STRINGSTRING
CD109 CD109 IL9 IL9 RFFL RFFL SERPINA5 SERPINA5 TIMP2 TIMP2 A2M A2M ARL6IP1 ARL6IP1 C5 C5 LAMP3 LAMP3 DHCR24 DHCR24 SERPINB9 SERPINB9 G1SN67_RABIT G1SN67_RABIT SERPINB13 SERPINB13 ITIH6 ITIH6 SERPINE2 SERPINE2 PIH1D1 PIH1D1 THBS1 THBS1 SPOCK3 SPOCK3 BIRC7 BIRC7 SERPINC1 SERPINC1 LAMTOR5 LAMTOR5 PRNP PRNP CRIM1 CRIM1 WFDC9 WFDC9 FETUB FETUB AGT AGT WFIKKN2 WFIKKN2 SERPINF1 SERPINF1 SERPINF2 SERPINF2 SERPING1 SERPING1 ENSOCUP00000049392 ENSOCUP00000049392 ITIH2 ITIH2 PSMF1 PSMF1 G1SDV6_RABIT G1SDV6_RABIT ITIH3 ITIH3 ANOS1 ANOS1 TNFSF14 TNFSF14 AVP AVP ENSOCUP00000045505 ENSOCUP00000045505 SERPINB6 SERPINB6 FAM124A FAM124A ENSOCUP00000043881 ENSOCUP00000043881 WFDC2 WFDC2 FABP1 FABP1 ENSOCUP00000043061 ENSOCUP00000043061 PLAUR PLAUR SPINT2 SPINT2 DNAJA3 DNAJA3 SPINK7 SPINK7 DPEP1 DPEP1 WFDC3 WFDC3 SERPINA4 SERPINA4 ENSOCUP00000040784 ENSOCUP00000040784 RPS6KA1 RPS6KA1 LOC100008810 LOC100008810 POR POR SERPINA7 SERPINA7 LOC100346690 LOC100346690 MICAL1 MICAL1 PARK7 PARK7 GHRHR GHRHR RPS6KA3 RPS6KA3 TNFAIP8 TNFAIP8 ENSOCUP00000037812 ENSOCUP00000037812 MAP2K5 MAP2K5 LOC100358221 LOC100358221 RECK RECK LOC100353846 LOC100353846 ENSOCUP00000036340 ENSOCUP00000036340 ENSOCUP00000036017 ENSOCUP00000036017 ENSOCUP00000035577 ENSOCUP00000035577 LOC100348825 LOC100348825 BIRC5 BIRC5 KNG1 KNG1 ENSOCUP00000032248 ENSOCUP00000032248 RNF34 RNF34 ENSOCUP00000031431 ENSOCUP00000031431 ENSOCUP00000031395 ENSOCUP00000031395 ENSOCUP00000030661 ENSOCUP00000030661 CST3 CST3 SERPINE3 SERPINE3 SPOCK1 SPOCK1 FURIN FURIN UBE2Z UBE2Z ENSOCUP00000028861 ENSOCUP00000028861 APLP2 APLP2 XIAP XIAP SPINK1 SPINK1 USP47 USP47 LOC100352842 LOC100352842 PRDX3 PRDX3 ENSOCUP00000027220 ENSOCUP00000027220 U3KNW9_RABIT U3KNW9_RABIT LOC103348521 LOC103348521 LOC103348242 LOC103348242 AHSG AHSG U3KMJ3_RABIT U3KMJ3_RABIT SPINK9 SPINK9 RARRES1 RARRES1 G1U9F5_RABIT G1U9F5_RABIT CSTA CSTA CST8 CST8 G1U822_RABIT G1U822_RABIT SERPINB12 SERPINB12 CSTL1 CSTL1 WFDC10A WFDC10A HRG HRG MMP9 MMP9 VTN VTN UBE2O UBE2O G1U377_RABIT G1U377_RABIT RENBP RENBP SH3RF1 SH3RF1 COL28A1 COL28A1 LOC100350897 LOC100350897 G1TYY7_RABIT G1TYY7_RABIT LXN LXN ITIH4 ITIH4 NGF NGF SERPINH1 SERPINH1 SPINK13 SPINK13 SIAH2 SIAH2 RAG1 RAG1 VIL1 VIL1 CDKN2D CDKN2D CST7 CST7 CSNK2A1 CSNK2A1 LOC100344662 LOC100344662 FNIP1 FNIP1 G1TMP2_RABIT G1TMP2_RABIT CSTB CSTB SERPINA3 SERPINA3 G1TLX8_RABIT G1TLX8_RABIT WFDC5 WFDC5 WFDC11 WFDC11 SERPINA1 SERPINA1 G1TG34_RABIT G1TG34_RABIT LTF LTF P15A_RABIT P15A_RABIT SERPINI1 SERPINI1 SERPINA12 SERPINA12 ITIH5 ITIH5 SERPINB5 SERPINB5 PTGS2 PTGS2 UCHL5 UCHL5 SFRP2 SFRP2 SERPINA6 SERPINA6 SERPINE1 SERPINE1 TIMP4 TIMP4 CAAP1 CAAP1 SPINT1 SPINT1 LOC100356501 LOC100356501 BIN1 BIN1 SERPINB2 SERPINB2 SERPINB7 SERPINB7 NLE1 NLE1 WFDC8 WFDC8 LOC100353214 LOC100353214 A2ML1 A2ML1 BIRC2 BIRC2 CRYAB CRYAB PAX2 PAX2 SPINT4 SPINT4 FAM124B FAM124B NR4A1 NR4A1 IGBP1 IGBP1 SORL1 SORL1 ITIH1 ITIH1 TIMP1 TIMP1 PAPLN PAPLN BCL2L12 BCL2L12 SERPINA9 SERPINA9 APP APP LOC100339150 LOC100339150 BIRC3 BIRC3 LOC100346672 LOC100346672 NOL3 NOL3 TRIAP1 TRIAP1 SERPINI2 SERPINI2 PCID2 PCID2 CSN2 CSN2 SERPINB11 SERPINB11 SERPIND1 SERPIND1 PCSK1N PCSK1N SPINK4 SPINK4 SPINK6 SPINK6 SPINK14 SPINK14 SPINK5 SPINK5 ADORA2A ADORA2A WFDC13 WFDC13 PEBP1 PEBP1 TIMP3 TIMP3 TFPI TFPI PAK2 PAK2 CD27 CD27 CAST CAST SERPINB10 SERPINB10 C4A C4A SERPINB8 SERPINB8 TNF TNF BIRC6 BIRC6
