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| | FBXO5 | F-box protein 5. (444 aa) |
| | CCT3 | T-complex protein 1 subunit gamma. (545 aa) |
| | BCL7A | BAF chromatin remodeling complex subunit BCL7A. (210 aa) |
| | CDCA5 | Cell division cycle associated 5. (301 aa) |
| | RMI2 | RecQ mediated genome instability 2. (148 aa) |
| | HNRNPD | Heterogeneous nuclear ribonucleoprotein D. (286 aa) |
| | NAT10 | RNA cytidine acetyltransferase; RNA cytidine acetyltransferase with specificity toward both 18S rRNA and tRNAs. Catalyzes the formation of N(4)-acetylcytidine (ac4C) in 18S rRNA. Required for early nucleolar cleavages of precursor rRNA at sites A0, A1 and A2 during 18S rRNA synthesis. Catalyzes the formation of ac4C in serine and leucine tRNAs. Requires the tRNA- binding adapter protein THUMPD1 for full tRNA acetyltransferase activity but not for 18S rRNA acetylation. (1030 aa) |
| | RIOK2 | RIO kinase 2. (552 aa) |
| | ATR | ATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family. (2643 aa) |
| | SMARCC1 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin subfamily c member 1. (1011 aa) |
| | PPP1R10 | Protein phosphatase 1 regulatory subunit 10. (820 aa) |
| | PML | Promyelocytic leukemia. (860 aa) |
| | RAD21 | RAD21 cohesin complex component. (630 aa) |
| | ANAPC5 | Anaphase promoting complex subunit 5. (755 aa) |
| | SLF2 | SMC5-SMC6 complex localization factor 2. (1167 aa) |
| | TERF1 | Telomeric repeat-binding factor; Binds the telomeric double-stranded 5'-TTAGGG-3' repeat. (435 aa) |
| | TOP2A | DNA topoisomerase 2; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double- strand breaks. (1513 aa) |
| | TINF2 | TERF1 interacting nuclear factor 2. (356 aa) |
| | STN1 | CST complex subunit STN1; Component of the CST complex proposed to act as a specialized replication factor promoting DNA replication under conditions of replication stress or natural replication barriers such as the telomere duplex. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. Initially the CST complex has been proposed to protect telomeres from DNA degradation. However, the CST complex has been shown to be involved in several aspects of telomere replication. (376 aa) |
| | FEN1 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (380 aa) |
| | SHCBP1L | CASH domain-containing protein. (303 aa) |
| | SLF1 | SMC5-SMC6 complex localization factor 1. (1015 aa) |
| | SMARCD2 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 2. (532 aa) |
| | USP44 | Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (710 aa) |
| | CDC6 | Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. (560 aa) |
| | RNF4 | RING-type domain-containing protein. (190 aa) |
| | CDC26 | Cell division cycle 26. (85 aa) |
| | ARID1A | AT-rich interaction domain 1A. (2089 aa) |
| | PIF1 | ATP-dependent DNA helicase PIF1; DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability. Efficiently unwinds G-quadruplex (G4) DNA structures and forked RNA-DNA hybrids. Resolves G4 structures, preventing replication pausing and double-strand breaks (DSBs) at G4 motifs. Involved in the maintenance of telomeric DNA. Inhibits telomere elongation, de novo telomere formation and telomere addition to DSBs via catalytic inhibition of telomerase. Reduces the processivity of telomerase by displacing active telomerase from DNA [...] (582 aa) |
| | MAD2L1BP | MAD2L1 binding protein. (274 aa) |
| | SMC2 | Structural maintenance of chromosomes 2. (1126 aa) |
