STRINGSTRING
WNT4 WNT4 HOXA9 HOXA9 G1TRE9_RABIT G1TRE9_RABIT ADAM6A ADAM6A LOC100339702 LOC100339702 H3-3A H3-3A KIF18A KIF18A ATN1 ATN1 G1TM34_RABIT G1TM34_RABIT G1TM10_RABIT G1TM10_RABIT ADAM6 ADAM6 LOC100344521 LOC100344521 RARA RARA ADAM21 ADAM21 LOC100338964 LOC100338964 FSHB FSHB WNT2B WNT2B SPATA2 SPATA2 ENSOCUP00000015809 ENSOCUP00000015809 FANCA FANCA GATA3 GATA3 TLR3 TLR3 TCF21 TCF21 SRD5A1 SRD5A1 SFRP2 SFRP2 ACVR2A ACVR2A CYP1B1 CYP1B1 RHOBTB3 RHOBTB3 HOXA10 HOXA10 LOC100356501 LOC100356501 TGFBR1 TGFBR1 MAMLD1 MAMLD1 ADGRG1 ADGRG1 KIT KIT YBX3 YBX3 KITLG KITLG ENSOCUP00000031621 ENSOCUP00000031621 MGRA MGRA FNDC3A FNDC3A ARID5B ARID5B ENSOCUP00000030103 ENSOCUP00000030103 ENSOCUP00000029917 ENSOCUP00000029917 ENSOCUP00000029342 ENSOCUP00000029342 LHCGR LHCGR DHH DHH LOC100339207 LOC100339207 GATA1 GATA1 SF1 SF1 ERCC1 ERCC1 G1U3U1_RABIT G1U3U1_RABIT KLHL10 KLHL10 ADAM29 ADAM29 G1TZR9_RABIT G1TZR9_RABIT LOC100358067 LOC100358067 LOC100339452 LOC100339452 ACE ACE SCAPER SCAPER H3F3B H3F3B ASPM ASPM TBC1D20 TBC1D20 LOC100357927 LOC100357927 G1T6B5_RABIT G1T6B5_RABIT NUP210L NUP210L ING2 ING2 INHA INHA SRD5A2 SRD5A2 ARID4A ARID4A CRKL CRKL INHBA INHBA EIF2S2 EIF2S2 WNT5A WNT5A FSHR FSHR TEX11 TEX11 CBL CBL NKX3-1 NKX3-1 AGO4 AGO4 SMAD4 SMAD4 BCL2L1 BCL2L1 REC8 REC8 PATZ1 PATZ1 GATA4 GATA4 G1SGI9_RABIT G1SGI9_RABIT PDGFRB PDGFRB UBB UBB LRP2 LRP2 TFAP2C TFAP2C HSD17B4 HSD17B4 NTRK1 NTRK1 LRRC6 LRRC6 MSH2 MSH2 NUDT1 NUDT1 G1SVE7_RABIT G1SVE7_RABIT TMF1 TMF1 PDGFRA PDGFRA NR0B1 NR0B1 NR5A1 NR5A1 ATRX ATRX BCL2L11 BCL2L11 CSMD2 CSMD2 ADAM15 ADAM15 BRIP1 BRIP1 ARID4B ARID4B FER FER BCL2 BCL2 GFRA1 GFRA1 ENSOCUP00000037873 ENSOCUP00000037873 ENSOCUP00000042027 ENSOCUP00000042027 ENSOCUP00000042043 ENSOCUP00000042043 INSR INSR PRDX4 PRDX4 BAX BAX WT1 WT1 WDR48 WDR48 TGFB2 TGFB2 RXFP2 RXFP2 INHBB INHBB ESR1 ESR1 PLEKHA1 PLEKHA1 TLR9 TLR9 CITED2 CITED2 RAB13 RAB13 BOK BOK ADAM30 ADAM30 LHX9 LHX9 BCL2L2 BCL2L2 SDC1 SDC1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
WNT4Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (487 aa)
HOXA9Homeobox protein; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Belongs to the Abd-B homeobox family. (276 aa)
G1TRE9_RABITUncharacterized protein. (828 aa)
ADAM6AUncharacterized protein. (729 aa)
LOC100339702Uncharacterized protein. (845 aa)
H3-3AHistone H3.3; Variant histone H3 which replaces conventional H3 in a wide range of nucleosomes in active genes. Constitutes the predominant form of histone H3 in non-dividing cells and is incorporated into chromatin independently of DNA synthesis. Deposited at sites of nucleosomal displacement throughout transcribed genes, suggesting that it represents an epigenetic imprint of transcriptionally active chromatin. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in [...] (136 aa)
KIF18AKinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (892 aa)
ATN1Atrophin 1. (1180 aa)
G1TM34_RABITUncharacterized protein. (1343 aa)
G1TM10_RABITUncharacterized protein. (750 aa)
ADAM6Uncharacterized protein. (731 aa)
LOC100344521Uncharacterized protein. (748 aa)
RARARetinoic acid receptor alpha. (462 aa)
ADAM21ADAM metallopeptidase domain 21. (711 aa)
LOC100338964Uncharacterized protein. (857 aa)
FSHBFollitropin subunit beta; Together with the alpha chain CGA constitutes follitropin, the follicle-stimulating hormone, and provides its biological specificity to the hormone heterodimer. Binds FSHR, a G protein-coupled receptor, on target cells to activate downstream signaling pathways. Follitropin is involved in follicle development and spermatogenesis in reproductive organs. (129 aa)
WNT2BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (397 aa)
SPATA2Spermatogenesis associated 2. (509 aa)
ENSOCUP00000015809Histone H3.3. (144 aa)
FANCAFA complementation group A. (1327 aa)
GATA3GATA binding protein 3. (444 aa)
TLR3TIR domain-containing protein; Belongs to the Toll-like receptor family. (867 aa)
TCF21Transcription factor 21. (179 aa)