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CD109CD109 molecule. (1318 aa)
IL9Interleukin 9. (143 aa)
RFFLRing finger and FYVE like domain containing E3 ubiquitin protein ligase. (361 aa)
SERPINA5SERPIN domain-containing protein; Belongs to the serpin family. (572 aa)
TIMP2Metalloproteinase inhibitor 2; Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor; Belongs to the protease inhibitor I35 (TIMP) family. (1218 aa)
A2MAlpha-2-macroglobulin. (1467 aa)
ARL6IP1ADP ribosylation factor like GTPase 6 interacting protein 1. (203 aa)
C5Complement C5. (1678 aa)
LAMP3Uncharacterized protein. (427 aa)
DHCR2424-dehydrocholesterol reductase. (516 aa)
SERPINB9Serpin family B member 9; Belongs to the serpin family. (376 aa)
G1SN67_RABITSERPIN domain-containing protein; Belongs to the serpin family. (190 aa)
SERPINB13SERPIN domain-containing protein; Belongs to the serpin family. (404 aa)
ITIH6Inter-alpha-trypsin inhibitor heavy chain family member 6. (1320 aa)
SERPINE2Serpin family E member 2; Belongs to the serpin family. (409 aa)
PIH1D1PIH1 domain containing 1. (291 aa)
THBS1Thrombospondin 1. (1171 aa)
SPOCK3SPARC (osteonectin), cwcv and kazal like domains proteoglycan 3. (344 aa)
BIRC7Baculoviral IAP repeat containing 7. (278 aa)
SERPINC1Serpin family C member 1; Belongs to the serpin family. (465 aa)
LAMTOR5Late endosomal/lysosomal adaptor, MAPK and MTOR activator 5. (91 aa)
PRNPMajor prion protein; Its primary physiological function is unclear. Has cytoprotective activity against internal or environmental stresses. May play a role in neuronal development and synaptic plasticity. May be required for neuronal myelin sheath maintenance. May play a role in iron uptake and iron homeostasis. Soluble oligomers are toxic to cultured neuroblastoma cells and induce apoptosis (in vitro). Association with GPC1 (via its heparan sulfate chains) targets PRNP to lipid rafts. Also provides Cu(2+) or ZN(2+) for the ascorbate-mediated GPC1 deaminase degradation of its heparan s [...] (252 aa)
CRIM1Cysteine rich transmembrane BMP regulator 1. (984 aa)
WFDC9WAP four-disulfide core domain 9. (93 aa)
FETUBFetuin B. (417 aa)
AGTAngiotensinogen; Belongs to the serpin family. (477 aa)
WFIKKN2WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2. (571 aa)
SERPINF1Serpin family F member 1; Belongs to the serpin family. (418 aa)
SERPINF2SERPIN domain-containing protein; Belongs to the serpin family. (533 aa)
SERPING1Plasma protease C1 inhibitor; Belongs to the serpin family. (521 aa)
ENSOCUP00000049392Uncharacterized protein. (134 aa)
ITIH2Uncharacterized protein. (1030 aa)
PSMF1Proteasome inhibitor subunit 1. (271 aa)
G1SDV6_RABITUncharacterized protein. (367 aa)
ITIH3Inter-alpha-trypsin inhibitor heavy chain H3; May act as a carrier of hyaluronan in serum or as a binding protein between hyaluronan and other matrix protein, including those on cell surfaces in tissues to regulate the localization, synthesis and degradation of hyaluronan which are essential to cells undergoing biological processes; Belongs to the ITIH family. (880 aa)
ANOS1Uncharacterized protein. (342 aa)
TNFSF14TNF superfamily member 14. (241 aa)
AVPUncharacterized protein. (285 aa)
