STRINGSTRING
PAPPA PAPPA PAM PAM SLC19A1 SLC19A1 CALCA CALCA ADCY7 ADCY7 TMED2 TMED2 LIF LIF VMP1 VMP1 LOC100356754 LOC100356754 GIP GIP ESR1 ESR1 STAT5B STAT5B SLC38A1 SLC38A1 EPO EPO STC1 STC1 POLR1B POLR1B PLA2G6 PLA2G6 G1SSD9_RABIT G1SSD9_RABIT CSMD2 CSMD2 NPPA NPPA GHSR GHSR ENDOU ENDOU G1SV95_RABIT G1SV95_RABIT TCF23 TCF23 NODAL NODAL CORIN CORIN ADM ADM ITGA3 ITGA3 GJB2 GJB2 FBLN1 FBLN1 TGFB3 TGFB3 A1CF A1CF AGRP AGRP UCP2 UCP2 ITGA5 ITGA5 LOC100357927 LOC100357927 ATP7A ATP7A ABCC8 ABCC8 PGR PGR H3F3B H3F3B ASH1L ASH1L ANGPT2 ANGPT2 EPOR EPOR HPGD HPGD TRIM28 TRIM28 PTGS2 PTGS2 UCN UCN ACE2 ACE2 ENSOCUP00000015809 ENSOCUP00000015809 VDR VDR RARA RARA SOD1 SOD1 H3-3A H3-3A RTL8C RTL8C PGF PGF WNT4 WNT4 NDP NDP MED1 MED1 FOS FOS IGFBP5 IGFBP5 STAT5A STAT5A G1U4T2_RABIT G1U4T2_RABIT MMP9 MMP9 IHH IHH PRDM14 PRDM14 PCSK5 PCSK5 LDOC1 LDOC1 PRDM1 PRDM1 PRDX3 PRDX3 MST1 MST1 ENSOCUP00000028121 ENSOCUP00000028121 PPARD PPARD STOX2 STOX2 PTN PTN ENSOCUP00000029342 ENSOCUP00000029342 ITGA2 ITGA2 TPPP3 TPPP3 GHRL GHRL SLC38A3 SLC38A3 SLC38A2 SLC38A2 EMP2 EMP2 TGFBR2 TGFBR2 ENSOCUP00000030661 ENSOCUP00000030661 ITGB4 ITGB4 CRHBP CRHBP LOC103345451 LOC103345451 CTSB CTSB ITGB3 ITGB3 RGS2 RGS2 IGFBP2 IGFBP2 ACSL4 ACSL4 BMPR2 BMPR2 RECK RECK ENSOCUP00000037329 ENSOCUP00000037329 ENSOCUP00000039579 ENSOCUP00000039579 HMX3 HMX3 FOSL1 FOSL1 ENSOCUP00000041840 ENSOCUP00000041840 ENSOCUP00000042027 ENSOCUP00000042027 FOSB FOSB ENSOCUP00000043938 ENSOCUP00000043938 ENSOCUP00000044284 ENSOCUP00000044284 ACOD1 ACOD1 ENSOCUP00000045925 ENSOCUP00000045925 CRH CRH CITED2 CITED2 SP3 SP3 DDR1 DDR1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PAPPAPappalysin 1. (1498 aa)
PAMPeptidylglycine alpha-amidating monooxygenase. (975 aa)
SLC19A1Solute carrier family 19 member 1. (557 aa)
CALCACalcitonin related polypeptide alpha. (140 aa)
ADCY7Adenylate cyclase type 7; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1080 aa)
TMED2GOLD domain-containing protein. (116 aa)
LIFLIF interleukin 6 family cytokine. (203 aa)
VMP1Vacuole membrane protein 1. (406 aa)
LOC100356754Sulfatase domain-containing protein. (630 aa)
GIPGastric inhibitory polypeptide. (153 aa)
ESR1Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. (598 aa)
STAT5BSignal transducer and activator of transcription. (786 aa)
SLC38A1Solute carrier family 38 member 1. (458 aa)
EPOErythropoietin; Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Binds to EPOR leading to EPOR dimerization and JAK2 activation thereby activating specific downstream effectors, including STAT1 and STAT3. Belongs to the EPO/TPO family. (195 aa)
STC1Stanniocalcin 1. (247 aa)
POLR1BDNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1135 aa)
PLA2G6Uncharacterized protein. (485 aa)
G1SSD9_RABITRGS domain-containing protein. (183 aa)
CSMD2CUB and Sushi multiple domains 2. (3633 aa)
NPPAAtrial natriuretic factor; Hormone playing a key role in cardiovascular homeostasis through regulation of natriuresis, diuresis, and vasodilation. Also plays a role in female pregnancy by promoting trophoblast invasion and spiral artery remodeling in uterus. Specifically binds and stimulates the cGMP production of the NPR1 receptor. Binds the clearance receptor NPR3 (By similarity); Belongs to the natriuretic peptide family. (153 aa)
GHSRGrowth hormone secretagogue receptor type 1; Receptor for ghrelin, coupled to G-alpha-11 proteins. Stimulates growth hormone secretion. Binds also other growth hormone releasing peptides (GHRP) (e.g. Met-enkephalin and GHRP-6) as well as non-peptide, low molecular weight secretagogues (e.g. L-692,429, MK- 0677, adenosine) (By similarity). (366 aa)
