36 items (Oryctolagus cuniculus) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

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experimentally determined

Predicted Interactions

gene neighborhood

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protein homology

Your Input:
	SPRED1	Sprouty related EVH1 domain containing 1. (444 aa)
	NOG	Noggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (232 aa)
	STAT1	Signal transducer and activator of transcription. (879 aa)
	CTNNB1	Catenin beta 1. (741 aa)
	SMO	Smoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (787 aa)
	SPRED3	Sprouty related EVH1 domain containing 3. (518 aa)
	ID1	Inhibitor of DNA binding 1, HLH protein. (154 aa)
	GRHL2	Grainyhead like transcription factor 2. (728 aa)
	SPRED2	Sprouty related EVH1 domain containing 2. (417 aa)
	OSR1	Odd-skipped related transcription factor 1. (266 aa)
	XDH	Uncharacterized protein. (1333 aa)
	FGF10	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (220 aa)
	NODAL	Nodal growth differentiation factor. (348 aa)
	SPRY2	Sprouty RTK signaling antagonist 2. (315 aa)
	SRSF6	Serine/arginine-rich-splicing factor 6. (215 aa)
	FRZB	Frizzled related protein. (318 aa)
	GDF3	Growth differentiation factor 3. (365 aa)
	CAV1	Caveolin-1; May act as a scaffolding protein within caveolar membranes. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (By similarity). Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependen [...] (178 aa)
	TBX3	Uncharacterized protein. (242 aa)
	SPRY1	Sprouty RTK signaling antagonist 1. (319 aa)
	HOXA7	Homeobox domain-containing protein. (234 aa)
	S1PR3	Sphingosine-1-phosphate receptor 3; Belongs to the G-protein coupled receptor 1 family. (367 aa)
	NOTCH4	Uncharacterized protein. (1854 aa)
	ACVRL1	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (327 aa)
	NKX6-3	Homeobox domain-containing protein. (263 aa)
	MMP9	Matrix metalloproteinase-9; Could play a role in bone osteoclastic resorption. Cleaves type IV and type V collagen into large C-terminal three quarter fragments and shorter N-terminal one quarter fragments (By similarity). (707 aa)
	JAG1	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1218 aa)
	FST	Follistatin. (310 aa)
	SIX2	SIX homeobox 2. (295 aa)
	HES1	Hes family bHLH transcription factor 1. (279 aa)
	TP63	Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. (680 aa)
	OVOL2	Ovo like zinc finger 2. (333 aa)
	ZEB1	Zinc finger E-box binding homeobox 1. (1080 aa)
	FOXJ2	Forkhead box J2. (614 aa)
	DLL1	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (754 aa)
	EZH2	Enhancer of zeste 2 polycomb repressive complex 2 subunit. (769 aa)

Your Current Organism:

Oryctolagus cuniculus

NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CAV1	CTNNB1	ENSOCUP00000012485	ENSOCUP00000032985	Caveolin-1; May act as a scaffolding protein within caveolar membranes. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (By similarity). Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependen [...]	Catenin beta 1.	0.700
CAV1	MMP9	ENSOCUP00000012485	ENSOCUP00000025066	Caveolin-1; May act as a scaffolding protein within caveolar membranes. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (By similarity). Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependen [...]	Matrix metalloproteinase-9; Could play a role in bone osteoclastic resorption. Cleaves type IV and type V collagen into large C-terminal three quarter fragments and shorter N-terminal one quarter fragments (By similarity).	0.574
CAV1	SPRED2	ENSOCUP00000012485	ENSOCUP00000004250	Caveolin-1; May act as a scaffolding protein within caveolar membranes. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (By similarity). Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependen [...]	Sprouty related EVH1 domain containing 2.	0.474
CTNNB1	CAV1	ENSOCUP00000032985	ENSOCUP00000012485	Catenin beta 1.	Caveolin-1; May act as a scaffolding protein within caveolar membranes. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (By similarity). Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependen [...]	0.700
CTNNB1	DLL1	ENSOCUP00000032985	ENSOCUP00000041831	Catenin beta 1.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.401
CTNNB1	EZH2	ENSOCUP00000032985	ENSOCUP00000041806	Catenin beta 1.	Enhancer of zeste 2 polycomb repressive complex 2 subunit.	0.764
CTNNB1	FGF10	ENSOCUP00000032985	ENSOCUP00000007347	Catenin beta 1.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.400
CTNNB1	FRZB	ENSOCUP00000032985	ENSOCUP00000008935	Catenin beta 1.	Frizzled related protein.	0.447
CTNNB1	JAG1	ENSOCUP00000032985	ENSOCUP00000002511	Catenin beta 1.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.474
CTNNB1	MMP9	ENSOCUP00000032985	ENSOCUP00000025066	Catenin beta 1.	Matrix metalloproteinase-9; Could play a role in bone osteoclastic resorption. Cleaves type IV and type V collagen into large C-terminal three quarter fragments and shorter N-terminal one quarter fragments (By similarity).	0.518
CTNNB1	SMO	ENSOCUP00000032985	ENSOCUP00000027051	Catenin beta 1.	Smoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family.	0.416
CTNNB1	ZEB1	ENSOCUP00000032985	ENSOCUP00000005634	Catenin beta 1.	Zinc finger E-box binding homeobox 1.	0.589
DLL1	CTNNB1	ENSOCUP00000041831	ENSOCUP00000032985	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Catenin beta 1.	0.401
DLL1	HES1	ENSOCUP00000041831	ENSOCUP00000022035	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Hes family bHLH transcription factor 1.	0.675
DLL1	JAG1	ENSOCUP00000041831	ENSOCUP00000002511	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.682
DLL1	NOTCH4	ENSOCUP00000041831	ENSOCUP00000014145	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Uncharacterized protein.	0.996
EZH2	CTNNB1	ENSOCUP00000041806	ENSOCUP00000032985	Enhancer of zeste 2 polycomb repressive complex 2 subunit.	Catenin beta 1.	0.764
EZH2	MMP9	ENSOCUP00000041806	ENSOCUP00000025066	Enhancer of zeste 2 polycomb repressive complex 2 subunit.	Matrix metalloproteinase-9; Could play a role in bone osteoclastic resorption. Cleaves type IV and type V collagen into large C-terminal three quarter fragments and shorter N-terminal one quarter fragments (By similarity).	0.458
EZH2	ZEB1	ENSOCUP00000041806	ENSOCUP00000005634	Enhancer of zeste 2 polycomb repressive complex 2 subunit.	Zinc finger E-box binding homeobox 1.	0.592
FGF10	CTNNB1	ENSOCUP00000007347	ENSOCUP00000032985	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Catenin beta 1.	0.400