STRINGSTRING
INHBA INHBA MSGN1 MSGN1 WNT5A WNT5A EOMES EOMES TBXT TBXT FOXF1 FOXF1 WNT11 WNT11 ACVR1 ACVR1 SETD2 SETD2 SRF SRF ITGB1 ITGB1 SMAD4 SMAD4 NF2 NF2 OSR1 OSR1 TAF10 TAF10 POU4F1 POU4F1 G1SSI3_RABIT G1SSI3_RABIT NUP133 NUP133 DLL3 DLL3 LHX2 LHX2 EPB41L5 EPB41L5 PALB2 PALB2 NODAL NODAL TEAD2 TEAD2 EYA1 EYA1 POGLUT1 POGLUT1 ITGA3 ITGA3 BMP4 BMP4 HAND1 HAND1 SMAD2 SMAD2 DKK1 DKK1 PAX2 PAX2 GDF3 GDF3 TBX1 TBX1 TBX19 TBX19 TBX3 TBX3 POFUT2 POFUT2 EXT1 EXT1 TLX2 TLX2 ACVR2A ACVR2A SFRP2 SFRP2 SHH SHH BMPR1A BMPR1A TWSG1 TWSG1 ZIC3 ZIC3 EPHA2 EPHA2 SNAI1 SNAI1 TCF15 TCF15 LDB1 LDB1 G1TQE3_RABIT G1TQE3_RABIT ETS2 ETS2 SIX2 SIX2 BMP7 BMP7 LOC100352574 LOC100352574 CTDNEP1 CTDNEP1 G1U373_RABIT G1U373_RABIT G1U3J0_RABIT G1U3J0_RABIT RPL38 RPL38 OVOL1 OVOL1 SMO SMO SMAD3 SMAD3 TBX6 TBX6 ITGA2 ITGA2 ITGB4 ITGB4 ITGB3 ITGB3 APELA APELA EXT2 EXT2 WNT3 WNT3 FGFR2 FGFR2 SMAD1 SMAD1 KDM6A KDM6A WLS WLS ENSOCUP00000036340 ENSOCUP00000036340 ENSOCUP00000036387 ENSOCUP00000036387 BMPR2 BMPR2 KDM6B KDM6B ENSOCUP00000037873 ENSOCUP00000037873 ENSOCUP00000037976 ENSOCUP00000037976 ENSOCUP00000040784 ENSOCUP00000040784 ITGA8 ITGA8 CITED2 CITED2 LOC100352102 LOC100352102 TP63 TP63 WNT3A WNT3A LEF1 LEF1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
INHBAInhibin subunit beta A. (424 aa)
MSGN1Mesogenin 1. (193 aa)
WNT5AProtein Wnt-5a; Ligand for members of the frizzled family of seven transmembrane receptors. Can activate or inhibit canonical Wnt signaling, depending on receptor context. In the presence of FZD4, activates beta-catenin signaling. In the presence of ROR2, inhibits the canonical Wnt pathway by promoting beta-catenin degradation through a GSK3-independent pathway which involves down-regulation of beta- catenin-induced reporter gene expression (By similarity). Suppression of the canonical pathway allows chondrogenesis to occur. Inhibits tumor formation. Stimulates cell migration. Decrease [...] (380 aa)
EOMESEomesodermin. (410 aa)
TBXTT-box transcription factor T. (365 aa)
FOXF1Forkhead box F1. (433 aa)
WNT11Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
ACVR1Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (509 aa)
SETD2Uncharacterized protein. (625 aa)
SRFSerum response factor. (685 aa)
ITGB1Integrin beta; Belongs to the integrin beta chain family. (830 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
NF2Neurofibromin 2. (626 aa)
OSR1Odd-skipped related transcription factor 1. (266 aa)
TAF10Transcription initiation factor TFIID subunit 10; TFIID is a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors; Belongs to the TAF10 family. (218 aa)
POU4F1POU domain protein. (339 aa)
G1SSI3_RABITCTCK domain-containing protein. (291 aa)
NUP133Nucleoporin 133. (1175 aa)
DLL3Delta like canonical Notch ligand 3. (605 aa)
LHX2LIM homeobox 2. (414 aa)
EPB41L5Erythrocyte membrane protein band 4.1 like 5. (731 aa)
PALB2Partner and localizer of BRCA2. (1182 aa)
NODALNodal growth differentiation factor. (348 aa)
TEAD2TEA domain transcription factor 2. (405 aa)
EYA1Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (622 aa)
POGLUT1Protein O-glucosyltransferase 1. (462 aa)
ITGA3Integrin subunit alpha 3; Belongs to the integrin alpha chain family. (1072 aa)
BMP4Bone morphogenetic protein 4; Induces cartilage and bone formation. Acts in concert with PTHLH/PTHRP to stimulate ductal outgrowth during embryonic mammary development and to inhibit hair follicle induction (By similarity). (409 aa)
