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| | HDAC2 | Histone deacetylase 2. (581 aa) |
| | PPP1R12A | Protein phosphatase 1 regulatory subunit. (1085 aa) |
| | ADCYAP1R1 | ADCYAP receptor type I; Belongs to the G-protein coupled receptor 2 family. (549 aa) |
| | SHANK2 | SH3 and multiple ankyrin repeat domains 2. (1891 aa) |
| | LOC100009483 | Sulfotransferase; Belongs to the sulfotransferase 1 family. (341 aa) |
| | LRP8 | LDL receptor related protein 8. (1029 aa) |
| | PON3 | Serum paraoxonase/lactonase 3; Has low activity towards the organophosphate paraxon and aromatic carboxylic acid esters (By similarity). Rapidly hydrolyzes lactones such as statin prodrugs (e.g. lovastatin). Hydrolyzes aromatic lactones and 5- or 6-member ring lactones with aliphatic substituents but not simple lactones or those with polar substituents. (378 aa) |
| | CPS1 | Carbamoyl-phosphate synthase 1. (1506 aa) |
| | GSTO1 | Glutathione S-transferase omega 1; Belongs to the GST superfamily. (283 aa) |
| | MEF2C | Myocyte enhancer factor 2C. (483 aa) |
| | ABAT | 4-aminobutyrate aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (549 aa) |
| | LOC100353174 | GST N-terminal domain-containing protein. (125 aa) |
| | TJP1 | Tight junction protein 1; Belongs to the MAGUK family. (1815 aa) |
| | AOX1 | Aldehyde oxidase 1; Oxidase with broad substrate specificity, oxidizing aromatic azaheterocycles, such as N1-methylnicotinamide, N-methylphthalazinium and phthalazine, as well as aldehydes, such as benzaldehyde, retinal, pyridoxal, and vanillin. Plays a key role in the metabolism of xenobiotics and drugs containing aromatic azaheterocyclic substituents. Participates in the bioactivation of prodrugs such as famciclovir, catalyzing the oxidation step from 6-deoxypenciclovir to penciclovir, which is a potent antiviral agent. Is probably involved in the regulation of reactive oxygen specie [...] (1335 aa) |
| | FBP1 | Fructose-1,6-bisphosphatase 1; Catalyzes the hydrolysis of fructose 1,6-bisphosphate to fructose 6-phosphate in the presence of divalent cations, acting as a rate-limiting enzyme in gluconeogenesis. Plays a role in regulating glucose sensing and insulin secretion of pancreatic beta-cells. Appears to modulate glycerol gluconeogenesis in liver. Important regulator of appetite and adiposity; increased expression of the protein in liver after nutrient excess increases circulating satiety hormones and reduces appetite-stimulating neuropeptides and thus seems to provide a feedback mechanism [...] (443 aa) |
| | MAP1B | Microtubule associated protein 1B. (2355 aa) |
| | ENSOCUP00000045925 | TGFb_propeptide domain-containing protein. (272 aa) |
| | AOX4 | Uncharacterized protein. (1344 aa) |
| | NR1I2 | Uncharacterized protein. (514 aa) |
| | ENSOCUP00000045545 | ANK_REP_REGION domain-containing protein. (123 aa) |
| | PMS2 | PMS1 homolog 2, mismatch repair system component. (910 aa) |
| | AIP | Peptidylprolyl isomerase. (184 aa) |
| | NFATC2 | Nuclear factor of activated T cells 2. (900 aa) |
| | PON2 | Paraoxonase 2. (375 aa) |
| | GCLC | Glutamate-cysteine ligase catalytic subunit. (664 aa) |
| | ENSOCUP00000044284 | TGFb_propeptide domain-containing protein. (260 aa) |
| | LOX | Lysyl oxidase. (419 aa) |
| | ENSOCUP00000043938 | Uncharacterized protein. (50 aa) |
| | PTPRM | Protein tyrosine phosphatase receptor type M. (1549 aa) |
| | TSPO | Uncharacterized protein. (516 aa) |
| | TXNIP | Thioredoxin interacting protein. (429 aa) |
| | CDH3 | Cadherin 3; Cadherins are calcium-dependent cell adhesion proteins. (1102 aa) |
| | FOSB | FosB proto-oncogene, AP-1 transcription factor subunit. (289 aa) |
| | ATG5 | Autophagy protein 5; Involved in autophagic vesicle formation. (245 aa) |
| | ENSOCUP00000043082 | Uncharacterized protein. (319 aa) |
| | ENSOCUP00000042987 | Thymidylat_synt domain-containing protein. (98 aa) |
| | XRCC1 | X-ray repair cross complementing 1. (610 aa) |