ENDOUEndonuclease, poly(U) specific. (369 aa)
G1SV95_RABITTransforming growth factor beta; Belongs to the TGF-beta family. (387 aa)
TCF23BHLH domain-containing protein. (377 aa)
NODALNodal growth differentiation factor. (348 aa)
CORINCorin, serine peptidase. (1109 aa)
ADMAdrenomedullin. (187 aa)
ITGA3Integrin subunit alpha 3; Belongs to the integrin alpha chain family. (1072 aa)
GJB2Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. (226 aa)
FBLN1Fibulin 1. (457 aa)
TGFB3Transforming growth factor beta 3. (458 aa)
A1CFAPOBEC1 complementation factor. (596 aa)
AGRPAgouti related neuropeptide. (132 aa)
UCP2Uncoupling protein 2; Belongs to the mitochondrial carrier (TC 2.A.29) family. (309 aa)
ITGA5Integrin subunit alpha 5; Belongs to the integrin alpha chain family. (1105 aa)
LOC100357927Histone domain-containing protein. (136 aa)
ATP7AATPase copper transporting alpha. (1499 aa)
ABCC8Uncharacterized protein. (1086 aa)
PGRProgesterone receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcriptional activator of several progesteron-dependent promoters in a variety of cell types. Involved in activation of SRC-dependent MAPK signaling on hormone stimulation; Belongs to the nuclear hormone receptor family. NR3 subfamily. (930 aa)
H3F3BHistone H3; Belongs to the histone H3 family. (136 aa)
ASH1LASH1 like histone lysine methyltransferase. (2966 aa)
ANGPT2Angiopoietin 2. (496 aa)
EPORErythropoietin receptor. (554 aa)
HPGD15-hydroxyprostaglandin dehydrogenase; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (262 aa)
TRIM28Tripartite motif containing 28. (857 aa)
PTGS2Prostaglandin G/H synthase 2; Converts arachidonate to prostaglandin H2 (PGH2), a committed step in prostanoid synthesis. Constitutively expressed in some tissues in physiological conditions, such as the endothelium, kidney and brain, and in pathological conditions, such as in cancer. PTGS2 is responsible for production of inflammatory prostaglandins. Up-regulation of PTGS2 is also associated with increased cell adhesion, phenotypic changes, resistance to apoptosis and tumor angiogenesis. In cancer cells, PTGS2 is a key step in the production of prostaglandin E2 (PGE2), which plays imp [...] (604 aa)
UCNUrocortin. (128 aa)
ACE2Angiotensin-converting enzyme. (805 aa)
ENSOCUP00000015809Histone H3.3. (144 aa)
VDRVitamin D receptor. (368 aa)
RARARetinoic acid receptor alpha. (462 aa)
SOD1Superoxide dismutase [Cu-Zn]; Destroys radicals which are normally produced within the cells and which are toxic to biological systems; Belongs to the Cu-Zn superoxide dismutase family. (153 aa)
H3-3AHistone H3.3; Variant histone H3 which replaces conventional H3 in a wide range of nucleosomes in active genes. Constitutes the predominant form of histone H3 in non-dividing cells and is incorporated into chromatin independently of DNA synthesis. Deposited at sites of nucleosomal displacement throughout transcribed genes, suggesting that it represents an epigenetic imprint of transcriptionally active chromatin. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in [...] (136 aa)
RTL8CRetrotransposon Gag like 8C. (130 aa)
PGFPlacental growth factor; Belongs to the PDGF/VEGF growth factor family. (170 aa)
WNT4Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (487 aa)
NDPNorrin cystine knot growth factor NDP. (133 aa)
