STRINGSTRING
EGF EGF GCG GCG TNKS1BP1 TNKS1BP1 BMP7 BMP7 GSK3A GSK3A CEMIP CEMIP SPHK1 SPHK1 LOC103345451 LOC103345451 ENSOCUP00000035983 ENSOCUP00000035983 ENSOCUP00000036387 ENSOCUP00000036387 ENSOCUP00000037329 ENSOCUP00000037329 S1PR2 S1PR2 ENSOCUP00000039970 ENSOCUP00000039970 ENSOCUP00000041840 ENSOCUP00000041840 ENSOCUP00000043082 ENSOCUP00000043082 ENSOCUP00000044284 ENSOCUP00000044284 ENSOCUP00000045925 ENSOCUP00000045925 WNT5A WNT5A RIPK2 RIPK2 STOX1 STOX1 UBE2K UBE2K PRKAG2 PRKAG2 PLK1 PLK1 G1SV95_RABIT G1SV95_RABIT APP APP CAB39 CAB39 WNK3 WNK3 CHI3L1 CHI3L1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
EGFPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1198 aa)
GCGGlucagon; Glucagon plays a key role in glucose metabolism and homeostasis. Regulates blood glucose by increasing gluconeogenesis and decreasing glycolysis (By similarity). (180 aa)
TNKS1BP1Tankyrase 1 binding protein 1. (1669 aa)
BMP7TGF_BETA_2 domain-containing protein. (170 aa)
GSK3AProtein kinase domain-containing protein; Belongs to the protein kinase superfamily. (401 aa)
CEMIPCell migration inducing hyaluronidase 1. (1420 aa)
SPHK1Sphingosine kinase 1. (455 aa)
LOC103345451TGFb_propeptide domain-containing protein. (203 aa)
ENSOCUP00000035983Uncharacterized protein. (108 aa)
ENSOCUP00000036387DIX domain-containing protein. (575 aa)
ENSOCUP00000037329TGFb_propeptide domain-containing protein. (263 aa)
S1PR2G_PROTEIN_RECEP_F1_2 domain-containing protein. (353 aa)
ENSOCUP00000039970Raptor_N domain-containing protein. (253 aa)
ENSOCUP00000041840TGFb_propeptide domain-containing protein. (219 aa)
ENSOCUP00000043082Uncharacterized protein. (319 aa)
ENSOCUP00000044284TGFb_propeptide domain-containing protein. (260 aa)
ENSOCUP00000045925TGFb_propeptide domain-containing protein. (272 aa)
WNT5AProtein Wnt-5a; Ligand for members of the frizzled family of seven transmembrane receptors. Can activate or inhibit canonical Wnt signaling, depending on receptor context. In the presence of FZD4, activates beta-catenin signaling. In the presence of ROR2, inhibits the canonical Wnt pathway by promoting beta-catenin degradation through a GSK3-independent pathway which involves down-regulation of beta- catenin-induced reporter gene expression (By similarity). Suppression of the canonical pathway allows chondrogenesis to occur. Inhibits tumor formation. Stimulates cell migration. Decrease [...] (380 aa)
RIPK2Receptor-interacting serine/threonine-protein kinase 2; Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. (538 aa)
STOX1Storkhead box 1. (977 aa)
UBE2KUbiquitin conjugating enzyme E2 K; Belongs to the ubiquitin-conjugating enzyme family. (200 aa)
PRKAG2Protein kinase AMP-activated non-catalytic subunit gamma 2. (543 aa)
PLK1Serine/threonine-protein kinase PLK. (604 aa)
G1SV95_RABITTransforming growth factor beta; Belongs to the TGF-beta family. (387 aa)
APPGamma-secretase C-terminal fragment 57; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those medi [...] (769 aa)
CAB39Calcium binding protein 39. (385 aa)
WNK3WNK lysine deficient protein kinase 3. (1793 aa)
CHI3L1Chitinase 3 like 1; Belongs to the glycosyl hydrolase 18 family. (383 aa)
Your Current Organism:
Oryctolagus cuniculus
NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits
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