32 items (Oryctolagus cuniculus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

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protein homology

Your Input:
	PDGFRA	Protein kinase domain-containing protein. (773 aa)
	FGF2	Fibroblast growth factor 2; Acts as a ligand for FGFR1, FGFR2, FGFR3 and FGFR4. Also acts as an integrin ligand which is required for FGF2 signaling. Binds to integrin ITGAV:ITGB3. Plays an important role in the regulation of cell survival, cell division, cell differentiation and cell migration. Functions as a potent mitogen in vitro. Can induce angiogenesis. Belongs to the heparin-binding growth factors family. (155 aa)
	PDGFRB	Platelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. (1147 aa)
	PIK3R4	Phosphoinositide-3-kinase regulatory subunit 4. (1373 aa)
	LYN	Tyrosine-protein kinase. (636 aa)
	G1SV95_RABIT	Transforming growth factor beta; Belongs to the TGF-beta family. (387 aa)
	FGR	Tyrosine-protein kinase. (527 aa)
	TNFAIP8L3	TNF alpha induced protein 8 like 3. (204 aa)
	NOD2	Nucleotide oligomerization domain 2 protein. (1013 aa)
	EPHA8	EPH receptor A8. (973 aa)
	TEK	TEK receptor tyrosine kinase. (1025 aa)
	FLT1	Fms related tyrosine kinase 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1479 aa)
	PTK2B	Protein tyrosine kinase 2 beta; Belongs to the protein kinase superfamily. Tyr protein kinase family. (996 aa)
	CCL21	C-C motif chemokine ligand 21. (131 aa)
	CDC42-2	Uncharacterized protein. (222 aa)
	LOC100358984	Uncharacterized protein; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (857 aa)
	PDGFB	Platelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (272 aa)
	LOC103345451	TGFb_propeptide domain-containing protein. (203 aa)
	ERBB4	Receptor protein-tyrosine kinase. (1308 aa)
	VAV3	Vav guanine nucleotide exchange factor 3. (964 aa)
	CD19	CD19 molecule. (573 aa)
	ENSOCUP00000037329	TGFb_propeptide domain-containing protein. (263 aa)
	CCL19	C-C motif chemokine. (109 aa)
	ENSOCUP00000041840	TGFb_propeptide domain-containing protein. (219 aa)
	ENSOCUP00000042043	Ig-like domain-containing protein. (212 aa)
	AMBRA1	Autophagy and beclin 1 regulator 1. (1300 aa)
	ENSOCUP00000044284	TGFb_propeptide domain-containing protein. (260 aa)
	ENSOCUP00000045925	TGFb_propeptide domain-containing protein. (272 aa)
	ATG14	Autophagy related 14. (551 aa)
	ENSOCUP00000047273	Uncharacterized protein. (231 aa)
	CDC42	Uncharacterized protein. (191 aa)
	ENSOCUP00000049280	SCY domain-containing protein. (136 aa)

Your Current Organism:

Oryctolagus cuniculus

NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AMBRA1	ATG14	ENSOCUP00000044129	ENSOCUP00000046270	Autophagy and beclin 1 regulator 1.	Autophagy related 14.	0.994
AMBRA1	PIK3R4	ENSOCUP00000044129	ENSOCUP00000002161	Autophagy and beclin 1 regulator 1.	Phosphoinositide-3-kinase regulatory subunit 4.	0.977
ATG14	AMBRA1	ENSOCUP00000046270	ENSOCUP00000044129	Autophagy related 14.	Autophagy and beclin 1 regulator 1.	0.994
ATG14	PIK3R4	ENSOCUP00000046270	ENSOCUP00000002161	Autophagy related 14.	Phosphoinositide-3-kinase regulatory subunit 4.	0.999
CCL19	CCL21	ENSOCUP00000038810	ENSOCUP00000020728	C-C motif chemokine.	C-C motif chemokine ligand 21.	0.946
CCL19	CD19	ENSOCUP00000038810	ENSOCUP00000036537	C-C motif chemokine.	CD19 molecule.	0.617
CCL21	CCL19	ENSOCUP00000020728	ENSOCUP00000038810	C-C motif chemokine ligand 21.	C-C motif chemokine.	0.946
CCL21	CD19	ENSOCUP00000020728	ENSOCUP00000036537	C-C motif chemokine ligand 21.	CD19 molecule.	0.605
CD19	CCL19	ENSOCUP00000036537	ENSOCUP00000038810	CD19 molecule.	C-C motif chemokine.	0.617
CD19	CCL21	ENSOCUP00000036537	ENSOCUP00000020728	CD19 molecule.	C-C motif chemokine ligand 21.	0.605
CD19	FGF2	ENSOCUP00000036537	ENSOCUP00000000416	CD19 molecule.	Fibroblast growth factor 2; Acts as a ligand for FGFR1, FGFR2, FGFR3 and FGFR4. Also acts as an integrin ligand which is required for FGF2 signaling. Binds to integrin ITGAV:ITGB3. Plays an important role in the regulation of cell survival, cell division, cell differentiation and cell migration. Functions as a potent mitogen in vitro. Can induce angiogenesis. Belongs to the heparin-binding growth factors family.	0.451
CD19	LYN	ENSOCUP00000036537	ENSOCUP00000002661	CD19 molecule.	Tyrosine-protein kinase.	0.909
CD19	VAV3	ENSOCUP00000036537	ENSOCUP00000036367	CD19 molecule.	Vav guanine nucleotide exchange factor 3.	0.734
CDC42	ERBB4	ENSOCUP00000047724	ENSOCUP00000035750	Uncharacterized protein.	Receptor protein-tyrosine kinase.	0.507
CDC42	FGF2	ENSOCUP00000047724	ENSOCUP00000000416	Uncharacterized protein.	Fibroblast growth factor 2; Acts as a ligand for FGFR1, FGFR2, FGFR3 and FGFR4. Also acts as an integrin ligand which is required for FGF2 signaling. Binds to integrin ITGAV:ITGB3. Plays an important role in the regulation of cell survival, cell division, cell differentiation and cell migration. Functions as a potent mitogen in vitro. Can induce angiogenesis. Belongs to the heparin-binding growth factors family.	0.450
CDC42	FGR	ENSOCUP00000047724	ENSOCUP00000007706	Uncharacterized protein.	Tyrosine-protein kinase.	0.533
CDC42	FLT1	ENSOCUP00000047724	ENSOCUP00000017088	Uncharacterized protein.	Fms related tyrosine kinase 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	0.410
CDC42	LYN	ENSOCUP00000047724	ENSOCUP00000002661	Uncharacterized protein.	Tyrosine-protein kinase.	0.601
CDC42	PTK2B	ENSOCUP00000047724	ENSOCUP00000018603	Uncharacterized protein.	Protein tyrosine kinase 2 beta; Belongs to the protein kinase superfamily. Tyr protein kinase family.	0.503
CDC42	VAV3	ENSOCUP00000047724	ENSOCUP00000036367	Uncharacterized protein.	Vav guanine nucleotide exchange factor 3.	0.892