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| | PDGFRB | Platelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. (1147 aa) |
| | SLC12A2 | Solute carrier family 12 member 2. (1127 aa) |
| | G1SGM6_RABIT | Uncharacterized protein. (186 aa) |
| | ADCY10 | Adenylate cyclase type 10; Catalyzes the formation of the signaling molecule cAMP. May function as sensor that mediates responses to changes in cellular bicarbonate and CO(2) levels (By similarity). Has a critical role in mammalian spermatogenesis by producing the cAMP which regulates cAMP- responsive nuclear factors indispensable for sperm maturation in the epididymis. Induces capacitation, the maturational process that sperm undergo prior to fertilization (By similarity). Involved in ciliary beat regulation (By similarity); Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1626 aa) |
| | CD36 | CD36 molecule; Belongs to the CD36 family. (472 aa) |
| | SLC22A1 | Solute carrier family 22 member 1; Translocates a broad array of organic cations with various structures and molecular weights including the model compounds 1- methyl-4-phenylpyridinium (MPP), tetraethylammonium (TEA), N-1- methylnicotinamide (NMN), 4-(4-(dimethylamino)styryl)-N- methylpyridinium (ASP), the endogenous compounds choline, guanidine, histamine, epinephrine, adrenaline, noradrenaline and dopamine, and the drugs quinine, and metformin. The transport of organic cations is inhibited by a broad array of compounds like tetramethylammonium (TMA), cocaine, lidocaine, NMDA recepto [...] (555 aa) |
| | ADCY8 | Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1251 aa) |
| | ADRB2 | Adrenoceptor beta 2. (437 aa) |
| | KCNK1 | Potassium channel subfamily K member 1; Ion channel that contributes to passive transmembrane potassium transport and to the regulation of the resting membrane potential in brain astrocytes, but also in kidney and in other tissues. Forms dimeric channels through which potassium ions pass in accordance with their electrochemical gradient. The channel is selective for K(+) ions at physiological potassium concentrations and at neutral pH, but becomes permeable to Na(+) at subphysiological K(+) levels and upon acidification of the extracellular medium. The homodimer has very low potassium [...] (336 aa) |
| | PARD6B | Par-6 family cell polarity regulator beta. (371 aa) |
| | SLC4A9 | Anion exchange protein 4; Probable apical anion exchanger of the beta-intercalated cells of kidney. May participate in HCO3(-) secretion. Belongs to the anion exchanger (TC 2.A.31) family. (955 aa) |
| | PATJ | PATJ crumbs cell polarity complex component. (1798 aa) |
| | DRAM2 | DNA damage regulated autophagy modulator 2. (266 aa) |
| | SLC24A4 | Solute carrier family 24 member 4; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (613 aa) |
| | PAPPA2 | Pappalysin 2. (1669 aa) |
| | ATP6AP2 | ATPase H+ transporting accessory protein 2. (350 aa) |
| | PLB1 | Phospholipase B1, membrane-associated; Membrane-associated phospholipase. Exhibits a calcium- independent broad substrate specificity including phospholipase A2/lysophospholipase activity. Can convert phosphatidylcholine to fatty acids and glycerophosphocholine. Could be involved in uptake of dietary lipids, possibly including long chain retinyl esters. Belongs to the 'GDSL' lipolytic enzyme family. Phospholipase B1 subfamily. (1443 aa) |
| | SLC44A4 | Solute carrier family 44 member 4; Belongs to the CTL (choline transporter-like) family. (830 aa) |
| | ABCG8 | ATP binding cassette subfamily G member 8. (695 aa) |
| | KIAA1614 | PDZ domain-containing protein. (1089 aa) |
| | CYBRD1 | Cytochrome b reductase 1. (284 aa) |
| | USH2A | Uncharacterized protein. (1543 aa) |
| | ABCC4 | ATP binding cassette subfamily C member 4. (1325 aa) |
| | MUC13 | SEA domain-containing protein. (303 aa) |
| | PRKCI | Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (596 aa) |
| | SPTBN2 | Spectrin beta chain; Belongs to the spectrin family. (2422 aa) |
| | ENPP3 | Ectonucleotide pyrophosphatase/phosphodiesterase 3. (940 aa) |
| | CFAP126 | Cilia and flagella associated protein 126. (178 aa) |
| | SHROOM4 | Shroom family member 4. (1545 aa) |
| | DUOX1 | Dual oxidase 1. (1586 aa) |
| | SLCO2B1 | Solute carrier organic anion transporter family member. (712 aa) |
| | ATP7A | ATPase copper transporting alpha. (1499 aa) |
| | PLD1 | Phospholipase. (1031 aa) |