| | ENSOCUP00000042867 | Uncharacterized protein. (340 aa) |
| | AHR | Aryl hydrocarbon receptor; Ligand-activated transcriptional activator. Binds to the XRE promoter region of genes it activates. Activates the expression of multiple phase I and II xenobiotic chemical metabolizing enzyme genes (such as the CYP1A1 gene). Mediates biochemical and toxic effects of halogenated aromatic hydrocarbons. Involved in cell-cycle regulation. Likely to play an important role in the development and maturation of many tissues. Regulates the circadian clock by inhibiting the basal and circadian expression of the core circadian component PER1. Inhibits PER1 by repressing [...] (887 aa) |
| | TRAF3IP2 | SEFIR domain-containing protein. (559 aa) |
| | LOC100349664 | Uncharacterized protein; Belongs to the cytochrome P450 family. (457 aa) |
| | ENSOCUP00000041840 | TGFb_propeptide domain-containing protein. (219 aa) |
| | CYP2S1 | Cytochrome P450 family 2 subfamily S member 1. (700 aa) |
| | ENSOCUP00000041375 | GST C-terminal domain-containing protein. (122 aa) |
| | DPEP1 | Dipeptidase 1; Hydrolyzes a wide range of dipeptides. Implicated in the renal metabolism of glutathione and its conjugates. Converts leukotriene D4 to leukotriene E4; it may play an important role in the regulation of leukotriene activity; Belongs to the metallo-dependent hydrolases superfamily. Peptidase M19 family. (524 aa) |
| | RB1 | RB transcriptional corepressor 1. (943 aa) |
| | SS18 | SS18 subunit of BAF chromatin remodeling complex. (418 aa) |
| | ENSOCUP00000040428 | Uncharacterized protein. (86 aa) |
| | JUN | BZIP domain-containing protein; Belongs to the bZIP family. (352 aa) |
| | FOSL1 | FOS like 1, AP-1 transcription factor subunit. (335 aa) |
| | POR | NADPH--cytochrome P450 reductase; This enzyme is required for electron transfer from NADP to cytochrome P450 in microsomes. It can also provide electron transfer to heme oxygenase and cytochrome B5; In the N-terminal section; belongs to the flavodoxin family. (439 aa) |
| | PFAS | Phosphoribosylformylglycinamidine synthase. (1362 aa) |
| | ENSOCUP00000039970 | Raptor_N domain-containing protein. (253 aa) |
| | LOC100328948 | Cytochrome P450 2B4; Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. In the epoxidation of arachidonic acid it has a unique preference for the 5,6-olefin. (619 aa) |
| | ENSOCUP00000039495 | Uncharacterized protein. (116 aa) |
| | HADH | Hydroxyacyl-CoA dehydrogenase. (424 aa) |
| | TFAP2B | Transcription factor AP-2 beta. (476 aa) |
| | ENSOCUP00000037329 | TGFb_propeptide domain-containing protein. (263 aa) |
| | CYP2B4 | Cytochrome P450 2B4. (565 aa) |
| | MAOB | Amine oxidase. (530 aa) |
| | TXN2 | Thioredoxin 2. (166 aa) |
| | VAV3 | Vav guanine nucleotide exchange factor 3. (964 aa) |
| | GRIN2A | Glutamate ionotropic receptor NMDA type subunit 2A. (1087 aa) |
| | BCL2 | BH4_2 domain-containing protein. (389 aa) |
| | RET | Proto-oncogene tyrosine-protein kinase receptor Ret; Receptor tyrosine-protein kinase involved in numerous cellular mechanisms including cell proliferation, neuronal navigation, cell migration, and cell differentiation upon binding with glial cell derived neurotrophic factor family ligands. (1113 aa) |
| | LOC100354078 | Uncharacterized protein. (538 aa) |
| | ENSOCUP00000035480 | ANK_REP_REGION domain-containing protein. (132 aa) |
| | CYP26B1 | Cytochrome P450 family 26 subfamily B member 1; Belongs to the cytochrome P450 family. (709 aa) |
| | CYBB | FAD-binding FR-type domain-containing protein. (570 aa) |
| | CYP2C30 | Cytochrome P450 2C30; Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. (528 aa) |
| | SLC6A2 | Transporter; Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. (653 aa) |
| | IGFBP2 | IGFBP N-terminal domain-containing protein. (442 aa) |
| | UMOD | Uromodulin. (794 aa) |
| | GPLD1 | Glycosylphosphatidylinositol specific phospholipase D1. (852 aa) |