ENSOCUP00000045505Uncharacterized protein. (1102 aa)
SERPINB6SERPIN domain-containing protein; Belongs to the serpin family. (606 aa)
FAM124AFamily with sequence similarity 124 member A. (808 aa)
ENSOCUP00000043881WAP domain-containing protein. (92 aa)
WFDC2WAP four-disulfide core domain protein 2; Broad range protease inhibitor. (140 aa)
FABP1FABP domain-containing protein. (194 aa)
ENSOCUP00000043061Uncharacterized protein. (103 aa)
PLAURPlasminogen activator, urokinase receptor. (365 aa)
SPINT2Serine peptidase inhibitor, Kunitz type 2. (252 aa)
DNAJA3Uncharacterized protein. (479 aa)
SPINK7Serine peptidase inhibitor, Kazal type 7 (putative). (88 aa)
DPEP1Dipeptidase 1; Hydrolyzes a wide range of dipeptides. Implicated in the renal metabolism of glutathione and its conjugates. Converts leukotriene D4 to leukotriene E4; it may play an important role in the regulation of leukotriene activity; Belongs to the metallo-dependent hydrolases superfamily. Peptidase M19 family. (524 aa)
WFDC3Uncharacterized protein. (125 aa)
SERPINA4SERPIN domain-containing protein; Belongs to the serpin family. (384 aa)
ENSOCUP00000040784Uncharacterized protein. (227 aa)
RPS6KA1Ribosomal protein S6 kinase. (813 aa)
LOC100008810Uncharacterized protein. (154 aa)
PORNADPH--cytochrome P450 reductase; This enzyme is required for electron transfer from NADP to cytochrome P450 in microsomes. It can also provide electron transfer to heme oxygenase and cytochrome B5; In the N-terminal section; belongs to the flavodoxin family. (439 aa)
SERPINA7Serpin family A member 7; Belongs to the serpin family. (466 aa)
LOC100346690SERPIN domain-containing protein; Belongs to the serpin family. (422 aa)
MICAL1Microtubule associated monooxygenase, calponin and LIM domain containing 1. (1084 aa)
PARK7Parkinsonism associated deglycase. (231 aa)
GHRHRUncharacterized protein; Belongs to the MIP/aquaporin (TC 1.A.8) family. (524 aa)
RPS6KA3Ribosomal protein S6 kinase. (751 aa)
TNFAIP8Uncharacterized protein. (447 aa)
ENSOCUP00000037812Uncharacterized protein. (1162 aa)
MAP2K5Mitogen-activated protein kinase kinase 5. (551 aa)
LOC100358221SERPIN domain-containing protein; Belongs to the serpin family. (419 aa)
RECKUncharacterized protein. (993 aa)
LOC100353846Uncharacterized protein. (1391 aa)
ENSOCUP00000036340EGF-like domain-containing protein. (81 aa)
ENSOCUP00000036017Uncharacterized protein. (176 aa)
ENSOCUP00000035577Uncharacterized protein. (517 aa)
LOC100348825Uncharacterized protein. (1436 aa)
BIRC5Uncharacterized protein. (164 aa)
KNG1Kininogen 1. (633 aa)
ENSOCUP00000032248Cystatin domain-containing protein. (152 aa)
RNF34Ring finger protein 34. (454 aa)
ENSOCUP00000031431SERPIN domain-containing protein; Belongs to the serpin family. (120 aa)
ENSOCUP00000031395Uncharacterized protein; Belongs to the serpin family. (216 aa)
ENSOCUP00000030661Thioredoxin domain-containing protein. (183 aa)
CST3Cystatin-C; This is a thiol proteinase inhibitor; Belongs to the cystatin family. (420 aa)
SERPINE3Serpin family E member 3; Belongs to the serpin family. (435 aa)
SPOCK1SPARC (osteonectin), cwcv and kazal like domains proteoglycan 1. (466 aa)
FURINFurin, paired basic amino acid cleaving enzyme; Belongs to the peptidase S8 family. (666 aa)
