STRINGSTRING
SNX25 SNX25 SIRT1 SIRT1 MYOCD MYOCD BCL9L BCL9L ASPN ASPN SPRY1 SPRY1 CAV1 CAV1 CAV2 CAV2 STRAP STRAP IL17RD IL17RD PPARA PPARA G1SV95_RABIT G1SV95_RABIT TET1 TET1 G1SSI3_RABIT G1SSI3_RABIT ENG ENG EMILIN1 EMILIN1 SAP130 SAP130 BRMS1L BRMS1L ZEB1 ZEB1 CD109 CD109 SMAD6 SMAD6 SPRED2 SPRED2 LTBP1 LTBP1 ITGA3 ITGA3 SPRY2 SPRY2 LATS1 LATS1 ZNF451 ZNF451 ING1 ING1 SAP30 SAP30 LDLRAD4 LDLRAD4 LATS2 LATS2 CITED2 CITED2 MPP5 MPP5 PIN1 PIN1 ITGA8 ITGA8 ENSOCUP00000045925 ENSOCUP00000045925 DAB2 DAB2 ENSOCUP00000044284 ENSOCUP00000044284 LOX LOX ENSOCUP00000041840 ENSOCUP00000041840 ENSOCUP00000041784 ENSOCUP00000041784 SPRED1 SPRED1 HDAC2 HDAC2 RNF111 RNF111 ENSOCUP00000039914 ENSOCUP00000039914 DNM2 DNM2 ENSOCUP00000037329 ENSOCUP00000037329 ENSOCUP00000036387 ENSOCUP00000036387 VEPH1 VEPH1 SIN3A SIN3A NREP NREP PMEPA1 PMEPA1 LOC103345451 LOC103345451 ADAM17 ADAM17 SMAD2 SMAD2 CIDEA CIDEA TGFB3 TGFB3 G1T1A1_RABIT G1T1A1_RABIT EP300 EP300 SNW1 SNW1 BMP2 BMP2 ING2 ING2 CDKN2B CDKN2B PBLD PBLD TGFBR3L TGFBR3L ENSOCUP00000030022 ENSOCUP00000030022 CITED1 CITED1 SMAD3 SMAD3 SPRED3 SPRED3 G1U940_RABIT G1U940_RABIT WNT1 WNT1 C4H20orf27 C4H20orf27 SMURF2 SMURF2 HTRA1 HTRA1 SKIL SKIL HSP90AB1 HSP90AB1 TGFBR3 TGFBR3 SDCBP SDCBP SMURF1 SMURF1 TRIM33 TRIM33 GIPC2 GIPC2 FLCN FLCN ZEB2 ZEB2 SOX11 SOX11 FERMT1 FERMT1 SMAD7 SMAD7 LOC100349668 LOC100349668 NRROS NRROS SLC2A10 SLC2A10 G1TUZ2_RABIT G1TUZ2_RABIT SAP30L SAP30L CREBBP CREBBP IL17F IL17F SMAD4 SMAD4 FBN1 FBN1 THBS1 THBS1 GLG1 GLG1 PDPK1 PDPK1 TP53 TP53 ARID4A ARID4A LEMD3 LEMD3 WFIKKN2 WFIKKN2 CAV3 CAV3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SNX25Sorting nexin 25. (841 aa)
SIRT1Sirtuin 1. (748 aa)
MYOCDMyocardin. (989 aa)
BCL9LBCL9 like. (1655 aa)
ASPNAsporin. (373 aa)
SPRY1Sprouty RTK signaling antagonist 1. (319 aa)
CAV1Caveolin-1; May act as a scaffolding protein within caveolar membranes. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (By similarity). Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependen [...] (178 aa)
CAV2Caveolin-2; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity. Acts as an accessory protein in conjunction with CAV1 in targeting to lipid rafts and driving caveolae formation. Positive regulator of cellular mitogenesis of the MAPK signaling pathway. Required for the insulin-stimulated nuclear translocation and activation of MAPK1 and STAT3, and the subsequent regulation of cell cycle progression (By similarity); Belongs to the caveolin family. (162 aa)
STRAPSerine/threonine kinase receptor associated protein. (350 aa)
IL17RDInterleukin 17 receptor D. (793 aa)
PPARAPeroxisome proliferator activated receptor alpha. (503 aa)
G1SV95_RABITTransforming growth factor beta; Belongs to the TGF-beta family. (387 aa)
TET1Tet methylcytosine dioxygenase 1. (2111 aa)
G1SSI3_RABITCTCK domain-containing protein. (291 aa)
ENGEndoglin. (758 aa)
EMILIN1Elastin microfibril interfacer 1. (982 aa)
SAP130Sin3A associated protein 130. (1083 aa)
BRMS1LBRMS1 like transcriptional repressor. (323 aa)
ZEB1Zinc finger E-box binding homeobox 1. (1080 aa)
CD109CD109 molecule. (1318 aa)
SMAD6MH2 domain-containing protein. (220 aa)
SPRED2Sprouty related EVH1 domain containing 2. (417 aa)
LTBP1Latent transforming growth factor beta binding protein 1. (1705 aa)
ITGA3Integrin subunit alpha 3; Belongs to the integrin alpha chain family. (1072 aa)
SPRY2Sprouty RTK signaling antagonist 2. (315 aa)
LATS1Large tumor suppressor kinase 1. (1124 aa)
ZNF451Zinc finger protein 451. (1209 aa)
ING1Inhibitor of growth protein. (233 aa)
SAP30Sin3A associated protein 30. (220 aa)
LDLRAD4Low density lipoprotein receptor class A domain containing 4. (307 aa)
LATS2Large tumor suppressor kinase 2. (1142 aa)
CITED2Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 2. (249 aa)
MPP5Membrane palmitoylated protein 5; Belongs to the MAGUK family. (698 aa)
PIN1Peptidyl-prolyl cis-trans isomerase. (224 aa)
ITGA8Integrin subunit alpha 8; Belongs to the integrin alpha chain family. (1100 aa)
ENSOCUP00000045925TGFb_propeptide domain-containing protein. (272 aa)
DAB2DAB adaptor protein 2. (769 aa)