| | SLC8A1 | J domain-containing protein; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (973 aa) |
| | ITGB3 | Integrin beta; Belongs to the integrin beta chain family. (873 aa) |
| | UCHL1 | Ubiquitin carboxyl-terminal hydrolase. (237 aa) |
| | CTNNB1 | Catenin beta 1. (741 aa) |
| | AOX3 | Uncharacterized protein. (1335 aa) |
| | RORA | RAR related orphan receptor A. (512 aa) |
| | HSF1 | Heat shock transcription factor 1. (680 aa) |
| | ENSOCUP00000031759 | Guanylate cyclase domain-containing protein. (312 aa) |
| | LOC103345451 | TGFb_propeptide domain-containing protein. (203 aa) |
| | MGRA | Mas-related G protein-coupled receptor A; Belongs to the G-protein coupled receptor 1 family. (325 aa) |
| | BRAF | B-Raf proto-oncogene, serine/threonine kinase. (767 aa) |
| | ENSOCUP00000031187 | TRF domain-containing protein. (274 aa) |
| | RPN2 | Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2; Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol- pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the en [...] (647 aa) |
| | CRHBP | Corticotropin releasing hormone binding protein. (382 aa) |
| | TGFBR2 | TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (592 aa) |
| | ENSOCUP00000030514 | Guanylate kinase-like domain-containing protein. (239 aa) |
| | LOC100359182 | Amino acid transporter. (665 aa) |
| | OTC | Ornithine carbamoyltransferase; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. (360 aa) |
| | ENSOCUP00000029917 | Uncharacterized protein. (169 aa) |
| | PDE4B | Phosphodiesterase. (736 aa) |
| | ITGA2 | Integrin subunit alpha 2; Belongs to the integrin alpha chain family. (1202 aa) |
| | CYP2J1 | Cytochrome P450 2J1; Catalyzes the N-demethylation of benzphetamine to formaldehyde. (517 aa) |
| | SRR | PALP domain-containing protein. (601 aa) |
| | CYP2C5 | Cytochrome P450 2C5. (510 aa) |
| | USP47 | Ubiquitin specific peptidase 47; Belongs to the peptidase C19 family. (1376 aa) |
| | ASS1 | Uncharacterized protein. (251 aa) |
| | LHCGR | Lutropin-choriogonadotropic hormone receptor; Receptor for lutropin-choriogonadotropic hormone. The activity of this receptor is mediated by G proteins which activate adenylate cyclase; Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily. (732 aa) |
| | NFE2L2 | Nuclear factor, erythroid 2 like 2. (677 aa) |
| | LOC100347060 | Uncharacterized protein. (147 aa) |
| | NPC1 | SSD domain-containing protein. (1289 aa) |
| | SULT2A1 | Sulfotransferase; Belongs to the sulfotransferase 1 family. (331 aa) |
| | BAK1 | BCL2 antagonist/killer 1. (210 aa) |
| | GSTA4 | Glutathione S-transferase alpha 4; Belongs to the GST superfamily. (289 aa) |
| | U3KM51_RABIT | Uncharacterized protein; Belongs to the carnitine/choline acetyltransferase family. (794 aa) |
| | G1U940_RABIT | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (178 aa) |
| | LOC100353460 | Uncharacterized protein; Belongs to the cytochrome P450 family. (490 aa) |
| | DRD3 | Dopamine receptor D3; Belongs to the G-protein coupled receptor 1 family. (399 aa) |
| | AOX2 | Aldehyde oxidase 3L1. (1343 aa) |
| | G1U6L7_RABIT | BHLH domain-containing protein. (316 aa) |
| | FZD3 | Frizzled class receptor 3; Belongs to the G-protein coupled receptor Fz/Smo family. (603 aa) |
| | ATP1A1 | Sodium/potassium-transporting ATPase subunit alpha-1; This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients (By similarity). May contribute to blood-heart barrier properties of endocardial endothelium and may control cardiac performance via endothelial Na(+)/H(+) exchange. (956 aa) |
| | KCNE2 | Potassium voltage-gated channel subfamily E member 2; Ancillary protein that assembles as a beta subunit with a voltage-gated potassium channel complex of pore-forming alpha subunits. Modulates the gating kinetics and enhances stability of the channel complex. Assembled with KCNB1 modulates the gating characteristics of the delayed rectifier voltage-dependent potassium channel KCNB1. Associated with KCNH2/HERG is proposed to form the rapidly activating component of the delayed rectifying potassium current in heart (IKr). May associate with KCNQ2 and/or KCNQ3 and modulate the native M-t [...] (123 aa) |