| | DDX11 | Helicase ATP-binding domain-containing protein. (330 aa) |
| | G1SQF5_RABIT | AAA domain-containing protein; Belongs to the AAA ATPase family. (401 aa) |
| | INO80E | INO80 complex subunit E. (244 aa) |
| | XRCC5 | X-ray repair cross complementing 5. (733 aa) |
| | NCAPG | Non-SMC condensin I complex subunit G. (1014 aa) |
| | ZWINT | ZW10 interacting kinetochore protein. (339 aa) |
| | INCENP | Inner centromere protein. (904 aa) |
| | SLX4 | SLX4 structure-specific endonuclease subunit. (1743 aa) |
| | ATRX | ATRX chromatin remodeler. (2472 aa) |
| | DUSP1 | Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (367 aa) |
| | HASPIN | Histone H3 associated protein kinase. (707 aa) |
| | NCAPD2 | Condensin complex subunit 1; Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases. (1394 aa) |
| | MAD2L1 | Mitotic arrest deficient 2 like 1. (205 aa) |
| | CDC23 | Cell division cycle 23. (597 aa) |
| | ATF7IP2 | Activating transcription factor 7 interacting protein 2. (685 aa) |
| | CDC16 | Cell division cycle 16. (560 aa) |
| | CCDC174 | Coiled-coil domain containing 174. (468 aa) |
| | PLK1 | Serine/threonine-protein kinase PLK. (604 aa) |
| | ACD | Uncharacterized protein. (136 aa) |
| | FBXO4 | F-box protein 4. (387 aa) |
| | PCID2 | PCI domain containing 2. (486 aa) |
| | NEK2 | NIMA related kinase 2. (451 aa) |
| | PBRM1 | Polybromo 1. (1689 aa) |
| | GNL3 | G protein nucleolar 3. (545 aa) |
| | PRKCQ | Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (675 aa) |
| | LMNA | Lamin A/C; Belongs to the intermediate filament family. (704 aa) |
| | DCP2 | Decapping mRNA 2. (420 aa) |
| | POT1 | Telo_bind domain-containing protein. (637 aa) |
| | INO80 | INO80 complex ATPase subunit. (1559 aa) |
| | FSHR | Follicle-stimulating hormone receptor; G protein-coupled receptor for follitropin, the follicle- stimulating hormone. Through cAMP production activates the downstream PI3K-AKT and ERK1/ERK2 signaling pathways. (703 aa) |
| | NEK7 | Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (326 aa) |
| | TNKS2 | Poly [ADP-ribose] polymerase. (1283 aa) |
| | TPR | Translocated promoter region, nuclear basket protein. (2362 aa) |
| | ATF7IP | Activating transcription factor 7 interacting protein. (1282 aa) |
| | SETDB1 | SET domain bifurcated histone lysine methyltransferase 1. (1292 aa) |
| | MCPH1 | Microcephalin 1. (761 aa) |
| | SMC5 | SMC_N domain-containing protein. (1144 aa) |
| | TASOR | Transcription activation suppressor. (1672 aa) |
| | ARID2 | AT-rich interaction domain 2. (1772 aa) |
| | MAPK1 | Mitogen-activated protein kinase. (364 aa) |
| | MAPK3 | Mitogen-activated protein kinase. (381 aa) |
| | KNTC1 | Kinetochore associated 1. (2195 aa) |
| | LOC100357927 | Histone domain-containing protein. (136 aa) |
| | MNAT1 | CDK-activating kinase assembly factor MAT1; Stabilizes the cyclin H-CDK7 complex to form a functional CDK-activating kinase (CAK) enzymatic complex. (309 aa) |
| | ANAPC7 | Anaphase promoting complex subunit 7. (597 aa) |
| | KHDC3L | MOEP19 domain-containing protein. (136 aa) |
| | ATM | Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3056 aa) |
| | PTTG1 | Uncharacterized protein. (201 aa) |
| | MRE11 | Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (680 aa) |
| | ERCC4 | ERCC excision repair 4, endonuclease catalytic subunit. (909 aa) |
| | H3F3B | Histone H3; Belongs to the histone H3 family. (136 aa) |
