(69 nodes) Regulation of cellular pH network (Oryctolagus cuniculus)

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Your Input:
	ENSOCUP00000048240	V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (135 aa)
	CLIC4	Chloride intracellular channel protein; Belongs to the chloride channel CLIC family. (322 aa)
	HVCN1	Hydrogen voltage gated channel 1. (316 aa)
	SLC4A3	Anion exchange protein 3; Plasma membrane anion exchange protein. (1173 aa)
	ENSOCUP00000046169	Uncharacterized protein. (207 aa)
	SLC9A8	Sodium/hydrogen exchanger; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. (547 aa)
	MAPK3	Mitogen-activated protein kinase. (381 aa)
	SLC11A1	Uncharacterized protein. (552 aa)
	SLAMF8	SLAM family member 8. (312 aa)
	DMXL1	Dmx like 1. (2952 aa)
	LOC100345885	Uncharacterized protein. (301 aa)
	AVP	Uncharacterized protein. (285 aa)
	GRN	Granulin precursor. (626 aa)
	AQP11	Aquaporin; Aquaporins facilitate the transport of water and small neutral solutes across cell membranes. (271 aa)
	GPR89B	Uncharacterized protein. (455 aa)
	ENSOCUP00000037059	Uncharacterized protein. (317 aa)
	BCL2	BH4_2 domain-containing protein. (389 aa)
	RNASEK	Ribonuclease K. (125 aa)
	CLN3	Battenin. (553 aa)
	CFTR	Cystic fibrosis transmembrane conductance regulator; Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane (By similarity). Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelia [...] (1481 aa)
	G1U4L1_RABIT	Uncharacterized protein. (195 aa)
	G1U338_RABIT	Uncharacterized protein. (211 aa)
	CA2	Carbonic anhydrase 2; Essential for bone resorption and osteoclast differentiation. Contributes to intracellular pH regulation in the duodenal upper villous epithelium during proton-coupled peptide absorption. Stimulates the chloride-bicarbonate exchange activity of SLC26A6 (By similarity). Reversible hydration of carbon dioxide; Belongs to the alpha-carbonic anhydrase family. (269 aa)
	SLC4A7	Anion exchange protein. (1249 aa)
	SLC4A1	Anion exchange protein. (981 aa)
	CHP1	Calcineurin like EF-hand protein 1. (194 aa)
	ATP6AP1L	Uncharacterized protein. (367 aa)
	RAB38	Uncharacterized protein. (243 aa)
	ATP6V0A1	V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (832 aa)
	SLC9C2	Solute carrier family 9 member C2 (putative). (1113 aa)
	ATP6AP2	ATPase H+ transporting accessory protein 2. (350 aa)
	SLC4A8	Anion exchange protein. (1027 aa)
	LACC1	Uncharacterized protein. (430 aa)
	CLN6	CLN6 transmembrane ER protein. (311 aa)
	ATP6AP1	Uncharacterized protein. (470 aa)
	ATP1A4	Sodium/potassium-transporting ATPase subunit alpha. (1027 aa)
	SLC4A5	Anion exchange protein. (1112 aa)
	UBE3A	Ubiquitin-protein ligase E3A; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and transfers it to its substrates. (881 aa)
	AVPR1A	Vasopressin V1a receptor; Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate a phosphatidyl- inositol-calcium second messenger system. Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily. (418 aa)
	SLC26A3	Chloride anion exchanger; Chloride/bicarbonate exchanger. Belongs to the SLC26A/SulP transporter (TC 2.A.53) family. (757 aa)
	RAB39A	RAB39A, member RAS oncogene family. (217 aa)
	SLC9A1	Sodium/hydrogen exchanger 1; Involved in pH regulation to eliminate acids generated by active metabolism or to counter adverse environmental conditions. Major proton extruding system driven by the inward sodium ion chemical gradient. Plays an important role in signal transduction; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. (816 aa)
	CXorf21	Chromosome X open reading frame 21. (298 aa)
	TMEM9	Transmembrane protein 9. (183 aa)
	SNAPIN	SNARE-associated protein Snapin; Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. Plays a role in intracellular vesicle trafficking and synaptic vesicle recycling; Belongs to t [...] (136 aa)
	CCDC115	Coiled-coil domain containing 115. (180 aa)
	SLC9A7	Sodium/hydrogen exchanger; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. (726 aa)
	CA7	Carbonic anhydrase 7; Belongs to the alpha-carbonic anhydrase family. (324 aa)
	VPS33A	Uncharacterized protein; Belongs to the STXBP/unc-18/SEC1 family. (595 aa)
	RAB7A	Ras-related protein Rab-7a; Key regulator in endo-lysosomal trafficking. Governs early- to-late endosomal maturation, microtubule minus-end as well as plus-end directed endosomal migration and positioning, and endosome-lysosome transport through different protein-protein interaction cascades (By similarity). Plays a central role, not only in endosomal traffic, but also in many other cellular and physiological events, such as growth- factor-mediated cell signaling, nutrient-transportor mediated nutrient uptake, neurotrophin transport in the axons of neurons and lipid metabolism (By simi [...] (207 aa)
	ATP6V1B2	Vacuolar proton pump subunit B; Non-catalytic subunit of the peripheral V1 complex of vacuolar ATPase; Belongs to the ATPase alpha/beta chains family. (511 aa)
	SLC26A6	Solute carrier family 26 member 6. (739 aa)
	MAPK1	Mitogen-activated protein kinase. (364 aa)
	ATP6V0A4	V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (834 aa)
	TM9SF4	Transmembrane 9 superfamily member; Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family. (654 aa)
	TMEM106B	Transmembrane protein 106B. (275 aa)
	SLC9A5	Sodium/hydrogen exchanger; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. (895 aa)
	SLC9C1	Solute carrier family 9 member C1. (1151 aa)
	TMEM165	GDT1 family protein. (313 aa)
	SLC9A9	Sodium/hydrogen exchanger; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. (644 aa)
	SLC4A10	Anion exchange protein. (1118 aa)
	LRRK2	Leucine rich repeat kinase 2. (2499 aa)
	AVPR1B	Vasopressin V1b receptor; Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate a phosphatidyl- inositol-calcium second messenger system. Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily. (417 aa)
	ATP5F1B	ATP synthase subunit beta; Produces ATP from ADP in the presence of a proton gradient across the membrane. (528 aa)
	SLC9A4	Sodium/hydrogen exchanger; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. (803 aa)
	DMXL2	Dmx like 2. (2884 aa)
	NOX1	NADPH oxidase 1. (564 aa)
	SLC9A6	Sodium/hydrogen exchanger; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. (701 aa)
	PPT1	Palmitoyl-protein thioesterase 1. (306 aa)

