18 items (Oryctolagus cuniculus) - STRING interaction network

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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Your Input:
	PRNP	Major prion protein; Its primary physiological function is unclear. Has cytoprotective activity against internal or environmental stresses. May play a role in neuronal development and synaptic plasticity. May be required for neuronal myelin sheath maintenance. May play a role in iron uptake and iron homeostasis. Soluble oligomers are toxic to cultured neuroblastoma cells and induce apoptosis (in vitro). Association with GPC1 (via its heparan sulfate chains) targets PRNP to lipid rafts. Also provides Cu(2+) or ZN(2+) for the ascorbate-mediated GPC1 deaminase degradation of its heparan s [...] (252 aa)
	TLR4	TIR domain-containing protein; Belongs to the Toll-like receptor family. (839 aa)
	TUSC2	Uncharacterized protein. (112 aa)
	G1SV95_RABIT	Transforming growth factor beta; Belongs to the TGF-beta family. (387 aa)
	TNFSF4	Tumor necrosis factor ligand superfamily member 4; Cytokine that binds to TNFRSF4. Co-stimulates T-cell proliferation and cytokine production. (216 aa)
	FOXP3	Forkhead box P3. (455 aa)
	NCKAP1L	NCK associated protein 1 like. (1181 aa)
	IL27RA	Interleukin 27 receptor subunit alpha. (634 aa)
	VSIR	V-set immunoregulatory receptor. (312 aa)
	IL12B	Interleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. (324 aa)
	DDIT3	DNA damage-inducible transcript 3 protein; Multifunctional transcription factor in ER stress response. Plays an essential role in the response to a wide variety of cell stresses and induces cell cycle arrest and apoptosis in response to ER stress. Plays a dual role both as an inhibitor of CCAAT/enhancer- binding protein (C/EBP) function and as an activator of other genes. Acts as a dominant-negative regulator of C/EBP-induced transcription: dimerizes with members of the C/EBP family, impairs their association with C/EBP binding sites in the promoter regions, and inhibits the expression [...] (168 aa)
	ENSOCUP00000027867	Uncharacterized protein. (167 aa)
	ENSOCUP00000045925	TGFb_propeptide domain-containing protein. (272 aa)
	ENSOCUP00000044284	TGFb_propeptide domain-containing protein. (260 aa)
	ENSOCUP00000041840	TGFb_propeptide domain-containing protein. (219 aa)
	ENSOCUP00000037329	TGFb_propeptide domain-containing protein. (263 aa)
	IL12A	Interleukin-12 subunit alpha; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated Killer cells, and stimulate the production of IFN-gamma by resting PBMC. (233 aa)
	LOC103345451	TGFb_propeptide domain-containing protein. (203 aa)

Your Current Organism:

Oryctolagus cuniculus

NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
DDIT3	FOXP3	ENSOCUP00000016579	ENSOCUP00000008733	DNA damage-inducible transcript 3 protein; Multifunctional transcription factor in ER stress response. Plays an essential role in the response to a wide variety of cell stresses and induces cell cycle arrest and apoptosis in response to ER stress. Plays a dual role both as an inhibitor of CCAAT/enhancer- binding protein (C/EBP) function and as an activator of other genes. Acts as a dominant-negative regulator of C/EBP-induced transcription: dimerizes with members of the C/EBP family, impairs their association with C/EBP binding sites in the promoter regions, and inhibits the expression [...]	Forkhead box P3.	0.492
ENSOCUP00000037329	ENSOCUP00000044284	ENSOCUP00000037329	ENSOCUP00000044284	TGFb_propeptide domain-containing protein.	TGFb_propeptide domain-containing protein.	0.412
ENSOCUP00000037329	FOXP3	ENSOCUP00000037329	ENSOCUP00000008733	TGFb_propeptide domain-containing protein.	Forkhead box P3.	0.542
ENSOCUP00000037329	LOC103345451	ENSOCUP00000037329	ENSOCUP00000031740	TGFb_propeptide domain-containing protein.	TGFb_propeptide domain-containing protein.	0.419
ENSOCUP00000037329	TLR4	ENSOCUP00000037329	ENSOCUP00000001909	TGFb_propeptide domain-containing protein.	TIR domain-containing protein; Belongs to the Toll-like receptor family.	0.587
ENSOCUP00000044284	ENSOCUP00000037329	ENSOCUP00000044284	ENSOCUP00000037329	TGFb_propeptide domain-containing protein.	TGFb_propeptide domain-containing protein.	0.412
ENSOCUP00000044284	FOXP3	ENSOCUP00000044284	ENSOCUP00000008733	TGFb_propeptide domain-containing protein.	Forkhead box P3.	0.542
ENSOCUP00000044284	TLR4	ENSOCUP00000044284	ENSOCUP00000001909	TGFb_propeptide domain-containing protein.	TIR domain-containing protein; Belongs to the Toll-like receptor family.	0.587
FOXP3	DDIT3	ENSOCUP00000008733	ENSOCUP00000016579	Forkhead box P3.	DNA damage-inducible transcript 3 protein; Multifunctional transcription factor in ER stress response. Plays an essential role in the response to a wide variety of cell stresses and induces cell cycle arrest and apoptosis in response to ER stress. Plays a dual role both as an inhibitor of CCAAT/enhancer- binding protein (C/EBP) function and as an activator of other genes. Acts as a dominant-negative regulator of C/EBP-induced transcription: dimerizes with members of the C/EBP family, impairs their association with C/EBP binding sites in the promoter regions, and inhibits the expression [...]	0.492
FOXP3	ENSOCUP00000037329	ENSOCUP00000008733	ENSOCUP00000037329	Forkhead box P3.	TGFb_propeptide domain-containing protein.	0.542
FOXP3	ENSOCUP00000044284	ENSOCUP00000008733	ENSOCUP00000044284	Forkhead box P3.	TGFb_propeptide domain-containing protein.	0.542
FOXP3	LOC103345451	ENSOCUP00000008733	ENSOCUP00000031740	Forkhead box P3.	TGFb_propeptide domain-containing protein.	0.542
FOXP3	TLR4	ENSOCUP00000008733	ENSOCUP00000001909	Forkhead box P3.	TIR domain-containing protein; Belongs to the Toll-like receptor family.	0.682
FOXP3	TNFSF4	ENSOCUP00000008733	ENSOCUP00000007420	Forkhead box P3.	Tumor necrosis factor ligand superfamily member 4; Cytokine that binds to TNFRSF4. Co-stimulates T-cell proliferation and cytokine production.	0.668
IL12A	IL12B	ENSOCUP00000037145	ENSOCUP00000014029	Interleukin-12 subunit alpha; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated Killer cells, and stimulate the production of IFN-gamma by resting PBMC.	Interleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC.	0.979
IL12B	IL12A	ENSOCUP00000014029	ENSOCUP00000037145	Interleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC.	Interleukin-12 subunit alpha; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated Killer cells, and stimulate the production of IFN-gamma by resting PBMC.	0.979
LOC103345451	ENSOCUP00000037329	ENSOCUP00000031740	ENSOCUP00000037329	TGFb_propeptide domain-containing protein.	TGFb_propeptide domain-containing protein.	0.419
LOC103345451	FOXP3	ENSOCUP00000031740	ENSOCUP00000008733	TGFb_propeptide domain-containing protein.	Forkhead box P3.	0.542
LOC103345451	TLR4	ENSOCUP00000031740	ENSOCUP00000001909	TGFb_propeptide domain-containing protein.	TIR domain-containing protein; Belongs to the Toll-like receptor family.	0.587
TLR4	ENSOCUP00000037329	ENSOCUP00000001909	ENSOCUP00000037329	TIR domain-containing protein; Belongs to the Toll-like receptor family.	TGFb_propeptide domain-containing protein.	0.587