STRINGSTRING
CDA CDA OSGIN2 OSGIN2 TRIM46 TRIM46 ULK2 ULK2 WNT3A WNT3A ENPP1 ENPP1 PHB PHB ENSOCUP00000047041 ENSOCUP00000047041 SLIT3 SLIT3 FGF13 FGF13 FBP1 FBP1 ENSOCUP00000045925 ENSOCUP00000045925 BCL6 BCL6 DAB2 DAB2 CTDP1 CTDP1 DCBLD2 DCBLD2 ENSOCUP00000044284 ENSOCUP00000044284 VGLL4 VGLL4 ENSOCUP00000041840 ENSOCUP00000041840 RB1 RB1 ENSOCUP00000040871 ENSOCUP00000040871 FHL1 FHL1 ENSOCUP00000039216 ENSOCUP00000039216 DNAJB2 DNAJB2 SEMA4A SEMA4A ENSOCUP00000037329 ENSOCUP00000037329 BMPR2 BMPR2 BCL2 BCL2 MINAR1 MINAR1 TP53TG5 TP53TG5 SEMA6A SEMA6A RGS2 RGS2 WNT3 WNT3 DIP2B DIP2B ENSOCUP00000033220 ENSOCUP00000033220 SMARCA2 SMARCA2 SMARCA4 SMARCA4 ENSOCUP00000031949 ENSOCUP00000031949 LOC103345451 LOC103345451 MAP2 MAP2 SEMA7A SEMA7A ENSOCUP00000029917 ENSOCUP00000029917 SLIT2 SLIT2 CRLF3 CRLF3 ADIPOR2 ADIPOR2 CDKL3 CDKL3 PPARD PPARD SMAD3 SMAD3 G1U940_RABIT G1U940_RABIT CDKN2AIP CDKN2AIP ULK1 ULK1 HRG HRG FSTL4 FSTL4 SH3BP4 SH3BP4 G1U3C4_RABIT G1U3C4_RABIT PRDM11 PRDM11 CDK5 CDK5 GSK3A GSK3A SIRT1 SIRT1 CAV3 CAV3 MAG MAG LOC100340625 LOC100340625 RYK RYK GREM1 GREM1 MYL10 MYL10 GJA1 GJA1 CDKN2D CDKN2D NPPB NPPB TSPYL2 TSPYL2 DCUN1D3 DCUN1D3 G1TI49_RABIT G1TI49_RABIT NTN1 NTN1 ACVRL1 ACVRL1 ACVR1B ACVR1B CAPRIN2 CAPRIN2 ST7L ST7L WNT5A WNT5A NME6 NME6 INHBA INHBA MUL1 MUL1 RERG RERG KIAA0319 KIAA0319 SPAG9 SPAG9 TCHP TCHP CGRRF1 CGRRF1 ARHGAP4 ARHGAP4 TP53 TP53 BCL11A BCL11A TOMM70 TOMM70 WNT11 WNT11 PTPRJ PTPRJ PML PML SEMA3B SEMA3B SEMA6C SEMA6C SEMA4G SEMA4G RACK1 RACK1 SEMA4C SEMA4C SLIT1 SLIT1 SMAD4 SMAD4 SEMA5A SEMA5A G1SLG9_RABIT G1SLG9_RABIT SERPINE2 SERPINE2 DCSTAMP DCSTAMP GAS2L1 GAS2L1 NRP1 NRP1 SEMA4F SEMA4F HYAL2 HYAL2 TGFB2 TGFB2 DRAXIN DRAXIN HYAL1 HYAL1 WT1 WT1 SEMA5B SEMA5B NDUFS3 NDUFS3 GNG4 GNG4 HNF4A HNF4A OSTN OSTN ADAM15 ADAM15 EAF2 EAF2 G1SSD9_RABIT G1SSD9_RABIT FOXP1 FOXP1 ZC3H12D ZC3H12D G6PD G6PD SEMA3G SEMA3G SERTAD2 SERTAD2 CDKN2C CDKN2C G1SV95_RABIT G1SV95_RABIT PPARA PPARA BMP10 BMP10 FRZB FRZB OSGIN1 OSGIN1 CCN3 CCN3 SEMA3F SEMA3F SEMA3A SEMA3A CDHR2 CDHR2 SEMA3D SEMA3D RTN4 RTN4 IP6K2 IP6K2 SOX17 SOX17 PPT1 PPT1 SEMA4D SEMA4D CCAR2 CCAR2 GDF2 GDF2 CDKN1B CDKN1B EI24 EI24 SESN2 SESN2 SEMA4B SEMA4B IFRD1 IFRD1 RNF6 RNF6 TRIM40 TRIM40 PSRC1 PSRC1 TNR TNR FLCN FLCN SPART SPART SERTAD1 SERTAD1 SFRP2 SFRP2 CDKN1A CDKN1A
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CDACytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis; Belongs to the cytidine and deoxycytidylate deaminase family. (119 aa)
OSGIN2Oxidative stress induced growth inhibitor family member 2. (531 aa)
TRIM46Tripartite motif containing 46. (907 aa)
ULK2Unc-51 like autophagy activating kinase 2. (1066 aa)
WNT3AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (400 aa)
ENPP1Uncharacterized protein. (908 aa)
PHBProhibitin. (303 aa)
ENSOCUP00000047041Uncharacterized protein. (493 aa)
SLIT3Slit guidance ligand 3. (1530 aa)
FGF13Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (271 aa)
FBP1Fructose-1,6-bisphosphatase 1; Catalyzes the hydrolysis of fructose 1,6-bisphosphate to fructose 6-phosphate in the presence of divalent cations, acting as a rate-limiting enzyme in gluconeogenesis. Plays a role in regulating glucose sensing and insulin secretion of pancreatic beta-cells. Appears to modulate glycerol gluconeogenesis in liver. Important regulator of appetite and adiposity; increased expression of the protein in liver after nutrient excess increases circulating satiety hormones and reduces appetite-stimulating neuropeptides and thus seems to provide a feedback mechanism [...] (443 aa)