| | SLC17A1 | Sodium-dependent phosphate transport protein 1; Important for the resorption of phosphate by the kidney. May be involved in actively transporting phosphate into cells via Na(+) cotransport in the renal brush border membrane. Plays a role in urate transport in the kidney; Belongs to the major facilitator superfamily. Sodium/anion cotransporter family. (467 aa) |
| | SLC17A4 | Solute carrier family 17 member 4. (489 aa) |
| | SLC26A2 | Sulfate transporter; Sulfate transporter. May play a role in endochondral bone formation; Belongs to the SLC26A/SulP transporter (TC 2.A.53) family. (739 aa) |
| | ATP6V0A4 | V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (834 aa) |
| | KCNE1 | Potassium voltage-gated channel subfamily E member 1; Ancillary protein that assembles as a beta subunit with a voltage-gated potassium channel complex of pore-forming alpha subunits. Modulates the gating kinetics and enhances stability of the channel complex. Assembled with KCNB1 modulates the gating characteristics of the delayed rectifier voltage-dependent potassium channel KCNB1. Assembled with KCNQ1/KVLQT1 is proposed to form the slowly activating delayed rectifier cardiac potassium (IKs) channel. The outward current reaches its steady state only after 50 seconds. Assembled with K [...] (130 aa) |
| | OSMR | Oncostatin M receptor. (1088 aa) |
| | SHROOM3 | ASD2 domain-containing protein. (137 aa) |
| | CDHR2 | Cadherin related family member 2. (1278 aa) |
| | HVCN1 | Hydrogen voltage gated channel 1. (316 aa) |
| | NAALADL1 | TFR_dimer domain-containing protein. (87 aa) |
| | SLC47A2 | Multidrug and toxin extrusion protein 2; Solute transporter for tetraethylammonium (TEA), 1-methyl-4- phenylpyridinium (MPP), cimetidine, N-methylnicotinamide, metformin, creatinine, guanidine, procainamide, topotecan, estrone sulfate, acyclovir, and ganciclovir. Responsible for the secretion of cationic drugs across the brush border membranes; Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family. (593 aa) |
| | ATP6V0D1 | ATPase H+ transporting V0 subunit d1. (541 aa) |
| | CLDN1 | Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (211 aa) |
| | DDR2 | Discoidin domain receptor tyrosine kinase 2. (848 aa) |
| | LHFPL5 | LHFPL tetraspan subfamily member 5. (219 aa) |
| | CTSK | Cathepsin K; Thiol protease involved in osteoclastic bone resorption and may participate partially in the disorder of bone remodeling. Displays potent endoprotease activity against fibrinogen at acid pH. May play an important role in extracellular matrix degradation. Involved in the release of thyroid hormone thyroxine (T4) by limited proteolysis of TG/thyroglobulin in the thyroid follicle lumen. Belongs to the peptidase C1 family. (329 aa) |
| | LRP2 | Uncharacterized protein. (2726 aa) |
| | ERBB2 | Receptor protein-tyrosine kinase. (1255 aa) |
| | SLC30A5 | Solute carrier family 30 member 5. (767 aa) |
| | ENSOCUP00000036340 | EGF-like domain-containing protein. (81 aa) |
| | STX3 | Syntaxin 3; Belongs to the syntaxin family. (264 aa) |
| | ENSOCUP00000036503 | Uncharacterized protein. (406 aa) |
| | SCNN1G | Amiloride-sensitive sodium channel subunit gamma; Sodium permeable non-voltage-sensitive ion channel inhibited by the diuretic amiloride. Mediates the electrodiffusion of the luminal sodium (and water, which follows osmotically) through the apical membrane of epithelial cells. Plays an essential role in electrolyte and blood pressure homeostasis, but also in airway surface liquid homeostasis, which is important for proper clearance of mucus. Controls the reabsorption of sodium in kidney, colon, lung and sweat glands. Also plays a role in taste perception. (710 aa) |
| | PLPP1 | Phospholipid phosphatase 1. (286 aa) |
| | RDX | Radixin. (643 aa) |
| | CLIC5 | Chloride intracellular channel protein; Belongs to the chloride channel CLIC family. (409 aa) |
| | TRPM6 | Transient receptor potential cation channel subfamily M member 6. (2007 aa) |
| | PDZD3 | PDZ domain containing 3. (647 aa) |
| | KCNK2 | Potassium two pore domain channel subfamily K member 2; Belongs to the two pore domain potassium channel (TC 1.A.1.8) family. (469 aa) |
| | ENSOCUP00000035897 | AJAP1_PANP_C domain-containing protein. (297 aa) |
| | IL6R | Interleukin 6 receptor. (569 aa) |
| | SLC6A20 | Transporter; Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. (592 aa) |