| | SLITRK5 | SLIT and NTRK like family member 5. (811 aa) |
| | CYP2D23 | Uncharacterized protein; Belongs to the cytochrome P450 family. (501 aa) |
| | DNMT3A | DNA methyltransferase 3 alpha; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. (843 aa) |
| | G1U2X0_RABIT | Uncharacterized protein; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (266 aa) |
| | CYP2D24 | Uncharacterized protein; Belongs to the cytochrome P450 family. (500 aa) |
| | LOC100347521 | Uncharacterized protein. (479 aa) |
| | EMX2 | Empty spiracles homeobox 2. (253 aa) |
| | SLC1A3 | Amino acid transporter. (542 aa) |
| | RECQL5 | ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily. (970 aa) |
| | GUK1 | Guanylate kinase-like domain-containing protein. (219 aa) |
| | CDH1 | Cadherin 1; Cadherins are calcium-dependent cell adhesion proteins. (884 aa) |
| | G1TYN6_RABIT | Uncharacterized protein; Belongs to the cytochrome P450 family. (466 aa) |
| | LOC100358544 | Uncharacterized protein. (1025 aa) |
| | G1TY19_RABIT | Uncharacterized protein; Belongs to the cytochrome P450 family. (474 aa) |
| | IL1B | Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. (234 aa) |
| | LOC100345193 | Uncharacterized protein; Belongs to the cytochrome P450 family. (494 aa) |
| | SMTNL1 | Smoothelin like 1. (459 aa) |
| | FOS | Fos proto-oncogene, AP-1 transcription factor subunit. (380 aa) |
| | LOC100353077 | Uncharacterized protein; Belongs to the cytochrome P450 family. (501 aa) |
| | ADIPOQ | C1q domain-containing protein. (244 aa) |
| | G1TUP7_RABIT | Uncharacterized protein; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (265 aa) |
| | ENSOCUP00000020435 | Cytochrome P450 2C16. (124 aa) |
| | PGF | Placental growth factor; Belongs to the PDGF/VEGF growth factor family. (170 aa) |
| | NPC1L1 | Niemann-Pick C1-like 1 protein. (1325 aa) |
| | G1TS28_RABIT | Uncharacterized protein; Belongs to the cytochrome P450 family. (485 aa) |
| | TRPA1 | Transient receptor potential cation channel subfamily A member 1; Belongs to the transient receptor (TC 1.A.4) family. (1117 aa) |
| | CYP2C4 | Cytochrome P450 2C4; Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. (487 aa) |
| | G1TQX9_RABIT | Uncharacterized protein. (475 aa) |
| | CBX7 | Chromobox 7. (345 aa) |
| | G1TPY1_RABIT | Uncharacterized protein. (492 aa) |
| | KCNK3 | Potassium channel subfamily K member. (347 aa) |
| | LOC100348276 | Uncharacterized protein; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (321 aa) |
| | S100A12 | Protein S100-A12; S100A12 is a calcium-, zinc- and copper-binding protein which plays a prominent role in the regulation of inflammatory processes and immune response. Its proinflammatory activity involves recruitment of leukocytes, promotion of cytokine and chemokine production, and regulation of leukocyte adhesion and migration. Acts as an alarmin or a danger associated molecular pattern (DAMP) molecule and stimulates innate immune cells via binding to receptor for advanced glycation endproducts (AGER). Binding to AGER activates the MAP-kinase and NF- kappa-B signaling pathways leadi [...] (95 aa) |
| | PTK2B | Protein tyrosine kinase 2 beta; Belongs to the protein kinase superfamily. Tyr protein kinase family. (996 aa) |
| | FMO1 | Dimethylaniline monooxygenase [N-oxide-forming] 1; This protein is involved in the oxidative metabolism of a variety of xenobiotics such as drugs and pesticides. Form I catalyzes the N-oxygenation of secondary and tertiary amines. (535 aa) |
| | LOC100348029 | Uncharacterized protein; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (277 aa) |
| | G1TMZ7_RABIT | Uncharacterized protein; Belongs to the cytochrome P450 family. (503 aa) |
