STRINGSTRING
ZIC3 ZIC3 PGR PGR NPHP3 NPHP3 ATP7A ATP7A FGF1 FGF1 MAPK3 MAPK3 MAPK1 MAPK1 NKIRAS2 NKIRAS2 TTC25 TTC25 HS6ST1 HS6ST1 HIKESHI HIKESHI PKD1 PKD1 TBX5 TBX5 MAN1A2 MAN1A2 AIMP2 AIMP2 TIMELESS TIMELESS SMPD3 SMPD3 FOXJ1 FOXJ1 EP300 EP300 TGFB3 TGFB3 SMAD2 SMAD2 FLT4 FLT4 BMP4 BMP4 TBX4 TBX4 ADA ADA ITGA3 ITGA3 SPRY2 SPRY2 RC3H2 RC3H2 NODAL NODAL FGF10 FGF10 G1SV95_RABIT G1SV95_RABIT FBXW7 FBXW7 RDH10 RDH10 MMP12 MMP12 BAG6 BAG6 GLI3 GLI3 PHEX PHEX ZFPM2 ZFPM2 PDPN PDPN HMGCS2 HMGCS2 CTSZ CTSZ LTA4H LTA4H CREB1 CREB1 STK40 STK40 HOPX HOPX KDR KDR GRHL2 GRHL2 ERRFI1 ERRFI1 G1SLK7_RABIT G1SLK7_RABIT HSD11B1 HSD11B1 LIF LIF DAG1 DAG1 PKDCC PKDCC SRF SRF PTK7 PTK7 NKIRAS1 NKIRAS1 GPC3 GPC3 PDGFRB PDGFRB WNT11 WNT11 FOXF1 FOXF1 SLC7A11 SLC7A11 HPS1 HPS1 LIPA LIPA ESRP2 ESRP2 RXFP1 RXFP1 YWHAZ YWHAZ FGF2 FGF2 WNT5A WNT5A PDGFRA PDGFRA COL3A1 COL3A1 RBBP9 RBBP9 EXT1 EXT1 NKX2-8 NKX2-8 TSHZ3 TSHZ3 WNT2 WNT2 SHH SHH BMPR1A BMPR1A ALDH1A2 ALDH1A2 TCF21 TCF21 DSPP DSPP SPRY1 SPRY1 HHIP HHIP SP3 SP3 CCBE1 CCBE1 CRH CRH GLI2 GLI2 ENSOCUP00000047220 ENSOCUP00000047220 ENSOCUP00000045925 ENSOCUP00000045925 PHF14 PHF14 AP3B1 AP3B1 ENSOCUP00000044284 ENSOCUP00000044284 LOX LOX MAN2A1 MAN2A1 ELK1 ELK1 ENSOCUP00000042043 ENSOCUP00000042043 ENSOCUP00000041840 ENSOCUP00000041840 PROX1 PROX1 ENSOCUP00000039914 ENSOCUP00000039914 SLC23A1 SLC23A1 JMJD6 JMJD6 ENSOCUP00000037873 ENSOCUP00000037873 FGF7 FGF7 ENSOCUP00000037329 ENSOCUP00000037329 BMPR2 BMPR2 THRB THRB FNDC3B FNDC3B CCDC39 CCDC39 FGFR2 FGFR2 FGF18 FGF18 CTNNB1 CTNNB1 NFIB NFIB THRA THRA CTSH CTSH ENSOCUP00000032400 ENSOCUP00000032400 LOC103345451 LOC103345451 SAV1 SAV1 TGFBR2 TGFBR2 SEC24B SEC24B ENSOCUP00000030022 ENSOCUP00000030022 ITGB6 ITGB6 CRISPLD2 CRISPLD2 NOS3 NOS3 ATXN1L ATXN1L IGFBP5 IGFBP5 G1U373_RABIT G1U373_RABIT MYOCD MYOCD HOXA5 HOXA5 ASXL1 ASXL1 TBX2 TBX2 HES1 HES1 EPAS1 EPAS1 GLI1 GLI1 G1TVW1_RABIT G1TVW1_RABIT DLG5 DLG5 STRA6 STRA6 LAMA1 LAMA1 G1TTB9_RABIT G1TTB9_RABIT ADAMTS2 ADAMTS2 AARD AARD SFTPD SFTPD CHI3L1 CHI3L1 DNAAF1 DNAAF1 G1TGC0_RABIT G1TGC0_RABIT SOX11 SOX11
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ZIC3Zic family member 3. (467 aa)
PGRProgesterone receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcriptional activator of several progesteron-dependent promoters in a variety of cell types. Involved in activation of SRC-dependent MAPK signaling on hormone stimulation; Belongs to the nuclear hormone receptor family. NR3 subfamily. (930 aa)
NPHP3TPR_REGION domain-containing protein. (1218 aa)
ATP7AATPase copper transporting alpha. (1499 aa)
FGF1Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (155 aa)
MAPK3Mitogen-activated protein kinase. (381 aa)
MAPK1Mitogen-activated protein kinase. (364 aa)
NKIRAS2NFKB inhibitor interacting Ras like 2. (191 aa)
TTC25Tetratricopeptide repeat domain 25. (830 aa)
HS6ST1Heparan-sulfate 6-O-sulfotransferase; 6-O-sulfation enzyme which catalyzes the transfer of sulfate from 3'-phosphoadenosine 5'-phosphosulfate (PAPS) to position 6 of the N-sulfoglucosamine residue (GlcNS) of heparan sulfate. (286 aa)
HIKESHIHeat shock protein nuclear import factor hikeshi. (197 aa)
PKD1Uncharacterized protein. (2465 aa)
TBX5T-box transcription factor 5. (518 aa)
MAN1A2alpha-1,2-Mannosidase; Belongs to the glycosyl hydrolase 47 family. (641 aa)