UBE2ZUbiquitin conjugating enzyme E2 Z. (291 aa)
ENSOCUP00000028861SERPIN domain-containing protein; Belongs to the serpin family. (321 aa)
APLP2Amyloid beta precursor like protein 2. (742 aa)
XIAPRING-type domain-containing protein. (633 aa)
SPINK1Serine peptidase inhibitor, Kazal type 1. (89 aa)
USP47Ubiquitin specific peptidase 47; Belongs to the peptidase C19 family. (1376 aa)
LOC100352842Uncharacterized protein. (1442 aa)
PRDX3Thioredoxin domain-containing protein. (307 aa)
ENSOCUP00000027220Anaphylatoxin-like domain-containing protein. (74 aa)
U3KNW9_RABITKazal-like domain-containing protein. (106 aa)
LOC103348521NTR domain-containing protein. (225 aa)
LOC103348242Uncharacterized protein. (146 aa)
AHSGAlpha-2-HS-glycoprotein; A cell adhesion protein that binds immature cells of the granulocyte lineage; Belongs to the fetuin family. (338 aa)
U3KMJ3_RABITSERPIN domain-containing protein; Belongs to the serpin family. (357 aa)
SPINK9Putative Kazal type 13 serine peptidase inhibitor. (85 aa)
RARRES1Retinoic acid receptor responder 1. (261 aa)
G1U9F5_RABITWAP domain-containing protein. (53 aa)
CSTACystatin A; Belongs to the cystatin family. (99 aa)
CST8Cystatin 8. (142 aa)
G1U822_RABITSERPIN domain-containing protein; Belongs to the serpin family. (480 aa)
SERPINB12SERPIN domain-containing protein; Belongs to the serpin family. (424 aa)
CSTL1Cystatin like 1. (144 aa)
WFDC10AWAP four-disulfide core domain 10A. (80 aa)
HRGHistidine-rich glycoprotein; Plasma glycoprotein that binds a number of ligands such as heme, heparin, heparan sulfate, thrombospondin, plasminogen, and divalent metal ions. Inhibits rosette formation. Acts as an adapter protein and implicated in regulating many processes such as immune complex and pathogen clearance, cell adhesion, angiogenesis, coagulation and fibrinolysis. Mediates clearance of necrotic cells through enhancing the phagocytosis of necrotic cells in a heparan sulfate-dependent pathway. This process can be regulated by the presence of certain HRG ligands such as hepari [...] (572 aa)
MMP9Matrix metalloproteinase-9; Could play a role in bone osteoclastic resorption. Cleaves type IV and type V collagen into large C-terminal three quarter fragments and shorter N-terminal one quarter fragments (By similarity). (707 aa)
VTNVitronectin; Vitronectin is a cell adhesion and spreading factor found in serum and tissues. Vitronectin interact with glycosaminoglycans and proteoglycans. Is recognized by certain members of the integrin family and serves as a cell-to-substrate adhesion molecule. Inhibitor of the membrane-damaging effect of the terminal cytolytic complement pathway. (475 aa)
UBE2OUbiquitin conjugating enzyme E2 O. (1446 aa)
G1U377_RABITCystatin domain-containing protein. (149 aa)
RENBPRenin binding protein. (428 aa)
SH3RF1SH3 domain containing ring finger 1. (896 aa)
COL28A1Collagen type XXVIII alpha 1 chain. (1146 aa)
LOC100350897Cystatin domain-containing protein. (141 aa)
G1TYY7_RABITCystatin domain-containing protein. (168 aa)
LXNLatexin. (222 aa)
ITIH4Uncharacterized protein. (905 aa)
NGFNerve growth factor. (157 aa)
SERPINH1SERPIN domain-containing protein; Belongs to the serpin family. (201 aa)
SPINK13Serine peptidase inhibitor, Kazal type 13 (putative). (94 aa)
