27 items (Oryctolagus cuniculus) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

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co-expression

protein homology

Your Input:
	IL18	Uncharacterized protein. (408 aa)
	NR1H4	Uncharacterized protein. (486 aa)
	IL23A	Interleukin 23 subunit alpha. (191 aa)
	PRKCQ	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (675 aa)
	IL2	Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells; Belongs to the IL-2 family. (153 aa)
	OSM	Uncharacterized protein. (333 aa)
	BTK	Tyrosine-protein kinase. (659 aa)
	ARID5A	AT-rich interaction domain 5A. (555 aa)
	NOD2	Nucleotide oligomerization domain 2 protein. (1013 aa)
	CCL1	C-C motif chemokine. (190 aa)
	IL21	Interleukin; Belongs to the IL-15/IL-21 family. (154 aa)
	RFTN1	Raftlin, lipid raft linker 1. (572 aa)
	IL12B	Interleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. (324 aa)
	IL23R	Interleukin 23 receptor. (622 aa)
	SPHK1	Sphingosine kinase 1. (455 aa)
	LOC103345451	TGFb_propeptide domain-containing protein. (203 aa)
	ENSOCUP00000033220	Prohibitin. (262 aa)
	MYD88	Uncharacterized protein. (476 aa)
	TYK2	Non-specific protein-tyrosine kinase. (1065 aa)
	ENSOCUP00000037329	TGFb_propeptide domain-containing protein. (263 aa)
	ENSOCUP00000041840	TGFb_propeptide domain-containing protein. (219 aa)
	ENSOCUP00000044284	TGFb_propeptide domain-containing protein. (260 aa)
	ENSOCUP00000045925	TGFb_propeptide domain-containing protein. (272 aa)
	G1SV95_RABIT	Transforming growth factor beta; Belongs to the TGF-beta family. (387 aa)
	SLAMF6	Ig-like domain-containing protein. (387 aa)
	PHB	Prohibitin. (303 aa)
	IL15	Interleukin-15; Cytokine that stimulates the proliferation of T-lymphocytes. Stimulation by IL15 requires interaction of IL15 with components of the IL2 receptor, including IL2RB and probably IL2RG but not IL2RA (By similarity). In neutrophils, stimulates phagocytosis probably by signaling through the IL15 receptor, which results in kinase SYK activation (By similarity). (162 aa)

Your Current Organism:

