STRINGSTRING
SERPING1 SERPING1 SERPINF1 SERPINF1 INHBA INHBA SLC1A2 SLC1A2 EDNRA EDNRA POLB POLB GNA12 GNA12 PDGFRB PDGFRB SLC12A2 SLC12A2 CASP2 CASP2 CALCA CALCA SCAP SCAP SMAD4 SMAD4 ALPL ALPL INHBB INHBB HYAL2 HYAL2 AVPR1B AVPR1B GNA13 GNA13 KMO KMO NR5A1 NR5A1 G1SV95_RABIT G1SV95_RABIT TYMS TYMS KRT25 KRT25 NUDT1 NUDT1 ENSOCUP00000007981 ENSOCUP00000007981 FBXO4 FBXO4 HELT HELT ADM ADM GJB2 GJB2 CD68 CD68 NTRK1 NTRK1 TGFB3 TGFB3 CLDN1 CLDN1 APAF1 APAF1 PAX5 PAX5 CDKN2B CDKN2B UCP2 UCP2 WRN WRN IGFBP1 IGFBP1 PAX2 PAX2 KRT16 KRT16 COL4A2 COL4A2 EDN1 EDN1 GCLM GCLM TNFRSF1B TNFRSF1B IGF1R IGF1R DDC DDC KRT28 KRT28 DMD DMD HTRA2 HTRA2 OGG1 OGG1 PITX3 PITX3 TFRC TFRC APOD APOD SOD1 SOD1 GJB6 GJB6 AVPR1A AVPR1A G1TQ93_RABIT G1TQ93_RABIT G1TQX9_RABIT G1TQX9_RABIT KL KL FOS FOS SEC63 SEC63 GSK3A GSK3A G1U2E4_RABIT G1U2E4_RABIT CARM1 CARM1 IGFBP5 IGFBP5 DNMT3A DNMT3A ALOX12 ALOX12 ERCC1 ERCC1 CANX CANX C1QA C1QA BAK1 BAK1 SLC32A1 SLC32A1 NFE2L2 NFE2L2 ASS1 ASS1 RNF165 RNF165 UCP3 UCP3 ADRA1A ADRA1A ELAVL4 ELAVL4 MBD3L1 MBD3L1 ERCC2 ERCC2 SRR SRR CIITA CIITA IRAK1 IRAK1 TGFBR2 TGFBR2 DNMBP DNMBP ENSOCUP00000030584 ENSOCUP00000030584 RPN2 RPN2 LOC103345451 LOC103345451 SIN3A SIN3A IGFBP2 IGFBP2 NPY5R NPY5R CTC1 CTC1 LOC108175406 LOC108175406 LOC100352221 LOC100352221 GFRA1 GFRA1 ENSOCUP00000037329 ENSOCUP00000037329 FOXO4 FOXO4 MBD2 MBD2 ENSOCUP00000041840 ENSOCUP00000041840 ENSOCUP00000042867 ENSOCUP00000042867 ENSOCUP00000042987 ENSOCUP00000042987 AMFR AMFR MPO MPO ENSOCUP00000043709 ENSOCUP00000043709 TSPO TSPO ENSOCUP00000044284 ENSOCUP00000044284 GCLC GCLC PPP3CA PPP3CA ENSOCUP00000045925 ENSOCUP00000045925 ABAT ABAT CASP9 CASP9 ENSOCUP00000047323 ENSOCUP00000047323 TP63 TP63
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SERPING1Plasma protease C1 inhibitor; Belongs to the serpin family. (521 aa)
SERPINF1Serpin family F member 1; Belongs to the serpin family. (418 aa)
INHBAInhibin subunit beta A. (424 aa)
SLC1A2Amino acid transporter. (579 aa)
EDNRAEndothelin receptor type A; Belongs to the G-protein coupled receptor 1 family. (427 aa)
POLBDNA polymerase; DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template- independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity. (406 aa)
GNA12G protein subunit alpha 12. (457 aa)
PDGFRBPlatelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. (1147 aa)
SLC12A2Solute carrier family 12 member 2. (1127 aa)
CASP2Caspase 2; Belongs to the peptidase C14A family. (451 aa)
CALCACalcitonin related polypeptide alpha. (140 aa)
SCAPSREBF chaperone. (1279 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
ALPLAlkaline phosphatase. (558 aa)
INHBBInhibin subunit beta B. (302 aa)
HYAL2Hyaluronidase. (475 aa)
AVPR1BVasopressin V1b receptor; Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate a phosphatidyl- inositol-calcium second messenger system. Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily. (417 aa)
GNA13G protein subunit alpha 13. (377 aa)
KMOKynurenine 3-monooxygenase; Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid, a neurotoxic NMDA receptor antagonist and potential endogenous inhibitor of NMDA receptor signaling in axonal targeting, synaptogenesis and apoptosis during brain development. Quinolinic acid may also affect NMDA receptor signaling in pancreatic beta cells, osteoblasts, myocardial cells, and the gastrointestinal tract. (485 aa)
