STRINGSTRING
SIRT1 SIRT1 G1U940_RABIT G1U940_RABIT LOC103345451 LOC103345451 ENSOCUP00000037329 ENSOCUP00000037329 ENSOCUP00000041840 ENSOCUP00000041840 RRP8 RRP8 C12H6orf89 C12H6orf89 JDP2 JDP2 ENSOCUP00000045925 ENSOCUP00000045925 BCL6 BCL6 ENSOCUP00000044284 ENSOCUP00000044284 TP53 TP53 PML PML AKAP8 AKAP8 NIPBL NIPBL PINK1 PINK1 LRRK2 LRRK2 G1SV95_RABIT G1SV95_RABIT SDR16C5 SDR16C5 AKAP8L AKAP8L ING2 ING2 SAP30BP SAP30BP G1TIG1_RABIT G1TIG1_RABIT PRKD1 PRKD1 APLNR APLNR PRKD2 PRKD2 LOC100357467 LOC100357467
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SIRT1Sirtuin 1. (748 aa)
G1U940_RABITCellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (178 aa)
LOC103345451TGFb_propeptide domain-containing protein. (203 aa)
ENSOCUP00000037329TGFb_propeptide domain-containing protein. (263 aa)
ENSOCUP00000041840TGFb_propeptide domain-containing protein. (219 aa)
RRP8Ribosomal RNA-processing protein 8; Essential component of the eNoSC (energy-dependent nucleolar silencing) complex, a complex that mediates silencing of rDNA in response to intracellular energy status and acts by recruiting histone- modifying enzymes. The eNoSC complex is able to sense the energy status of cell: upon glucose starvation, elevation of NAD(+)/NADP(+) ratio activates SIRT1, leading to histone H3 deacetylation followed by dimethylation of H3 at 'Lys-9' (H3K9me2) by SUV39H1 and the formation of silent chromatin in the rDNA locus. In the complex, RRP8 binds to H3K9me2 and pr [...] (475 aa)
C12H6orf89Uncharacterized protein. (311 aa)
JDP2Jun dimerization protein 2. (184 aa)
ENSOCUP00000045925TGFb_propeptide domain-containing protein. (272 aa)
BCL6BCL6 transcription repressor. (723 aa)
ENSOCUP00000044284TGFb_propeptide domain-containing protein. (260 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...] (391 aa)
PMLPromyelocytic leukemia. (860 aa)
AKAP8A-kinase anchoring protein 8; Belongs to the AKAP95 family. (665 aa)
NIPBLNipped-B protein. (2580 aa)
PINK1PTEN induced kinase 1. (569 aa)
LRRK2Leucine rich repeat kinase 2. (2499 aa)
G1SV95_RABITTransforming growth factor beta; Belongs to the TGF-beta family. (387 aa)
SDR16C5Short chain dehydrogenase/reductase family 16C member 5; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (309 aa)
AKAP8LA-kinase anchoring protein 8 like; Belongs to the AKAP95 family. (633 aa)
ING2Inhibitor of growth protein. (283 aa)
SAP30BPSAP30 binding protein. (365 aa)
G1TIG1_RABITUncharacterized protein. (421 aa)
PRKD1Serine/threonine-protein kinase; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. (832 aa)
APLNRApelin receptor; Belongs to the G-protein coupled receptor 1 family. (380 aa)
PRKD2Serine/threonine-protein kinase; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. (870 aa)
LOC100357467Uncharacterized protein; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (335 aa)
Your Current Organism:
Oryctolagus cuniculus
NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits
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