| | APC | APC regulator of WNT signaling pathway. (2871 aa) |
| | LIG4 | DNA ligase. (911 aa) |
| | ANAPC4 | Anaphase-promoting complex subunit 4; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. Belongs to the APC4 family. (809 aa) |
| | WAPL | WAPL cohesin release factor. (1196 aa) |
| | TRIM28 | Tripartite motif containing 28. (857 aa) |
| | SMG1 | SMG1 nonsense mediated mRNA decay associated PI3K related kinase; Belongs to the PI3/PI4-kinase family. (3635 aa) |
| | UCHL5 | Ubiquitin carboxyl-terminal hydrolase. (609 aa) |
| | MCRS1 | Microspherule protein 1. (427 aa) |
| | MAP3K4 | Mitogen-activated protein kinase kinase kinase 4. (1496 aa) |
| | TAL1 | TAL bHLH transcription factor 1, erythroid differentiation factor. (319 aa) |
| | CCT6 | T-complex protein 1 subunit zeta; Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role, in vitro, in the folding of actin and tubulin; Belongs to the TCP-1 chaperonin family. (531 aa) |
| | TNKS | Poly [ADP-ribose] polymerase. (1326 aa) |
| | PARP1 | Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair. (1013 aa) |
| | MAPK15 | Mitogen-activated protein kinase. (619 aa) |
| | ACTL6A | Actin like 6A; Belongs to the actin family. (429 aa) |
| | CDT1 | Chromatin licensing and DNA replication factor 1. (365 aa) |
| | G1TFS8_RABIT | Uncharacterized protein. (123 aa) |
| | ANAPC1 | Anaphase promoting complex subunit 1. (1944 aa) |
| | ENSOCUP00000015809 | Histone H3.3. (144 aa) |
| | G1TGL9_RABIT | Uncharacterized protein. (399 aa) |
| | RAD50 | Zinc-hook domain-containing protein. (1269 aa) |
| | NAF1 | Nuclear assembly factor 1 ribonucleoprotein. (482 aa) |
| | ZWILCH | Zwilch kinetochore protein. (587 aa) |
| | TCP1 | Uncharacterized protein. (556 aa) |
| | HECW2 | HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2. (1536 aa) |
| | SLX1A | GIY-YIG domain-containing protein. (134 aa) |
| | MAP2K7 | Mitogen-activated protein kinase kinase 7. (435 aa) |
| | G1TLL0_RABIT | Uncharacterized protein. (667 aa) |
| | CCT5 | Chaperonin containing TCP1 subunit 5. (541 aa) |
| | H3-3A | Histone H3.3; Variant histone H3 which replaces conventional H3 in a wide range of nucleosomes in active genes. Constitutes the predominant form of histone H3 in non-dividing cells and is incorporated into chromatin independently of DNA synthesis. Deposited at sites of nucleosomal displacement throughout transcribed genes, suggesting that it represents an epigenetic imprint of transcriptionally active chromatin. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in [...] (136 aa) |
| | GEN1 | GEN1 Holliday junction 5' flap endonuclease. (904 aa) |
| | ANAPC11 | RING-type domain-containing protein. (84 aa) |
| | MOS | MOS proto-oncogene, serine/threonine kinase; Belongs to the protein kinase superfamily. (348 aa) |
| | LOC100343999 | Telo_bind domain-containing protein. (580 aa) |
| | DKC1 | Dyskerin pseudouridine synthase 1. (512 aa) |
| | SENP6 | SUMO specific peptidase 6. (1044 aa) |
| | G1TTM1_RABIT | Bromo domain-containing protein. (95 aa) |
| | CDC27 | Cell division cycle 27. (825 aa) |
| | HNRNPA2B1 | Heterogeneous nuclear ribonucleoprotein A2/B1. (352 aa) |
| | TRIP13 | AAA domain-containing protein; Belongs to the AAA ATPase family. (432 aa) |
| | ZW10 | Zw10 kinetochore protein. (864 aa) |
| | SETDB2 | SET domain bifurcated histone lysine methyltransferase 2. (702 aa) |
| | BCL7B | BAF chromatin remodeling complex subunit BCL7B. (204 aa) |
