STRINGSTRING
IFNAR1 IFNAR1 CXCR2 CXCR2 TRIM16 TRIM16 GREM2 GREM2 WFIKKN2 WFIKKN2 FGF2 FGF2 CXCR4 CXCR4 G1SGM6_RABIT G1SGM6_RABIT TNFRSF9 TNFRSF9 ACVR1 ACVR1 SOST SOST LIFR LIFR ZFP36 ZFP36 CCR1 CCR1 CCR2 CCR2 THBS1 THBS1 CD74 CD74 UCMA UCMA IL17F IL17F XCR1 XCR1 HYAL2 HYAL2 TNFRSF11A TNFRSF11A G1SPA3_RABIT G1SPA3_RABIT PDPN PDPN HJV HJV CD109 CD109 IL22RA1 IL22RA1 IL1R1 IL1R1 CHRD CHRD ENG ENG IL31RA IL31RA IL6ST IL6ST CCR9 CCR9 IL12RB2 IL12RB2 KLHL20 KLHL20 LTBP1 LTBP1 CER1 CER1 GDF5 GDF5 ACKR3 ACKR3 TGFB3 TGFB3 COPS5 COPS5 CCR8 CCR8 IL18BP IL18BP SOSTDC1 SOSTDC1 OSMR OSMR IFNGR1 IFNGR1 IL13RA1 IL13RA1 TNFRSF1B TNFRSF1B IL27RA IL27RA IL13RA2 IL13RA2 LRRC32 LRRC32 IL5RA IL5RA SCUBE3 SCUBE3 IL20RA IL20RA TGFBR3 TGFBR3 IL12B IL12B IL1RL1 IL1RL1 IL18R1 IL18R1 ACKR4 ACKR4 IL1R2 IL1R2 BMPR1A BMPR1A LEPR LEPR TWSG1 TWSG1 ACVRL1 ACVRL1 ACKR2 ACKR2 IFNAR2 IFNAR2 TSKU TSKU CCR7 CCR7 CXCR5 CXCR5 IL2RG IL2RG KCP KCP NRROS NRROS CCR10 CCR10 GREM1 GREM1 IL1RN IL1RN TCAP TCAP IL22RA2 IL22RA2 CCR6 CCR6 CCRL2 CCRL2 G1U454_RABIT G1U454_RABIT NBL1 NBL1 CX3CR1 CX3CR1 IL23R IL23R BMPER BMPER IL10RA IL10RA CXCR1 CXCR1 CSF2RA CSF2RA TGFBR2 TGFBR2 CSF3R CSF3R CXCR3 CXCR3 ENSOCUP00000032400 ENSOCUP00000032400 IL20RB IL20RB CHRDL2 CHRDL2 CSF1R CSF1R KIT KIT CHRDL1 CHRDL1 TGFBR1 TGFBR1 IL6R IL6R IL9R IL9R BMPR2 BMPR2 IL12A IL12A PARK7 PARK7 ITGAV ITGAV IL3RA IL3RA NOG NOG FZD4 FZD4 BMPR1B BMPR1B CNTFR CNTFR LOC100338113 LOC100338113 HAX1 HAX1 TNFRSF1A TNFRSF1A
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
IFNAR1Interferon alpha and beta receptor subunit 1. (541 aa)
CXCR2C-X-C chemokine receptor type 2; Receptor for interleukin-8 which is a powerful neutrophil chemotactic factor. Binding of IL-8 to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. Binds to IL-8 with high affinity. Also binds with high affinity to CXCL3, GRO/MGSA and NAP-2 (By similarity). (357 aa)
TRIM16Uncharacterized protein. (551 aa)
GREM2Gremlin 2, DAN family BMP antagonist. (184 aa)
WFIKKN2WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2. (571 aa)
FGF2Fibroblast growth factor 2; Acts as a ligand for FGFR1, FGFR2, FGFR3 and FGFR4. Also acts as an integrin ligand which is required for FGF2 signaling. Binds to integrin ITGAV:ITGB3. Plays an important role in the regulation of cell survival, cell division, cell differentiation and cell migration. Functions as a potent mitogen in vitro. Can induce angiogenesis. Belongs to the heparin-binding growth factors family. (155 aa)
CXCR4C-X-C motif chemokine receptor 4; Belongs to the G-protein coupled receptor 1 family. (366 aa)
G1SGM6_RABITUncharacterized protein. (186 aa)
TNFRSF9TNF receptor superfamily member 9. (258 aa)
ACVR1Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (509 aa)
SOSTSclerostin. (257 aa)
LIFRLIF receptor subunit alpha. (1091 aa)
ZFP36ZFP36 ring finger protein. (338 aa)
CCR1Chemokine receptor; Belongs to the G-protein coupled receptor 1 family. (351 aa)
CCR2G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (369 aa)
THBS1Thrombospondin 1. (1171 aa)
CD74CD74 molecule. (375 aa)