SIAH2E3 ubiquitin-protein ligase; E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. (310 aa)
RAG1V(D)J recombination-activating protein 1; Catalytic component of the RAG complex, a multiprotein complex that mediates the DNA cleavage phase during V(D)J recombination. V(D)J recombination assembles a diverse repertoire of immunoglobulin and T-cell receptor genes in developing B and T- lymphocytes through rearrangement of different V (variable), in some cases D (diversity), and J (joining) gene segments. In the RAG complex, RAG1 mediates the DNA-binding to the conserved recombination signal sequences (RSS) and catalyzes the DNA cleavage activities by introducing a double-strand break [...] (1128 aa)
VIL1Villin 1. (813 aa)
CDKN2DANK_REP_REGION domain-containing protein. (310 aa)
CST7Cystatin F. (164 aa)
CSNK2A1Casein kinase II subunit alpha; Catalytic subunit of a constitutively active serine/threonine-protein kinase complex that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine. Regulates numerous cellular processes, such as cell cycle progression, apoptosis and transcription, as well as viral infection. May act as a regulatory node which integrates and coordinates numerous signals leading to an appropriate cellular response. During mitosis, functions as a component of the p53/TP53-dependent spindle assembly checkpoin [...] (391 aa)
LOC100344662Uncharacterized protein. (469 aa)
FNIP1Folliculin interacting protein 1. (1166 aa)
G1TMP2_RABITCystatin domain-containing protein. (145 aa)
CSTBCystatin B; Belongs to the cystatin family. (77 aa)
SERPINA3Serpin family A member 3; Belongs to the serpin family. (419 aa)
G1TLX8_RABITRING-type domain-containing protein. (248 aa)
WFDC5WAP four-disulfide core domain 5. (122 aa)
WFDC11WAP four-disulfide core domain 11. (86 aa)
SERPINA1Alpha-1-antiproteinase F; Inhibitor of serine proteases. The primary target is elastase, but also has a moderate affinity for plasmin and thrombin; Belongs to the serpin family. (458 aa)
G1TG34_RABITWAP domain-containing protein. (75 aa)
LTFLactotransferrin; Belongs to the transferrin family. (708 aa)
P15A_RABIT15 kDa protein A; Binds to bacterial lipopolysaccharides (LPS), potentiates strongly the early antibacterial effects of BPI. Inhibits the late lethal action of BPI. (137 aa)
SERPINI1Serpin family I member 1; Belongs to the serpin family. (493 aa)
SERPINA12Serpin family A member 12; Belongs to the serpin family. (422 aa)
ITIH5Inter-alpha-trypsin inhibitor heavy chain 5. (940 aa)
SERPINB5Serpin family B member 5; Belongs to the serpin family. (375 aa)
PTGS2Prostaglandin G/H synthase 2; Converts arachidonate to prostaglandin H2 (PGH2), a committed step in prostanoid synthesis. Constitutively expressed in some tissues in physiological conditions, such as the endothelium, kidney and brain, and in pathological conditions, such as in cancer. PTGS2 is responsible for production of inflammatory prostaglandins. Up-regulation of PTGS2 is also associated with increased cell adhesion, phenotypic changes, resistance to apoptosis and tumor angiogenesis. In cancer cells, PTGS2 is a key step in the production of prostaglandin E2 (PGE2), which plays imp [...] (604 aa)
UCHL5Ubiquitin carboxyl-terminal hydrolase. (609 aa)
SFRP2Secreted frizzled related protein 2. (295 aa)