NR5A1Nuclear receptor subfamily 5 group A member 1. (461 aa)
G1SV95_RABITTransforming growth factor beta; Belongs to the TGF-beta family. (387 aa)
TYMSThymidylate synthetase. (310 aa)
KRT25Keratin 25; Belongs to the intermediate filament family. (450 aa)
NUDT1Nudix hydrolase 1; Belongs to the Nudix hydrolase family. (156 aa)
ENSOCUP00000007981annotation not available (384 aa)
FBXO4F-box protein 4. (387 aa)
HELTHelt bHLH transcription factor. (242 aa)
ADMAdrenomedullin. (187 aa)
GJB2Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. (226 aa)
CD68CD68 molecule. (334 aa)
NTRK1Tyrosine-protein kinase receptor. (823 aa)
TGFB3Transforming growth factor beta 3. (458 aa)
CLDN1Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (211 aa)
APAF1Apoptotic peptidase activating factor 1. (1183 aa)
PAX5Paired box 5. (371 aa)
CDKN2BCyclin dependent kinase inhibitor 2B. (138 aa)
UCP2Uncoupling protein 2; Belongs to the mitochondrial carrier (TC 2.A.29) family. (309 aa)
WRNWRN RecQ like helicase. (1360 aa)
IGFBP1Insulin like growth factor binding protein 1. (270 aa)
PAX2Paired box 2. (448 aa)
KRT16Keratin 16; Belongs to the intermediate filament family. (567 aa)
COL4A2Collagen type IV alpha 2 chain. (1564 aa)
EDN1Big endothelin-1; Endothelins are endothelium-derived vasoconstrictor peptides (By similarity). Probable ligand for G-protein coupled receptors EDNRA and EDNRB which activates PTK2B, BCAR1, BCAR3 and, GTPases RAP1 and RHOA cascade in glomerular mesangial cells (By similarity). Belongs to the endothelin/sarafotoxin family. (202 aa)
GCLMGlutamate-cysteine ligase modifier subunit. (388 aa)
TNFRSF1BTNF receptor superfamily member 1B. (425 aa)
IGF1RTyrosine-protein kinase receptor. (1464 aa)
DDCDopa decarboxylase. (485 aa)
KRT28Keratin 28; Belongs to the intermediate filament family. (459 aa)
DMDUncharacterized protein. (956 aa)
HTRA2HtrA serine peptidase 2. (458 aa)
OGG1OGG_N domain-containing protein. (192 aa)
PITX3Homeobox protein. (302 aa)
TFRCTransferrin receptor. (763 aa)
APODApolipoprotein D; APOD occurs in the macromolecular complex with lecithin- transport and binding of bilin. Appears to be able to transport a variety of ligands in a number of different contexts; Belongs to the calycin superfamily. Lipocalin family. (233 aa)
SOD1Superoxide dismutase [Cu-Zn]; Destroys radicals which are normally produced within the cells and which are toxic to biological systems; Belongs to the Cu-Zn superoxide dismutase family. (153 aa)
GJB6Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. (261 aa)
AVPR1AVasopressin V1a receptor; Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate a phosphatidyl- inositol-calcium second messenger system. Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily. (418 aa)
G1TQ93_RABITUncharacterized protein. (772 aa)
G1TQX9_RABITUncharacterized protein. (475 aa)
KLKlotho. (1005 aa)
FOSFos proto-oncogene, AP-1 transcription factor subunit. (380 aa)
SEC63J domain-containing protein. (716 aa)
GSK3AProtein kinase domain-containing protein; Belongs to the protein kinase superfamily. (401 aa)
G1U2E4_RABITUncharacterized protein. (147 aa)
CARM1Coactivator associated arginine methyltransferase 1; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. (556 aa)
IGFBP5Insulin like growth factor binding protein 5. (271 aa)
DNMT3ADNA methyltransferase 3 alpha; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. (843 aa)
ALOX12Arachidonate 12-lipoxygenase, 12S type. (663 aa)