| | PKIB | cAMP-dependent protein kinase inhibitor beta. (129 aa) |
| | TERF2 | Telomeric repeat-binding factor; Binds the telomeric double-stranded 5'-TTAGGG-3' repeat. (541 aa) |
| | CENPV | GFA domain-containing protein. (303 aa) |
| | DPF2 | Double PHD fingers 2. (465 aa) |
| | NABP2 | Nucleic acid binding protein 2. (211 aa) |
| | ANAPC15-2 | Uncharacterized protein. (123 aa) |
| | ERCC1 | Uncharacterized protein. (226 aa) |
| | G1U6C6_RABIT | RING-type domain-containing protein. (214 aa) |
| | NUMA1 | Nuclear mitotic apparatus protein 1. (2116 aa) |
| | XRCC3 | DNA repair protein; Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions; Belongs to the RecA family. RAD51 subfamily. (344 aa) |
| | TFPT | Uncharacterized protein. (386 aa) |
| | U3KMS1_RABIT | Uncharacterized protein. (584 aa) |
| | PRAP1 | Uncharacterized protein. (189 aa) |
| | U3KPG4_RABIT | Uncharacterized protein. (481 aa) |
| | PPHLN1 | Periphilin 1. (450 aa) |
| | MACROH2A1 | H2A histone family member Y; Belongs to the histone H2A family. (418 aa) |
| | BAZ1B | Bromodomain adjacent to zinc finger domain 1B. (1446 aa) |
| | CCT4 | T-complex protein 1 subunit delta. (551 aa) |
| | SMARCC2 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin subfamily c member 2. (1207 aa) |
| | INO80B | PAPA-1 domain-containing protein. (392 aa) |
| | ENSOCUP00000029342 | Histone domain-containing protein. (82 aa) |
| | ENSOCUP00000029552 | Uncharacterized protein. (160 aa) |
| | NBN | Nibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. (762 aa) |
| | CENPE | Centromere protein E; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (2697 aa) |
| | GNL3L | G protein nucleolar 3 like. (613 aa) |
| | ENSOCUP00000031127 | Uncharacterized protein. (310 aa) |
| | ENSOCUP00000031187 | TRF domain-containing protein. (274 aa) |
| | NEK6 | Protein kinase domain-containing protein. (547 aa) |
| | CUL3 | Cullin 3; Belongs to the cullin family. (771 aa) |
| | MAD1L1 | Uncharacterized protein. (434 aa) |
| | ANAPC15 | Uncharacterized protein. (208 aa) |
| | BUB1 | BUB1 mitotic checkpoint serine/threonine kinase. (1057 aa) |
| | MORC2 | MORC family CW-type zinc finger 2. (1022 aa) |
| | SMARCA2 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2. (1595 aa) |
| | MAPKAPK5 | MAPK activated protein kinase 5. (537 aa) |
| | ENSOCUP00000032614 | Uncharacterized protein. (136 aa) |
| | ARID1B | AT-rich interaction domain 1B. (1600 aa) |
| | RUVBL1 | RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding. (485 aa) |
| | CTNNB1 | Catenin beta 1. (741 aa) |
| | MCM2 | DNA helicase; Belongs to the MCM family. (902 aa) |
| | PSMG2 | Proteasome assembly chaperone 2. (404 aa) |
| | ENSOCUP00000033208 | SMC_N domain-containing protein. (86 aa) |
| | ENSOCUP00000033443 | Uncharacterized protein. (121 aa) |
| | SIN3A | SIN3 transcription regulator family member A. (1241 aa) |
| | BIRC5 | Uncharacterized protein. (164 aa) |
| | TRAPPC12 | Trafficking protein particle complex 12. (977 aa) |
| | NDC80 | NDC80 kinetochore complex component. (673 aa) |
| | CDK2 | Cyclin dependent kinase 2; Belongs to the protein kinase superfamily. (346 aa) |
| | DPF3 | Double PHD fingers 3. (388 aa) |
| | ACTR8 | Actin-related protein 8; Plays an important role in the functional organization of mitotic chromosomes. Exhibits low basal ATPase activity, and unable to polymerize; Belongs to the actin family. ARP8 subfamily. (624 aa) |
| | SMG5 | SMG5 nonsense mediated mRNA decay factor. (1151 aa) |