Oryctolagus cuniculus

NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BTK	MYD88	ENSOCUP00000009153	ENSOCUP00000034296	Tyrosine-protein kinase.	Uncharacterized protein.	0.875
ENSOCUP00000037329	ENSOCUP00000044284	ENSOCUP00000037329	ENSOCUP00000044284	TGFb_propeptide domain-containing protein.	TGFb_propeptide domain-containing protein.	0.412
ENSOCUP00000037329	IL18	ENSOCUP00000037329	ENSOCUP00000004555	TGFb_propeptide domain-containing protein.	Uncharacterized protein.	0.424
ENSOCUP00000037329	IL21	ENSOCUP00000037329	ENSOCUP00000013142	TGFb_propeptide domain-containing protein.	Interleukin; Belongs to the IL-15/IL-21 family.	0.700
ENSOCUP00000037329	LOC103345451	ENSOCUP00000037329	ENSOCUP00000031740	TGFb_propeptide domain-containing protein.	TGFb_propeptide domain-containing protein.	0.419
ENSOCUP00000044284	ENSOCUP00000037329	ENSOCUP00000044284	ENSOCUP00000037329	TGFb_propeptide domain-containing protein.	TGFb_propeptide domain-containing protein.	0.412
ENSOCUP00000044284	IL18	ENSOCUP00000044284	ENSOCUP00000004555	TGFb_propeptide domain-containing protein.	Uncharacterized protein.	0.424
ENSOCUP00000044284	IL21	ENSOCUP00000044284	ENSOCUP00000013142	TGFb_propeptide domain-containing protein.	Interleukin; Belongs to the IL-15/IL-21 family.	0.700
IL12B	IL18	ENSOCUP00000014029	ENSOCUP00000004555	Interleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC.	Uncharacterized protein.	0.467
IL12B	IL2	ENSOCUP00000014029	ENSOCUP00000008701	Interleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC.	Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells; Belongs to the IL-2 family.	0.408
IL12B	IL23A	ENSOCUP00000014029	ENSOCUP00000006251	Interleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC.	Interleukin 23 subunit alpha.	0.988
IL12B	IL23R	ENSOCUP00000014029	ENSOCUP00000025563	Interleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC.	Interleukin 23 receptor.	0.972
IL12B	TYK2	ENSOCUP00000014029	ENSOCUP00000036146	Interleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC.	Non-specific protein-tyrosine kinase.	0.478
IL15	IL18	ENSOCUP00000007620	ENSOCUP00000004555	Interleukin-15; Cytokine that stimulates the proliferation of T-lymphocytes. Stimulation by IL15 requires interaction of IL15 with components of the IL2 receptor, including IL2RB and probably IL2RG but not IL2RA (By similarity). In neutrophils, stimulates phagocytosis probably by signaling through the IL15 receptor, which results in kinase SYK activation (By similarity).	Uncharacterized protein.	0.880
IL15	IL2	ENSOCUP00000007620	ENSOCUP00000008701	Interleukin-15; Cytokine that stimulates the proliferation of T-lymphocytes. Stimulation by IL15 requires interaction of IL15 with components of the IL2 receptor, including IL2RB and probably IL2RG but not IL2RA (By similarity). In neutrophils, stimulates phagocytosis probably by signaling through the IL15 receptor, which results in kinase SYK activation (By similarity).	Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells; Belongs to the IL-2 family.	0.854
IL15	IL21	ENSOCUP00000007620	ENSOCUP00000013142	Interleukin-15; Cytokine that stimulates the proliferation of T-lymphocytes. Stimulation by IL15 requires interaction of IL15 with components of the IL2 receptor, including IL2RB and probably IL2RG but not IL2RA (By similarity). In neutrophils, stimulates phagocytosis probably by signaling through the IL15 receptor, which results in kinase SYK activation (By similarity).	Interleukin; Belongs to the IL-15/IL-21 family.	0.810
IL15	IL23R	ENSOCUP00000007620	ENSOCUP00000025563	Interleukin-15; Cytokine that stimulates the proliferation of T-lymphocytes. Stimulation by IL15 requires interaction of IL15 with components of the IL2 receptor, including IL2RB and probably IL2RG but not IL2RA (By similarity). In neutrophils, stimulates phagocytosis probably by signaling through the IL15 receptor, which results in kinase SYK activation (By similarity).	Interleukin 23 receptor.	0.778
IL15	MYD88	ENSOCUP00000007620	ENSOCUP00000034296	Interleukin-15; Cytokine that stimulates the proliferation of T-lymphocytes. Stimulation by IL15 requires interaction of IL15 with components of the IL2 receptor, including IL2RB and probably IL2RG but not IL2RA (By similarity). In neutrophils, stimulates phagocytosis probably by signaling through the IL15 receptor, which results in kinase SYK activation (By similarity).	Uncharacterized protein.	0.529
IL15	OSM	ENSOCUP00000007620	ENSOCUP00000008790	Interleukin-15; Cytokine that stimulates the proliferation of T-lymphocytes. Stimulation by IL15 requires interaction of IL15 with components of the IL2 receptor, including IL2RB and probably IL2RG but not IL2RA (By similarity). In neutrophils, stimulates phagocytosis probably by signaling through the IL15 receptor, which results in kinase SYK activation (By similarity).	Uncharacterized protein.	0.470
IL15	TYK2	ENSOCUP00000007620	ENSOCUP00000036146	Interleukin-15; Cytokine that stimulates the proliferation of T-lymphocytes. Stimulation by IL15 requires interaction of IL15 with components of the IL2 receptor, including IL2RB and probably IL2RG but not IL2RA (By similarity). In neutrophils, stimulates phagocytosis probably by signaling through the IL15 receptor, which results in kinase SYK activation (By similarity).	Non-specific protein-tyrosine kinase.	0.654