SERPINA6Corticosteroid-binding globulin; Major transport protein for glucocorticoids and progestins in the blood of almost all vertebrate species; Belongs to the serpin family. (451 aa)
SERPINE1Serpin family E member 1; Belongs to the serpin family. (362 aa)
TIMP4Metalloproteinase inhibitor 4; Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor; Belongs to the protease inhibitor I35 (TIMP) family. (224 aa)
CAAP1Caspase activity and apoptosis inhibitor 1. (356 aa)
SPINT1Serine peptidase inhibitor, Kunitz type 1. (506 aa)
LOC100356501Kazal-like domain-containing protein. (84 aa)
BIN1Bridging integrator 1. (554 aa)
SERPINB2Serine proteinase inhibitor, clade B, member 2 (Predicted); Belongs to the serpin family. (417 aa)
SERPINB7Serine proteinase inhibitor, clade B, member 7 (Predicted); Belongs to the serpin family. (380 aa)
NLE1Notchless homolog 1. (485 aa)
WFDC8WAP four-disulfide core domain 8. (242 aa)
LOC100353214Uncharacterized protein. (173 aa)
A2ML1Alpha-2-macroglobulin like 1. (1451 aa)
BIRC2Baculoviral IAP repeat containing 2. (601 aa)
CRYABAlpha-crystallin B chain; May contribute to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions; Belongs to the small heat shock protein (HSP20) family. (175 aa)
PAX2Paired box 2. (448 aa)
SPINT4Serine peptidase inhibitor, Kunitz type 4. (101 aa)
FAM124BFamily with sequence similarity 124 member B. (460 aa)
NR4A1Nuclear receptor subfamily 4 group A member 1. (784 aa)
IGBP1Uncharacterized protein. (339 aa)
SORL1Sortilin-related receptor; Sorting receptor that directs several proteins to their correct location within the cell. Along with AP-1 complex, involved Golgi apparatus - endosome sorting. Sorting receptor for APP, regulating its intracellular trafficking and processing into amyloidogenic-beta peptides. Retains APP in the trans-Golgi network, hence preventing its transit through late endosomes where amyloid beta peptides Abeta40 and Abeta42 are generated. May also sort newly produced amyloid-beta peptides to lysosomes for catabolism. Does not affect APP trafficking from the endoplasmic r [...] (2213 aa)
ITIH1Uncharacterized protein. (910 aa)
TIMP1Metalloproteinase inhibitor 1; Metalloproteinase inhibitor that functions by forming one to one complexes with target metalloproteinases, such as collagenases, and irreversibly inactivates them by binding to their catalytic zinc cofactor. Acts on MMP1, MMP2, MMP3, MMP7, MMP8, MMP9, MMP10, MMP11, MMP12, MMP13 and MMP16. Does not act on MMP14. Also functions as a growth factor that regulates cell differentiation, migration and cell death and activates cellular signaling cascades via CD63 and ITGB1. Plays a role in integrin signaling (By similarity). (256 aa)
PAPLNPapilin, proteoglycan like sulfated glycoprotein. (1205 aa)
BCL2L12BCL2 like 12. (267 aa)
SERPINA9Serpin family A member 9; Belongs to the serpin family. (472 aa)
APPGamma-secretase C-terminal fragment 57; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those medi [...] (769 aa)
LOC100339150SERPIN domain-containing protein; Belongs to the serpin family. (390 aa)
BIRC3Baculoviral IAP repeat containing 3. (591 aa)
LOC100346672Uncharacterized protein. (1673 aa)
NOL3Nucleolar protein 3. (212 aa)
TRIAP1TP53 regulated inhibitor of apoptosis 1. (76 aa)