ERCC1Uncharacterized protein. (226 aa)
CANXCalnexin. (622 aa)
C1QAComplement C1q A chain. (324 aa)
BAK1BCL2 antagonist/killer 1. (210 aa)
SLC32A1Solute carrier family 32 member 1. (394 aa)
NFE2L2Nuclear factor, erythroid 2 like 2. (677 aa)
ASS1Uncharacterized protein. (251 aa)
RNF165Ring finger protein 165. (364 aa)
UCP3Uncoupling protein 3; Belongs to the mitochondrial carrier (TC 2.A.29) family. (309 aa)
ADRA1AAlpha-1A adrenergic receptor; This alpha-adrenergic receptor mediates its action by association with G proteins that activate a phosphatidylinositol- calcium second messenger system. Its effect is mediated by G(q) and G(11) proteins. Nuclear ADRA1A-ADRA1B heterooligomers regulate phenylephrine (PE)-stimulated ERK signaling in cardiac myocytes (By similarity); Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRA1A sub-subfamily. (466 aa)
ELAVL4ELAV-like protein; Belongs to the RRM elav family. (402 aa)
MBD3L1MBDa domain-containing protein. (230 aa)
ERCC2ERCC excision repair 2, TFIIH core complex helicase subunit. (805 aa)
SRRPALP domain-containing protein. (601 aa)
CIITAClass II major histocompatibility complex transactivator. (1175 aa)
IRAK1Interleukin 1 receptor associated kinase 1. (534 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (592 aa)
DNMBPDynamin binding protein. (1573 aa)
ENSOCUP00000030584Uncharacterized protein. (513 aa)
RPN2Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2; Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol- pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the en [...] (647 aa)
LOC103345451TGFb_propeptide domain-containing protein. (203 aa)
SIN3ASIN3 transcription regulator family member A. (1241 aa)
IGFBP2IGFBP N-terminal domain-containing protein. (442 aa)
NPY5RNeuropeptide Y receptor Y5. (455 aa)
CTC1CST telomere replication complex component 1. (1251 aa)
LOC108175406Uncharacterized protein. (210 aa)
LOC100352221CARM1 domain-containing protein; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. (463 aa)
GFRA1GDNF family receptor alpha-1; Receptor for GDNF. Mediates the GDNF-induced autophosphorylation and activation of the RET receptor. Belongs to the GDNFR family. (468 aa)
ENSOCUP00000037329TGFb_propeptide domain-containing protein. (263 aa)
FOXO4Forkhead box O4. (503 aa)
MBD2Methyl-CpG binding domain protein 2. (347 aa)
ENSOCUP00000041840TGFb_propeptide domain-containing protein. (219 aa)
ENSOCUP00000042867Uncharacterized protein. (340 aa)
ENSOCUP00000042987Thymidylat_synt domain-containing protein. (98 aa)
AMFRAutocrine motility factor receptor. (643 aa)
MPOMyeloperoxidase. (725 aa)
ENSOCUP00000043709annotation not available (199 aa)
TSPOUncharacterized protein. (516 aa)
ENSOCUP00000044284TGFb_propeptide domain-containing protein. (260 aa)
GCLCGlutamate-cysteine ligase catalytic subunit. (664 aa)
PPP3CASerine/threonine-protein phosphatase. (695 aa)
ENSOCUP00000045925TGFb_propeptide domain-containing protein. (272 aa)
ABAT4-aminobutyrate aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (549 aa)
CASP9Caspase 9; Belongs to the peptidase C14A family. (466 aa)
ENSOCUP00000047323Fork-head domain-containing protein. (261 aa)
TP63Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. (680 aa)
Your Current Organism:
Oryctolagus cuniculus
NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits
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