AIMP2Aminoacyl tRNA synthetase complex interacting multifunctional protein 2. (322 aa)
TIMELESSTimeless circadian regulator. (1201 aa)
SMPD3Sphingomyelin phosphodiesterase 3. (657 aa)
FOXJ1Forkhead box J1. (421 aa)
EP300E1A binding protein p300. (2418 aa)
TGFB3Transforming growth factor beta 3. (458 aa)
SMAD2Mothers against decapentaplegic homolog. (467 aa)
FLT4Fms related tyrosine kinase 4; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1390 aa)
BMP4Bone morphogenetic protein 4; Induces cartilage and bone formation. Acts in concert with PTHLH/PTHRP to stimulate ductal outgrowth during embryonic mammary development and to inhibit hair follicle induction (By similarity). (409 aa)
TBX4T-box transcription factor 4. (550 aa)
ADAAdenosine deaminase. (363 aa)
ITGA3Integrin subunit alpha 3; Belongs to the integrin alpha chain family. (1072 aa)
SPRY2Sprouty RTK signaling antagonist 2. (315 aa)
RC3H2Ring finger and CCCH-type domains 2. (1132 aa)
NODALNodal growth differentiation factor. (348 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (220 aa)
G1SV95_RABITTransforming growth factor beta; Belongs to the TGF-beta family. (387 aa)
FBXW7F-box and WD repeat domain containing 7. (780 aa)
RDH10Retinol dehydrogenase 10; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (341 aa)
MMP12Macrophage metalloelastase; May be involved in tissue injury and remodeling. Has significant elastolytic activity. Can accept large and small amino acids at the P1' site, but has a preference for leucine. Aromatic or hydrophobic residues are preferred at the P1 site, with small hydrophobic residues (preferably alanine) occupying P3 (By similarity). Belongs to the peptidase M10A family. (464 aa)
BAG6BCL2 associated athanogene 6. (1162 aa)
GLI3GLI family zinc finger 3. (1575 aa)
PHEXPhosphate regulating endopeptidase homolog X-linked. (749 aa)
ZFPM2Zinc finger protein, FOG family member 2. (1159 aa)
PDPNUncharacterized protein. (164 aa)
HMGCS23-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase. (534 aa)
CTSZCathepsin Z; Belongs to the peptidase C1 family. (471 aa)
LTA4HLeukotriene A(4) hydrolase; Belongs to the peptidase M1 family. (611 aa)
CREB1cAMP responsive element binding protein 1. (341 aa)
STK40Serine/threonine kinase 40. (435 aa)
HOPXHomeobox domain-containing protein. (73 aa)
KDRUncharacterized protein; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1356 aa)
GRHL2Grainyhead like transcription factor 2. (728 aa)
ERRFI1ERBB receptor feedback inhibitor 1. (459 aa)
G1SLK7_RABITUncharacterized protein. (255 aa)
HSD11B1Corticosteroid 11-beta-dehydrogenase isozyme 1; Catalyzes reversibly the conversion of cortisol to the inactive metabolite cortisone. (318 aa)
LIFLIF interleukin 6 family cytokine. (203 aa)
DAG1Alpha-dystroglycan; The dystroglycan complex is involved in a number of processes including laminin and basement membrane assembly, sacrolemmal stability, cell survival, peripheral nerve myelination, nodal structure, cell migration, and epithelial polarization. Beta-dystroglycan is a transmembrane protein that plays important roles in connecting the extracellular matrix to the cytoskeleton. Acts as a cell adhesion receptor in both muscle and non- muscle tissues. Receptor for both DMD and UTRN and, through these interactions, scaffolds axin to the cytoskeleton. Also functions in cell ad [...] (895 aa)