SERPINI2Serpin family I member 2; Belongs to the serpin family. (405 aa)
PCID2PCI domain containing 2. (486 aa)
CSN2Beta-casein; Important role in determination of the surface properties of the casein micelles. (228 aa)
SERPINB11SERPIN domain-containing protein; Belongs to the serpin family. (408 aa)
SERPIND1Heparin cofactor 2; Thrombin inhibitor activated by the glycosaminoglycans, heparin or dermatan sulfate. In the presence of the latter, HC-II becomes the predominant thrombin inhibitor in place of antithrombin III (AT). (480 aa)
PCSK1NProprotein convertase subtilisin/kexin type 1 inhibitor. (260 aa)
SPINK4Serine peptidase inhibitor, Kazal type 4. (86 aa)
SPINK6Serine peptidase inhibitor, Kazal type 6. (80 aa)
SPINK14Serine peptidase inhibitor, Kazal type 14 (putative). (96 aa)
SPINK5Serine peptidase inhibitor, Kazal type 5. (1087 aa)
ADORA2AAdenosine receptor A2; Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family. (409 aa)
WFDC13WAP four-disulfide core domain 13. (93 aa)
PEBP1Hippocampal cholinergic neurostimulating peptide; Binds ATP, opioids and phosphatidylethanolamine. Has lower affinity for phosphatidylinositol and phosphatidylcholine. Serine protease inhibitor which inhibits thrombin, neuropsin and chymotrypsin but not trypsin, tissue type plasminogen activator and elastase (By similarity). Inhibits the kinase activity of RAF1 by inhibiting its activation and by dissociating the RAF1/MEK complex and acting as a competitive inhibitor of MEK phosphorylation (By similarity). Belongs to the phosphatidylethanolamine-binding protein family. (187 aa)
TIMP3Metalloproteinase inhibitor 3; Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. May form part of a tissue-specific acute response to remodeling stimuli (By similarity). (211 aa)
TFPITissue factor pathway inhibitor; Inhibits factor X (X(a)) directly and, in a Xa-dependent way, inhibits VIIa/tissue factor activity, presumably by forming a quaternary Xa/LACI/VIIa/TF complex. It possesses an antithrombotic action and also the ability to associate with lipoproteins in plasma. (300 aa)
PAK2Serine/threonine-protein kinase PAK 2; Serine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell motility, cell cycle progression, apoptosis or proliferation. Acts as downstream effector of the small GTPases CDC42 and RAC1. Activation by the binding of active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues. Full-length PAK2 stimulates cell survival and cell growth. Phosphorylates MAPK4 and MAPK6 and activates the downstream targ [...] (524 aa)
CD27CD27 molecule. (260 aa)
CASTErythrocyte calpastatin; Specific inhibition of calpain (calcium-dependent cysteine protease). Plays a key role in postmortem tenderization of meat and have been proposed to be involved in muscle protein degradation in living tissue. (823 aa)
SERPINB10SERPIN domain-containing protein; Belongs to the serpin family. (396 aa)
C4AUncharacterized protein. (1743 aa)
SERPINB8SERPIN domain-containing protein; Belongs to the serpin family. (374 aa)
TNFTumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (234 aa)
BIRC6Baculoviral IAP repeat containing 6. (4863 aa)
Your Current Organism:
Oryctolagus cuniculus
NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits
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