| | PSEN2 | Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (539 aa) |
| | SLC23A1 | Solute carrier family 23 member 1. (652 aa) |
| | ENSOCUP00000038326 | Uncharacterized protein. (103 aa) |
| | GHRHR | Uncharacterized protein; Belongs to the MIP/aquaporin (TC 1.A.8) family. (524 aa) |
| | MAL | Mal, T cell differentiation protein. (157 aa) |
| | ATP1B1 | Sodium/potassium-transporting ATPase subunit beta-1; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. The beta subunit regulates, through assembly of alpha/beta heterodimers, the number of sodium pumps transported to the plasma membrane (By similarity). (312 aa) |
| | KISS1 | Uncharacterized protein. (244 aa) |
| | EZR | Ezrin; Probably involved in connections of major cytoskeletal structures to the plasma membrane (By similarity). In epithelial cells, required for the formation of microvilli and membrane ruffles on the apical pole. Along with PLEKHG6, required for normal macropinocytosis (By similarity). (653 aa) |
| | DUOX2 | Dual oxidase 2. (1545 aa) |
| | DPEP1 | Dipeptidase 1; Hydrolyzes a wide range of dipeptides. Implicated in the renal metabolism of glutathione and its conjugates. Converts leukotriene D4 to leukotriene E4; it may play an important role in the regulation of leukotriene activity; Belongs to the metallo-dependent hydrolases superfamily. Peptidase M19 family. (524 aa) |
| | CRB1 | Crumbs cell polarity complex component 1. (1405 aa) |
| | PTH1R | Uncharacterized protein; Belongs to the G-protein coupled receptor 2 family. (619 aa) |
| | DLL1 | Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (754 aa) |
| | SLC34A1 | Sodium-dependent phosphate transport protein 2A; Involved in actively transporting phosphate into cells via Na(+) cotransport in the renal brush border membrane. Probably mediates 70-80% of the apical influx. (671 aa) |
| | SLC5A2 | Sodium/nucleoside cotransporter; Actively transports uridine into cells by Na(+) cotransport. May play a role in reabsorption of nucleosides from glomerular filtrate by the proximal tubule in kidney, and in the regulation of cardiac contractility by adenosine. (787 aa) |
| | TDGF1 | EGF-like domain-containing protein. (259 aa) |
| | CNTFR | Ciliary neurotrophic factor receptor. (415 aa) |
| | ITPK1 | Inositol-tetrakisphosphate 1-kinase. (455 aa) |
| | ENSOCUP00000045339 | Uncharacterized protein. (163 aa) |
| | HAX1 | Uncharacterized protein. (426 aa) |
| | HPN | Hepsin; Belongs to the peptidase S1 family. (579 aa) |
| | ENSOCUP00000045951 | Uncharacterized protein. (144 aa) |
| | TJP1 | Tight junction protein 1; Belongs to the MAGUK family. (1815 aa) |
| | SLC9A3 | Sodium/hydrogen exchanger 3; Involved in pH regulation to eliminate acids generated by active metabolism or to counter adverse environmental conditions. Major proton extruding system driven by the inward sodium ion chemical gradient. Plays an important role in signal transduction. (813 aa) |
| | AKAP7 | A-kinase anchoring protein 7. (448 aa) |
| | TLR9 | TIR domain-containing protein. (1027 aa) |
| | AQP2 | Aquaporin-2; Forms a water-specific channel that provides the plasma membranes of renal collecting duct with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient; Belongs to the MIP/aquaporin (TC 1.A.8) family. (303 aa) |
| | MPP5 | Membrane palmitoylated protein 5; Belongs to the MAGUK family. (698 aa) |
| | SLC7A1 | Solute carrier family 7 member 1. (646 aa) |
| | PARD3 | Par-3 family cell polarity regulator. (1340 aa) |
| | ATP12A | Potassium-transporting ATPase alpha chain 2; Catalyzes the hydrolysis of ATP coupled with the exchange of H(+) and K(+) ions across the plasma membrane. Responsible for potassium absorption in various tissues; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIC subfamily. (1080 aa) |
| | CD44 | CD44 molecule (Indian blood group). (761 aa) |
| | SHANK2 | SH3 and multiple ankyrin repeat domains 2. (1891 aa) |
| | MTCL1 | Microtubule crosslinking factor 1. (1660 aa) |
| | GNAS | GNAS complex locus. (977 aa) |
| | MFRP | Membrane frizzled-related protein. (619 aa) |
| | ENSOCUP00000049916 | Uncharacterized protein. (284 aa) |
| | SORBS2 | Sorbin and SH3 domain containing 2. (1230 aa) |
| | SLC26A4 | Pendrin; Sodium-independent transporter of chloride and iodide. Belongs to the SLC26A/SulP transporter (TC 2.A.53) family. (786 aa) |
| | JAG1 | Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1218 aa) |