SRD5A13-oxo-5-alpha-steroid 4-dehydrogenase; Converts testosterone into 5-alpha-dihydrotestosterone and progesterone or corticosterone into their corresponding 5-alpha-3- oxosteroids. It plays a central role in sexual differentiation and androgen physiology. (255 aa)
SFRP2Secreted frizzled related protein 2. (295 aa)
ACVR2ASerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (556 aa)
CYP1B1Cytochrome P450 family 1 subfamily B member 1; Belongs to the cytochrome P450 family. (542 aa)
RHOBTB3Rho related BTB domain containing 3. (611 aa)
HOXA10Homeobox A10. (421 aa)
LOC100356501Kazal-like domain-containing protein. (84 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (486 aa)
MAMLD1Mastermind like domain containing 1. (1044 aa)
ADGRG1Adhesion G protein-coupled receptor G1; Belongs to the G-protein coupled receptor 2 family. (888 aa)
KITMast/stem cell growth factor receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (970 aa)
YBX3Y-box binding protein 3. (453 aa)
KITLGKit ligand; Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. Belongs to the SCF family. (276 aa)
ENSOCUP00000031621Uncharacterized protein. (1225 aa)
MGRAMas-related G protein-coupled receptor A; Belongs to the G-protein coupled receptor 1 family. (325 aa)
FNDC3AFibronectin type III domain containing 3A. (1198 aa)
ARID5BAT-rich interaction domain 5B. (1191 aa)
ENSOCUP00000030103Uncharacterized protein. (520 aa)
ENSOCUP00000029917Uncharacterized protein. (169 aa)
ENSOCUP00000029342Histone domain-containing protein. (82 aa)
LHCGRLutropin-choriogonadotropic hormone receptor; Receptor for lutropin-choriogonadotropic hormone. The activity of this receptor is mediated by G proteins which activate adenylate cyclase; Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily. (732 aa)
DHHDesert hedgehog signaling molecule. (388 aa)
LOC100339207Uncharacterized protein. (743 aa)
GATA1GATA binding protein 1. (413 aa)
SF1CCHC-type domain-containing protein. (630 aa)
ERCC1Uncharacterized protein. (226 aa)
G1U3U1_RABITUncharacterized protein. (1426 aa)
KLHL10Kelch like family member 10. (608 aa)
ADAM29Uncharacterized protein. (703 aa)
G1TZR9_RABITUncharacterized protein. (166 aa)
LOC100358067Uncharacterized protein. (750 aa)
LOC100339452Uncharacterized protein. (809 aa)
ACEAngiotensin-converting enzyme, soluble form; Converts angiotensin I to angiotensin II by release of the terminal His-Leu, this results in an increase of the vasoconstrictor activity of angiotensin. Also able to inactivate bradykinin, a potent vasodilator. Has also a glycosidase activity which releases GPI- anchored proteins from the membrane by cleaving the mannose linkage in the GPI moiety (By similarity); Belongs to the peptidase M2 family. (1284 aa)
SCAPERS-phase cyclin A associated protein in the ER. (1399 aa)
H3F3BHistone H3; Belongs to the histone H3 family. (136 aa)
ASPMUncharacterized protein. (1883 aa)
TBC1D20TBC1 domain family member 20. (403 aa)
LOC100357927Histone domain-containing protein. (136 aa)
G1T6B5_RABITUncharacterized protein. (746 aa)
NUP210LNucleoporin 210 like. (1885 aa)
ING2Inhibitor of growth protein. (283 aa)
INHAInhibin alpha chain; Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition; Belongs to the TGF-beta family. (364 aa)
SRD5A23-oxo-5-alpha-steroid 4-dehydrogenase; Converts testosterone into 5-alpha-dihydrotestosterone and progesterone or corticosterone into their corresponding 5-alpha-3- oxosteroids. It plays a central role in sexual differentiation and androgen physiology. (254 aa)
ARID4AAT-rich interaction domain 4A. (1255 aa)
CRKLCRK like proto-oncogene, adaptor protein. (303 aa)
INHBAInhibin subunit beta A. (424 aa)
EIF2S2Eukaryotic translation initiation factor 2 subunit 2; eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. This complex binds to a 40S ribosomal subunit, followed by mRNA binding to form a 43S preinitiation complex. Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF-2 and release of an eIF-2-GDP binary complex. In order for eIF-2 to recycle and catalyze another round of initiation, the GDP bound to eIF-2 must exchange with GTP by way of a reaction catalyz [...] (333 aa)