| | CYP2F1 | Cytochrome P450 family 2 subfamily F member 1; Belongs to the cytochrome P450 family. (491 aa) |
| | RHBDD3 | Rhomboid domain containing 3. (375 aa) |
| | G1TLX8_RABIT | RING-type domain-containing protein. (248 aa) |
| | G1TLX2_RABIT | Uncharacterized protein. (162 aa) |
| | G1TLJ2_RABIT | Uncharacterized protein; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (277 aa) |
| | RORC | RAR related orphan receptor C. (514 aa) |
| | G1TKW9_RABIT | Uncharacterized protein; Belongs to the cytochrome P450 family. (416 aa) |
| | SOD1 | Superoxide dismutase [Cu-Zn]; Destroys radicals which are normally produced within the cells and which are toxic to biological systems; Belongs to the Cu-Zn superoxide dismutase family. (153 aa) |
| | CYP46A1 | Cytochrome P450 family 46 subfamily A member 1. (481 aa) |
| | KCNH2 | Potassium voltage-gated channel subfamily H member 2; Pore-forming (alpha) subunit of voltage-gated inwardly rectifying potassium channel. Channel properties are modulated by cAMP and subunit assembly. Mediates the rapidly activating component of the delayed rectifying potassium current in heart (IKr) (By similarity). (1108 aa) |
| | EMX1 | Empty spiracles homeobox 1. (241 aa) |
| | CBR1 | Carbonyl reductase [NADPH] 1; NADPH-dependent reductase with broad substrate specificity. Catalyzes the reduction of a wide variety of carbonyl compounds including quinones, prostaglandins, menadione, plus various xenobiotics. Catalyzes the reduction of the antitumor anthracyclines doxorubicin and daunorubicin to the cardiotoxic compounds doxorubicinol and daunorubicinol. Can convert prostaglandin E2 to prostaglandin F2- alpha. Can bind glutathione, which explains its higher affinity for glutathione-conjugated substrates. Catalyzes the reduction of S- nitrosoglutathione (By similarity). (378 aa) |
| | HTR1B | 5-hydroxytryptamine receptor 1B; G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various alkaloids and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity. Arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Regulates the release of 5-hydroxytryptamine, dopami [...] (389 aa) |
| | LOC100347582 | Dimethylaniline monooxygenase [N-oxide-forming]. (532 aa) |
| | PPM1E | Protein phosphatase, Mg2+/Mn2+ dependent 1E. (637 aa) |
| | LOC100346323 | Uncharacterized protein. (240 aa) |
| | CHEK2 | Checkpoint kinase 2. (538 aa) |
| | CPB2 | Carboxypeptidase B2. (424 aa) |
| | VEGFC | Vascular endothelial growth factor C; Belongs to the PDGF/VEGF growth factor family. (418 aa) |
| | GATA3 | GATA binding protein 3. (444 aa) |
| | TLR3 | TIR domain-containing protein; Belongs to the Toll-like receptor family. (867 aa) |
| | CYP1A1 | Cytochrome P450 1A1; A cytochrome P450 monooxygenase involved in the metabolism of various endogenous substrates, including fatty acids, steroid hormones and vitamins. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds. Exhibits high catalytic activity for the formation of hydroxyestrogens from estrone (E1) and 17beta-estradiol (E2), namely 2-hydroxy [...] (518 aa) |
| | GAD2 | Glutamate decarboxylase 2. (585 aa) |
| | TFRC | Transferrin receptor. (763 aa) |
| | TENT4A | Terminal nucleotidyltransferase 4A. (542 aa) |
| | SRD5A1 | 3-oxo-5-alpha-steroid 4-dehydrogenase; Converts testosterone into 5-alpha-dihydrotestosterone and progesterone or corticosterone into their corresponding 5-alpha-3- oxosteroids. It plays a central role in sexual differentiation and androgen physiology. (255 aa) |
| | CBR3 | Carbonyl reductase 3; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (295 aa) |
| | SFRP2 | Secreted frizzled related protein 2. (295 aa) |
| | RAD54B | Uncharacterized protein. (932 aa) |
| | CYP1B1 | Cytochrome P450 family 1 subfamily B member 1; Belongs to the cytochrome P450 family. (542 aa) |
| | OGG1 | OGG_N domain-containing protein. (192 aa) |
| | WNK4 | WNK lysine deficient protein kinase 4. (1266 aa) |
| | SMPD1 | Sphingomyelin phosphodiesterase; Converts sphingomyelin to ceramide. (627 aa) |