| | SLC34A2 | Solute carrier family 34 member 2. (715 aa) |
| | STXBP3 | Syntaxin binding protein 3; Belongs to the STXBP/unc-18/SEC1 family. (556 aa) |
| | ATP1B2 | Sodium/potassium-transporting ATPase subunit beta-2; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. The exact function of the beta-2 subunit is not known (By similarity). (290 aa) |
| | CSPG4 | Chondroitin sulfate proteoglycan 4. (2310 aa) |
| | G1SJA2_RABIT | Anoctamin. (745 aa) |
| | SLC5A8 | Solute carrier family 5 member 8; Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family. (596 aa) |
| | SPEF1 | Sperm flagellar 1. (236 aa) |
| | SLC29A1 | Solute carrier family 29 member 1 (Augustine blood group). (456 aa) |
| | SI | Sucrase-isomaltase, intestinal; Plays an important role in the final stage of carbohydrate digestion. Isomaltase activity is specific for both alpha-1,4- and alpha-1,6-oligosaccharides. (1827 aa) |
| | SLC4A11 | Solute carrier family 4 member 11. (882 aa) |
| | SLC39A8 | Solute carrier family 39 member 8. (437 aa) |
| | PKHD1 | PKHD1 ciliary IPT domain containing fibrocystin/polyductin. (3985 aa) |
| | TRPV4 | Transient receptor potential cation channel subfamily V member 4; Belongs to the transient receptor (TC 1.A.4) family. (679 aa) |
| | OTOA | Otoancorin. (1138 aa) |
| | KCNC2 | Potassium voltage-gated channel subfamily C member 2; Belongs to the potassium channel family. (638 aa) |
| | SLC2A2 | Solute carrier family 2 member 2; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (521 aa) |
| | PROM2 | Prominin 2. (834 aa) |
| | KNCN | Kinocilin. (119 aa) |
| | SLC38A1 | Solute carrier family 38 member 1. (458 aa) |
| | HYAL2 | Hyaluronidase. (475 aa) |
| | IL18 | Uncharacterized protein. (408 aa) |
| | ZMYND10 | Uncharacterized protein. (210 aa) |
| | NOD1 | Nucleotide binding oligomerization domain containing 1. (953 aa) |
| | ABCG5 | ATP binding cassette subfamily G member 5. (633 aa) |
| | SLC10A2 | Ileal sodium/bile acid cotransporter; Plays a critical role in the sodium-dependent reabsorption of bile acids from the lumen of the small intestine. Plays a key role in cholesterol metabolism (By similarity). (347 aa) |
| | SLC3A1 | RBAT protein. (677 aa) |
| | STC1 | Stanniocalcin 1. (247 aa) |
| | PDPN | Uncharacterized protein. (164 aa) |
| | MARVELD2 | MARVEL domain containing 2. (607 aa) |
| | SLC9A4 | Sodium/hydrogen exchanger; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. (803 aa) |
| | G1SQB5_RABIT | ZP domain-containing protein. (568 aa) |
| | ATP6V1A | ATPase H+ transporting V1 subunit A. (585 aa) |
| | MREG | Melanoregulin. (215 aa) |
| | SLC23A2 | Solute carrier family 23 member 2. (651 aa) |
| | SLC14A2 | Urea transporter 2; Specialized low-affinity vasopressin-regulated urea transporter. Mediates rapid transepithelial urea transport across the inner medullary collecting duct and plays a major role in the urinary concentrating mechanism. (895 aa) |
| | G1SRP4_RABIT | Uncharacterized protein. (417 aa) |
| | G1SSC0_RABIT | Protein kinase domain-containing protein. (98 aa) |
| | LOC100348238 | Uncharacterized protein. (1149 aa) |
| | ADGRG2 | Adhesion G protein-coupled receptor G2; Belongs to the G-protein coupled receptor 2 family. (1002 aa) |
| | TRPV5 | Transient receptor potential cation channel subfamily V member 5; Constitutively active calcium selective cation channel thought to be involved in Ca(2+) reabsorption in kidney and intestine. Required for normal Ca(2+) reabsorption in the kidney distal convoluted tubules (By similarity). The channel is activated by low internal calcium level and the current exhibits an inward rectification. A Ca(2+)-dependent feedback regulation includes fast channel inactivation and slow current decay. Heteromeric assembly with TRPV6 seems to modify channel properties. TRPV5-TRPV6 heteromultimeric con [...] (730 aa) |
| | THY1 | Thy-1 cell surface antigen. (161 aa) |
| | SLC11A2 | Solute carrier family 11 member 2. (589 aa) |
| | GJA1 | Gap junction alpha-1 protein; Gap junction protein that acts as a regulator of bladder capacity. A gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. May play a critical role in the physiology of hearing by participating in the recycling of potassium to the cochlear endolymph. Negative regulator of bladder functional capacity: acts by enhancing intercellular electrical and chemical transmission, thus sensitizing bladder muscles to cholinergic neural stimuli a [...] (356 aa) |