| | CTC1 | CST telomere replication complex component 1. (1251 aa) |
| | ENSOCUP00000035878 | Uncharacterized protein. (125 aa) |
| | MPHOSPH8 | M-phase phosphoprotein 8. (885 aa) |
| | ACTR5 | Actin related protein 5; Belongs to the actin family. (652 aa) |
| | HNRNPA2B1-2 | Heterogeneous nuclear ribonucleoprotein A2/B1. (340 aa) |
| | INO80D | INO80 complex subunit D. (1022 aa) |
| | WBP1 | WW domain binding protein 1. (388 aa) |
| | KAT5 | Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (620 aa) |
| | ENSOCUP00000039364 | Protein kinase domain-containing protein. (328 aa) |
| | NCAPH | Condensin complex subunit 2; Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. (734 aa) |
| | ENSOCUP00000039489 | Uncharacterized protein; Belongs to the TCP-1 chaperonin family. (77 aa) |
| | TENT4B | Terminal nucleotidyltransferase 4B. (471 aa) |
| | SMC4 | Structural maintenance of chromosomes protein. (1267 aa) |
| | NSMCE2 | NSE2 (MMS21) homolog, SMC5-SMC6 complex SUMO ligase. (282 aa) |
| | RB1 | RB transcriptional corepressor 1. (943 aa) |
| | SMARCD1 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 1. (525 aa) |
| | DYNC1LI1 | Dynein light intermediate chain; Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in binding dynein to membranous organelles or chromosomes. (586 aa) |
| | ENSOCUP00000042027 | Histone domain-containing protein. (116 aa) |
| | NFRKB | Nuclear factor related to kappaB binding protein. (1311 aa) |
| | XRCC1 | X-ray repair cross complementing 1. (610 aa) |
| | XRCC4 | X-ray repair cross complementing 4. (348 aa) |
| | DHX36 | DEAH-box helicase 36. (1468 aa) |
| | ENSOCUP00000044444 | MOEP19 domain-containing protein. (156 aa) |
| | LCMT1 | Leucine carboxyl methyltransferase 1; Methylates the carboxyl group of the C-terminal leucine residue of protein phosphatase 2A catalytic subunits to form alpha- leucine ester residues; Belongs to the methyltransferase superfamily. LCMT family. (343 aa) |
| | HNRNPU | Heterogeneous nuclear ribonucleoprotein U. (844 aa) |
| | FAM178B | Uncharacterized protein. (460 aa) |
| | ENSOCUP00000045898 | Protein kinase domain-containing protein. (192 aa) |
| | BUB1B | Uncharacterized protein. (1063 aa) |
| | SPDL1 | Protein Spindly; Required for the localization of dynein and dynactin to the mitotic kintochore. Dynein is believed to control the initial lateral interaction between the kinetochore and spindle microtubules and to facilitate the subsequent formation of end-on kinetochore-microtubule attachments mediated by the NDC80 complex. Also required for correct spindle orientation. Does not appear to be required for the removal of spindle assembly checkpoint (SAC) proteins from the kinetochore upon bipolar spindle attachment. (621 aa) |
| | AXIN2 | Axin 2. (816 aa) |
| | RUVBL2 | RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding. (463 aa) |
| | YLPM1 | YLP motif containing 1. (1853 aa) |
| | ZNF304 | Zinc finger protein 304. (676 aa) |
| | CCT2 | Uncharacterized protein. (576 aa) |
| | FBXO42 | F-box protein 42. (761 aa) |
| | SMARCD3 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3. (565 aa) |
| | EXOSC10 | Exosome component 10. (934 aa) |
| | ENSOCUP00000049162 | Histone acetyltransferase; Belongs to the acetyltransferase family. GCN5 subfamily. (793 aa) |
| | SMG6 | SMG6 nonsense mediated mRNA decay factor. (1435 aa) |
| | ENSOCUP00000049983 | Uncharacterized protein. (319 aa) |