ENSOCUP00000044284TGFb_propeptide domain-containing protein. (260 aa)
LOXLysyl oxidase. (419 aa)
ENSOCUP00000041840TGFb_propeptide domain-containing protein. (219 aa)
ENSOCUP00000041784Uncharacterized protein. (118 aa)
SPRED1Sprouty related EVH1 domain containing 1. (444 aa)
HDAC2Histone deacetylase 2. (581 aa)
RNF111Ring finger protein 111. (993 aa)
ENSOCUP00000039914PLAC domain-containing protein. (118 aa)
DNM2Dynamin 2; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (846 aa)
ENSOCUP00000037329TGFb_propeptide domain-containing protein. (263 aa)
ENSOCUP00000036387DIX domain-containing protein. (575 aa)
VEPH1Ventricular zone expressed PH domain containing 1. (833 aa)
SIN3ASIN3 transcription regulator family member A. (1241 aa)
NREPUncharacterized protein. (68 aa)
PMEPA1Prostate transmembrane protein, androgen induced 1. (291 aa)
LOC103345451TGFb_propeptide domain-containing protein. (203 aa)
ADAM17ADAM metallopeptidase domain 17. (827 aa)
SMAD2Mothers against decapentaplegic homolog. (467 aa)
CIDEACell death inducing DFFA like effector a. (218 aa)
TGFB3Transforming growth factor beta 3. (458 aa)
G1T1A1_RABITUncharacterized protein. (68 aa)
EP300E1A binding protein p300. (2418 aa)
SNW1SNW domain containing 1. (536 aa)
BMP2Bone morphogenetic protein 2; Induces cartilage and bone formation. Stimulates the differentiation of myoblasts into osteoblasts via the EIF2AK3- EIF2A- ATF4 pathway. BMP2 activation of EIF2AK3 stimulates phosphorylation of EIF2A which leads to increased expression of ATF4 which plays a central role in osteoblast differentiation. In addition stimulates TMEM119, which upregulates the expression of ATF4. (271 aa)
ING2Inhibitor of growth protein. (283 aa)
CDKN2BCyclin dependent kinase inhibitor 2B. (138 aa)
PBLDPhenazine biosynthesis like protein domain containing. (288 aa)
TGFBR3LTransforming growth factor beta receptor 3 like. (313 aa)
ENSOCUP00000030022PLAC domain-containing protein. (120 aa)
CITED1Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 1. (360 aa)
SMAD3SMAD family member 3. (230 aa)
SPRED3Sprouty related EVH1 domain containing 3. (518 aa)
G1U940_RABITCellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (178 aa)
WNT1Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (370 aa)
C4H20orf27Uncharacterized protein. (386 aa)
SMURF2E3 ubiquitin-protein ligase. (747 aa)
HTRA1HtrA serine peptidase 1. (338 aa)
SKILSKI like proto-oncogene. (683 aa)
HSP90AB1Heat shock protein HSP 90-beta; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co- chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. Engages with a range of client protein classes via its interact [...] (726 aa)
TGFBR3Transforming growth factor beta receptor 3. (851 aa)
SDCBPSyndecan binding protein. (312 aa)
SMURF1E3 ubiquitin-protein ligase. (737 aa)
TRIM33Tripartite motif containing 33. (1059 aa)
GIPC2GIPC PDZ domain containing family member 2. (259 aa)
FLCNFolliculin. (579 aa)
ZEB2Zinc finger E-box binding homeobox 2. (1188 aa)
SOX11Transcription factor SOX. (446 aa)
FERMT1Fermitin family member 1. (694 aa)
SMAD7Mothers against decapentaplegic homolog. (549 aa)
LOC100349668Uncharacterized protein. (512 aa)
NRROSNegative regulator of reactive oxygen species. (692 aa)
SLC2A10Solute carrier family 2 member 10; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (483 aa)
G1TUZ2_RABITUncharacterized protein. (494 aa)
SAP30LSAP30 like. (189 aa)
CREBBPCREB binding protein. (2403 aa)
IL17FInterleukin 17F. (163 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
FBN1Fibrillin 1. (2831 aa)
THBS1Thrombospondin 1. (1171 aa)
GLG1Golgi glycoprotein 1. (1225 aa)
PDPK13-phosphoinositide dependent protein kinase 1; Belongs to the protein kinase superfamily. (325 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...] (391 aa)
ARID4AAT-rich interaction domain 4A. (1255 aa)
LEMD3LEM domain containing 3. (915 aa)
WFIKKN2WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2. (571 aa)
CAV3Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (151 aa)
Your Current Organism:
Oryctolagus cuniculus
NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits
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