| | KL | Klotho. (1005 aa) |
| | ATP6V1B1 | Vacuolar proton pump subunit B; Non-catalytic subunit of the peripheral V1 complex of vacuolar ATPase; Belongs to the ATPase alpha/beta chains family. (512 aa) |
| | SLC26A3 | Chloride anion exchanger; Chloride/bicarbonate exchanger. Belongs to the SLC26A/SulP transporter (TC 2.A.53) family. (757 aa) |
| | MAL2 | Mal, T cell differentiation protein 2 (gene/pseudogene). (175 aa) |
| | MYO7A | Myosin VIIA; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2148 aa) |
| | G1TML2_RABIT | SEA domain-containing protein. (455 aa) |
| | S100G | Protein S100; Belongs to the S-100 family. (138 aa) |
| | GJB6 | Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. (261 aa) |
| | AGER | Advanced glycosylation end-product specific receptor. (401 aa) |
| | ANXA1 | Annexin A1; Plays important roles in the innate immune response as effector of glucocorticoid-mediated responses and regulator of the inflammatory process. Has anti-inflammatory activity. Plays a role in glucocorticoid-mediated down-regulation of the early phase of the inflammatory response. Promotes resolution of inflammation and wound healing (By similarity). Functions at least in part by activating the formyl peptide receptors and downstream signaling cascades. Promotes chemotaxis of granulocytes and monocytes via activation of the formyl peptide receptors (By similarity). Contribut [...] (334 aa) |
| | SCNN1A | Amiloride-sensitive sodium channel subunit alpha; Sodium permeable non-voltage-sensitive ion channel inhibited by the diuretic amiloride. Mediates the electrodiffusion of the luminal sodium (and water, which follows osmotically) through the apical membrane of epithelial cells. Plays an essential role in electrolyte and blood pressure homeostasis, but also in airway surface liquid homeostasis, which is important for proper clearance of mucus. Controls the reabsorption of sodium in kidney, colon, lung and eccrine sweat glands. Also plays a role in taste perception. (491 aa) |
| | CIB1 | Uncharacterized protein. (143 aa) |
| | SLC4A5 | Anion exchange protein. (1112 aa) |
| | P2RY4 | Pyrimidinergic receptor P2Y4; Belongs to the G-protein coupled receptor 1 family. (416 aa) |
| | AQP6 | Aquaporin 6; Belongs to the MIP/aquaporin (TC 1.A.8) family. (266 aa) |
| | SLC1A1 | Excitatory amino acid transporter 3; Sodium-dependent, high-affinity amino acid transporter that mediates the uptake of L-glutamate and also L-aspartate and D-aspartate. Can also transport L-cysteine (By similarity). Functions as a symporter that transports one amino acid molecule together with two or three Na(+) ions and one proton, in parallel with the counter-transport of one K(+) ion. Mediates Cl(-) flux that is not coupled to amino acid transport; this avoids the accumulation of negative charges due to aspartate and Na(+) symport. Plays an important role in L-glutamate and L-aspar [...] (524 aa) |
| | FXYD1 | Phospholemman; Associates with and regulates the activity of the sodium/potassium-transporting ATPase (NKA) which transports Na(+) out of the cell and K(+) into the cell. Inhibits NKA activity in its unphosphorylated state and stimulates activity when phosphorylated. Reduces glutathionylation of the NKA beta-1 subunit ATP1B1, thus reversing glutathionylation-mediated inhibition of ATP1B1. Contributes to female sexual development by maintaining the excitability of neurons which secrete gonadotropin-releasing hormone. Belongs to the FXYD family. (119 aa) |
| | SHROOM1 | Uncharacterized protein. (766 aa) |
| | PODXL | Podocalyxin; Involved in the regulation of both adhesion and cell morphology and cancer progression. Functions as an anti-adhesive molecule that maintains an open filtration pathway between neighboring foot processes in the podocyte by charge repulsion. Acts as a pro- adhesive molecule, enhancing the adherence of cells to immobilized ligands, increasing the rate of migration and cell-cell contacts in an integrin-dependent manner. Induces the formation of apical actin- dependent microvilli. Involved in the formation of a preapical plasma membrane subdomain to set up initial epithelial p [...] (506 aa) |
| | SLC26A9 | Solute carrier family 26 member 9; DIDS- and thiosulfate- sensitive anion exchanger mediating chloride, sulfate and oxalate transport. Belongs to the SLC26A/SulP transporter (TC 2.A.53) family. (791 aa) |