MED1Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1580 aa)
FOSFos proto-oncogene, AP-1 transcription factor subunit. (380 aa)
IGFBP5Insulin like growth factor binding protein 5. (271 aa)
STAT5ASignal transducer and activator of transcription. (793 aa)
G1U4T2_RABITSulfatase domain-containing protein. (576 aa)
MMP9Matrix metalloproteinase-9; Could play a role in bone osteoclastic resorption. Cleaves type IV and type V collagen into large C-terminal three quarter fragments and shorter N-terminal one quarter fragments (By similarity). (707 aa)
IHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (410 aa)
PRDM14PR/SET domain 14. (568 aa)
PCSK5Proprotein convertase subtilisin/kexin type 5; Belongs to the peptidase S8 family. (1859 aa)
LDOC1DUF4939 domain-containing protein. (165 aa)
PRDM1PR/SET domain 1. (889 aa)
PRDX3Thioredoxin domain-containing protein. (307 aa)
MST1Macrophage stimulating 1; Belongs to the peptidase S1 family. (773 aa)
ENSOCUP00000028121GOLD domain-containing protein. (178 aa)
PPARDUncharacterized protein. (420 aa)
STOX2Storkhead box 2. (926 aa)
PTNPleiotrophin. (242 aa)
ENSOCUP00000029342Histone domain-containing protein. (82 aa)
ITGA2Integrin subunit alpha 2; Belongs to the integrin alpha chain family. (1202 aa)
TPPP3Uncharacterized protein. (63 aa)
GHRLUncharacterized protein. (234 aa)
SLC38A3Solute carrier family 38 member 3. (521 aa)
SLC38A2Solute carrier family 38 member 2. (563 aa)
EMP2Epithelial membrane protein 2; Functions as a key regulator of cell membrane composition by regulating proteins surface expression. Also, plays a role in regulation of processes including cell migration, cell proliferation, cell contraction and cell adhesion; Belongs to the PMP-22/EMP/MP20 family. (259 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (592 aa)
ENSOCUP00000030661Thioredoxin domain-containing protein. (183 aa)
ITGB4Integrin beta. (1708 aa)
CRHBPCorticotropin releasing hormone binding protein. (382 aa)
LOC103345451TGFb_propeptide domain-containing protein. (203 aa)
CTSBCathepsin B; Belongs to the peptidase C1 family. (456 aa)
ITGB3Integrin beta; Belongs to the integrin beta chain family. (873 aa)
RGS2RGS domain-containing protein. (229 aa)
IGFBP2IGFBP N-terminal domain-containing protein. (442 aa)
ACSL4Acyl-CoA synthetase long chain family member 4. (711 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1060 aa)
RECKUncharacterized protein. (993 aa)
ENSOCUP00000037329TGFb_propeptide domain-containing protein. (263 aa)
ENSOCUP00000039579DUF4939 domain-containing protein. (139 aa)
HMX3H6 family homeobox 3. (340 aa)
FOSL1FOS like 1, AP-1 transcription factor subunit. (335 aa)
ENSOCUP00000041840TGFb_propeptide domain-containing protein. (219 aa)
ENSOCUP00000042027Histone domain-containing protein. (116 aa)
FOSBFosB proto-oncogene, AP-1 transcription factor subunit. (289 aa)
ENSOCUP00000043938Uncharacterized protein. (50 aa)
ENSOCUP00000044284TGFb_propeptide domain-containing protein. (260 aa)
ACOD1Aconitate decarboxylase 1. (499 aa)
ENSOCUP00000045925TGFb_propeptide domain-containing protein. (272 aa)
CRHCRF domain-containing protein. (194 aa)
CITED2Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 2. (249 aa)
SP3Sp3 transcription factor. (715 aa)
DDR1Discoidin domain receptor tyrosine kinase 1. (1040 aa)
Your Current Organism:
Oryctolagus cuniculus
NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits
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