STRINGSTRING
IL18 IL18 LY86 LY86 TNF TNF G1SV95_RABIT G1SV95_RABIT PLCG2 PLCG2 MAPK1 MAPK1 MAPK3 MAPK3 PRKCE PRKCE NFKBIA NFKBIA CD180 CD180 PTAFR PTAFR CCL2 CCL2 IL1B IL1B G1U1Z9_RABIT G1U1Z9_RABIT NOS3 NOS3 IRAK1 IRAK1 LOC103345451 LOC103345451 MALT1 MALT1 ENSOCUP00000033799 ENSOCUP00000033799 MYD88 MYD88 SCARB1 SCARB1 ENSOCUP00000037329 ENSOCUP00000037329 ENSOCUP00000041840 ENSOCUP00000041840 CD6 CD6 ENSOCUP00000044284 ENSOCUP00000044284 ENSOCUP00000045339 ENSOCUP00000045339 ENSOCUP00000045925 ENSOCUP00000045925 RIPK2 RIPK2 TLR4 TLR4 IRAK2 IRAK2 LYN LYN
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
IL18Uncharacterized protein. (408 aa)
LY86Lymphocyte antigen 86. (157 aa)
TNFTumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (234 aa)
G1SV95_RABITTransforming growth factor beta; Belongs to the TGF-beta family. (387 aa)
PLCG21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1267 aa)
MAPK1Mitogen-activated protein kinase. (364 aa)
MAPK3Mitogen-activated protein kinase. (381 aa)
PRKCEProtein kinase C epsilon type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays essential roles in the regulation of multiple cellular processes linked to cytoskeletal proteins, such as cell adhesion, motility, migration and cell cycle, functions in neuron growth and ion channel regulation, and is involved in immune response, cancer cell invasion and regulation of apoptosis. Mediates cell adhesion to the extracellular matrix via integrin- dependent signaling, by mediating angiotensin-2-induced activation of integrin beta- [...] (744 aa)
NFKBIANFKB inhibitor alpha. (314 aa)
CD180CD180 molecule. (661 aa)
PTAFRPlatelet activating factor receptor; Belongs to the G-protein coupled receptor 1 family. (342 aa)
CCL2C-C motif chemokine 2; Acts as a ligand for C-C chemokine receptor CCR2 (By similarity). Signals through binding and activation of CCR2 and induces a strong chemotactic response and mobilization of intracellular calcium ions (By similarity). Exhibits a chemotactic activity for monocytes and basophils but not neutrophils or eosinophils (By similarity). Plays an important role in mediating peripheral nerve injury-induced neuropathic pain (By similarity). Increases NMDA-mediated synaptic transmission in both dopamine D1 and D2 receptor-containing neurons, which may be caused by MAPK/ERK-d [...] (125 aa)
IL1BInterleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. (234 aa)
G1U1Z9_RABITUncharacterized protein. (242 aa)
NOS3Nitric oxide synthase; Produces nitric oxide (NO). (1209 aa)
IRAK1Interleukin 1 receptor associated kinase 1. (534 aa)
LOC103345451TGFb_propeptide domain-containing protein. (203 aa)
MALT1MALT1 paracaspase. (799 aa)
ENSOCUP00000033799Uncharacterized protein. (545 aa)
MYD88Uncharacterized protein. (476 aa)
SCARB1Scavenger receptor class B member 1; Belongs to the CD36 family. (614 aa)
ENSOCUP00000037329TGFb_propeptide domain-containing protein. (263 aa)
ENSOCUP00000041840TGFb_propeptide domain-containing protein. (219 aa)
CD6CD6 molecule. (683 aa)
ENSOCUP00000044284TGFb_propeptide domain-containing protein. (260 aa)
ENSOCUP00000045339Uncharacterized protein. (163 aa)
ENSOCUP00000045925TGFb_propeptide domain-containing protein. (272 aa)
RIPK2Receptor-interacting serine/threonine-protein kinase 2; Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. (538 aa)
TLR4TIR domain-containing protein; Belongs to the Toll-like receptor family. (839 aa)
IRAK2Interleukin 1 receptor associated kinase 2. (592 aa)
LYNTyrosine-protein kinase. (636 aa)
Your Current Organism:
Oryctolagus cuniculus
NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits
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