WNT5AProtein Wnt-5a; Ligand for members of the frizzled family of seven transmembrane receptors. Can activate or inhibit canonical Wnt signaling, depending on receptor context. In the presence of FZD4, activates beta-catenin signaling. In the presence of ROR2, inhibits the canonical Wnt pathway by promoting beta-catenin degradation through a GSK3-independent pathway which involves down-regulation of beta- catenin-induced reporter gene expression (By similarity). Suppression of the canonical pathway allows chondrogenesis to occur. Inhibits tumor formation. Stimulates cell migration. Decrease [...] (380 aa)
FSHRFollicle-stimulating hormone receptor; G protein-coupled receptor for follitropin, the follicle- stimulating hormone. Through cAMP production activates the downstream PI3K-AKT and ERK1/ERK2 signaling pathways. (703 aa)
TEX11Testis expressed 11. (926 aa)
CBLCbl proto-oncogene. (837 aa)
NKX3-1NK3 homeobox 1. (159 aa)
AGO4Protein argonaute-4; Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs. (861 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
BCL2L1Bcl-X. (233 aa)
REC8REC8 meiotic recombination protein. (559 aa)
PATZ1POZ and AT hook containing zinc finger 1 long C isoform (Predicted). (687 aa)
GATA4GATA binding protein 4. (444 aa)
G1SGI9_RABITUncharacterized protein. (358 aa)
PDGFRBPlatelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. (1147 aa)
UBBUbiquitin; Ubiquitin exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair; Lys-11- [...] (288 aa)
LRP2Uncharacterized protein. (2726 aa)
TFAP2CTranscription factor AP-2 gamma. (454 aa)
HSD17B4Hydroxysteroid 17-beta dehydrogenase 4. (741 aa)
NTRK1Tyrosine-protein kinase receptor. (823 aa)
LRRC6Leucine rich repeat containing 6. (471 aa)
MSH2DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (865 aa)
NUDT1Nudix hydrolase 1; Belongs to the Nudix hydrolase family. (156 aa)
G1SVE7_RABITUncharacterized protein. (752 aa)
TMF1TATA element modulatory factor 1. (1097 aa)
PDGFRAProtein kinase domain-containing protein. (773 aa)
NR0B1Nuclear receptor subfamily 0 group B member 1. (471 aa)
NR5A1Nuclear receptor subfamily 5 group A member 1. (461 aa)
ATRXATRX chromatin remodeler. (2472 aa)
BCL2L11Bcl-2-like protein 11; Induces apoptosis and anoikis. Belongs to the Bcl-2 family. (194 aa)
CSMD2CUB and Sushi multiple domains 2. (3633 aa)
ADAM15ADAM metallopeptidase domain 15. (881 aa)
BRIP1BRCA1 interacting protein C-terminal helicase 1. (1212 aa)
ARID4BAT-rich interaction domain 4B. (1313 aa)
FERTyrosine-protein kinase. (452 aa)
BCL2BH4_2 domain-containing protein. (389 aa)
GFRA1GDNF family receptor alpha-1; Receptor for GDNF. Mediates the GDNF-induced autophosphorylation and activation of the RET receptor. Belongs to the GDNFR family. (468 aa)
ENSOCUP00000037873Uncharacterized protein. (411 aa)
ENSOCUP00000042027Histone domain-containing protein. (116 aa)
ENSOCUP00000042043Ig-like domain-containing protein. (212 aa)
INSRTyrosine-protein kinase receptor. (1377 aa)
PRDX4Peroxiredoxin 4. (278 aa)
BAXBCL2 associated X, apoptosis regulator. (192 aa)
WT1WT1 transcription factor. (302 aa)
WDR48WD repeat domain 48. (867 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
RXFP2Relaxin family peptide receptor 2. (745 aa)
INHBBInhibin subunit beta B. (302 aa)
ESR1Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. (598 aa)
PLEKHA1Pleckstrin homology domain containing A1. (405 aa)
TLR9TIR domain-containing protein. (1027 aa)
CITED2Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 2. (249 aa)
RAB13Uncharacterized protein. (237 aa)
BOKBCL2 family apoptosis regulator BOK. (145 aa)
ADAM30ADAM metallopeptidase domain 30. (903 aa)
LHX9LIM homeobox 9. (388 aa)
BCL2L2BCL2 like 2. (193 aa)
SDC1Syndecan; Cell surface proteoglycan; Belongs to the syndecan proteoglycan family. (401 aa)
Your Current Organism:
Oryctolagus cuniculus
NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits
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