STRINGSTRING
BAX BAX LEF1 LEF1 TP63 TP63 GLI2 GLI2 ENSOCUP00000045925 ENSOCUP00000045925 ENSOCUP00000044284 ENSOCUP00000044284 ENSOCUP00000042043 ENSOCUP00000042043 ENSOCUP00000041840 ENSOCUP00000041840 HDAC2 HDAC2 HDAC1 HDAC1 ROGDI ROGDI ENSOCUP00000037329 ENSOCUP00000037329 RELT RELT STIM1 STIM1 ENSOCUP00000034777 ENSOCUP00000034777 CTNNB1 CTNNB1 LOC103345451 LOC103345451 ENSOCUP00000031222 ENSOCUP00000031222 ITGB6 ITGB6 SMO SMO TRAF6 TRAF6 LHX8 LHX8 G1U4G3_RABIT G1U4G3_RABIT AMBN AMBN KLK5 KLK5 BMP7 BMP7 ODAM ODAM WNT6 WNT6 FGF4 FGF4 CNNM4 CNNM4 EDAR EDAR DSPP DSPP BMPR1A BMPR1A SHH SHH ACVR2A ACVR2A HAND2 HAND2 SERPINE1 SERPINE1 EDA EDA SLC24A4 SLC24A4 TBX1 TBX1 FAM20A FAM20A HTRA1 HTRA1 SOSTDC1 SOSTDC1 ATF2 ATF2 SCN10A SCN10A SMPD3 SMPD3 HAND1 HAND1 BMP4 BMP4 G1T067_RABIT G1T067_RABIT NECTIN1 NECTIN1 ADM ADM PPARA PPARA FGF10 FGF10 G1SV95_RABIT G1SV95_RABIT DLX3 DLX3 NGFR NGFR BCL2L11 BCL2L11 ENAM ENAM GLI3 GLI3 WDR72 WDR72 KLK4 KLK4 NF2 NF2 FST FST PERP PERP DLX1 DLX1 ANKRD11 ANKRD11 MMP20 MMP20 AMTN AMTN LRP4 LRP4 PDGFRA PDGFRA
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
BAXBCL2 associated X, apoptosis regulator. (192 aa)
LEF1Lymphoid enhancer binding factor 1. (414 aa)
TP63Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. (680 aa)
GLI2GLI family zinc finger 2. (1575 aa)
ENSOCUP00000045925TGFb_propeptide domain-containing protein. (272 aa)
ENSOCUP00000044284TGFb_propeptide domain-containing protein. (260 aa)
ENSOCUP00000042043Ig-like domain-containing protein. (212 aa)
ENSOCUP00000041840TGFb_propeptide domain-containing protein. (219 aa)
HDAC2Histone deacetylase 2. (581 aa)
HDAC1Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (550 aa)
ROGDIRogdi atypical leucine zipper. (246 aa)
ENSOCUP00000037329TGFb_propeptide domain-containing protein. (263 aa)
RELTRELT TNF receptor. (465 aa)
STIM1Stromal interaction molecule 1. (789 aa)
ENSOCUP00000034777Uncharacterized protein. (55 aa)
CTNNB1Catenin beta 1. (741 aa)
LOC103345451TGFb_propeptide domain-containing protein. (203 aa)
ENSOCUP00000031222ANK_REP_REGION domain-containing protein. (421 aa)
ITGB6Integrin beta; Belongs to the integrin beta chain family. (787 aa)
SMOSmoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (787 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (552 aa)
LHX8LIM homeobox 8. (377 aa)
G1U4G3_RABITUncharacterized protein. (258 aa)
AMBNAmeloblastin. (421 aa)
KLK5Kallikrein related peptidase 5; Belongs to the peptidase S1 family. (349 aa)
BMP7TGF_BETA_2 domain-containing protein. (170 aa)
ODAMOdontogenic, ameloblast associated. (279 aa)
WNT6Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (338 aa)
FGF4Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (203 aa)
CNNM4Cyclin and CBS domain divalent metal cation transport mediator 4. (870 aa)
EDAREctodysplasin A receptor. (449 aa)
DSPPUncharacterized protein. (657 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
SHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (451 aa)
ACVR2ASerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (556 aa)
HAND2BHLH domain-containing protein. (426 aa)
SERPINE1Serpin family E member 1; Belongs to the serpin family. (362 aa)
EDAEctodysplasin A; Belongs to the tumor necrosis factor family. (386 aa)
SLC24A4Solute carrier family 24 member 4; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (613 aa)
TBX1Uncharacterized protein. (440 aa)
FAM20AFAM20A golgi associated secretory pathway pseudokinase. (539 aa)
HTRA1HtrA serine peptidase 1. (338 aa)
SOSTDC1Sclerostin domain containing 1. (206 aa)
ATF2Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. (498 aa)
SCN10ASodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (1814 aa)
SMPD3Sphingomyelin phosphodiesterase 3. (657 aa)
HAND1Heart- and neural crest derivatives-expressed protein 1; Transcription factor that plays an essential role in both trophoblast giant cell differentiation and in cardiac morphogenesis (By similarity). Binds the DNA sequence 5'-NRTCTG-3' (non-canonical E-box) (By similarity). Acts as a transcriptional repressor of SOX15 (By similarity). In the adult, could be required for ongoing expression of cardiac-specific genes (By similarity). (215 aa)
BMP4Bone morphogenetic protein 4; Induces cartilage and bone formation. Acts in concert with PTHLH/PTHRP to stimulate ductal outgrowth during embryonic mammary development and to inhibit hair follicle induction (By similarity). (409 aa)
G1T067_RABITFam20C domain-containing protein. (543 aa)
NECTIN1Nectin cell adhesion molecule 1. (514 aa)
ADMAdrenomedullin. (187 aa)
PPARAPeroxisome proliferator activated receptor alpha. (503 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (220 aa)
G1SV95_RABITTransforming growth factor beta; Belongs to the TGF-beta family. (387 aa)
DLX3Distal-less homeobox 3. (287 aa)
NGFRNerve growth factor receptor. (407 aa)
BCL2L11Bcl-2-like protein 11; Induces apoptosis and anoikis. Belongs to the Bcl-2 family. (194 aa)
ENAMEnamelin. (1134 aa)
GLI3GLI family zinc finger 3. (1575 aa)
WDR72WD repeat domain 72. (1111 aa)
KLK4Kallikrein related peptidase 4; Belongs to the peptidase S1 family. (257 aa)
NF2Neurofibromin 2. (626 aa)
FSTFollistatin. (310 aa)
PERPUncharacterized protein. (193 aa)
DLX1Distal-less homeobox 1. (255 aa)
ANKRD11Uncharacterized protein. (1815 aa)
MMP20Matrix metallopeptidase 20. (483 aa)
AMTNAmelotin. (194 aa)
LRP4LDL receptor related protein 4. (1899 aa)
PDGFRAProtein kinase domain-containing protein. (773 aa)
Your Current Organism:
Oryctolagus cuniculus
NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits
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