| | CYP2C2 | Cytochrome P450 2C2; Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. In the epoxidation of arachidonic acid it generates only 14,15- and 11,12-cis-epoxyeicosatrienoic acids. (490 aa) |
| | LOC100350716 | Carn_acyltransf domain-containing protein; Belongs to the carnitine/choline acetyltransferase family. (808 aa) |
| | ABCG8 | ATP binding cassette subfamily G member 8. (695 aa) |
| | DDC | Dopa decarboxylase. (485 aa) |
| | ABCC4 | ATP binding cassette subfamily C member 4. (1325 aa) |
| | NPPC | Uncharacterized protein. (351 aa) |
| | ABCC8 | Uncharacterized protein. (1086 aa) |
| | CDKN1B | Cyclin dependent kinase inhibitor 1B. (198 aa) |
| | GCLM | Glutamate-cysteine ligase modifier subunit. (388 aa) |
| | NCKAP1L | NCK associated protein 1 like. (1181 aa) |
| | RNF149 | Uncharacterized protein. (150 aa) |
| | LOC100353428 | Glutathione S-transferase. (232 aa) |
| | G1T462_RABIT | Uncharacterized protein. (287 aa) |
| | TP53I13 | Tumor protein p53 inducible protein 13. (382 aa) |
| | PMS1 | PMS1 homolog 1, mismatch repair system component. (893 aa) |
| | CDK4 | Cyclin dependent kinase 4; Belongs to the protein kinase superfamily. (392 aa) |
| | ACER2 | Alkaline ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid. (292 aa) |
| | PLIN2 | Perilipin; Belongs to the perilipin family. (499 aa) |
| | PCSK1 | Proprotein convertase subtilisin/kexin type 1. (751 aa) |
| | G1T2D5_RABIT | Uncharacterized protein; Belongs to the cytochrome P450 family. (621 aa) |
| | DRD2 | Dopamine receptor D2; Belongs to the G-protein coupled receptor 1 family. (443 aa) |
| | GABRG3 | Gamma-aminobutyric acid type A receptor gamma3 subunit; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (460 aa) |
| | RBM22 | RNA binding motif protein 22. (420 aa) |
| | TNFRSF11B | Tumor necrosis factor receptor superfamily member 11B; Acts as decoy receptor for TNFSF11/RANKL and thereby neutralizes its function in osteoclastogenesis. (401 aa) |
| | XPC | XPC complex subunit, DNA damage recognition and repair factor. (1003 aa) |
| | SRP68 | Signal recognition particle subunit SRP68; Signal-recognition-particle assembly has a crucial role in targeting secretory proteins to the rough endoplasmic reticulum membrane; Belongs to the SRP68 family. (622 aa) |
| | NTRK1 | Tyrosine-protein kinase receptor. (823 aa) |
| | HMOX1 | Heme oxygenase 1. (288 aa) |
| | ADAM17 | ADAM metallopeptidase domain 17. (827 aa) |
| | SLC26A5 | Prestin; Motor protein that converts auditory stimuli to length changes in outer hair cells and mediates sound amplification in the mammalian hearing organ; Belongs to the SLC26A/SulP transporter (TC 2.A.53) family. (744 aa) |
| | CA9 | Carbonic anhydrase 9; Belongs to the alpha-carbonic anhydrase family. (435 aa) |
| | CYP1A2 | Cytochrome P450 1A2; A cytochrome P450 monooxygenase involved in the metabolism of various endogenous substrates, including fatty acids, steroid hormones and vitamins. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds. Exhibits high catalytic activity for the formation of hydroxyestrogens from estrone (E1) and 17beta-estradiol (E2), namely 2-hydroxy E1 and E [...] (541 aa) |
| | ITGA3 | Integrin subunit alpha 3; Belongs to the integrin alpha chain family. (1072 aa) |
| | HTR2A | 5-hydroxytryptamine receptor 2A. (469 aa) |
| | HADHA | Hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha; Belongs to the enoyl-CoA hydratase/isomerase family. (797 aa) |
| | LPO | Lactoperoxidase. (710 aa) |
| | GSTM3 | Glutathione S-transferase. (279 aa) |
| | FMO5 | Dimethylaniline monooxygenase [N-oxide-forming] 5; In contrast with other forms of FMO it does not seem to be a drug-metabolizing enzyme. (558 aa) |
| | CD69 | CD69 molecule. (201 aa) |
| | P2RX7 | P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. Belongs to the P2X receptor family. (595 aa) |