ENSOCUP00000045925TGFb_propeptide domain-containing protein. (272 aa)
BCL6BCL6 transcription repressor. (723 aa)
DAB2DAB adaptor protein 2. (769 aa)
CTDP1RNA polymerase II subunit A C-terminal domain phosphatase; This promotes the activity of RNA polymerase II. (846 aa)
DCBLD2Discoidin, CUB and LCCL domain containing 2. (760 aa)
ENSOCUP00000044284TGFb_propeptide domain-containing protein. (260 aa)
VGLL4Vestigial like family member 4. (352 aa)
ENSOCUP00000041840TGFb_propeptide domain-containing protein. (219 aa)
RB1RB transcriptional corepressor 1. (943 aa)
ENSOCUP00000040871Uncharacterized protein. (164 aa)
FHL1Four and a half LIM domains 1. (348 aa)
ENSOCUP00000039216Uncharacterized protein. (183 aa)
DNAJB2DnaJ heat shock protein family (Hsp40) member B2. (324 aa)
SEMA4ASemaphorin 4A; Belongs to the semaphorin family. (977 aa)
ENSOCUP00000037329TGFb_propeptide domain-containing protein. (263 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1060 aa)
BCL2BH4_2 domain-containing protein. (389 aa)
MINAR1Membrane integral NOTCH2 associated receptor 1. (953 aa)
TP53TG5Uncharacterized protein. (304 aa)
SEMA6ASemaphorin 6A; Belongs to the semaphorin family. (1038 aa)
RGS2RGS domain-containing protein. (229 aa)
WNT3Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (358 aa)
DIP2BDisco interacting protein 2 homolog B. (1621 aa)
ENSOCUP00000033220Prohibitin. (262 aa)
SMARCA2SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2. (1595 aa)
SMARCA4SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4. (1653 aa)
ENSOCUP00000031949Uncharacterized protein. (217 aa)
LOC103345451TGFb_propeptide domain-containing protein. (203 aa)
MAP2Microtubule-associated protein. (1921 aa)
SEMA7ASema domain-containing protein; Belongs to the semaphorin family. (408 aa)
ENSOCUP00000029917Uncharacterized protein. (169 aa)
SLIT2Slit guidance ligand 2. (1542 aa)
CRLF3Cytokine receptor like factor 3. (440 aa)
ADIPOR2Adiponectin receptor 2. (486 aa)
CDKL3Cyclin dependent kinase like 3. (673 aa)
PPARDUncharacterized protein. (420 aa)
SMAD3SMAD family member 3. (230 aa)
G1U940_RABITCellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (178 aa)
CDKN2AIPCDKN2A interacting protein. (798 aa)
ULK1Unc-51 like autophagy activating kinase 1. (1001 aa)
HRGHistidine-rich glycoprotein; Plasma glycoprotein that binds a number of ligands such as heme, heparin, heparan sulfate, thrombospondin, plasminogen, and divalent metal ions. Inhibits rosette formation. Acts as an adapter protein and implicated in regulating many processes such as immune complex and pathogen clearance, cell adhesion, angiogenesis, coagulation and fibrinolysis. Mediates clearance of necrotic cells through enhancing the phagocytosis of necrotic cells in a heparan sulfate-dependent pathway. This process can be regulated by the presence of certain HRG ligands such as hepari [...] (572 aa)
FSTL4Follistatin like 4. (807 aa)
SH3BP4SH3 domain binding protein 4. (963 aa)
G1U3C4_RABITALMS_motif domain-containing protein. (102 aa)
PRDM11PR/SET domain 11. (1177 aa)
CDK5Cyclin dependent kinase 5; Belongs to the protein kinase superfamily. (292 aa)
GSK3AProtein kinase domain-containing protein; Belongs to the protein kinase superfamily. (401 aa)
