STRINGSTRING
ENSOCUP00000040571 ENSOCUP00000040571 DNAJA3 DNAJA3 GSN GSN ENSOCUP00000043309 ENSOCUP00000043309 ENSOCUP00000044347 ENSOCUP00000044347 MUL1 MUL1 PPM1F PPM1F XDH XDH CASP8AP2 CASP8AP2 REST REST G1SGB1_RABIT G1SGB1_RABIT CASP2 CASP2 PML PML ROBO1 ROBO1 FAM162A FAM162A AIFM1 AIFM1 RACK1 RACK1 CCN1 CCN1 NKX3-1 NKX3-1 PYCARD PYCARD NOD1 NOD1 BAX BAX VCP VCP TNF TNF G1SSE7_RABIT G1SSE7_RABIT BCL2L11 BCL2L11 NGFR NGFR PDCD2 PDCD2 ARL6IP5 ARL6IP5 S100A9 S100A9 NODAL NODAL ACVR1C ACVR1C S100A8 S100A8 TNFSF15 TNFSF15 APAF1 APAF1 G1T288_RABIT G1T288_RABIT ACER2 ACER2 EIF2AK3 EIF2AK3 HSPD1 HSPD1 HTRA2 HTRA2 MAP3K5 MAP3K5 BID BID CLEC7A CLEC7A JAK2 JAK2 SYK SYK LOC100354468 LOC100354468 LOC100346888 LOC100346888 G1TI49_RABIT G1TI49_RABIT G1TJ07_RABIT G1TJ07_RABIT GPER1 GPER1 LOC100341515 LOC100341515 FIS1 FIS1 RPS3 RPS3 LOC100344662 LOC100344662 ENSOCUP00000019830 ENSOCUP00000019830 MTCH1 MTCH1 LOC100353673 LOC100353673 CASP10 CASP10 F2R F2R CTSD CTSD G1TUF2_RABIT G1TUF2_RABIT G1TUQ7_RABIT G1TUQ7_RABIT LOC108178730 LOC108178730 LOC100340625 LOC100340625 PDCD5 PDCD5 DAPK1 DAPK1 CASP9 CASP9 ST18 ST18 BOK BOK LOC100357840 LOC100357840 FASLG FASLG DIABLO DIABLO SIRT1 SIRT1 P2RX1 P2RX1 ALOX12 ALOX12 PINX1 PINX1 ANP32B ANP32B BAK1 BAK1 SMAD3 SMAD3 SENP1 SENP1 GRAMD4 GRAMD4 DLC1 DLC1 PMAIP1 PMAIP1 F3 F3 HIP1 HIP1 LOC100359182 LOC100359182 TFAP4 TFAP4 ENSOCUP00000045399 ENSOCUP00000045399 MALT1 MALT1 HSF1 HSF1 CTSH CTSH FAS FAS ATP2A3 ATP2A3 ENSOCUP00000037600 ENSOCUP00000037600 UACA UACA IFT57 IFT57
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ENSOCUP00000040571MOEP19 domain-containing protein. (187 aa)
DNAJA3Uncharacterized protein. (479 aa)
GSNGelsolin. (828 aa)
ENSOCUP00000043309Uncharacterized protein. (105 aa)
ENSOCUP00000044347KH type-2 domain-containing protein. (196 aa)
MUL1Mitochondrial E3 ubiquitin protein ligase 1. (352 aa)
PPM1FProtein phosphatase, Mg2+/Mn2+ dependent 1F. (446 aa)
XDHUncharacterized protein. (1333 aa)
CASP8AP2Caspase 8 associated protein 2. (1950 aa)
RESTRE1 silencing transcription factor. (930 aa)
G1SGB1_RABITMOEP19 domain-containing protein. (121 aa)
CASP2Caspase 2; Belongs to the peptidase C14A family. (451 aa)
PMLPromyelocytic leukemia. (860 aa)
ROBO1Roundabout guidance receptor 1. (1651 aa)
FAM162AFamily with sequence similarity 162 member A. (155 aa)
AIFM1Apoptosis inducing factor mitochondria associated 1. (613 aa)
RACK1WD_REPEATS_REGION domain-containing protein. (424 aa)
CCN1Cellular communication network factor 1. (386 aa)
NKX3-1NK3 homeobox 1. (159 aa)
PYCARDPYD and CARD domain containing. (196 aa)
NOD1Nucleotide binding oligomerization domain containing 1. (953 aa)
BAXBCL2 associated X, apoptosis regulator. (192 aa)
VCPValosin containing protein; Belongs to the AAA ATPase family. (806 aa)
TNFTumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (234 aa)
G1SSE7_RABITUncharacterized protein; Belongs to the peptidase C14A family. (306 aa)
BCL2L11Bcl-2-like protein 11; Induces apoptosis and anoikis. Belongs to the Bcl-2 family. (194 aa)
NGFRNerve growth factor receptor. (407 aa)
PDCD2Programmed cell death 2. (344 aa)
ARL6IP5PRA1 family protein. (188 aa)
S100A9Protein S100-A9; S100A9 is a calcium- and zinc-binding protein which plays a prominent role in the regulation of inflammatory processes and immune response. It can induce neutrophil chemotaxis, adhesion, can increase the bactericidal activity of neutrophils by promoting phagocytosis via activation of SYK, PI3K/AKT, and ERK1/2 and can induce degranulation of neutrophils by a MAPK-dependent mechanism. Predominantly found as calprotectin (S100A8/A9) which has a wide plethora of intra- and extracellular functions. The intracellular functions include: facilitating leukocyte arachidonic acid [...] (132 aa)
NODALNodal growth differentiation factor. (348 aa)
ACVR1CReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (493 aa)
S100A8Protein S100; Belongs to the S-100 family. (89 aa)
TNFSF15TNF superfamily member 15. (340 aa)
APAF1Apoptotic peptidase activating factor 1. (1183 aa)