PKDCCProtein kinase domain containing, cytoplasmic. (372 aa)
SRFSerum response factor. (685 aa)
PTK7Protein tyrosine kinase 7 (inactive); Belongs to the protein kinase superfamily. Tyr protein kinase family. (978 aa)
NKIRAS1NFKB inhibitor interacting Ras like 1. (192 aa)
GPC3Glypican 3; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. (580 aa)
PDGFRBPlatelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. (1147 aa)
WNT11Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
FOXF1Forkhead box F1. (433 aa)
SLC7A11Solute carrier family 7 member 11. (502 aa)
HPS1HPS1 biogenesis of lysosomal organelles complex 3 subunit 1. (703 aa)
LIPALipase; Belongs to the AB hydrolase superfamily. Lipase family. (409 aa)
ESRP2Epithelial splicing regulatory protein 2. (719 aa)
RXFP1Relaxin family peptide receptor 1. (714 aa)
YWHAZTyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta; Belongs to the 14-3-3 family. (252 aa)
FGF2Fibroblast growth factor 2; Acts as a ligand for FGFR1, FGFR2, FGFR3 and FGFR4. Also acts as an integrin ligand which is required for FGF2 signaling. Binds to integrin ITGAV:ITGB3. Plays an important role in the regulation of cell survival, cell division, cell differentiation and cell migration. Functions as a potent mitogen in vitro. Can induce angiogenesis. Belongs to the heparin-binding growth factors family. (155 aa)
WNT5AProtein Wnt-5a; Ligand for members of the frizzled family of seven transmembrane receptors. Can activate or inhibit canonical Wnt signaling, depending on receptor context. In the presence of FZD4, activates beta-catenin signaling. In the presence of ROR2, inhibits the canonical Wnt pathway by promoting beta-catenin degradation through a GSK3-independent pathway which involves down-regulation of beta- catenin-induced reporter gene expression (By similarity). Suppression of the canonical pathway allows chondrogenesis to occur. Inhibits tumor formation. Stimulates cell migration. Decrease [...] (380 aa)
PDGFRAProtein kinase domain-containing protein. (773 aa)
COL3A1Collagen type III alpha 1 chain. (1462 aa)
RBBP9RB binding protein 9, serine hydrolase. (186 aa)
EXT1Exostosin glycosyltransferase 1; Belongs to the glycosyltransferase 47 family. (746 aa)
NKX2-8NK2 homeobox 8. (236 aa)
TSHZ3Teashirt zinc finger homeobox 3. (1077 aa)
WNT2Protein Wnt-2; Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters (By similarity). (360 aa)
SHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (451 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
ALDH1A2Aldehyde dehydrogenase 1 family member A2; Belongs to the aldehyde dehydrogenase family. (590 aa)
TCF21Transcription factor 21. (179 aa)
DSPPUncharacterized protein. (657 aa)
SPRY1Sprouty RTK signaling antagonist 1. (319 aa)
HHIPHedgehog interacting protein. (700 aa)
SP3Sp3 transcription factor. (715 aa)
CCBE1Collagen and calcium binding EGF domains 1. (405 aa)
CRHCRF domain-containing protein. (194 aa)
GLI2GLI family zinc finger 2. (1575 aa)
ENSOCUP00000047220Uncharacterized protein. (573 aa)
ENSOCUP00000045925TGFb_propeptide domain-containing protein. (272 aa)
PHF14PHD finger protein 14. (899 aa)
AP3B1AP-3 complex subunit beta; Belongs to the adaptor complexes large subunit family. (1187 aa)