SIRT1Sirtuin 1. (748 aa)
CAV3Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (151 aa)
MAGUncharacterized protein. (58 aa)
LOC100340625ANK_REP_REGION domain-containing protein. (324 aa)
RYKReceptor like tyrosine kinase. (553 aa)
GREM1Gremlin 1, DAN family BMP antagonist. (240 aa)
MYL10Myosin light chain 10. (167 aa)
GJA1Gap junction alpha-1 protein; Gap junction protein that acts as a regulator of bladder capacity. A gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. May play a critical role in the physiology of hearing by participating in the recycling of potassium to the cochlear endolymph. Negative regulator of bladder functional capacity: acts by enhancing intercellular electrical and chemical transmission, thus sensitizing bladder muscles to cholinergic neural stimuli a [...] (356 aa)
CDKN2DANK_REP_REGION domain-containing protein. (310 aa)
NPPBUncharacterized protein. (139 aa)
TSPYL2TSPY like 2; Belongs to the nucleosome assembly protein (NAP) family. (728 aa)
DCUN1D3DCN1-like protein. (304 aa)
G1TI49_RABITWD_REPEATS_REGION domain-containing protein. (223 aa)
NTN1Netrin 1. (533 aa)
ACVRL1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (327 aa)
ACVR1BReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (474 aa)
CAPRIN2Caprin family member 2. (1044 aa)
ST7LUncharacterized protein. (575 aa)
WNT5AProtein Wnt-5a; Ligand for members of the frizzled family of seven transmembrane receptors. Can activate or inhibit canonical Wnt signaling, depending on receptor context. In the presence of FZD4, activates beta-catenin signaling. In the presence of ROR2, inhibits the canonical Wnt pathway by promoting beta-catenin degradation through a GSK3-independent pathway which involves down-regulation of beta- catenin-induced reporter gene expression (By similarity). Suppression of the canonical pathway allows chondrogenesis to occur. Inhibits tumor formation. Stimulates cell migration. Decrease [...] (380 aa)
NME6Nucleoside diphosphate kinase. (190 aa)
INHBAInhibin subunit beta A. (424 aa)
MUL1Mitochondrial E3 ubiquitin protein ligase 1. (352 aa)
RERGRAS like estrogen regulated growth inhibitor. (199 aa)
KIAA0319KIAA0319. (1139 aa)
SPAG9Sperm associated antigen 9. (1149 aa)
TCHPTrichoplein keratin filament binding. (356 aa)
CGRRF1Cell growth regulator with ring finger domain 1. (332 aa)
ARHGAP4Rho GTPase activating protein 4. (924 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...] (391 aa)
BCL11ABAF chromatin remodeling complex subunit BCL11A. (975 aa)
TOMM70Translocase of outer mitochondrial membrane 70. (608 aa)
WNT11Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
PTPRJProtein tyrosine phosphatase receptor type J. (1330 aa)
PMLPromyelocytic leukemia. (860 aa)
SEMA3BSemaphorin 3B; Belongs to the semaphorin family. (757 aa)
SEMA6CSema domain-containing protein; Belongs to the semaphorin family. (948 aa)
SEMA4GSemaphorin 4G; Belongs to the semaphorin family. (843 aa)
RACK1WD_REPEATS_REGION domain-containing protein. (424 aa)
SEMA4CSemaphorin 4C; Belongs to the semaphorin family. (832 aa)
SLIT1Slit guidance ligand 1. (1452 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
SEMA5ASemaphorin 5A. (978 aa)
G1SLG9_RABITUncharacterized protein. (111 aa)
SERPINE2Serpin family E member 2; Belongs to the serpin family. (409 aa)
DCSTAMPDC_STAMP domain-containing protein. (283 aa)
