node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
APP | EGF | ENSOCUP00000009130 | ENSOCUP00000014095 | Gamma-secretase C-terminal fragment 57; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those medi [...] | Pro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. | 0.572 |
APP | ENSOCUP00000037329 | ENSOCUP00000009130 | ENSOCUP00000037329 | Gamma-secretase C-terminal fragment 57; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those medi [...] | TGFb_propeptide domain-containing protein. | 0.407 |
APP | ENSOCUP00000044284 | ENSOCUP00000009130 | ENSOCUP00000044284 | Gamma-secretase C-terminal fragment 57; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those medi [...] | TGFb_propeptide domain-containing protein. | 0.407 |
APP | GSK3A | ENSOCUP00000009130 | ENSOCUP00000022877 | Gamma-secretase C-terminal fragment 57; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those medi [...] | Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. | 0.603 |
APP | LOC103345451 | ENSOCUP00000009130 | ENSOCUP00000031740 | Gamma-secretase C-terminal fragment 57; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those medi [...] | TGFb_propeptide domain-containing protein. | 0.407 |
BMP7 | EGF | ENSOCUP00000022037 | ENSOCUP00000014095 | TGF_BETA_2 domain-containing protein. | Pro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. | 0.567 |
BMP7 | ENSOCUP00000037329 | ENSOCUP00000022037 | ENSOCUP00000037329 | TGF_BETA_2 domain-containing protein. | TGFb_propeptide domain-containing protein. | 0.566 |
BMP7 | ENSOCUP00000044284 | ENSOCUP00000022037 | ENSOCUP00000044284 | TGF_BETA_2 domain-containing protein. | TGFb_propeptide domain-containing protein. | 0.566 |
BMP7 | LOC103345451 | ENSOCUP00000022037 | ENSOCUP00000031740 | TGF_BETA_2 domain-containing protein. | TGFb_propeptide domain-containing protein. | 0.566 |
BMP7 | WNT5A | ENSOCUP00000022037 | ENSOCUP00000000333 | TGF_BETA_2 domain-containing protein. | Protein Wnt-5a; Ligand for members of the frizzled family of seven transmembrane receptors. Can activate or inhibit canonical Wnt signaling, depending on receptor context. In the presence of FZD4, activates beta-catenin signaling. In the presence of ROR2, inhibits the canonical Wnt pathway by promoting beta-catenin degradation through a GSK3-independent pathway which involves down-regulation of beta- catenin-induced reporter gene expression (By similarity). Suppression of the canonical pathway allows chondrogenesis to occur. Inhibits tumor formation. Stimulates cell migration. Decrease [...] | 0.593 |
CAB39 | PRKAG2 | ENSOCUP00000009771 | ENSOCUP00000005586 | Calcium binding protein 39. | Protein kinase AMP-activated non-catalytic subunit gamma 2. | 0.815 |
EGF | APP | ENSOCUP00000014095 | ENSOCUP00000009130 | Pro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. | Gamma-secretase C-terminal fragment 57; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those medi [...] | 0.572 |
EGF | BMP7 | ENSOCUP00000014095 | ENSOCUP00000022037 | Pro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. | TGF_BETA_2 domain-containing protein. | 0.567 |
EGF | ENSOCUP00000037329 | ENSOCUP00000014095 | ENSOCUP00000037329 | Pro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. | TGFb_propeptide domain-containing protein. | 0.826 |
EGF | ENSOCUP00000044284 | ENSOCUP00000014095 | ENSOCUP00000044284 | Pro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. | TGFb_propeptide domain-containing protein. | 0.826 |
EGF | GCG | ENSOCUP00000014095 | ENSOCUP00000019727 | Pro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. | Glucagon; Glucagon plays a key role in glucose metabolism and homeostasis. Regulates blood glucose by increasing gluconeogenesis and decreasing glycolysis (By similarity). | 0.469 |
EGF | GSK3A | ENSOCUP00000014095 | ENSOCUP00000022877 | Pro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. | Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. | 0.469 |
EGF | LOC103345451 | ENSOCUP00000014095 | ENSOCUP00000031740 | Pro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. | TGFb_propeptide domain-containing protein. | 0.826 |
EGF | WNT5A | ENSOCUP00000014095 | ENSOCUP00000000333 | Pro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. | Protein Wnt-5a; Ligand for members of the frizzled family of seven transmembrane receptors. Can activate or inhibit canonical Wnt signaling, depending on receptor context. In the presence of FZD4, activates beta-catenin signaling. In the presence of ROR2, inhibits the canonical Wnt pathway by promoting beta-catenin degradation through a GSK3-independent pathway which involves down-regulation of beta- catenin-induced reporter gene expression (By similarity). Suppression of the canonical pathway allows chondrogenesis to occur. Inhibits tumor formation. Stimulates cell migration. Decrease [...] | 0.621 |
ENSOCUP00000036387 | GSK3A | ENSOCUP00000036387 | ENSOCUP00000022877 | DIX domain-containing protein. | Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. | 0.964 |