ENSOCUP00000044284TGFb_propeptide domain-containing protein. (260 aa)
LOXLysyl oxidase. (419 aa)
MAN2A1Alpha-mannosidase. (1172 aa)
ELK1ETS transcription factor ELK1. (512 aa)
ENSOCUP00000042043Ig-like domain-containing protein. (212 aa)
ENSOCUP00000041840TGFb_propeptide domain-containing protein. (219 aa)
PROX1Prospero homeobox 1. (737 aa)
ENSOCUP00000039914PLAC domain-containing protein. (118 aa)
SLC23A1Solute carrier family 23 member 1. (652 aa)
JMJD6Jumonji domain containing 6, arginine demethylase and lysine hydroxylase. (410 aa)
ENSOCUP00000037873Uncharacterized protein. (411 aa)
FGF7Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (194 aa)
ENSOCUP00000037329TGFb_propeptide domain-containing protein. (263 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1060 aa)
THRBThyroid hormone receptor beta. (476 aa)
FNDC3BFibronectin type III domain containing 3B. (1207 aa)
CCDC39Coiled-coil domain containing 39. (939 aa)
FGFR2Fibroblast growth factor receptor. (894 aa)
FGF18Fibroblast growth factor 18; Belongs to the heparin-binding growth factors family. (231 aa)
CTNNB1Catenin beta 1. (741 aa)
NFIBNuclear factor 1; Recognizes and binds the palindromic sequence 5'- TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication. (586 aa)
THRAThyroid hormone receptor alpha. (452 aa)
CTSHUncharacterized protein; Belongs to the peptidase C1 family. (601 aa)
ENSOCUP00000032400Uncharacterized protein. (531 aa)
LOC103345451TGFb_propeptide domain-containing protein. (203 aa)
SAV1Salvador family WW domain containing protein 1. (392 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (592 aa)
SEC24BSEC24 homolog B, COPII coat complex component. (1229 aa)
ENSOCUP00000030022PLAC domain-containing protein. (120 aa)
ITGB6Integrin beta; Belongs to the integrin beta chain family. (787 aa)
CRISPLD2Cysteine rich secretory protein LCCL domain containing 2. (471 aa)
NOS3Nitric oxide synthase; Produces nitric oxide (NO). (1209 aa)
ATXN1LAtaxin 1 like. (667 aa)
IGFBP5Insulin like growth factor binding protein 5. (271 aa)
G1U373_RABITSRCR domain-containing protein; Belongs to the heparin-binding growth factors family. (200 aa)
MYOCDMyocardin. (989 aa)
HOXA5Homeobox A5. (381 aa)
ASXL1ASXL transcriptional regulator 1. (1512 aa)
TBX2T-box transcription factor 2. (662 aa)
HES1Hes family bHLH transcription factor 1. (279 aa)
EPAS1Endothelial PAS domain protein 1. (902 aa)
GLI1GLI family zinc finger 1. (1103 aa)
G1TVW1_RABITFe2OG dioxygenase domain-containing protein. (273 aa)
DLG5Discs large MAGUK scaffold protein 5; Belongs to the MAGUK family. (1112 aa)
STRA6Stimulated by retinoic acid 6. (729 aa)
LAMA1Laminin subunit alpha 1. (3030 aa)
G1TTB9_RABITUncharacterized protein. (200 aa)
ADAMTS2ADAM metallopeptidase with thrombospondin type 1 motif 2. (1174 aa)
AARDAlanine and arginine rich domain containing protein. (163 aa)
SFTPDSurfactant protein D. (350 aa)
CHI3L1Chitinase 3 like 1; Belongs to the glycosyl hydrolase 18 family. (383 aa)
DNAAF1Dynein assembly factor 1, axonemal. (368 aa)
G1TGC0_RABITUncharacterized protein. (214 aa)
SOX11Transcription factor SOX. (446 aa)
Your Current Organism:
Oryctolagus cuniculus
NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits
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