GAS2L1GAR domain-containing protein. (221 aa)
NRP1Neuropilin; Belongs to the neuropilin family. (950 aa)
SEMA4FSsemaphorin 4F; Belongs to the semaphorin family. (721 aa)
HYAL2Hyaluronidase. (475 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
DRAXINDraxin; Chemorepulsive axon guidance protein required for the development of spinal cord and forebrain commissures. Acts as a chemorepulsive guidance protein for commissural axons during development. Able to inhibit or repel neurite outgrowth from dorsal spinal cord. Inhibits the stabilization of cytosolic beta-catenin (CTNNB1) via its interaction with LRP6, thereby acting as an antagonist of Wnt signaling pathway. (337 aa)
HYAL1Hyaluronidase. (497 aa)
WT1WT1 transcription factor. (302 aa)
SEMA5BSemaphorin 5B. (1077 aa)
NDUFS3NADH:ubiquinone oxidoreductase core subunit S3; Belongs to the complex I 30 kDa subunit family. (263 aa)
GNG4Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (197 aa)
HNF4AHepatocyte nuclear factor 4 alpha. (468 aa)
OSTNOsteocrin. (132 aa)
ADAM15ADAM metallopeptidase domain 15. (881 aa)
EAF2ELL associated factor 2. (263 aa)
G1SSD9_RABITRGS domain-containing protein. (183 aa)
FOXP1Fork-head domain-containing protein. (714 aa)
ZC3H12DUncharacterized protein. (282 aa)
G6PDGlucose-6-phosphate 1-dehydrogenase; Catalyzes the rate-limiting step of the oxidative pentose- phosphate pathway, which represents a route for the dissimilation of carbohydrates besides glycolysis. (581 aa)
SEMA3GSemaphorin 3G; Belongs to the semaphorin family. (777 aa)
SERTAD2SERTA domain containing 2. (307 aa)
CDKN2CCyclin dependent kinase inhibitor 2C. (168 aa)
G1SV95_RABITTransforming growth factor beta; Belongs to the TGF-beta family. (387 aa)
PPARAPeroxisome proliferator activated receptor alpha. (503 aa)
BMP10Bone morphogenetic protein 10. (428 aa)
FRZBFrizzled related protein. (318 aa)
OSGIN1Uncharacterized protein. (304 aa)
CCN3Cellular communication network factor 3. (357 aa)
SEMA3FSemaphorin 3F; Belongs to the semaphorin family. (784 aa)
SEMA3ASemaphorin 3A; Belongs to the semaphorin family. (770 aa)
CDHR2Cadherin related family member 2. (1278 aa)
SEMA3DSemaphorin 3D; Belongs to the semaphorin family. (777 aa)
RTN4Reticulon. (1110 aa)
IP6K2Inositol hexakisphosphate kinase 2; Converts inositol hexakisphosphate (InsP6) to diphosphoinositol pentakisphosphate (InsP7/PP-InsP5). (425 aa)
SOX17HMG box domain-containing protein. (165 aa)
PPT1Palmitoyl-protein thioesterase 1. (306 aa)
SEMA4DSemaphorin 4D; Belongs to the semaphorin family. (864 aa)
CCAR2Cell cycle and apoptosis regulator 2. (1178 aa)
GDF2Growth differentiation factor 2. (434 aa)
CDKN1BCyclin dependent kinase inhibitor 1B. (198 aa)
EI24EI24 autophagy associated transmembrane protein. (340 aa)
SESN2Sestrin 2. (480 aa)
SEMA4BSemaphorin 4B; Belongs to the semaphorin family. (832 aa)
IFRD1Interferon related developmental regulator 1. (451 aa)
RNF6Ring finger protein 6. (683 aa)
TRIM40Tripartite motif containing 40. (229 aa)
PSRC1Proline and serine rich coiled-coil 1. (363 aa)
TNRTenascin R. (1359 aa)
FLCNFolliculin. (579 aa)
SPARTSpartin. (679 aa)
SERTAD1SERTA domain containing 1. (224 aa)
SFRP2Secreted frizzled related protein 2. (295 aa)
CDKN1AUncharacterized protein. (231 aa)
Your Current Organism:
Oryctolagus cuniculus
NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits
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