| | ADORA2A | Adenosine receptor A2; Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family. (409 aa) |
| | GSTO2 | Glutathione S-transferase omega 2; Belongs to the GST superfamily. (337 aa) |
| | TYMS | Thymidylate synthetase. (310 aa) |
| | HTR2B | 5-hydroxytryptamine receptor 2B. (503 aa) |
| | G1SV95_RABIT | Transforming growth factor beta; Belongs to the TGF-beta family. (387 aa) |
| | SCNN1B | Amiloride-sensitive sodium channel subunit beta; Sodium permeable non-voltage-sensitive ion channel inhibited by the diuretic amiloride. Mediates the electrodiffusion of the luminal sodium (and water, which follows osmotically) through the apical membrane of epithelial cells. Plays an essential role in electrolyte and blood pressure homeostasis, but also in airway surface liquid homeostasis, which is important for proper clearance of mucus. Controls the reabsorption of sodium in kidney, colon, lung and sweat glands. Also plays a role in taste perception; Belongs to the amiloride-sensit [...] (641 aa) |
| | TOP1 | DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus r [...] (767 aa) |
| | MAP2K6 | Mitogen-activated protein kinase kinase 6; Belongs to the protein kinase superfamily. (334 aa) |
| | SST | Somatostatin. (116 aa) |
| | PDE3A | Phosphodiesterase. (1128 aa) |
| | ACACB | Acetyl-CoA carboxylase beta. (2373 aa) |
| | NUDT15 | Nudix hydrolase 15. (161 aa) |
| | ENG | Endoglin. (758 aa) |
| | EHMT2 | Euchromatic histone lysine methyltransferase 2. (1211 aa) |
| | ANKRD1 | Ankyrin repeat domain-containing protein 1; May play an important role in endothelial cell activation. May act as a nuclear transcription factor that negatively regulates the expression of cardiac genes (By similarity). (319 aa) |
| | HNF4A | Hepatocyte nuclear factor 4 alpha. (468 aa) |
| | CYP2A10 | Cytochrome P450 2A10; Catalyzes the oxygenation of a variety of substrates, including ethanol and procarcinogens such as N-nitrosodiethylamine and phenacetin. Exhibits a high coumarin 7-hydroxylase activity. Converts also testosterone to androstenedione. (494 aa) |
| | XRCC5 | X-ray repair cross complementing 5. (733 aa) |
| | CCNO | Cyclin O; Belongs to the cyclin family. (514 aa) |
| | G1SQJ4_RABIT | Uncharacterized protein; Belongs to the cytochrome P450 family. (458 aa) |
| | CMBL | Carboxymethylenebutenolidase homolog. (245 aa) |
| | HMGCS2 | 3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase. (534 aa) |
| | LOC100351599 | Uncharacterized protein; Belongs to the cytochrome P450 family. (491 aa) |
| | GNPAT | Dihydroxyacetone phosphate acyltransferase. (679 aa) |
| | CREB1 | cAMP responsive element binding protein 1. (341 aa) |
| | NCEH1 | Neutral cholesterol ester hydrolase 1. (439 aa) |
| | ABCG5 | ATP binding cassette subfamily G member 5. (633 aa) |
| | TGFB2 | Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa) |
| | RAD54L | RAD54 like. (747 aa) |
| | FMO2 | Dimethylaniline monooxygenase [N-oxide-forming] 2; This protein is involved in the oxidative metabolism of a variety of xenobiotics such as drugs and pesticides. (535 aa) |
| | PNP | Purine nucleoside phosphorylase; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. (289 aa) |
| | PRKAA2 | Non-specific serine/threonine protein kinase. (537 aa) |
| | ABCD3 | ATP binding cassette subfamily D member 3. (658 aa) |
| | GIP | Gastric inhibitory polypeptide. (153 aa) |
| | SULT1C3 | Sulfotransferase; Belongs to the sulfotransferase 1 family. (300 aa) |
| | NKX3-1 | NK3 homeobox 1. (159 aa) |
| | PCNA | Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (261 aa) |
| | TPMT | Thiopurine S-methyltransferase. (245 aa) |
| | THBS1 | Thrombospondin 1. (1171 aa) |
| | FMO3 | Dimethylaniline monooxygenase [N-oxide-forming] 3; Essential hepatic enzyme that catalyzes the oxygenation of a wide variety of nitrogen- and sulfur-containing compounds including drugs as well as dietary compounds. Plays an important role in the metabolism of trimethylamine (TMA), via the production of trimethylamine N-oxide (TMAO) metabolite. TMA is generated by the action of gut microbiota using dietary precursors such as choline, choline containing compounds, betaine or L-carnitine. By regulating TMAO concentration, FMO3 directly impacts both platelet responsiveness and rate of thr [...] (531 aa) |