UCMAUpper zone of growth plate and cartilage matrix associated. (138 aa)
IL17FInterleukin 17F. (163 aa)
XCR1X-C motif chemokine receptor 1; Belongs to the G-protein coupled receptor 1 family. (351 aa)
HYAL2Hyaluronidase. (475 aa)
TNFRSF11ATNFR-Cys domain-containing protein. (349 aa)
G1SPA3_RABITUncharacterized protein. (226 aa)
PDPNUncharacterized protein. (164 aa)
HJVHemojuvelin BMP co-receptor. (427 aa)
CD109CD109 molecule. (1318 aa)
IL22RA1Interleukin 22 receptor subunit alpha 1. (679 aa)
IL1R1Interleukin 1 receptor type 1. (699 aa)
CHRDChordin. (636 aa)
ENGEndoglin. (758 aa)
IL31RAInterleukin 31 receptor A. (730 aa)
IL6STInterleukin 6 signal transducer. (918 aa)
CCR9C-C motif chemokine receptor 9; Belongs to the G-protein coupled receptor 1 family. (369 aa)
IL12RB2Interleukin 12 receptor subunit beta 2. (883 aa)
KLHL20BTB domain-containing protein. (609 aa)
LTBP1Latent transforming growth factor beta binding protein 1. (1705 aa)
CER1Cerberus 1, DAN family BMP antagonist. (267 aa)
GDF5Growth differentiation factor 5 preproprotein (Predicted). (500 aa)
ACKR3Atypical chemokine receptor 3; Belongs to the G-protein coupled receptor 1 family. (336 aa)
TGFB3Transforming growth factor beta 3. (458 aa)
COPS5COP9 signalosome subunit 5. (334 aa)
CCR8C-C motif chemokine receptor 8; Belongs to the G-protein coupled receptor 1 family. (355 aa)
IL18BPInterleukin 18 binding protein isoform 1. (188 aa)
SOSTDC1Sclerostin domain containing 1. (206 aa)
OSMROncostatin M receptor. (1088 aa)
IFNGR1Interferon gamma receptor 1. (471 aa)
IL13RA1Interleukin 13 receptor subunit alpha 1. (519 aa)
TNFRSF1BTNF receptor superfamily member 1B. (425 aa)
IL27RAInterleukin 27 receptor subunit alpha. (634 aa)
IL13RA2Interleukin 13 receptor subunit alpha 2. (361 aa)
LRRC32Leucine rich repeat containing 32. (664 aa)
IL5RAIL6Ra-bind domain-containing protein. (332 aa)
SCUBE3Signal peptide, CUB domain and EGF like domain containing 3. (1027 aa)
IL20RAInterleukin 20 receptor subunit alpha. (548 aa)
TGFBR3Transforming growth factor beta receptor 3. (851 aa)
IL12BInterleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. (324 aa)
IL1RL1Interleukin 1 receptor like 1. (550 aa)
IL18R1Uncharacterized protein. (540 aa)
ACKR4Atypical chemokine receptor 4; Belongs to the G-protein coupled receptor 1 family. (350 aa)
IL1R2Interleukin 1 receptor type 2. (425 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
LEPRLeptin receptor. (1164 aa)
TWSG1Twisted gastrulation BMP signaling modulator 1. (202 aa)
ACVRL1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (327 aa)
ACKR2Atypical chemokine receptor 2; Belongs to the G-protein coupled receptor 1 family. (401 aa)
IFNAR2Uncharacterized protein. (523 aa)
TSKUTsukushi, small leucine rich proteoglycan. (399 aa)
CCR7C-C motif chemokine receptor 7; Belongs to the G-protein coupled receptor 1 family. (378 aa)
CXCR5C-X-C motif chemokine receptor 5; Belongs to the G-protein coupled receptor 1 family. (374 aa)
IL2RGUncharacterized protein. (171 aa)
KCPKielin cysteine rich BMP regulator. (1203 aa)
NRROSNegative regulator of reactive oxygen species. (692 aa)
