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FGFBP1 FGFBP1 CIB1 CIB1 ANXA1 ANXA1 PRKD1 PRKD1 ETS1 ETS1 PRKCA PRKCA G1U7S6_RABIT G1U7S6_RABIT NOS3 NOS3 NFE2L2 NFE2L2 PDGFB PDGFB LOC103345451 LOC103345451 FGF18 FGF18 CD40 CD40 MAP3K3 MAP3K3 SP1 SP1 ENSOCUP00000037329 ENSOCUP00000037329 HIF1A HIF1A AKT3 AKT3 FGFR1 FGFR1 ENSOCUP00000041840 ENSOCUP00000041840 ANGPT1 ANGPT1 SRPX2 SRPX2 NUS1 NUS1 HSPB1 HSPB1 HMOX1 HMOX1 ADAM17 ADAM17 G1SV95_RABIT G1SV95_RABIT PLK2 PLK2 ATP5F1B ATP5F1B RHOJ RHOJ KDR KDR AMOT AMOT NRP1 NRP1 ATP5F1A ATP5F1A THBS1 THBS1 P2RX4 P2RX4 PDPK1 PDPK1 FGF2 FGF2 ENSOCUP00000044284 ENSOCUP00000044284 PLCG1 PLCG1 ENSOCUP00000045925 ENSOCUP00000045925 PRKD2 PRKD2 ANGPT4 ANGPT4 ALOX12 ALOX12 SIRT1 SIRT1 JCAD JCAD VEGFC VEGFC
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
FGFBP1Fibroblast growth factor binding protein 1. (245 aa)
CIB1Uncharacterized protein. (143 aa)
ANXA1Annexin A1; Plays important roles in the innate immune response as effector of glucocorticoid-mediated responses and regulator of the inflammatory process. Has anti-inflammatory activity. Plays a role in glucocorticoid-mediated down-regulation of the early phase of the inflammatory response. Promotes resolution of inflammation and wound healing (By similarity). Functions at least in part by activating the formyl peptide receptors and downstream signaling cascades. Promotes chemotaxis of granulocytes and monocytes via activation of the formyl peptide receptors (By similarity). Contribut [...] (334 aa)
PRKD1Serine/threonine-protein kinase; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. (832 aa)
ETS1Uncharacterized protein. (533 aa)
PRKCAProtein kinase C alpha type; Calcium-activated, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that is involved in positive and negative regulation of cell proliferation, apoptosis, differentiation, migration and adhesion, cardiac hypertrophy, angiogenesis, platelet function and inflammation, by directly phosphorylating targets such as RAF1, BCL2, CSPG4, TNNT2/CTNT, or activating signaling cascades involving MAPK1/3 (ERK1/2) and RAP1GAP. Depending on the cell type, is involved in cell proliferation and cell growth arrest by positive and negative regul [...] (664 aa)
G1U7S6_RABITUncharacterized protein. (209 aa)
NOS3Nitric oxide synthase; Produces nitric oxide (NO). (1209 aa)
NFE2L2Nuclear factor, erythroid 2 like 2. (677 aa)
PDGFBPlatelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (272 aa)
LOC103345451TGFb_propeptide domain-containing protein. (203 aa)
FGF18Fibroblast growth factor 18; Belongs to the heparin-binding growth factors family. (231 aa)
CD40Uncharacterized protein. (494 aa)
MAP3K3Mitogen-activated protein kinase kinase kinase 3. (681 aa)
SP1Sp1 transcription factor. (792 aa)
ENSOCUP00000037329TGFb_propeptide domain-containing protein. (263 aa)
HIF1AUncharacterized protein. (851 aa)
AKT3Non-specific serine/threonine protein kinase. (511 aa)
FGFR1Fibroblast growth factor receptor. (823 aa)
ENSOCUP00000041840TGFb_propeptide domain-containing protein. (219 aa)
ANGPT1Angiopoietin 1. (551 aa)
SRPX2Sushi repeat containing protein X-linked 2. (465 aa)
NUS1NUS1 dehydrodolichyl diphosphate synthase subunit. (293 aa)
HSPB1Heat shock protein family B (small) member 1; Belongs to the small heat shock protein (HSP20) family. (204 aa)
HMOX1Heme oxygenase 1. (288 aa)
ADAM17ADAM metallopeptidase domain 17. (827 aa)
G1SV95_RABITTransforming growth factor beta; Belongs to the TGF-beta family. (387 aa)
PLK2Serine/threonine-protein kinase PLK. (666 aa)
ATP5F1BATP synthase subunit beta; Produces ATP from ADP in the presence of a proton gradient across the membrane. (528 aa)
RHOJRas homolog family member J. (214 aa)
KDRUncharacterized protein; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1356 aa)
AMOTAngiomotin. (1091 aa)
NRP1Neuropilin; Belongs to the neuropilin family. (950 aa)
ATP5F1AATP synthase subunit alpha; Produces ATP from ADP in the presence of a proton gradient across the membrane. (553 aa)
THBS1Thrombospondin 1. (1171 aa)
P2RX4P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. (387 aa)
PDPK13-phosphoinositide dependent protein kinase 1; Belongs to the protein kinase superfamily. (325 aa)
FGF2Fibroblast growth factor 2; Acts as a ligand for FGFR1, FGFR2, FGFR3 and FGFR4. Also acts as an integrin ligand which is required for FGF2 signaling. Binds to integrin ITGAV:ITGB3. Plays an important role in the regulation of cell survival, cell division, cell differentiation and cell migration. Functions as a potent mitogen in vitro. Can induce angiogenesis. Belongs to the heparin-binding growth factors family. (155 aa)
ENSOCUP00000044284TGFb_propeptide domain-containing protein. (260 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1266 aa)
ENSOCUP00000045925TGFb_propeptide domain-containing protein. (272 aa)
PRKD2Serine/threonine-protein kinase; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. (870 aa)
ANGPT4Angiopoietin 4. (487 aa)
ALOX12Arachidonate 12-lipoxygenase, 12S type. (663 aa)
SIRT1Sirtuin 1. (748 aa)
JCADJunctional cadherin 5 associated. (1271 aa)
VEGFCVascular endothelial growth factor C; Belongs to the PDGF/VEGF growth factor family. (418 aa)
Your Current Organism:
Oryctolagus cuniculus
NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits
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