STRINGSTRING
PTCH1 PTCH1 PCNA PCNA ESR1 ESR1 ESR2 ESR2 NRIP1 NRIP1 POU4F1 POU4F1 H2AFV H2AFV G1SV95_RABIT G1SV95_RABIT RARA RARA ENSOCUP00000042867 ENSOCUP00000042867 ENSOCUP00000042997 ENSOCUP00000042997 TXNIP TXNIP ENSOCUP00000044284 ENSOCUP00000044284 ENSOCUP00000045925 ENSOCUP00000045925 MAP1B MAP1B RUVBL2 RUVBL2 CASP9 CASP9 ENSOCUP00000048959 ENSOCUP00000048959 ADCYAP1R1 ADCYAP1R1 ENSOCUP00000039801 ENSOCUP00000039801 FAM210B FAM210B UCN UCN SRD5A1 SRD5A1 ALDH1A2 ALDH1A2 AREG AREG CYP1B1 CYP1B1 OGG1 OGG1 FGF10 FGF10 CSN1S1 CSN1S1 ENSOCUP00000037329 ENSOCUP00000037329 ENSOCUP00000035227 ENSOCUP00000035227 IGFBP2 IGFBP2 ENSOCUP00000034091 ENSOCUP00000034091 SSTR3 SSTR3 CTNNB1 CTNNB1 HSF1 HSF1 LOC103345451 LOC103345451 CRHBP CRHBP ENSOCUP00000030584 ENSOCUP00000030584 ENSOCUP00000029917 ENSOCUP00000029917 ENSOCUP00000029775 ENSOCUP00000029775 ITGA2 ITGA2 MBD3L1 MBD3L1 ASS1 ASS1 DHH DHH HTR5A HTR5A IHH IHH MYOD1 MYOD1 DNMT3A DNMT3A SLC6A1 SLC6A1 BMP7 BMP7 MMP15 MMP15 BCL2L2 BCL2L2 KIF18A KIF18A G1TNN7_RABIT G1TNN7_RABIT STXBP1 STXBP1 GPER1 GPER1 G1TJP7_RABIT G1TJP7_RABIT GJB2 GJB2 EGFR EGFR STAT3 STAT3 STRN3 STRN3 MYOG MYOG POU4F2 POU4F2 CDKN1B CDKN1B IGF1R IGF1R ENSOCUP00000040431 ENSOCUP00000040431 MBD2 MBD2 ENSOCUP00000041840 ENSOCUP00000041840 NCOA3 NCOA3 KAT5 KAT5 TACR1 TACR1 SOCS2 SOCS2 HNRNPD HNRNPD PAM PAM PDGFRB PDGFRB G1SGC2_RABIT G1SGC2_RABIT CCDC62 CCDC62 PTGFR PTGFR AIFM1 AIFM1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PTCH1Patched 1. (1321 aa)
PCNAProliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (261 aa)
ESR1Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. (598 aa)
ESR2Estrogen receptor 2. (523 aa)
NRIP1Nuclear receptor interacting protein 1. (1157 aa)
POU4F1POU domain protein. (339 aa)
H2AFVHistone H2A.V; Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post- translational modifications of histones, also called histone code, and nucleosome remodeling. May be involved in the formation of constitutive heterochromatin. May be required for c [...] (129 aa)
G1SV95_RABITTransforming growth factor beta; Belongs to the TGF-beta family. (387 aa)
RARARetinoic acid receptor alpha. (462 aa)
ENSOCUP00000042867Uncharacterized protein. (340 aa)
ENSOCUP00000042997Kazal-like domain-containing protein. (117 aa)
TXNIPThioredoxin interacting protein. (429 aa)
ENSOCUP00000044284TGFb_propeptide domain-containing protein. (260 aa)
ENSOCUP00000045925TGFb_propeptide domain-containing protein. (272 aa)
MAP1BMicrotubule associated protein 1B. (2355 aa)
RUVBL2RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding. (463 aa)
CASP9Caspase 9; Belongs to the peptidase C14A family. (466 aa)
ENSOCUP00000048959Uncharacterized protein. (2771 aa)
ADCYAP1R1ADCYAP receptor type I; Belongs to the G-protein coupled receptor 2 family. (549 aa)
ENSOCUP00000039801Histone_H2A_C domain-containing protein; Belongs to the histone H2A family. (89 aa)
FAM210BDUF1279 domain-containing protein. (195 aa)
UCNUrocortin. (128 aa)
SRD5A13-oxo-5-alpha-steroid 4-dehydrogenase; Converts testosterone into 5-alpha-dihydrotestosterone and progesterone or corticosterone into their corresponding 5-alpha-3- oxosteroids. It plays a central role in sexual differentiation and androgen physiology. (255 aa)
ALDH1A2Aldehyde dehydrogenase 1 family member A2; Belongs to the aldehyde dehydrogenase family. (590 aa)
AREGAmphiregulin. (275 aa)
CYP1B1Cytochrome P450 family 1 subfamily B member 1; Belongs to the cytochrome P450 family. (542 aa)
OGG1OGG_N domain-containing protein. (192 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (220 aa)
CSN1S1Alpha-S1-casein; Important role in the capacity of milk to transport calcium phosphate. (141 aa)