| | ATP4B | Potassium-transporting ATPase subunit beta; Required for stabilization and maturation of the catalytic proton pump alpha subunit and may also involved in cell adhesion and establishing epithelial cell polarity. (291 aa) |
| | CIB3 | Calcium and integrin binding family member 3. (187 aa) |
| | AKR1A1 | Aldo-keto reductase family 1 member A1. (481 aa) |
| | LOC100346670 | Uncharacterized protein; Belongs to the tetraspanin (TM4SF) family. (379 aa) |
| | ENSOCUP00000034710 | Uncharacterized protein. (391 aa) |
| | CFTR | Cystic fibrosis transmembrane conductance regulator; Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane (By similarity). Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelia [...] (1481 aa) |
| | IGFBP2 | IGFBP N-terminal domain-containing protein. (442 aa) |
| | SLC22A5 | MFS domain-containing protein. (557 aa) |
| | ENSOCUP00000034544 | FERM domain-containing protein. (508 aa) |
| | ENSOCUP00000034349 | Uncharacterized protein. (160 aa) |
| | SLC12A3 | Uncharacterized protein. (1027 aa) |
| | SLC6A18 | Transporter; Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. (458 aa) |
| | ENSOCUP00000033799 | Uncharacterized protein. (545 aa) |
| | UMOD | Uromodulin. (794 aa) |
| | MPDZ | Multiple PDZ domain crumbs cell polarity complex component. (2107 aa) |
| | PDE4D | Phosphodiesterase. (808 aa) |
| | ITGB3 | Integrin beta; Belongs to the integrin beta chain family. (873 aa) |
| | PROM1 | Prominin 1. (868 aa) |
| | SLC4A7 | Anion exchange protein. (1249 aa) |
| | CD34 | CD34 molecule. (415 aa) |
| | RAB27B | RAB27B, member RAS oncogene family. (241 aa) |
| | LCT-2 | Lactase-phlorizin hydrolase; LPH splits lactose in the small intestine; Belongs to the glycosyl hydrolase 1 family. (1926 aa) |
| | RIPOR2 | RHO family interacting cell polarization regulator 2. (1110 aa) |
| | CTSB | Cathepsin B; Belongs to the peptidase C1 family. (456 aa) |
| | DSTYK | Dual serine/threonine and tyrosine protein kinase. (952 aa) |
| | RAPGEF6 | Uncharacterized protein. (1531 aa) |
| | ENSOCUP00000031621 | Uncharacterized protein. (1225 aa) |
| | SLC2A13 | Solute carrier family 2 member 13; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (573 aa) |
| | LMO7 | LIM domain 7. (1837 aa) |
| | ABCC5 | ATP binding cassette subfamily C member 5. (1439 aa) |
| | LOC100359182 | Amino acid transporter. (665 aa) |
| | EMP2 | Epithelial membrane protein 2; Functions as a key regulator of cell membrane composition by regulating proteins surface expression. Also, plays a role in regulation of processes including cell migration, cell proliferation, cell contraction and cell adhesion; Belongs to the PMP-22/EMP/MP20 family. (259 aa) |
| | TNIK | TRAF2 and NCK interacting kinase. (1771 aa) |
| | SLC38A3 | Solute carrier family 38 member 3. (521 aa) |
| | LOC100351165 | Uncharacterized protein. (435 aa) |
| | SLC7A9 | B(0,+)-type amino acid transporter 1; Involved in the high-affinity, sodium-independent transport of cystine and neutral and dibasic amino acids (system b(0,+)-like activity). Thought to be responsible for the high-affinity reabsorption of cystine in the kidney tubule; Belongs to the amino acid-polyamine-organocation (APC) superfamily. (540 aa) |
| | STK26 | Serine/threonine kinase 26. (416 aa) |
| | CD300LG | CD300 molecule like family member g. (387 aa) |
| | ENSOCUP00000027691 | Uncharacterized protein. (508 aa) |
| | EXOC1 | Exocyst complex component 1. (919 aa) |
| | SLC2A1 | Solute carrier family 2, facilitated glucose transporter member 1; Facilitative glucose transporter, which is responsible for constitutive or basal glucose uptake. Has a very broad substrate specificity; can transport a wide range of aldoses including both pentoses and hexoses. Most important energy carrier of the brain: present at the blood-brain barrier and assures the energy-independent, facilitative transport of glucose into the brain. Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily. (512 aa) |
| | CUBN | Cubilin. (3539 aa) |
| | AQP10 | Aquaporin 10; Belongs to the MIP/aquaporin (TC 1.A.8) family. (293 aa) |
| | G1U7S6_RABIT | Uncharacterized protein. (209 aa) |
| | SAPCD2 | Suppressor APC domain containing 2. (344 aa) |
| | ECRG4 | ECRG4 augurin precursor. (148 aa) |
| | G1U6T3_RABIT | Transporter; Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. (576 aa) |