HAND1Heart- and neural crest derivatives-expressed protein 1; Transcription factor that plays an essential role in both trophoblast giant cell differentiation and in cardiac morphogenesis (By similarity). Binds the DNA sequence 5'-NRTCTG-3' (non-canonical E-box) (By similarity). Acts as a transcriptional repressor of SOX15 (By similarity). In the adult, could be required for ongoing expression of cardiac-specific genes (By similarity). (215 aa)
SMAD2Mothers against decapentaplegic homolog. (467 aa)
DKK1Dickkopf-like protein 1. (268 aa)
PAX2Paired box 2. (448 aa)
GDF3Growth differentiation factor 3. (365 aa)
TBX1Uncharacterized protein. (440 aa)
TBX19T-box transcription factor 19. (448 aa)
TBX3Uncharacterized protein. (242 aa)
POFUT2Uncharacterized protein. (156 aa)
EXT1Exostosin glycosyltransferase 1; Belongs to the glycosyltransferase 47 family. (746 aa)
TLX2T cell leukemia homeobox 2. (284 aa)
ACVR2ASerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (556 aa)
SFRP2Secreted frizzled related protein 2. (295 aa)
SHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (451 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
TWSG1Twisted gastrulation BMP signaling modulator 1. (202 aa)
ZIC3Zic family member 3. (467 aa)
EPHA2EPH receptor A2. (1031 aa)
SNAI1Snail family transcriptional repressor 1. (238 aa)
TCF15Transcription factor 15. (199 aa)
LDB1LIM domain binding 1. (410 aa)
G1TQE3_RABITFork-head domain-containing protein. (520 aa)
ETS2ETS proto-oncogene 2, transcription factor; Transcription factor; Belongs to the ETS family. (468 aa)
SIX2SIX homeobox 2. (295 aa)
BMP7TGF_BETA_2 domain-containing protein. (170 aa)
LOC100352574Uncharacterized protein; Belongs to the eukaryotic ribosomal protein eL38 family. (70 aa)
CTDNEP1CTD nuclear envelope phosphatase 1. (256 aa)
G1U373_RABITSRCR domain-containing protein; Belongs to the heparin-binding growth factors family. (200 aa)
G1U3J0_RABITUncharacterized protein; Belongs to the eukaryotic ribosomal protein eL38 family. (70 aa)
RPL38Uncharacterized protein; Belongs to the eukaryotic ribosomal protein eL38 family. (130 aa)
OVOL1Ovo like transcriptional repressor 1. (251 aa)
SMOSmoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (787 aa)
SMAD3SMAD family member 3. (230 aa)
TBX6T-box transcription factor 6. (488 aa)
ITGA2Integrin subunit alpha 2; Belongs to the integrin alpha chain family. (1202 aa)
ITGB4Integrin beta. (1708 aa)
ITGB3Integrin beta; Belongs to the integrin beta chain family. (873 aa)
APELAUncharacterized protein. (54 aa)
EXT2Exostosin glycosyltransferase 2. (1147 aa)
WNT3Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (358 aa)
FGFR2Fibroblast growth factor receptor. (894 aa)
SMAD1Mothers against decapentaplegic homolog. (465 aa)
KDM6ALysine demethylase 6A. (1401 aa)
WLSWnt ligand secretion mediator. (543 aa)
ENSOCUP00000036340EGF-like domain-containing protein. (81 aa)
ENSOCUP00000036387DIX domain-containing protein. (575 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1060 aa)
KDM6BLysine demethylase 6B. (1733 aa)
ENSOCUP00000037873Uncharacterized protein. (411 aa)
ENSOCUP00000037976Uncharacterized protein; Belongs to the eukaryotic ribosomal protein eL38 family. (70 aa)
ENSOCUP00000040784Uncharacterized protein. (227 aa)
ITGA8Integrin subunit alpha 8; Belongs to the integrin alpha chain family. (1100 aa)
CITED2Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 2. (249 aa)
LOC100352102Uncharacterized protein. (256 aa)
TP63Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. (680 aa)
WNT3AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (400 aa)
LEF1Lymphoid enhancer binding factor 1. (414 aa)
Your Current Organism:
Oryctolagus cuniculus
NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits
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