G1T288_RABITCytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (104 aa)
ACER2Alkaline ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid. (292 aa)
EIF2AK3Eukaryotic translation initiation factor 2 alpha kinase 3. (1033 aa)
HSPD1Uncharacterized protein; Belongs to the chaperonin (HSP60) family. (573 aa)
HTRA2HtrA serine peptidase 2. (458 aa)
MAP3K5Mitogen-activated protein kinase kinase kinase 5. (1316 aa)
BIDBH3-interacting domain death agonist; Counters the protective effect of Bcl-2. (210 aa)
CLEC7AC-type lectin domain containing 7A. (247 aa)
JAK2Tyrosine-protein kinase. (1132 aa)
SYKTyrosine-protein kinase. (630 aa)
LOC100354468Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
LOC100346888MOEP19 domain-containing protein. (127 aa)
G1TI49_RABITWD_REPEATS_REGION domain-containing protein. (223 aa)
G1TJ07_RABITMOEP19 domain-containing protein. (155 aa)
GPER1G protein-coupled estrogen receptor 1; Belongs to the G-protein coupled receptor 1 family. (361 aa)
LOC100341515Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
FIS1Fission, mitochondrial 1. (207 aa)
RPS3Ribosomal protein S3; Belongs to the universal ribosomal protein uS3 family. (281 aa)
LOC100344662Uncharacterized protein. (469 aa)
ENSOCUP00000019830annotation not available (105 aa)
MTCH1Mitochondrial carrier 1; Belongs to the mitochondrial carrier (TC 2.A.29) family. (419 aa)
LOC100353673Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (153 aa)
CASP10Caspase-10; Belongs to the peptidase C14A family. (469 aa)
F2RCoagulation factor II thrombin receptor; Belongs to the G-protein coupled receptor 1 family. (460 aa)
CTSDPeptidase A1 domain-containing protein; Belongs to the peptidase A1 family. (255 aa)
G1TUF2_RABITUncharacterized protein. (103 aa)
G1TUQ7_RABITCytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
LOC108178730Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
LOC100340625ANK_REP_REGION domain-containing protein. (324 aa)
PDCD5Programmed cell death 5. (181 aa)
DAPK1Death associated protein kinase 1. (1493 aa)
CASP9Caspase 9; Belongs to the peptidase C14A family. (466 aa)
ST18ST18 C2H2C-type zinc finger transcription factor. (1072 aa)
BOKBCL2 family apoptosis regulator BOK. (145 aa)
LOC100357840Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
FASLGFas ligand; Belongs to the tumor necrosis factor family. (259 aa)
DIABLOUncharacterized protein. (272 aa)
SIRT1Sirtuin 1. (748 aa)
P2RX1P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. (399 aa)
ALOX12Arachidonate 12-lipoxygenase, 12S type. (663 aa)
PINX1PIN2 (TERF1) interacting telomerase inhibitor 1. (364 aa)
ANP32BAcidic nuclear phosphoprotein 32 family member B. (321 aa)
BAK1BCL2 antagonist/killer 1. (210 aa)
SMAD3SMAD family member 3. (230 aa)
SENP1SUMO specific peptidase 1. (645 aa)
GRAMD4GRAM domain containing 4. (603 aa)
DLC1DLC1 Rho GTPase activating protein. (1590 aa)
PMAIP1Phorbol-12-myristate-13-acetate-induced protein 1. (54 aa)
F3Tissue factor; Initiates blood coagulation by forming a complex with circulating factor VII or VIIa. The [TF:VIIa] complex activates factors IX or X by specific limited proteolysis. TF plays a role in normal hemostasis by initiating the cell-surface assembly and propagation of the coagulation protease cascade. (397 aa)
HIP1Huntingtin interacting protein 1. (1088 aa)
LOC100359182Amino acid transporter. (665 aa)
TFAP4Transcription factor AP-4. (585 aa)
ENSOCUP00000045399Uncharacterized protein. (182 aa)
MALT1MALT1 paracaspase. (799 aa)
HSF1Heat shock transcription factor 1. (680 aa)
CTSHUncharacterized protein; Belongs to the peptidase C1 family. (601 aa)
FASUncharacterized protein. (484 aa)
ATP2A3Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1074 aa)
ENSOCUP00000037600MOEP19 domain-containing protein. (173 aa)
UACAUveal autoantigen with coiled-coil domains and ankyrin repeats. (1418 aa)
IFT57Intraflagellar transport 57. (452 aa)
Your Current Organism:
Oryctolagus cuniculus
NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits
Server load: low (32%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.