| | FZD3 | Frizzled class receptor 3; Belongs to the G-protein coupled receptor Fz/Smo family. (603 aa) |
| | G1U649_RABIT | Uncharacterized protein. (526 aa) |
| | ATP1A1 | Sodium/potassium-transporting ATPase subunit alpha-1; This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients (By similarity). May contribute to blood-heart barrier properties of endocardial endothelium and may control cardiac performance via endothelial Na(+)/H(+) exchange. (956 aa) |
| | SLC16A3 | Solute carrier family 16 member 3. (436 aa) |
| | UPK2 | Uncharacterized protein. (184 aa) |
| | RAB18 | Uncharacterized protein. (206 aa) |
| | ACE2 | Angiotensin-converting enzyme. (805 aa) |
| | P2RX2 | P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. Belongs to the P2X receptor family. (511 aa) |
| | TEK | TEK receptor tyrosine kinase. (1025 aa) |
| | SLC46A1 | MFS domain-containing protein. (473 aa) |
| | FZD6 | Frizzled class receptor 6; Belongs to the G-protein coupled receptor Fz/Smo family. (712 aa) |
| | SIPA1L3 | Signal induced proliferation associated 1 like 3. (1777 aa) |
| | RAPGEF2 | Rap guanine nucleotide exchange factor 2. (1659 aa) |
| | PLET1 | Uncharacterized protein. (212 aa) |
| | AHCYL1 | Adenosylhomocysteinase like 1; Belongs to the adenosylhomocysteinase family. (530 aa) |
| | CPO | Carboxypeptidase O. (387 aa) |
| | ATP6V0D2 | V-type proton ATPase subunit; Subunit of the integral membrane V0 complex of vacuolar ATPase. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. Belongs to the V-ATPase V0D/AC39 subunit family. (350 aa) |
| | ADAM17 | ADAM metallopeptidase domain 17. (827 aa) |
| | PARD3B | Par-3 family cell polarity regulator beta. (1205 aa) |
| | ABCC2 | Canalicular multispecific organic anion transporter 1; Mediates hepatobiliary excretion of numerous organic anions and conjugated organic anions such as methotrexate, 17beta-estradiol 17-glucosiduronic acid and leukotriene C4. Also transports sulfated bile salt such as taurolithocholate sulfate. May function as a cellular cisplatin transporter (By similarity). (1543 aa) |
| | SLC5A12 | Solute carrier family 5 member 12; Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family. (619 aa) |
| | SLC5A1 | Sodium/glucose cotransporter 1; Actively transports glucose into cells by Na(+) cotransport with a Na(+) to glucose coupling ratio of 2:1. Efficient substrate transport in mammalian kidney is provided by the concerted action of a low affinity high capacity and a high affinity low capacity Na(+)/glucose cotransporter arranged in series along kidney proximal tubules. (662 aa) |
| | P2RY6 | Pyrimidinergic receptor P2Y6. (350 aa) |
| | RHCG | Ammonium transporter Rh type C; Functions as an electroneutral and bidirectional ammonium transporter. May regulate transepithelial ammonia secretion (By similarity); Belongs to the ammonium transporter (TC 2.A.49) family. Rh subfamily. (466 aa) |
| | ERBB3 | Erb-b2 receptor tyrosine kinase 3. (1339 aa) |
| | SLC4A10 | Anion exchange protein. (1118 aa) |
| | UPK1B | Tetraspanin. (260 aa) |
| | SCNN1B | Amiloride-sensitive sodium channel subunit beta; Sodium permeable non-voltage-sensitive ion channel inhibited by the diuretic amiloride. Mediates the electrodiffusion of the luminal sodium (and water, which follows osmotically) through the apical membrane of epithelial cells. Plays an essential role in electrolyte and blood pressure homeostasis, but also in airway surface liquid homeostasis, which is important for proper clearance of mucus. Controls the reabsorption of sodium in kidney, colon, lung and sweat glands. Also plays a role in taste perception; Belongs to the amiloride-sensit [...] (641 aa) |
| | PRKG2 | cGMP-dependent protein kinase. (762 aa) |
| | SLC39A14 | Solute carrier family 39 member 14. (611 aa) |
| | PTEN | Phosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (403 aa) |
| | PARD6A | Par-6 family cell polarity regulator alpha. (346 aa) |
| | CNKSR3 | CNKSR family member 3. (555 aa) |
| | LOC100345682 | Uncharacterized protein. (1724 aa) |
| | ATP4A | Potassium-transporting ATPase alpha chain 1; Catalyzes the hydrolysis of ATP coupled with the exchange of H(+) and K(+) ions across the plasma membrane. Responsible for acid production in the stomach; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIC subfamily. (1030 aa) |
| | ENPEP | Aminopeptidase. (956 aa) |