Your Current Organism:

Oryctolagus cuniculus

NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AQP11	SLC4A5	ENSOCUP00000043459	ENSOCUP00000016226	Aquaporin; Aquaporins facilitate the transport of water and small neutral solutes across cell membranes.	Anion exchange protein.	0.460
ATP1A4	MAPK1	ENSOCUP00000015184	ENSOCUP00000011783	Sodium/potassium-transporting ATPase subunit alpha.	Mitogen-activated protein kinase.	0.911
ATP1A4	MAPK3	ENSOCUP00000015184	ENSOCUP00000011800	Sodium/potassium-transporting ATPase subunit alpha.	Mitogen-activated protein kinase.	0.911
ATP1A4	SLC9A1	ENSOCUP00000015184	ENSOCUP00000022999	Sodium/potassium-transporting ATPase subunit alpha.	Sodium/hydrogen exchanger 1; Involved in pH regulation to eliminate acids generated by active metabolism or to counter adverse environmental conditions. Major proton extruding system driven by the inward sodium ion chemical gradient. Plays an important role in signal transduction; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.	0.669
ATP1A4	SLC9A4	ENSOCUP00000015184	ENSOCUP00000005263	Sodium/potassium-transporting ATPase subunit alpha.	Sodium/hydrogen exchanger; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.	0.516
ATP1A4	SLC9A5	ENSOCUP00000015184	ENSOCUP00000008663	Sodium/potassium-transporting ATPase subunit alpha.	Sodium/hydrogen exchanger; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.	0.632
ATP1A4	SLC9A7	ENSOCUP00000015184	ENSOCUP00000003662	Sodium/potassium-transporting ATPase subunit alpha.	Sodium/hydrogen exchanger; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.	0.463
ATP1A4	SLC9A8	ENSOCUP00000015184	ENSOCUP00000009655	Sodium/potassium-transporting ATPase subunit alpha.	Sodium/hydrogen exchanger; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.	0.502
ATP1A4	SLC9A9	ENSOCUP00000015184	ENSOCUP00000008535	Sodium/potassium-transporting ATPase subunit alpha.	Sodium/hydrogen exchanger; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.	0.462
ATP5F1B	ATP6V1B2	ENSOCUP00000005273	ENSOCUP00000000876	ATP synthase subunit beta; Produces ATP from ADP in the presence of a proton gradient across the membrane.	Vacuolar proton pump subunit B; Non-catalytic subunit of the peripheral V1 complex of vacuolar ATPase; Belongs to the ATPase alpha/beta chains family.	0.736
ATP6AP1	ATP6AP2	ENSOCUP00000015144	ENSOCUP00000013112	Uncharacterized protein.	ATPase H+ transporting accessory protein 2.	0.987
ATP6AP1	ATP6V0A1	ENSOCUP00000015144	ENSOCUP00000013049	Uncharacterized protein.	V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.	0.992
ATP6AP1	ATP6V0A4	ENSOCUP00000015144	ENSOCUP00000011660	Uncharacterized protein.	V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.	0.991
ATP6AP1	ATP6V1B2	ENSOCUP00000015144	ENSOCUP00000000876	Uncharacterized protein.	Vacuolar proton pump subunit B; Non-catalytic subunit of the peripheral V1 complex of vacuolar ATPase; Belongs to the ATPase alpha/beta chains family.	0.972
ATP6AP1	CCDC115	ENSOCUP00000015144	ENSOCUP00000004416	Uncharacterized protein.	Coiled-coil domain containing 115.	0.880
ATP6AP1	ENSOCUP00000048240	ENSOCUP00000015144	ENSOCUP00000048240	Uncharacterized protein.	V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.	0.708
ATP6AP1	PPT1	ENSOCUP00000015144	ENSOCUP00000011012	Uncharacterized protein.	Palmitoyl-protein thioesterase 1.	0.442
ATP6AP1	RNASEK	ENSOCUP00000015144	ENSOCUP00000036047	Uncharacterized protein.	Ribonuclease K.	0.895
ATP6AP1L	ATP6AP2	ENSOCUP00000012120	ENSOCUP00000013112	Uncharacterized protein.	ATPase H+ transporting accessory protein 2.	0.766
ATP6AP1L	ATP6V0A1	ENSOCUP00000012120	ENSOCUP00000013049	Uncharacterized protein.	V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.	0.708