| | LYN | Tyrosine-protein kinase. (636 aa) |
| | CRYZ | Crystallin zeta. (329 aa) |
| | PTCH1 | Patched 1. (1321 aa) |
| | DUSP6 | Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (381 aa) |
| | CDK1 | Cyclin dependent kinase 1; Belongs to the protein kinase superfamily. (297 aa) |
| | TERF1 | Telomeric repeat-binding factor; Binds the telomeric double-stranded 5'-TTAGGG-3' repeat. (435 aa) |
| | ACAA1 | Acetyl-CoA acyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family. (396 aa) |
| | VKORC1 | Vitamin K epoxide reductase complex subunit 1. (162 aa) |
| | CYP2U1 | Cytochrome P450 family 2 subfamily U member 1; Belongs to the cytochrome P450 family. (548 aa) |
| | GSTP1 | Uncharacterized protein. (436 aa) |
| | GATA4 | GATA binding protein 4. (444 aa) |
| | PRNP | Major prion protein; Its primary physiological function is unclear. Has cytoprotective activity against internal or environmental stresses. May play a role in neuronal development and synaptic plasticity. May be required for neuronal myelin sheath maintenance. May play a role in iron uptake and iron homeostasis. Soluble oligomers are toxic to cultured neuroblastoma cells and induce apoptosis (in vitro). Association with GPC1 (via its heparan sulfate chains) targets PRNP to lipid rafts. Also provides Cu(2+) or ZN(2+) for the ascorbate-mediated GPC1 deaminase degradation of its heparan s [...] (252 aa) |
| | TIGAR | TP53 induced glycolysis regulatory phosphatase. (265 aa) |
| | NOS2 | Nitric oxide synthase, inducible; Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. In macrophages, NO mediates tumoricidal and bactericidal actions. Also has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such PTGS2/COX2. As component of the iNOS-S100A8/9 transnitrosylase complex involved in the selective inflammatory stimulus-dependent S- nitrosylation of GAPDH implicated in regulation of the GAIT complex activity and probably multiple targets including ANXA5, EZR, MSN and VIM. Involved in i [...] (1146 aa) |
| | ATR | ATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family. (2643 aa) |
| | REST | RE1 silencing transcription factor. (930 aa) |
| | PAX4 | Paired box 4. (350 aa) |
| | PAM | Peptidylglycine alpha-amidating monooxygenase. (975 aa) |
| | GNA12 | G protein subunit alpha 12. (457 aa) |
| | PDE4A | Phosphodiesterase. (700 aa) |
| | ABCB11 | Bile salt export pump; Catalyzes the secretion of conjugated bile salts across the canalicular membrane of hepatocytes in an ATP-dependent manner. Transports taurine-conjugated bile salts more rapidly than glycine- conjugated bile salts. (1325 aa) |
| | SRD5A2 | 3-oxo-5-alpha-steroid 4-dehydrogenase; Converts testosterone into 5-alpha-dihydrotestosterone and progesterone or corticosterone into their corresponding 5-alpha-3- oxosteroids. It plays a central role in sexual differentiation and androgen physiology. (254 aa) |
| | TP53 | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...] (391 aa) |
| | N6AMT1 | N-6 adenine-specific DNA methyltransferase 1. (214 aa) |
| | PPM1F | Protein phosphatase, Mg2+/Mn2+ dependent 1F. (446 aa) |
| | PRKAA1 | Non-specific serine/threonine protein kinase. (656 aa) |
| | CRKL | CRK like proto-oncogene, adaptor protein. (303 aa) |
| | SLC1A2 | Amino acid transporter. (579 aa) |
| | AS3MT | Arsenite methyltransferase. (375 aa) |
| | INHBA | Inhibin subunit beta A. (424 aa) |
| | LOC100353031 | Dimethylaniline monooxygenase [N-oxide-forming]. (543 aa) |
| | MCM7 | DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (719 aa) |
| | CYP26A1 | Cytochrome P450 family 26 subfamily A member 1; Belongs to the cytochrome P450 family. (497 aa) |
