP00000037873 HDAC1 HDAC1 ITGAV ITGAV LEO1 LEO1 ENSOCUP00000041840 ENSOCUP00000041840 GRB2 GRB2 ENSOCUP00000044284 ENSOCUP00000044284 ENSOCUP00000045925 ENSOCUP00000045925 KIF16B KIF16B MED12 MED12 NR0B1 NR0B1 DUSP2 DUSP2 EOMES EOMES INHBA INHBA MMP8 MMP8 HSBP1 HSBP1 DUSP5 DUSP5 GATA4 GATA4 SETD2 SETD2 DUSP4 DUSP4 SMAD4 SMAD4 LAMB3 LAMB3 WNT8A WNT8A DUSP1 DUSP1 EPB41L5 EPB41L5 G1SV95_RABIT G1SV95_RABIT NODAL NODAL LAMA3 LAMA3 BMP4 BMP4 SMAD2 SMAD2 DKK1 DKK1 SOX17 SOX17 COL4A2 COL4A2 CTR9 CTR9 ITGA5 ITGA5 GDF3 GDF3 PAX9 PAX9 ITGB5 ITGB5 LAMB1 LAMB1 EXT1 EXT1 COL12A1 COL12A1 BPTF BPTF CDC73 CDC73 BMPR1A BMPR1A LDB1 LDB1 MIXL1 MIXL1 MMP15 MMP15
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PELOProtein pelota homolog; May function in recognizing stalled ribosomes and triggering endonucleolytic cleavage of the mRNA, a mechanism to release non- functional ribosomes and degrade damaged mRNAs. (385 aa)
ITGA4Integrin subunit alpha 4; Belongs to the integrin alpha chain family. (1031 aa)
RTF1RTF1 homolog, Paf1/RNA polymerase II complex component. (710 aa)
COL8A1Collagen alpha-1(VIII) chain; Macromolecular component of the subendothelium. Major component of the Descemet's membrane (basement membrane) of corneal endothelial cells. Also component of the endothelia of blood vessels. Necessary for migration and proliferation of vascular smooth muscle cells and thus, has a potential role in the maintenance of vessel wall integrity and structure, in particular in atherogenesis (By similarity). (744 aa)
G1U373_RABITSRCR domain-containing protein; Belongs to the heparin-binding growth factors family. (200 aa)
VTNVitronectin; Vitronectin is a cell adhesion and spreading factor found in serum and tissues. Vitronectin interact with glycosaminoglycans and proteoglycans. Is recognized by certain members of the integrin family and serves as a cell-to-substrate adhesion molecule. Inhibitor of the membrane-damaging effect of the terminal cytolytic complement pathway. (475 aa)
PINX1PIN2 (TERF1) interacting telomerase inhibitor 1. (364 aa)
MMP9Matrix metalloproteinase-9; Could play a role in bone osteoclastic resorption. Cleaves type IV and type V collagen into large C-terminal three quarter fragments and shorter N-terminal one quarter fragments (By similarity). (707 aa)
SMAD3SMAD family member 3. (230 aa)
LOC103345451TGFb_propeptide domain-containing protein. (203 aa)
PAF1PAF1 homolog, Paf1/RNA polymerase II complex component. (780 aa)
COL11A1Collagen type XI alpha 1 chain. (1857 aa)
CTNNB1Catenin beta 1. (741 aa)
APELAUncharacterized protein. (54 aa)
ENSOCUP00000034777Uncharacterized protein. (55 aa)
ENSOCUP00000037329TGFb_propeptide domain-containing protein. (263 aa)
ENSOCUP00000037873Uncharacterized protein. (411 aa)
HDAC1Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (550 aa)
ITGAVIntegrin subunit alpha V; Belongs to the integrin alpha chain family. (1047 aa)
LEO1LEO1 homolog, Paf1/RNA polymerase II complex component. (701 aa)
ENSOCUP00000041840TGFb_propeptide domain-containing protein. (219 aa)
GRB2Growth factor receptor bound protein 2. (278 aa)
ENSOCUP00000044284TGFb_propeptide domain-containing protein. (260 aa)
ENSOCUP00000045925TGFb_propeptide domain-containing protein. (272 aa)
KIF16BKinesin motor domain-containing protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1860 aa)
MED12Mediator complex subunit 12. (2142 aa)
NR0B1Nuclear receptor subfamily 0 group B member 1. (471 aa)
DUSP2Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (314 aa)
EOMESEomesodermin. (410 aa)
INHBAInhibin subunit beta A. (424 aa)
MMP8Matrix metallopeptidase 8. (355 aa)
HSBP1Heat shock factor binding protein 1. (76 aa)
DUSP5Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (394 aa)
GATA4GATA binding protein 4. (444 aa)
SETD2Uncharacterized protein. (625 aa)
DUSP4Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (386 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
LAMB3Laminin subunit beta 3. (1157 aa)
WNT8AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (352 aa)
DUSP1Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (367 aa)
EPB41L5Erythrocyte membrane protein band 4.1 like 5. (731 aa)
G1SV95_RABITTransforming growth factor beta; Belongs to the TGF-beta family. (387 aa)
NODALNodal growth differentiation factor. (348 aa)
LAMA3Laminin subunit alpha 3. (3340 aa)
BMP4Bone morphogenetic protein 4; Induces cartilage and bone formation. Acts in concert with PTHLH/PTHRP to stimulate ductal outgrowth during embryonic mammary development and to inhibit hair follicle induction (By similarity). (409 aa)
SMAD2Mothers against decapentaplegic homolog. (467 aa)
DKK1Dickkopf-like protein 1. (268 aa)
SOX17HMG box domain-containing protein. (165 aa)
COL4A2Collagen type IV alpha 2 chain. (1564 aa)
CTR9CTR9 homolog, Paf1/RNA polymerase II complex component. (1173 aa)
ITGA5Integrin subunit alpha 5; Belongs to the integrin alpha chain family. (1105 aa)
GDF3Growth differentiation factor 3. (365 aa)
PAX9Paired box 9. (332 aa)
ITGB5Integrin beta; Belongs to the integrin beta chain family. (799 aa)
LAMB1Laminin subunit beta 1. (1736 aa)
EXT1Exostosin glycosyltransferase 1; Belongs to the glycosyltransferase 47 family. (746 aa)
COL12A1Collagen alpha-1(XII) chain; Type XII collagen interacts with type I collagen-containing fibrils, the COL1 domain could be associated with the surface of the fibrils, and the COL2 and NC3 domains may be localized in the perifibrillar matrix; Belongs to the fibril-associated collagens with interrupted helices (FACIT) family. (3112 aa)
BPTFBromodomain PHD finger transcription factor. (2934 aa)
CDC73Cell division cycle 73. (728 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
LDB1LIM domain binding 1. (410 aa)
MIXL1Mix paired-like homeobox. (234 aa)
MMP15U6 snRNA phosphodiesterase; Phosphodiesterase responsible for the U6 snRNA 3' end processing. Acts as an exoribonuclease (RNase) responsible for trimming the poly(U) tract of the last nucleotides in the pre-U6 snRNA molecule, leading to the formation of mature U6 snRNA 3' end-terminated with a 2',3'-cyclic phosphate; Belongs to the peptidase M10A family. (822 aa)
Your Current Organism:
Oryctolagus cuniculus
NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits
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