(45 nodes) Regulation of smooth muscle cell migration network (Oryctolagus cuniculus)

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second shell of interactors

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Your Input:
	NDRG4	NDRG family member 4. (387 aa)
	NFE2L2	Nuclear factor, erythroid 2 like 2. (677 aa)
	PDGFB	Platelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (272 aa)
	PPARD	Uncharacterized protein. (420 aa)
	ITGA2	Integrin subunit alpha 2; Belongs to the integrin alpha chain family. (1202 aa)
	SLIT2	Slit guidance ligand 2. (1542 aa)
	ITGB3	Integrin beta; Belongs to the integrin beta chain family. (873 aa)
	BCL2	BH4_2 domain-containing protein. (389 aa)
	S1PR2	G_PROTEIN_RECEP_F1_2 domain-containing protein. (353 aa)
	FOXO4	Forkhead box O4. (503 aa)
	MEF2C	Myocyte enhancer factor 2C. (483 aa)
	LPAR1	Lysophosphatidic acid receptor 1; Belongs to the G-protein coupled receptor 1 family. (391 aa)
	ABHD2	Abhydrolase domain containing 2. (425 aa)
	DOCK5	Dedicator of cytokinesis 5; Belongs to the DOCK family. (1853 aa)
	TPM1	Tropomyosin alpha-1 chain; Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments; Belongs to the tropomyosin family. (326 aa)
	ATP7A	ATPase copper transporting alpha. (1499 aa)
	SERPINE1	Serpin family E member 1; Belongs to the serpin family. (362 aa)
	CYP1B1	Cytochrome P450 family 1 subfamily B member 1; Belongs to the cytochrome P450 family. (542 aa)
	ADAMTS1	ADAM metallopeptidase with thrombospondin type 1 motif 1. (887 aa)
	CCN4	Cellular communication network factor 4. (337 aa)
	BMPR1A	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
	P2RY6	Pyrimidinergic receptor P2Y6. (350 aa)
	G1TLX8_RABIT	RING-type domain-containing protein. (248 aa)
	ADIPOQ	C1q domain-containing protein. (244 aa)
	IGF1	Insulin-like growth factor I; The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]- 2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse maturation. Ca(2+)-dependent exo [...] (195 aa)
	AIF1	Allograft inflammatory factor 1. (147 aa)
	HAS2	Uncharacterized protein. (556 aa)
	PLAU	Urokinase-type plasminogen activator short chain A; Specifically cleaves the zymogen plasminogen to form the active enzyme plasmin; Belongs to the peptidase S1 family. (433 aa)
	MYOCD	Myocardin. (989 aa)
	IGFBP5	Insulin like growth factor binding protein 5. (271 aa)
	VTN	Vitronectin; Vitronectin is a cell adhesion and spreading factor found in serum and tissues. Vitronectin interact with glycosaminoglycans and proteoglycans. Is recognized by certain members of the integrin family and serves as a cell-to-substrate adhesion molecule. Inhibitor of the membrane-damaging effect of the terminal cytolytic complement pathway. (475 aa)
	NR4A3	Nuclear receptor subfamily 4 group A member 3. (636 aa)
	TACR1	Tachykinin receptor 1; Belongs to the G-protein coupled receptor 1 family. (407 aa)
	GNA12	G protein subunit alpha 12. (457 aa)
	PDGFRB	Platelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. (1147 aa)
	TLR4	TIR domain-containing protein; Belongs to the Toll-like receptor family. (839 aa)
	IL18	Uncharacterized protein. (408 aa)
	PDGFA	Platelet-derived growth factor subunit A; Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen for cells of mesenchymal origin. Required for normal lung alveolar septum formation during embryogenesis, normal development of the gastrointestinal tract, normal development of Leydig cells and spermatogenesis. Required for normal oligodendrocyte development and normal myelination in the spinal cord and cerebellum. Plays an important role in wound healing. Signaling is modulated by t [...] (150 aa)
	GNA13	G protein subunit alpha 13. (377 aa)
	NF1	Neurofibromin 1. (2841 aa)
	DOCK4	Dedicator of cytokinesis 4; Belongs to the DOCK family. (1952 aa)
	SORL1	Sortilin-related receptor; Sorting receptor that directs several proteins to their correct location within the cell. Along with AP-1 complex, involved Golgi apparatus - endosome sorting. Sorting receptor for APP, regulating its intracellular trafficking and processing into amyloidogenic-beta peptides. Retains APP in the trans-Golgi network, hence preventing its transit through late endosomes where amyloid beta peptides Abeta40 and Abeta42 are generated. May also sort newly produced amyloid-beta peptides to lysosomes for catabolism. Does not affect APP trafficking from the endoplasmic r [...] (2213 aa)
	DDR2	Discoidin domain receptor tyrosine kinase 2. (848 aa)
	DOCK7	Dedicator of cytokinesis 7; Belongs to the DOCK family. (1990 aa)
	TRIB1	Tribbles pseudokinase 1. (206 aa)