CCR10C-C motif chemokine receptor 10; Belongs to the G-protein coupled receptor 1 family. (362 aa)
GREM1Gremlin 1, DAN family BMP antagonist. (240 aa)
IL1RNInterleukin-1 receptor antagonist protein; Inhibits the activity of interleukin-1 by binding to receptor IL1R1 and preventing its association with the coreceptor IL1RAP for signaling. Has no interleukin-1 like activity; Belongs to the IL-1 family. (221 aa)
TCAPTitin-cap. (179 aa)
IL22RA2Interleukin 22 receptor subunit alpha 2. (231 aa)
CCR6C-C motif chemokine receptor 6; Belongs to the G-protein coupled receptor 1 family. (375 aa)
CCRL2G_PROTEIN_RECEP_F1_2 domain-containing protein. (354 aa)
G1U454_RABITUncharacterized protein. (190 aa)
NBL1NBL1, DAN family BMP antagonist. (169 aa)
CX3CR1CX3C chemokine receptor 1; Receptor for the CX3C chemokine fractalkine (CX3CL1); binds to CX3CL1 and mediates both its adhesive and migratory functions. (356 aa)
IL23RInterleukin 23 receptor. (622 aa)
BMPERBMP binding endothelial regulator. (685 aa)
IL10RAInterleukin 10 receptor subunit alpha. (540 aa)
CXCR1C-X-C chemokine receptor type 1; Receptor to interleukin-8, which is a powerful neutrophils chemotactic factor. Binding of IL-8 to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activate a phosphatidylinositol-calcium second messenger system. (355 aa)
CSF2RAFibronectin type-III domain-containing protein. (443 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (592 aa)
CSF3RColony stimulating factor 3 receptor. (1027 aa)
CXCR3C-X-C motif chemokine receptor 3; Belongs to the G-protein coupled receptor 1 family. (370 aa)
ENSOCUP00000032400Uncharacterized protein. (531 aa)
IL20RBInterleukin 20 receptor subunit beta. (307 aa)
CHRDL2Chordin like 2. (637 aa)
CSF1RColony stimulating factor 1 receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (973 aa)
KITMast/stem cell growth factor receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (970 aa)
CHRDL1Chordin like 1. (578 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (486 aa)
IL6RInterleukin 6 receptor. (569 aa)
IL9RInterleukin 9 receptor. (576 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1060 aa)
IL12AInterleukin-12 subunit alpha; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated Killer cells, and stimulate the production of IFN-gamma by resting PBMC. (233 aa)
PARK7Parkinsonism associated deglycase. (231 aa)
ITGAVIntegrin subunit alpha V; Belongs to the integrin alpha chain family. (1047 aa)
IL3RAUncharacterized protein. (394 aa)
NOGNoggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (232 aa)
FZD4Frizzled class receptor 4; Belongs to the G-protein coupled receptor Fz/Smo family. (537 aa)
BMPR1BSerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (543 aa)
CNTFRCiliary neurotrophic factor receptor. (415 aa)
LOC100338113Uncharacterized protein. (282 aa)
HAX1Uncharacterized protein. (426 aa)
TNFRSF1ATNF receptor superfamily member 1A. (472 aa)
Your Current Organism:
Oryctolagus cuniculus
NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits
Server load: low (12%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.