STRINGSTRING
DYSF DYSF LBP LBP TLR9 TLR9 GRN GRN LOC100348748 LOC100348748 JUN JUN ENSOCUP00000039002 ENSOCUP00000039002 ENSOCUP00000038700 ENSOCUP00000038700 JMJD6 JMJD6 ADGRF5 ADGRF5 NMI NMI SLC11A1 SLC11A1 IL13 IL13 PLA2G10 PLA2G10 TLR4 TLR4 CSF2 CSF2 IFI35 IFI35 PLA2G3 PLA2G3 CLU CLU FER1L5 FER1L5 TNF TNF FOXP1 FOXP1 CX3CL1 CX3CL1 APP APP PLCG2 PLCG2 IFNGR1 IFNGR1 L3HYPDH L3HYPDH PRKCE PRKCE IL33 IL33 CRTC3 CRTC3 WNK4 WNK4 JAK2 JAK2 SYK SYK TLR3 TLR3 SUCNR1 SUCNR1 TMEM106A TMEM106A AGER AGER TREX1 TREX1 PLA2G10-2 PLA2G10-2 AIF1 AIF1 TYROBP TYROBP C5AR1 C5AR1 CX3CR1 CX3CR1 IL4 IL4 IFNGR2 IFNGR2 C1QA C1QA
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
DYSFDysferlin. (2121 aa)
LBPLipopolysaccharide-binding protein; Plays a role in the innate immune response. Binds to the lipid A moiety of bacterial lipopolysaccharides (LPS), a glycolipid present in the outer membrane of all Gram-negative bacteria. Acts as an affinity enhancer for CD14, facilitating its association with LPS (By similarity). Promotes the release of cytokines in response to bacterial lipopolysaccharide. Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family. (496 aa)
TLR9TIR domain-containing protein. (1027 aa)
GRNGranulin precursor. (626 aa)
LOC100348748IGv domain-containing protein. (604 aa)
JUNBZIP domain-containing protein; Belongs to the bZIP family. (352 aa)
ENSOCUP00000039002Uncharacterized protein. (163 aa)
ENSOCUP00000038700Uncharacterized protein. (149 aa)
JMJD6Jumonji domain containing 6, arginine demethylase and lysine hydroxylase. (410 aa)
ADGRF5Adhesion G protein-coupled receptor F5; Belongs to the G-protein coupled receptor 2 family. (1405 aa)
NMIN-myc and STAT interactor. (367 aa)
SLC11A1Uncharacterized protein. (552 aa)
IL13Interleukin 13. (138 aa)
PLA2G10Phospholipase A(2). (163 aa)
TLR4TIR domain-containing protein; Belongs to the Toll-like receptor family. (839 aa)
CSF2Uncharacterized protein. (144 aa)
IFI35Uncharacterized protein. (371 aa)
PLA2G3Phospholipase A2 group III. (636 aa)
CLUClusterin alpha chain; Functions as extracellular chaperone that prevents aggregation of non native proteins. Prevents stress-induced aggregation of blood plasma proteins. Inhibits formation of amyloid fibrils by APP, APOC2, B2M, CALCA, CSN3, SNCA and aggregation-prone LYZ variants (in vitro). Does not require ATP. Maintains partially unfolded proteins in a state appropriate for subsequent refolding by other chaperones, such as HSPA8/HSC70. Does not refold proteins by itself. Binding to cell surface receptors triggers internalization of the chaperone-client complex and subsequent lysos [...] (518 aa)
FER1L5Fer-1 like family member 5. (2028 aa)
TNFTumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (234 aa)
FOXP1Fork-head domain-containing protein. (714 aa)
CX3CL1C-X3-C motif chemokine ligand 1. (404 aa)
APPGamma-secretase C-terminal fragment 57; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those medi [...] (769 aa)
PLCG21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1267 aa)
IFNGR1Interferon gamma receptor 1. (471 aa)
L3HYPDHTrans-L-3-hydroxyproline dehydratase. (354 aa)
PRKCEProtein kinase C epsilon type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays essential roles in the regulation of multiple cellular processes linked to cytoskeletal proteins, such as cell adhesion, motility, migration and cell cycle, functions in neuron growth and ion channel regulation, and is involved in immune response, cancer cell invasion and regulation of apoptosis. Mediates cell adhesion to the extracellular matrix via integrin- dependent signaling, by mediating angiotensin-2-induced activation of integrin beta- [...] (744 aa)
IL33Uncharacterized protein. (142 aa)
CRTC3CREB regulated transcription coactivator 3. (621 aa)
WNK4WNK lysine deficient protein kinase 4. (1266 aa)
JAK2Tyrosine-protein kinase. (1132 aa)
SYKTyrosine-protein kinase. (630 aa)
TLR3TIR domain-containing protein; Belongs to the Toll-like receptor family. (867 aa)
SUCNR1Succinate receptor 1; Belongs to the G-protein coupled receptor 1 family. (359 aa)
TMEM106ATransmembrane protein 106A. (257 aa)
AGERAdvanced glycosylation end-product specific receptor. (401 aa)
TREX1Three prime repair exonuclease 1. (314 aa)
PLA2G10-2Phospholipase A(2). (152 aa)
AIF1Allograft inflammatory factor 1. (147 aa)
TYROBPTYRO protein tyrosine kinase binding protein. (110 aa)
C5AR1C5a anaphylatoxin chemotactic receptor 1; Receptor for the chemotactic and inflammatory peptide anaphylatoxin C5a. The ligand interacts with at least two sites on the receptor: a high-affinity site on the extracellular N- terminus, and a second site in the transmembrane region which activates downstream signaling events. Receptor activation stimulates chemotaxis, granule enzyme release, intracellular calcium release and superoxide anion production (By similarity). (348 aa)
CX3CR1CX3C chemokine receptor 1; Receptor for the CX3C chemokine fractalkine (CX3CL1); binds to CX3CL1 and mediates both its adhesive and migratory functions. (356 aa)
IL4Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Positively regulates IL31RA expression in macrophages. Stimulates autophagy in dendritic cells by interfering with mTORC1 signaling and through the induction of RUFY4; Belongs to the IL- [...] (144 aa)
IFNGR2Interferon gamma receptor 2. (449 aa)
C1QAComplement C1q A chain. (324 aa)
Your Current Organism:
Oryctolagus cuniculus
NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits
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