| | SLC9A1 | Sodium/hydrogen exchanger 1; Involved in pH regulation to eliminate acids generated by active metabolism or to counter adverse environmental conditions. Major proton extruding system driven by the inward sodium ion chemical gradient. Plays an important role in signal transduction; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. (816 aa) |
| | GNAT3 | G protein subunit alpha transducin 3. (354 aa) |
| | KCNE4 | MinK-related peptide 3. (168 aa) |
| | NPC1L1 | Niemann-Pick C1-like 1 protein. (1325 aa) |
| | SLC6A9 | Transporter; Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. (652 aa) |
| | TMEM235 | Uncharacterized protein. (248 aa) |
| | SLC7A8 | Large neutral amino acids transporter small subunit 2; Sodium-independent, high-affinity transport of small and large neutral amino acids such as alanine, serine, threonine, cysteine, phenylalanine, tyrosine, leucine, arginine and tryptophan, when associated with SLC3A2/4F2hc. Acts as an amino acid exchanger. Has higher affinity for L-phenylalanine than LAT1 but lower affinity for glutamine and serine. L-alanine is transported at physiological concentrations. Plays a role in basolateral (re)absorption of neutral amino acids. Involved in the uptake of methylmercury (MeHg) when administe [...] (535 aa) |
| | C1QTNF5 | C1q and TNF related 5. (243 aa) |
| | SLC12A1 | Solute carrier family 12 member 1; Renal sodium, potassium and chloride ion cotransporter that mediates the transepithelial NaCl reabsorption in the thick ascending limb and plays an essential role in the urinary concentration and volume regulation. Electrically silent transporter system. Belongs to the SLC12A transporter family. (1098 aa) |
| | VANGL2 | Vang-like protein. (521 aa) |
| | SLC16A1 | Solute carrier family 16 member 1. (501 aa) |
| | UPK3A | Uroplakin 3A. (287 aa) |
| | LOC100351418 | Uncharacterized protein. (413 aa) |
| | MSN | FERM domain-containing protein. (577 aa) |
| | LCT | Lactase-phlorizin hydrolase. (1925 aa) |
| | ATP1B3 | Sodium/potassium-transporting ATPase subunit beta-3; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. The exact function of the beta-3 subunit is not known (By similarity); Belongs to the X(+)/potassium ATPases subunit beta family. (274 aa) |
| | SLC26A6 | Solute carrier family 26 member 6. (739 aa) |
| | PTPRO | Uncharacterized protein. (1215 aa) |
| | PRKAA1 | Non-specific serine/threonine protein kinase. (656 aa) |
| | ATP6V1B2 | Vacuolar proton pump subunit B; Non-catalytic subunit of the peripheral V1 complex of vacuolar ATPase; Belongs to the ATPase alpha/beta chains family. (511 aa) |
| | SLC6A6 | Transporter; Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. (675 aa) |
| | SLC16A2 | Solute carrier family 16 member 2. (539 aa) |
| | SLC3A2 | 4F2 cell-surface antigen heavy chain; Component of several heterodimeric amino acid transporter complexes. The precise substrate specificity depends on the other subunit in the heterodimer (By similarity). The heterodimer with SLC3A2 functions as sodium-independent, high-affinity transporter that mediates uptake of large neutral amino acids such as phenylalanine, tyrosine, L-DOPA, leucine, histidine, methionine and tryptophan. The complexes with SLC7A6 and SLC7A7 mediate uptake of dibasic amino acids. The complexes function as amino acid exchangers. Required for targeting of SLC7A5 and [...] (571 aa) |
| | MYO1A | Myosin IA; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1043 aa) |
| | ABCB11 | Bile salt export pump; Catalyzes the secretion of conjugated bile salts across the canalicular membrane of hepatocytes in an ATP-dependent manner. Transports taurine-conjugated bile salts more rapidly than glycine- conjugated bile salts. (1325 aa) |
| | FAT1 | FAT atypical cadherin 1. (4588 aa) |
| | SLC9A3R1 | Na(+)/H(+) exchange regulatory cofactor NHE-RF1; Scaffold protein that connects plasma membrane proteins with members of the ezrin/moesin/radixin family and thereby helps to link them to the actin cytoskeleton and to regulate their surface expression. Necessary for recycling of internalized ADRB2. Was first known to play a role in the regulation of the activity and subcellular location of SLC9A3. Necessary for cAMP-mediated phosphorylation and inhibition of SLC9A3. Involved in sperm capacitation. May participate in the regulation of the chloride and bicarbonate homeostasis in spermatoz [...] (356 aa) |
| | SLC19A1 | Solute carrier family 19 member 1. (557 aa) |
