STRINGSTRING
MMP8 MMP8 LAMTOR5 LAMTOR5 NIBAN2 NIBAN2 POU4F1 POU4F1 G1SV95_RABIT G1SV95_RABIT ACD ACD IRF4 IRF4 EP300 EP300 DDRGK1 DDRGK1 POU4F2 POU4F2 HAND2 HAND2 EGF EGF TRIM28 TRIM28 JAK2 JAK2 TXN TXN ENSOCUP00000037329 ENSOCUP00000037329 CTNNB1 CTNNB1 LOC103345451 LOC103345451 ITGA2 ITGA2 ERCC2 ERCC2 TRAF6 TRAF6 NME1 NME1 MMP9 MMP9 MYOCD MYOCD HES1 HES1 PARK2 PARK2 IGF1 IGF1 ISL1 ISL1 ENSOCUP00000045925 ENSOCUP00000045925 ENSOCUP00000044284 ENSOCUP00000044284 ENSOCUP00000043061 ENSOCUP00000043061 ENSOCUP00000042868 ENSOCUP00000042868 PLAUR PLAUR ENSOCUP00000041840 ENSOCUP00000041840 RB1 RB1 SIRT2 SIRT2 PARK7 PARK7 PAX6 PAX6 PARP1 PARP1 GATA3 GATA3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
MMP8Matrix metallopeptidase 8. (355 aa)
LAMTOR5Late endosomal/lysosomal adaptor, MAPK and MTOR activator 5. (91 aa)
NIBAN2Niban apoptosis regulator 2. (709 aa)
POU4F1POU domain protein. (339 aa)
G1SV95_RABITTransforming growth factor beta; Belongs to the TGF-beta family. (387 aa)
ACDUncharacterized protein. (136 aa)
IRF4Interferon regulatory factor 4. (451 aa)
EP300E1A binding protein p300. (2418 aa)
DDRGK1DDRGK domain containing 1. (418 aa)
POU4F2POU domain protein. (392 aa)
HAND2BHLH domain-containing protein. (426 aa)
EGFPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1198 aa)
TRIM28Tripartite motif containing 28. (857 aa)
JAK2Tyrosine-protein kinase. (1132 aa)
TXNThioredoxin; Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions (By similarity). Plays a role in the reversible S-nitrosylation of cysteine residues in target proteins, and thereby contributes to the response to intracellular nitric oxide. Nitrosylates the active site Cys of CASP3 in response to nitric oxide (NO), and thereby inhibits caspase-3 activity. Induces the FOS/JUN AP-1 DNA binding activity in ionizing radiation (IR) cells through its oxidation/reduction status [...] (105 aa)
ENSOCUP00000037329TGFb_propeptide domain-containing protein. (263 aa)
CTNNB1Catenin beta 1. (741 aa)
LOC103345451TGFb_propeptide domain-containing protein. (203 aa)
ITGA2Integrin subunit alpha 2; Belongs to the integrin alpha chain family. (1202 aa)
ERCC2ERCC excision repair 2, TFIIH core complex helicase subunit. (805 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (552 aa)
NME1Nucleoside diphosphate kinase. (152 aa)
MMP9Matrix metalloproteinase-9; Could play a role in bone osteoclastic resorption. Cleaves type IV and type V collagen into large C-terminal three quarter fragments and shorter N-terminal one quarter fragments (By similarity). (707 aa)
MYOCDMyocardin. (989 aa)
HES1Hes family bHLH transcription factor 1. (279 aa)
PARK2E3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. (394 aa)
IGF1Insulin-like growth factor I; The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]- 2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse maturation. Ca(2+)-dependent exo [...] (195 aa)
ISL1ISL LIM homeobox 1. (349 aa)
ENSOCUP00000045925TGFb_propeptide domain-containing protein. (272 aa)
ENSOCUP00000044284TGFb_propeptide domain-containing protein. (260 aa)
ENSOCUP00000043061Uncharacterized protein. (103 aa)
ENSOCUP00000042868RBR-type E3 ubiquitin transferase. (139 aa)
PLAURPlasminogen activator, urokinase receptor. (365 aa)
ENSOCUP00000041840TGFb_propeptide domain-containing protein. (219 aa)
RB1RB transcriptional corepressor 1. (943 aa)
SIRT2Sirtuin 2. (509 aa)
PARK7Parkinsonism associated deglycase. (231 aa)
PAX6Uncharacterized protein. (436 aa)
PARP1Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair. (1013 aa)
GATA3GATA binding protein 3. (444 aa)
Your Current Organism:
Oryctolagus cuniculus
NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits
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