ENSOCUP00000037329TGFb_propeptide domain-containing protein. (263 aa)
ENSOCUP00000035227Histone H2A; Belongs to the histone H2A family. (118 aa)
IGFBP2IGFBP N-terminal domain-containing protein. (442 aa)
ENSOCUP00000034091Histone H2A; Belongs to the histone H2A family. (137 aa)
SSTR3Somatostatin receptor 3. (370 aa)
CTNNB1Catenin beta 1. (741 aa)
HSF1Heat shock transcription factor 1. (680 aa)
LOC103345451TGFb_propeptide domain-containing protein. (203 aa)
CRHBPCorticotropin releasing hormone binding protein. (382 aa)
ENSOCUP00000030584Uncharacterized protein. (513 aa)
ENSOCUP00000029917Uncharacterized protein. (169 aa)
ENSOCUP00000029775DUF1279 domain-containing protein. (199 aa)
ITGA2Integrin subunit alpha 2; Belongs to the integrin alpha chain family. (1202 aa)
MBD3L1MBDa domain-containing protein. (230 aa)
ASS1Uncharacterized protein. (251 aa)
DHHDesert hedgehog signaling molecule. (388 aa)
HTR5A5-hydroxytryptamine receptor 5A. (358 aa)
IHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (410 aa)
MYOD1Myogenic factor; Induces fibroblasts to differentiate into myoblasts. Acts as a transcriptional activator that promotes transcription of muscle- specific target genes and plays a role in muscle differentiation. (323 aa)
DNMT3ADNA methyltransferase 3 alpha; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. (843 aa)
SLC6A1Transporter; Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. (254 aa)
BMP7TGF_BETA_2 domain-containing protein. (170 aa)
MMP15U6 snRNA phosphodiesterase; Phosphodiesterase responsible for the U6 snRNA 3' end processing. Acts as an exoribonuclease (RNase) responsible for trimming the poly(U) tract of the last nucleotides in the pre-U6 snRNA molecule, leading to the formation of mature U6 snRNA 3' end-terminated with a 2',3'-cyclic phosphate; Belongs to the peptidase M10A family. (822 aa)
BCL2L2BCL2 like 2. (193 aa)
KIF18AKinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (892 aa)
G1TNN7_RABITUncharacterized protein. (571 aa)
STXBP1Syntaxin binding protein 1; Belongs to the STXBP/unc-18/SEC1 family. (590 aa)
GPER1G protein-coupled estrogen receptor 1; Belongs to the G-protein coupled receptor 1 family. (361 aa)
G1TJP7_RABITSANT domain-containing protein. (1611 aa)
GJB2Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. (226 aa)
EGFRReceptor protein-tyrosine kinase. (1193 aa)
STAT3Signal transducer and activator of transcription. (770 aa)
STRN3Striatin 3. (713 aa)
MYOGMyogenin. (225 aa)
POU4F2POU domain protein. (392 aa)
CDKN1BCyclin dependent kinase inhibitor 1B. (198 aa)
IGF1RTyrosine-protein kinase receptor. (1464 aa)
ENSOCUP00000040431Histone H2A; Belongs to the histone H2A family. (97 aa)
MBD2Methyl-CpG binding domain protein 2. (347 aa)
ENSOCUP00000041840TGFb_propeptide domain-containing protein. (219 aa)
NCOA3Nuclear receptor coactivator. (1444 aa)
KAT5Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (620 aa)
TACR1Tachykinin receptor 1; Belongs to the G-protein coupled receptor 1 family. (407 aa)
SOCS2Suppressor of cytokine signaling 2. (307 aa)
HNRNPDHeterogeneous nuclear ribonucleoprotein D. (286 aa)
PAMPeptidylglycine alpha-amidating monooxygenase. (975 aa)
PDGFRBPlatelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. (1147 aa)
G1SGC2_RABITHistone H2A; Belongs to the histone H2A family. (124 aa)
CCDC62Coiled-coil domain containing 62. (710 aa)
PTGFRProstaglandin F receptor; Belongs to the G-protein coupled receptor 1 family. (366 aa)
AIFM1Apoptosis inducing factor mitochondria associated 1. (613 aa)
Your Current Organism:
Oryctolagus cuniculus
NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits
Server load: low (20%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.