35 items (Oryctolagus cuniculus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	CDK1	Cyclin dependent kinase 1; Belongs to the protein kinase superfamily. (297 aa)
	EFCAB7	EF-hand calcium binding domain 7. (624 aa)
	FLNA	Uncharacterized protein. (2617 aa)
	IPO5	Importin 5. (1082 aa)
	PIK3R1	Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
	HYAL2	Hyaluronidase. (475 aa)
	GLI3	GLI family zinc finger 3. (1575 aa)
	G1SV95_RABIT	Transforming growth factor beta; Belongs to the TGF-beta family. (387 aa)
	UBR5	Ubiquitin protein ligase E3 component n-recognin 5. (2769 aa)
	HDAC3	Histone deacetylase 3; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4), and some other non-histone substrates. Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (493 aa)
	LEP	Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] (167 aa)
	ZC3H12A	Zinc finger CCCH-type containing 12A. (580 aa)
	RBM22	RNA binding motif protein 22. (420 aa)
	BAG3	BCL2 associated athanogene 3. (805 aa)
	JUP	Junction plakoglobin. (745 aa)
	TPR	Translocated promoter region, nuclear basket protein. (2362 aa)
	HCLS1	Hematopoietic cell-specific Lyn substrate 1. (487 aa)
	PSEN1	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (557 aa)
	TRIM28	Tripartite motif containing 28. (857 aa)
	SHH	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. (451 aa)
	JAK2	Tyrosine-protein kinase. (1132 aa)
	PRKD1	Serine/threonine-protein kinase; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. (832 aa)
	ZPR1	Uncharacterized protein. (462 aa)
	CDH1	Cadherin 1; Cadherins are calcium-dependent cell adhesion proteins. (884 aa)
	B7NZQ1_RABIT	FLNA protein (Predicted). (780 aa)
	ECT2	Epithelial cell transforming 2. (952 aa)
	SMO	Smoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (787 aa)
	PRKCD	Uncharacterized protein. (807 aa)
	CHP2	Calcineurin like EF-hand protein 2. (229 aa)
	LOC103345451	TGFb_propeptide domain-containing protein. (203 aa)
	ENSOCUP00000037329	TGFb_propeptide domain-containing protein. (263 aa)
	ENSOCUP00000041840	TGFb_propeptide domain-containing protein. (219 aa)
	ENSOCUP00000044284	TGFb_propeptide domain-containing protein. (260 aa)
	ENSOCUP00000045925	TGFb_propeptide domain-containing protein. (272 aa)
	DMAP1	DNA methyltransferase 1 associated protein 1. (501 aa)

Your Current Organism:

Oryctolagus cuniculus

NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
B7NZQ1_RABIT	BAG3	ENSOCUP00000023360	ENSOCUP00000010054	FLNA protein (Predicted).	BCL2 associated athanogene 3.	0.565
B7NZQ1_RABIT	HCLS1	ENSOCUP00000023360	ENSOCUP00000010712	FLNA protein (Predicted).	Hematopoietic cell-specific Lyn substrate 1.	0.645
BAG3	B7NZQ1_RABIT	ENSOCUP00000010054	ENSOCUP00000023360	BCL2 associated athanogene 3.	FLNA protein (Predicted).	0.565
BAG3	FLNA	ENSOCUP00000010054	ENSOCUP00000000761	BCL2 associated athanogene 3.	Uncharacterized protein.	0.563
BAG3	PIK3R1	ENSOCUP00000010054	ENSOCUP00000004433	BCL2 associated athanogene 3.	Phosphoinositide-3-kinase regulatory subunit 1.	0.441
CDH1	HCLS1	ENSOCUP00000022250	ENSOCUP00000010712	Cadherin 1; Cadherins are calcium-dependent cell adhesion proteins.	Hematopoietic cell-specific Lyn substrate 1.	0.423
CDH1	JUP	ENSOCUP00000022250	ENSOCUP00000010375	Cadherin 1; Cadherins are calcium-dependent cell adhesion proteins.	Junction plakoglobin.	0.996
CDH1	PSEN1	ENSOCUP00000022250	ENSOCUP00000012504	Cadherin 1; Cadherins are calcium-dependent cell adhesion proteins.	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family.	0.775
CDK1	ECT2	ENSOCUP00000002479	ENSOCUP00000023606	Cyclin dependent kinase 1; Belongs to the protein kinase superfamily.	Epithelial cell transforming 2.	0.927
CDK1	FLNA	ENSOCUP00000002479	ENSOCUP00000000761	Cyclin dependent kinase 1; Belongs to the protein kinase superfamily.	Uncharacterized protein.	0.488
CDK1	JAK2	ENSOCUP00000002479	ENSOCUP00000014491	Cyclin dependent kinase 1; Belongs to the protein kinase superfamily.	Tyrosine-protein kinase.	0.416
CDK1	TPR	ENSOCUP00000002479	ENSOCUP00000010563	Cyclin dependent kinase 1; Belongs to the protein kinase superfamily.	Translocated promoter region, nuclear basket protein.	0.507
ECT2	CDK1	ENSOCUP00000023606	ENSOCUP00000002479	Epithelial cell transforming 2.	Cyclin dependent kinase 1; Belongs to the protein kinase superfamily.	0.927
ENSOCUP00000037329	ENSOCUP00000044284	ENSOCUP00000037329	ENSOCUP00000044284	TGFb_propeptide domain-containing protein.	TGFb_propeptide domain-containing protein.	0.412
ENSOCUP00000037329	HYAL2	ENSOCUP00000037329	ENSOCUP00000004554	TGFb_propeptide domain-containing protein.	Hyaluronidase.	0.411
ENSOCUP00000037329	JAK2	ENSOCUP00000037329	ENSOCUP00000014491	TGFb_propeptide domain-containing protein.	Tyrosine-protein kinase.	0.410
ENSOCUP00000037329	LEP	ENSOCUP00000037329	ENSOCUP00000008782	TGFb_propeptide domain-containing protein.	Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...]	0.408
ENSOCUP00000037329	LOC103345451	ENSOCUP00000037329	ENSOCUP00000031740	TGFb_propeptide domain-containing protein.	TGFb_propeptide domain-containing protein.	0.419
ENSOCUP00000044284	ENSOCUP00000037329	ENSOCUP00000044284	ENSOCUP00000037329	TGFb_propeptide domain-containing protein.	TGFb_propeptide domain-containing protein.	0.412
ENSOCUP00000044284	HYAL2	ENSOCUP00000044284	ENSOCUP00000004554	TGFb_propeptide domain-containing protein.	Hyaluronidase.	0.411