(48 nodes) Myofibril assembly network (Oryctolagus cuniculus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	TMOD1	Tropomodulin 1. (359 aa)
	NKX2-5	NK2 homeobox 5. (326 aa)
	PDGFRA	Protein kinase domain-containing protein. (773 aa)
	MYL9	Myosin light chain 9. (172 aa)
	FHOD3	Formin homology 2 domain containing 3. (1602 aa)
	PDGFRB	Platelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. (1147 aa)
	WDR1	WD repeat domain 1. (590 aa)
	SRF	Serum response factor. (685 aa)
	ITGB1	Integrin beta; Belongs to the integrin beta chain family. (830 aa)
	ACTC1	Actin, alpha skeletal muscle, intermediate form; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. (377 aa)
	LMOD3	Leiomodin 3. (556 aa)
	CSRP2	Uncharacterized protein. (407 aa)
	CFL2	Cofilin 2; Belongs to the actin-binding proteins ADF family. (195 aa)
	MYPN	Myopalladin. (1381 aa)
	BMP10	Bone morphogenetic protein 10. (428 aa)
	CSRP1	Cysteine and glycine rich protein 1. (236 aa)
	NRAP	Nebulin related anchoring protein. (1743 aa)
	TMOD3	Uncharacterized protein. (352 aa)
	MYOM2	Myomesin 2. (1415 aa)
	TPM1	Tropomyosin alpha-1 chain; Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments; Belongs to the tropomyosin family. (326 aa)
	MEF2A	Myocyte enhancer factor 2A. (511 aa)
	MYOZ1	Uncharacterized protein. (310 aa)
	KLHL41	Kelch like family member 41. (606 aa)
	G1TRH9_RABIT	Uncharacterized protein. (116 aa)
	ADPRHL1	ADP-ribosylhydrolase like 1. (353 aa)
	TCAP	Titin-cap. (179 aa)
	TMOD4	Tropomodulin 4 (Predicted). (345 aa)
	MYH11	Myosin-11; Muscle contraction. (1944 aa)
	CASQ1	Calsequestrin-1; Calsequestrin is a high-capacity, moderate affinity, calcium- binding protein and thus acts as an internal calcium store in muscle. Calcium ions are bound by clusters of acidic residues at the protein surface, often at the interface between subunits. Can bind around 80 Ca(2+) ions. Regulates the release of lumenal Ca(2+) via the calcium release channel RYR1; this plays an important role in triggering muscle contraction. Negatively regulates store-operated Ca(2+) entry (SOCE) activity (By similarity). (395 aa)
	SYNPO2L	Synaptopodin 2 like. (744 aa)
	LMOD1	Leiomodin 1. (915 aa)
	ENSOCUP00000028754	LIM zinc-binding domain-containing protein. (74 aa)
	MYOZ2	Myozenin 2. (282 aa)
	LMOD2	Leiomodin 2. (579 aa)
	ENSOCUP00000033355	annotation not available (74 aa)
	CAPN3	Uncharacterized protein; Belongs to the peptidase C2 family. (820 aa)
	CSRP3	Cysteine and glycine rich protein 3. (245 aa)
	MYLK3	Myosin light chain kinase 3. (862 aa)
	LDB3	LIM domain binding 3. (768 aa)
	TMOD2	Tropomodulin 2. (378 aa)
	PROX1	Prospero homeobox 1. (737 aa)
	NEBL	Nebulette. (1035 aa)
	ENSOCUP00000042043	Ig-like domain-containing protein. (212 aa)
	PGM5	Phosphoglucomutase 5. (652 aa)
	FLII	FLII actin remodeling protein. (818 aa)
	FLNC	Filamin C. (2628 aa)
	ACTN2	Actinin alpha 2. (893 aa)
	NEB	Nebulin. (6666 aa)

Your Current Organism:

Oryctolagus cuniculus

NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACTC1	ACTN2	ENSOCUP00000006542	ENSOCUP00000047925	Actin, alpha skeletal muscle, intermediate form; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.	Actinin alpha 2.	0.835
ACTC1	CFL2	ENSOCUP00000006542	ENSOCUP00000008091	Actin, alpha skeletal muscle, intermediate form; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.	Cofilin 2; Belongs to the actin-binding proteins ADF family.	0.878
ACTC1	CSRP3	ENSOCUP00000006542	ENSOCUP00000036808	Actin, alpha skeletal muscle, intermediate form; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.	Cysteine and glycine rich protein 3.	0.554
ACTC1	FLNC	ENSOCUP00000006542	ENSOCUP00000047084	Actin, alpha skeletal muscle, intermediate form; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.	Filamin C.	0.568
ACTC1	KLHL41	ENSOCUP00000006542	ENSOCUP00000019433	Actin, alpha skeletal muscle, intermediate form; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.	Kelch like family member 41.	0.632
ACTC1	LMOD1	ENSOCUP00000006542	ENSOCUP00000027533	Actin, alpha skeletal muscle, intermediate form; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.	Leiomodin 1.	0.828
ACTC1	LMOD2	ENSOCUP00000006542	ENSOCUP00000030857	Actin, alpha skeletal muscle, intermediate form; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.	Leiomodin 2.	0.795
ACTC1	LMOD3	ENSOCUP00000006542	ENSOCUP00000007075	Actin, alpha skeletal muscle, intermediate form; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.	Leiomodin 3.	0.822
ACTC1	MYH11	ENSOCUP00000006542	ENSOCUP00000024188	Actin, alpha skeletal muscle, intermediate form; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.	Myosin-11; Muscle contraction.	0.686
ACTC1	MYL9	ENSOCUP00000006542	ENSOCUP00000000554	Actin, alpha skeletal muscle, intermediate form; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.	Myosin light chain 9.	0.629
ACTC1	MYOM2	ENSOCUP00000006542	ENSOCUP00000011314	Actin, alpha skeletal muscle, intermediate form; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.	Myomesin 2.	0.460
ACTC1	MYOZ2	ENSOCUP00000006542	ENSOCUP00000030208	Actin, alpha skeletal muscle, intermediate form; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.	Myozenin 2.	0.560
ACTC1	MYPN	ENSOCUP00000006542	ENSOCUP00000008560	Actin, alpha skeletal muscle, intermediate form; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.	Myopalladin.	0.552
ACTC1	NEB	ENSOCUP00000006542	ENSOCUP00000048133	Actin, alpha skeletal muscle, intermediate form; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.	Nebulin.	0.639
ACTC1	NKX2-5	ENSOCUP00000006542	ENSOCUP00000000038	Actin, alpha skeletal muscle, intermediate form; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.	NK2 homeobox 5.	0.567
ACTC1	SRF	ENSOCUP00000006542	ENSOCUP00000002515	Actin, alpha skeletal muscle, intermediate form; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.	Serum response factor.	0.444
ACTC1	TCAP	ENSOCUP00000006542	ENSOCUP00000021853	Actin, alpha skeletal muscle, intermediate form; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.	Titin-cap.	0.530
ACTC1	TMOD1	ENSOCUP00000006542	ENSOCUP00000011899	Actin, alpha skeletal muscle, intermediate form; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.	Tropomodulin 1.	0.668
ACTC1	TMOD2	ENSOCUP00000006542	ENSOCUP00000040239	Actin, alpha skeletal muscle, intermediate form; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.	Tropomodulin 2.	0.451
ACTC1	TMOD3	ENSOCUP00000006542	ENSOCUP00000011176	Actin, alpha skeletal muscle, intermediate form; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.	Uncharacterized protein.	0.470