STRINGSTRING
MMP27 MMP27 MMP8 MMP8 MMP21 MMP21 MMP13 MMP13 MMP20 MMP20 MMP26 MMP26 MMP28 MMP28 G1SN82_RABIT G1SN82_RABIT ADAM15 ADAM15 MMP24 MMP24 CTSS CTSS CTSK CTSK MMP16 MMP16 RETREG2 RETREG2 RETREG3 RETREG3 MMP3 MMP3 MMP7 MMP7 LOC100347623 LOC100347623 LOC100356256 LOC100356256 MMP10 MMP10 MRC2 MRC2 RETREG1 RETREG1 ADAMTS2 ADAMTS2 MMP11 MMP11 MMP15 MMP15 MMP9 MMP9 CTSB CTSB MMP2 MMP2 PEPD PEPD MMP1 MMP1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
MMP27Matrix metallopeptidase 27. (527 aa)
MMP8Matrix metallopeptidase 8. (355 aa)
MMP21Matrix metallopeptidase 21; Belongs to the peptidase M10A family. (567 aa)
MMP13Collagenase 3; Plays a role in the degradation of extracellular matrix proteins including fibrillar collagen, fibronectin, TNC and ACAN. Cleaves triple helical collagens, including type I, type II and type III collagen, but has the highest activity with soluble type II collagen. Can also degrade collagen type IV, type XIV and type X. May also function by activating or degrading key regulatory proteins, such as TGFB1 and CCN2. Plays a role in wound healing, tissue remodeling, cartilage degradation, bone development, bone mineralization and ossification. Required for normal embryonic bon [...] (471 aa)
MMP20Matrix metallopeptidase 20. (483 aa)
MMP26Matrix metallopeptidase 26. (265 aa)
MMP28Matrix metallopeptidase 28. (521 aa)
G1SN82_RABITZnMc domain-containing protein. (300 aa)
ADAM15ADAM metallopeptidase domain 15. (881 aa)
MMP24Matrix metallopeptidase 24. (617 aa)
CTSSCathepsin S; Belongs to the peptidase C1 family. (340 aa)
CTSKCathepsin K; Thiol protease involved in osteoclastic bone resorption and may participate partially in the disorder of bone remodeling. Displays potent endoprotease activity against fibrinogen at acid pH. May play an important role in extracellular matrix degradation. Involved in the release of thyroid hormone thyroxine (T4) by limited proteolysis of TG/thyroglobulin in the thyroid follicle lumen. Belongs to the peptidase C1 family. (329 aa)
MMP16Matrix metallopeptidase 16. (607 aa)
RETREG2Reticulophagy regulator family member 2. (493 aa)
RETREG3Reticulophagy regulator family member 3. (545 aa)
MMP3Stromelysin-1; Can degrade fibronectin, laminin, gelatins of type I, III, IV, and V; collagens III, IV, X, and IX, and cartilage proteoglycans. Activates procollagenase; Belongs to the peptidase M10A family. (478 aa)
MMP7Matrix metallopeptidase 7. (273 aa)
LOC100347623Uncharacterized protein; Belongs to the peptidase C1 family. (333 aa)
LOC100356256Uncharacterized protein; Belongs to the peptidase C1 family. (369 aa)
MMP10Matrix metallopeptidase 10. (477 aa)
MRC2Mannose receptor C type 2. (1040 aa)
RETREG1Reticulophagy regulator 1. (531 aa)
ADAMTS2ADAM metallopeptidase with thrombospondin type 1 motif 2. (1174 aa)
MMP11Matrix metallopeptidase 11. (492 aa)
MMP15U6 snRNA phosphodiesterase; Phosphodiesterase responsible for the U6 snRNA 3' end processing. Acts as an exoribonuclease (RNase) responsible for trimming the poly(U) tract of the last nucleotides in the pre-U6 snRNA molecule, leading to the formation of mature U6 snRNA 3' end-terminated with a 2',3'-cyclic phosphate; Belongs to the peptidase M10A family. (822 aa)
MMP9Matrix metalloproteinase-9; Could play a role in bone osteoclastic resorption. Cleaves type IV and type V collagen into large C-terminal three quarter fragments and shorter N-terminal one quarter fragments (By similarity). (707 aa)
CTSBCathepsin B; Belongs to the peptidase C1 family. (456 aa)
MMP272 kDa type IV collagenase; Ubiquitinous metalloproteinase that is involved in diverse functions such as remodeling of the vasculature, angiogenesis, tissue repair, tumor invasion, inflammation, and atherosclerotic plaque rupture. As well as degrading extracellular matrix proteins, can also act on several nonmatrix proteins such as big endothelial 1 and beta- type CGRP promoting vasoconstriction. Also cleaves KISS at a Gly-|-Leu bond. Appears to have a role in myocardial cell death pathways. Contributes to myocardial oxidative stress by regulating the activity of GSK3beta. Cleaves GSK3 [...] (710 aa)
PEPDPeptidase D. (481 aa)
MMP1Interstitial collagenase; Cleaves collagens of types I, II, and III at one site in the helical domain. Also cleaves collagens of types VII and X; Belongs to the peptidase M10A family. (475 aa)
Your Current Organism:
Oryctolagus cuniculus
NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits
Server load: low (18%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.