Your Current Organism:

Oryctolagus cuniculus

NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADAMTS1	SERPINE1	ENSOCUP00000014065	ENSOCUP00000013814	ADAM metallopeptidase with thrombospondin type 1 motif 1.	Serpin family E member 1; Belongs to the serpin family.	0.493
ADIPOQ	BCL2	ENSOCUP00000020897	ENSOCUP00000036189	C1q domain-containing protein.	BH4_2 domain-containing protein.	0.442
ADIPOQ	IGF1	ENSOCUP00000020897	ENSOCUP00000021389	C1q domain-containing protein.	Insulin-like growth factor I; The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]- 2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse maturation. Ca(2+)-dependent exo [...]	0.718
ADIPOQ	IL18	ENSOCUP00000020897	ENSOCUP00000004555	C1q domain-containing protein.	Uncharacterized protein.	0.470
ADIPOQ	SERPINE1	ENSOCUP00000020897	ENSOCUP00000013814	C1q domain-containing protein.	Serpin family E member 1; Belongs to the serpin family.	0.435
ADIPOQ	TLR4	ENSOCUP00000020897	ENSOCUP00000001909	C1q domain-containing protein.	TIR domain-containing protein; Belongs to the Toll-like receptor family.	0.607
AIF1	TLR4	ENSOCUP00000021741	ENSOCUP00000001909	Allograft inflammatory factor 1.	TIR domain-containing protein; Belongs to the Toll-like receptor family.	0.406
BCL2	ADIPOQ	ENSOCUP00000036189	ENSOCUP00000020897	BH4_2 domain-containing protein.	C1q domain-containing protein.	0.442
BCL2	FOXO4	ENSOCUP00000036189	ENSOCUP00000040374	BH4_2 domain-containing protein.	Forkhead box O4.	0.411
BCL2	G1TLX8_RABIT	ENSOCUP00000036189	ENSOCUP00000017982	BH4_2 domain-containing protein.	RING-type domain-containing protein.	0.482
BCL2	IGF1	ENSOCUP00000036189	ENSOCUP00000021389	BH4_2 domain-containing protein.	Insulin-like growth factor I; The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]- 2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse maturation. Ca(2+)-dependent exo [...]	0.724
BCL2	IL18	ENSOCUP00000036189	ENSOCUP00000004555	BH4_2 domain-containing protein.	Uncharacterized protein.	0.617
BCL2	ITGA2	ENSOCUP00000036189	ENSOCUP00000029512	BH4_2 domain-containing protein.	Integrin subunit alpha 2; Belongs to the integrin alpha chain family.	0.409
BCL2	NFE2L2	ENSOCUP00000036189	ENSOCUP00000026975	BH4_2 domain-containing protein.	Nuclear factor, erythroid 2 like 2.	0.626
BCL2	NR4A3	ENSOCUP00000036189	ENSOCUP00000000639	BH4_2 domain-containing protein.	Nuclear receptor subfamily 4 group A member 3.	0.449
BCL2	PDGFRB	ENSOCUP00000036189	ENSOCUP00000001483	BH4_2 domain-containing protein.	Platelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells.	0.475
BCL2	PLAU	ENSOCUP00000036189	ENSOCUP00000023296	BH4_2 domain-containing protein.	Urokinase-type plasminogen activator short chain A; Specifically cleaves the zymogen plasminogen to form the active enzyme plasmin; Belongs to the peptidase S1 family.	0.405
BCL2	TLR4	ENSOCUP00000036189	ENSOCUP00000001909	BH4_2 domain-containing protein.	TIR domain-containing protein; Belongs to the Toll-like receptor family.	0.795
DDR2	ITGA2	ENSOCUP00000009847	ENSOCUP00000029512	Discoidin domain receptor tyrosine kinase 2.	Integrin subunit alpha 2; Belongs to the integrin alpha chain family.	0.415
DDR2	PDGFRB	ENSOCUP00000009847	ENSOCUP00000001483	Discoidin domain receptor tyrosine kinase 2.	Platelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells.	0.517